Emotion regulation among Chinese and German children and adolescents: a binational comparative study

peer reviewedEmotion regulation has been a central research topic in developmental psychology and psychopathology for several decades. Habitual use of adaptive (e.g., cognitive reappraisal) or maladaptive strategies (e.g., expressive suppression) may influence psychosocial adjustment in children and adolescents. Despite consensus on the influence of culture on emotion regulation, little is known about cultural differences in emotion regulation in children and adolescents. In this study, the Emotion Regulation Questionnaire for Children and Adolescents (ERQ-CA) was used and tested for its measurement invariance between Chinese and German children and adolescents. Cultural similarities and differences in the use of cognitive reappraisal and expressive suppression were examined, as well as the associations of these strategies with behavior problems and prosocial behavior. The sample consisted of 765 Chinese and 431 German students (Mage = 12.46 years, SD = 1.12). Multi-group confirmatory factor analysis revealed partial scalar measurement invariance of the ERQ-CA. A latent mean comparison showed more frequent use of both strategies in Chinese compared to German students. The results of the multi-group structural equation model showed similar patterns of relationships between emotion regulation strategies and youth behavior across groups. Cognitive reappraisal was associated with fewer behavior problems and more prosocial behavior, whereas expressive suppression was related to more behavior problems. In summary, the current findings indicate that the ERQ-CA allows comparisons of emotion regulation between Chinese and German children and adolescents. Furthermore, the relevance of the cultural context for emotion regulation and the promotion of adaptive regulation strategies is highlighted

Effect of Developmentally Adapted Cognitive Processing Therapy for Youth With Symptoms of Posttraumatic Stress Disorder After Childhood Sexual and Physical Abuse

Importance: Despite the high prevalence, evidence-based treatments for abuse-related posttraumatic stress disorder (PTSD) in adolescents have rarely been studied. Objective: To examine whether developmentally adapted cognitive processing therapy (D-CPT) is more effective than a wait-list condition with treatment advice (WL/TA) among adolescents with PTSD related to childhood abuse. Design, Setting, and Participants: This rater-blinded, multicenter, randomized clinical trial (stratified by center) enrolled treatment-seeking adolescents and young adults (aged 14-21 years) with childhood abuse-related PTSD at 3 university outpatient clinics in Germany from July 2013 to June 2015, with the last follow-up interview conducted by May 2016. Of 194 patients, 88 were eligible for randomization. Interventions: Participants received D-CPT or WL/TA. Cognitive processing therapy was enhanced by a motivational and alliance-building phase, by including emotion regulation and consideration of typical developmental tasks, and by higher session frequency in the trauma-focused core CPT phase. In WL/TA, participants received treatment advice with respective recommendations of clinicians and were offered D-CPT after 7 months. Main Outcomes and Measures: All outcomes were assessed before treatment (baseline), approximately 8 weeks after the start of treatment, after the end of treatment (posttreatment), and at the 3-month follow-up. The primary outcome, PTSD symptom severity, was assessed in clinical interview (Clinician-Administered PTSD Scale for Children and Adolescents for DSM-IV [CAPS-CA]). Secondary outcomes were self-reported PTSD severity, depression, borderline symptoms, behavior problems, and dissociation. Results: The 88 participants (75 [85%] female) had a mean age of 18.1 years (95% CI, 17.6-18.6 years). In the intention-to-treat analysis, the 44 participants receiving D-CPT (39 [89%] female) demonstrated greater improvement than the 44 WL/TA participants (36 [82%] female) in terms of PTSD severity (mean CAPS-CA scores, 24.7 [95% CI, 16.6-32.7] vs 47.5 [95% CI, 37.9-57.1]; Hedges g = 0.90). This difference was maintained through the follow-up (mean CAPS-CA scores, 25.9 [95% CI, 16.2-35.6] vs 47.3 [95% CI, 37.8-56.8]; Hedges g = 0.80). Treatment success was greatest during the trauma-focused core phase. The D-CPT participants also showed greater and stable improvement in all secondary outcomes, with between-groups effect sizes ranging from 0.65 to 1.08 at the posttreatment assessment (eg, for borderline symptoms, 14.1 [95% CI, 8.0-20.2] vs 32.0 [95% CI, 23.8-40.2]; Hedges g = 0.91). Conclusions and Relevance: Adolescents and young adults with abuse-related PTSD benefited more from D-CPT than from WL/TA. Treatment success was stable at the follow-up and generalized to borderline symptoms and other comorbidities

Differences between water permeability of astomatous and stomatous cuticular membranes: effects of air humidity in two species of contrasting drought-resistance strategy

