Agglutinated foraminifera from the Turonian–Coniacian boundary interval in Europe – paleoenvironmental remarks and stratigraphy

Agglutinated foraminiferal assemblages of the Turonian–Coniacian from the GSSP (Global Boundary Stratotype Section and Point) of Salzgitter–Salder (Subhercynian Cretaceous Basin, Germany) and other sections, including Bielefeld–Ostwestfalendamm (Münsterland Cretaceous Basin, Germany) and the Dover–Langdon Stairs (Anglo-Paris Basin, England), from the temperate European shelf realm were studied in order to collect additional stratigraphic and paleoenvironmental information. Stable carbon isotopes were measured for the Bielefeld–Ostwestfalendamm section to establish a reliable stratigraphic correlation with other sections. Highly diverse agglutinated foraminiferal assemblages were obtained from sections in the German basins, whereas the fauna from Dover is less rich in taxa and less abundant. In the German basinal sections, a morphogroup analysis of agglutinated foraminifera and the calculated diversities imply normal marine settings and oligotrophic to mesotrophic bottom-water conditions. Furthermore, acmes of agglutinated foraminifera correlate between different sections and can be used for paleoenvironmental analysis. Three acmes of the species Ammolagena contorta are recorded for the Turonian–Coniacian (perplexus to lower striatoconcentricus zones, lower scupini Zone, and hannovrensis Zone) and likely imply a shift to more oligotrophic bottom-water conditions. In the upper scupini Zone below the Turonian–Coniacian boundary, an acme of Bulbobaculites problematicus likely indicates enhanced nutrient availability. In general, agglutinated foraminiferal morphogroups display a gradual shift from Turonian oligotrophic environments towards more mesotrophic conditions in the latest Turonian and Coniacian

What Works in Early Childhood Education Programs?: A Meta-Analysis of Preschool Enhancement Programs

Research Findings: This study uses data from a comprehensive meta-analytic database of early childhood education (ECE) program evaluations published between 1960 and 2007 in the United States to examine the incremental effects of adding enhancement program components to ECE programs on children’s cognitive abilities, pre-academic skills, behavioral, health, and socio-emotional outcomes. Preschool enhancement programs include parenting programs, skill-based curricula, and teacher professional development programming. Our findings suggest that the addition of parent programs and skill-based curricula to ECE programs can result in improvements to a range of children’s ECE outcomes leading to better school readiness. We found no differences in the impacts of ECE programs with or without additional professional development enhancements. Practice or Policy: Designing fully-developed parent programs by explicitly targeting parents, developing academically focused and skill-based curricula, and providing additional teacher professional development enhancements to existing ECE programs can have a substantial impact on a range of children’s ECE outcomes leading to better school readiness. Further research is needed in order to determine what conditions are essential to enhancement program success as well as what conditions have negligible effects on or inhibit children’s school readiness

A Survey of NAPNAP Members’ Clinical and Professional Research Priorities

Introduction The purpose of this methodological article is to describe the development, implementation, and analysis of the survey used to determine NAPNAP members\u27 ranking of research priorities, to describe the top priorities ranked by participants, and to determine if priorities differed by area of practice (primary, acute, or specialty care) or participant age. Method A cross-sectional descriptive design with an online survey was used. Completed by 324 NAPNAP members, the survey consisted of a demographic section and 90 statements in two domains: Clinical Priorities and Professional Role Priorities. Results Survey respondents strongly supported the top priorities with an average overall mean score of 4.0 or above on a 5-point Likert scale. Only three of the top 10 clinical and professional priorities differed by area of practice. No clinical priorities and only three professional priorities differed by age. Discussion The survey results were used to develop the NAPNAP Research Agenda. Both the survey results and the agenda can provide guidance for the NAPNAP Board, committees and interests groups as they develop initiatives and programs

Transcriptional profiling of rat hypothalamus response to 2,3,7,8-tetrachlorodibenzo-p-dioxin

In some mammals, halogenated aromatic hydrocarbon (HAH) exposure causes wasting syndrome, defined as significant weight loss associated with lethal outcomes. The most potent HAH in causing wasting is 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD), which exerts its toxic effects through the aryl hydrocarbon receptor (AHR). Since TCDD toxicity is thought to predominantly arise from dysregulation of AHR-transcribed genes, it was hypothesized that wasting syndrome is a result of to TCDD-induced dysregulation of genes involved in regulation of food-intake. As the hypothalamus is the central nervous systems' regulatory center for food-intake and energy balance. Therefore, mRNA abundances in hypothalamic tissue from two rat strains with widely differing sensitivities to TCDD-induced wasting syndrome: TCDD-sensitive Long-Evans rats and TCDD-resistant Han/Wistar rats, 23 h after exposure to TCDD (100 mu g/kg) or corn oil vehicle. TCDD exposure caused minimal transcriptional dysregulation in the hypothalamus, with only 6 genes significantly altered in Long-Evans rats and 15 genes in Han/Wistar rats. Two of the most dysregulated genes were Cyp1a1 and Nqo1, which are induced by TCDD across a wide range of tissues and are considered sensitive markers of TCDD exposure. The minimal response of the hypothalamic transcriptome to a lethal dose of TCDD at an early time-point suggests that the hypothalamus is not the predominant site of initial events leading to hypophagia and associated wasting. TCDD may affect feeding behaviour via events upstream or downstream of the hypothalamus, and further work is required to evaluate this at the level of individual hypothalamic nuclei and subregions. (C) 2014 The Authors. Published by Elsevier Ireland Ltd.Peer reviewe

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

Peer reviewe

Genomic analyses in Cornelia de Lange Syndrome and related diagnoses: Novel candidate genes, <scp>genotype–phenotype</scp> correlations and common mechanisms

Cornelia de Lange Syndrome (CdLS) is a rare, dominantly inherited multisystem developmental disorder characterized by highly variable manifestations of growth and developmental delays, upper limb involvement, hypertrichosis, cardiac, gastrointestinal, craniofacial, and other systemic features. Pathogenic variants in genes encoding cohesin complex structural subunits and regulatory proteins (NIPBL, SMC1A, SMC3, HDAC8, and RAD21) are the major pathogenic contributors to CdLS. Heterozygous or hemizygous variants in the genes encoding these five proteins have been found to be contributory to CdLS, with variants in NIPBL accounting for the majority (&gt;60%) of cases, and the only gene identified to date that results in the severe or classic form of CdLS when mutated. Pathogenic variants in cohesin genes other than NIPBL tend to result in a less severe phenotype. Causative variants in additional genes, such as ANKRD11, EP300, AFF4, TAF1, and BRD4, can cause a CdLS‐like phenotype. The common role that these genes, and others, play as critical regulators of developmental transcriptional control has led to the conditions they cause being referred to as disorders of transcriptional regulation (or “DTRs”). Here, we report the results of a comprehensive molecular analysis in a cohort of 716 probands with typical and atypical CdLS in order to delineate the genetic contribution of causative variants in cohesin complex genes as well as novel candidate genes, genotype–phenotype correlations, and the utility of genome sequencing in understanding the mutational landscape in this population

Dissociating neural signatures of mental state retrodiction and classification based on facial expressions

Posed facial expressions of actors have often been used as stimuli to induce mental state inferences, in order to investigate “Theory of Mind” processes. However, such stimuli make it difficult to determine whether perceivers are using a basic or more elaborated mentalizing strategy. The current study used as stimuli covert recordings of target individuals who viewed various emotional expressions, which caused them to spontaneously mimic these expressions. Perceivers subsequently judged these subtle emotional expressions of the targets: In one condition (“classification”) participants were instructed to classify the target’s expression (i.e., match it to a sample) and in another condition (“retrodicting”) participants were instructed to retrodict (i.e., infer which emotional expression the target was viewing). When instructed to classify, participants showed more prevalent activations in event-related brain potentials (ERPs) at earlier and mid-latency ERP components N170, P200 and P300-600. By contrast, when instructed to retrodict participants showed enhanced late frontal and rontotemporal ERPs (N800-1000), with more sustained activity over the right than the left hemisphere. These findings reveal different cortical processes involved when retrodicting about a facial expression compared to merely classifying it, despite comparable performance on the behavioural tas