Cuticular water permeabilities of adaxial and abaxial leaf surfaces and their dependence on relative air humidity (RH) applied in long-term and short-term regimes have been analysed for Hedera helix, native in a temperate climate, and Zamioculcas zamiifolia, native in subtropical regions. The water permeability of cuticular membranes (CM) isolated from the adaxial (astomatous) and abaxial (stomatous) leaf sides was measured using a method which allowed the separation of water diffusion through the remnants of the original stomatal pores from water diffusion through the solid cuticle. The long-term effects of low (20–40%) or high (60–80%) RH applied during plant growth and leaf ontogeny (‘growth RH’) and the short-term effects of applying 2% or 100% RH while measuring permeability (‘measurement RH’) were investigated. With both species, water permeability of the solid stomatous CM was significantly higher than the permeability of the astomatous CM. Adaxial cuticles of plants grown in humid air were more permeable to water than those from dry air. The adaxial CM of the drought-tolerant H. helix was more permeable and more sensitive to growth RH than the adaxial CM of Z. zamiifolia, a species avoiding water stress. However, permeability of the solid abaxial CM was similar in both species and independent of growth RH. The lack of a humidity response in the abaxial CM is attributed to a higher degree of cuticular hydration resulting from stomatal transpiration. The ecophysiological significance of higher permeability of the solid stomatous CM compared to the astomatous CM is discussed

Laseranwendung in der Augenheilkunde

Die Augenheilkunde stellt eine der medizinischen Fachdisziplinen dar, die Laserstrahlung schon sehr früh einsetzten und heute bei verschiedenen Erkrankungen anwenden. Zur Diagnostik und Therapie der Glaukome, bei Netzhauterkrankungen, aber auch zur Behandlung von Fehlsichtigkeiten werden verschiedene Lasertypen erfolgreich eingesetzt.Ophthalmology represents a medical field where laser technology was established very early and where lasers are nowadays frequently used. In the diagnosis and treatment of glaucoma, for treatment of retinal disorders as well as for refractive surgery different types of lasers are used

Jahrbuch Wirtschaftsrecht Schweiz – EU - Überblick und Kommentar 2023/24

Der vorliegende 19. Band der Jahrbuchreihe „Wirtschaftsrecht Schweiz – EU“ dokumentiert die aktuellen Entwicklungen in zentralen Bereichen des EU-Wirtschaftsrechts und deren Bedeutung für die Schweiz. Berücksichtigt werden diverse wirtschaftsrelevante Rechtsgebiete, u.a. Kapitalmarktrecht, Immaterialgüterrecht, Arbeitsrecht, Steuerrecht und Wettbewerbsrecht. Das Jahrbuch richtet sich an Unternehmens‑, Wirtschafts- und VerwaltungsjuristInnen sowie an RichterInnen und RechtsanwältInnen und bietet ihnen einen kompakten Überblick über die wichtigsten Gesetzgebungsvorstösse, neue Rechtsakte und ergangene Urteile im vergangenen Jahr 2023. Auch diese Ausgabe des Jahrbuchs erscheint wiederum im Verlag EIZ Publishing, und zwar als frei verfügbares E-Book (open access) sowie in gedruckter Form (print on demand)

Jahrbuch Wirtschaftsrecht Schweiz - EU - Überblick und Kommentar 2022/23

Der vorliegende 18. Band der Jahrbuchreihe „Wirtschaftsrecht Schweiz – EU“ dokumentiert die aktuellen Entwicklungen in zentralen Bereichen des EU-Wirtschaftsrechts und deren Bedeutung für die Schweiz. Berücksichtigt werden diverse wirtschaftsrelevante Rechtsgebiete, u.a. Kapitalmarktrecht, Immaterialgüterrecht, Arbeitsrecht, Steuerrecht und Wettbewerbsrecht. Das Jahrbuch richtet sich an Unternehmens-, Wirtschafts- und VerwaltungsjuristInnen sowie an RichterInnen und RechtsanwältInnen und bietet ihnen einen kompakten Überblick über die wichtigsten Gesetzgebungsvorstösse, neue Rechtsakte und ergangene Urteile im vergangenen Jahr 2022

Chromosome-scale genome assembly provides insights into rye biology, evolution and agronomic potential

Rye (Secale cereale L.) is an exceptionally climate-resilient cereal crop, used extensively to produce improved wheat varieties via introgressive hybridization and possessing the entire repertoire of genes necessary to enable hybrid breeding. Rye is allogamous and only recently domesticated, thus giving cultivated ryes access to a diverse and exploitable wild gene pool. To further enhance the agronomic potential of rye, we produced a chromosome-scale annotated assembly of the 7.9-gigabase rye genome and extensively validated its quality by using a suite of molecular genetic resources. We demonstrate applications of this resource with a broad range of investigations. We present findings on cultivated rye's incomplete genetic isolation from wild relatives, mechanisms of genome structural evolution, pathogen resistance, low-temperature tolerance, fertility control systems for hybrid breeding and the yield benefits of rye-wheat introgressions.Peer reviewe

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value &lt; 1 × 10-5) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p &lt; 1 × 10-5). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52 × 10-10, odds ratio 1.15 [1.10-1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04-1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression