〈Research Note〉A Corpus-Linguistic Analysis of Media Discourses on Nuclear Phaseout in Japan, 2011-2014

The Fukushima Daiichi nuclear disaster led to catastrophic environmental and economic consequences in Japan, leading to a temporary shift in public attitudes towards nuclear energy not only in Japan but globally. In 2011, the Japanese DPJ-led government gained worldwide attention for their plan to phaseout.However, while some countries seized the opportunity to transition away from nuclear energy and to expand the use of renewable energy sources, the succeeding Japanese government eventually decided to restart nuclear plants in 2012 and to continue to rely on nuclear energy in its energy mix for the time being, despite growing public distrust in the safety of nuclear facilities.In this article, we will present the results of a corpus-assisted discourse analysis of the contexts and framings of nuclear phase-out by contrasting data from one newspaper (Yomiuri Shinbun) and social media (Twitter) in the period of 2011-2014. Our analysis not only shows the growing media convergence between social media and the mass media and thus their close interrelatedness but also instances in whichsocial media has become more influential than the legacy media outlets

Transforming identities and co-constructing careers of career counselors

New theories for practice, which take account of contextual shifts such as labor market volatility, are essential for maintaining the professional status of career counseling. Career construction theory (CCT), as an exemplar of an innovative, contextually sensitive approach not only provides a way of making sense of the turbulent landscapes in which career transitions are taking place, but also provides practical tools to facilitate individual adaptation to change. However, development and evaluation of new theories and related tools have tended to overlook the career development and support needs of career counselors in the adoption and integration of these approaches into their practice with clients, as well as into their own career development. Here, the focus is on supporting the continuing professional development of career counselors as crucial for the enhancement of practice, through the provision in 2017 of an open access online learning program relating to the changing world of work, with facilitation of dialogue and reflection. The adaptive responses of an international group of participants facing challenges of identity transformation in the workplace, which emerged as they worked through the online learning resource, are examined. Four hundred and two international participants registered, with 86 actively engaging in the course, which was made available over three months, with content analysis of their online dialogue providing insights into the processes of psycho-social adaptation to the career-related challenges they faced. The learning design and course delivery were underpinned by the theory of professional identity transformation (PIT), with a commitment to supporting participants both individually collectively to shape their evolving roles and identities in ways compatible with their life themes. In order to progress toward that goal, processes of co-construction, also central to career construction theory, emerged strongly from the content analysis of data

Erratum to: ‘Early prediction of acute kidney injury after transapical and transaortic aortic valve implantation with urinary G1 cell cycle arrest biomarkers’

Background: Acute kidney injury (AKI) is a common complication following transcatheter aortic valve implantation (TAVI) leading to increased mortality and morbidity. Urinary G1 cell cycle arrest proteins TIMP-2 and IGFBP7 have recently been suggested as sensitive biomarkers for early detection of AKI in critically ill patients. However, the precise role of urinary TIMP-2 and IGFBP7 in patients undergoing TAVI is unknown. Methods: In a prospective observational trial, 40 patients undergoing TAVI (either transaortic or transapical) were enrolled. Serial measurements of TIMP-2 and IGFBP7 were performed in the early post interventional course. The primary clinical endpoint was the occurrence of AKI stage 2/3 according to the KDIGO classification. Results: Now we show, that ROC analyses of [TIMP-2]*[IGFBP7] on day one after TAVI reveals a sensitivity of 100 % and a specificity of 90 % for predicting AKI 2/3 (AUC 0.971, 95 % CI 0.914-1.0, SE 0.0299, p = 0.001, cut-off 1.03). In contrast, preoperative and postoperative serum creatinine levels as well as glomerular filtration rate (GFR) and perioperative change in GFR did not show any association with the development of AKI. Furthermore, [TIMP2]*[IGFBP7] remained stable in patients with AKI = 1, but its levels increased significantly as early as 24 h after TAVI in patients who developed AKI 2/3 in the further course (4.77 +/- 3.21 vs. 0.48 +/- 0.68, p = 0.022). Mean patients age was 81.2 +/- 5.6 years, 16 patients were male (40.0 %). 35 patients underwent transapical and five patients transaortic TAVI. 15 patients (37.5 %) developed any kind of AKI;eight patients (20 %) met the primary endpoint and seven patients required renal replacement therapy (RRT) within 72 h after surgery. Conclusion: Early elevation of urinary cell cycle arrest biomarkers after TAVI is associated with the development of postoperative AKI. [TIMP-2]*[ IGFBP7] provides an excellent diagnostic accuracy in the prediction of AKI that is superior to that of serum creatinine

Design of Active Waweguide OMT for Radio Astronomy Receiver Array in the 3 MM Band

We describe the design of an integrated cryogenic receiver module based on an “active” waveguide Orthomode Transducer (OMT) for dual-polarization radio astronomy observations across 75-116 GHz (3-mm band). The receiver module consists of passive and active sections that can be incorporated in a very compact mechanical assembly suitable for integration in a focal plane array. The passive section of the receiver module employs a broadband backward-coupler waveguide OMT while the active section consists of ultra-low noise MMIC (Monolithic Microwave Integrated Circuit) amplifiers

Design of Power Stage of INAF GAIA Board for biasing of AETHRA WP1 downconverter

The GAIA digital board developed by INAF was designed to bias up to ten stages of cryogenic low noise amplifiers (LNAs) and to deliver a maximum drain current Idmax50 mA with a drain voltage Vdmax5 V for each of them. The GAIA board monitors and controls each of the stages independently. However, such board cannot be employed to monitor and control the AETHRA WP1 75-116 GHz downconverter module as the power amplifiers of the fully-integrated MMIC developed at IAF, integrated into the downconverter module, require current values of up to 300 mA each, that is six times greater than what GAIA can deliver. Therefore, a power stage of the GAIA board has to be developed to comply with the high-current bias requirements of the AETHRA WP1 downconverter. Here, we describe the design of the power stage of the GAIA board, named PSG (Power Stage Gaia). The PSG is a four-layer digital bias board, to be connected in series with GAIA, capable of delivering up to 10 × high-current stages. One GAIA board is used to monitor and control one PSG board. The latter is an extension of GAIA and cannot be used independently of it. Therefore, one GAIA board plus one PSG board must be used in conjunction to monitor and control up to 10 high-current stages of the AETHRA WP1 downconverter. The version 1.2 of the GAIA board, developed for biasing, monitoring and controlling of the LNAs, cannot be used in conjunction with the PSG but requires a small modification to allow data interchange between the two boards. A new GAIA board, version 1.5, must be used in conjunction with the PSG

Silica in Protoplanetary Disks

Mid-infrared spectra of a few T Tauri stars (TTS) taken with the Infrared Spectrograph (IRS) on board the Spitzer Space Telescope show prominent narrow emission features indicating silica (crystalline silicon dioxide). Silica is not a major constituent of the interstellar medium; therefore, any silica present in the circumstellar protoplanetary disks of TTS must be largely the result of processing of primitive dust material in the disks surrouding these stars. We model the silica emission features in our spectra using the opacities of various polymorphs of silica and their amorphous versions computed from earth-based laboratory measurements. This modeling indicates that the two polymorphs of silica, tridymite and cristobalite, which form at successively higher temperatures and low pressures, are the dominant forms of silica in the TTS of our sample. These high temperature, low pressure polymorphs of silica present in protoplanetary disks are consistent with a grain composed mostly of tridymite named Ada found in the cometary dust samples collected from the STARDUST mission to Comet 81P/Wild 2. The silica in these protoplanetary disks may arise from incongruent melting of enstatite or from incongruent melting of amorphous pyroxene, the latter being analogous to the former. The high temperatures of 1200K-1300K and rapid cooling required to crystallize tridymite or cristobalite set constraints on the mechanisms that could have formed the silica in these protoplanetary disks, suggestive of processing of these grains during the transient heating events hypothesized to create chondrules.Comment: 47 pages, 9 figures, to appear in the 1 January, 2009 issue of the Astrophysical Journa

A genome-wide association study identifies an association between variants in EFCAB4B gene and periodontal disease in an Italian isolated population

Background and Objective: Periodontitis in one of the most prevalent dental dis- eases. Despite numerous studies have investigated its aetiopathogenetic factors, few works have focused on its genetic predisposition and most of them took into account only candidate genes. Therefore, we conducted a Genome Wide Association Study in an Italian isolated population aimed at uncovering genetic variants that pre- dispose to this disorder. Methods: Diagnosis of chronic periodontitis was made following the criteria of the American Academy of Periodontology. Patients with chronic periodontitis were grouped into different categories: slight, severe, localized and generalized. A control group composed by people without signs of periodontitis or gingivitis was defined. DNA was genotyped using 370k Illumina chips. Linear mixed model regression was used to test the association between each single nucleotide polymorphism (SNP) (in- dependent variable) and the periodontitis status (dependent variable), controlling for confounders sex, age and smoking. The genomic kinship matrix was also used as random effect. Results: Four SNPs on the gene EFCAB4B resulted significantly associated to local- ized periodontitis (P < 5 7 10 128), with the best hit on the rs242016 SNP (P = 1.5 7 10 128). Conclusions: We have identified a novel significant association between the EFCAB4B gene and localized periodontitis. These results open a new perspective in the understanding of genetic factors contributing to this common disorder

Perfusion CT best predicts outcome after radioembolization of liver metastases: a comparison of radionuclide and CT imaging techniques

Objective: To determine the best predictor for the response to and survival with transarterial radioembolisation (RE) with 90yttrium microspheres in patients with liver metastases. Methods: Forty consecutive patients with liver metastases undergoing RE were evaluated with multiphase CT, perfusion CT and 99mTc-MAA SPECT. Arterial perfusion (AP) from perfusion CT, HU values from the arterial (aHU) and portal venous phase (pvHU) CT, and 99mTc-MAA uptake ratio of metastases were determined. Morphologic response was evaluated after 4months and available in 30 patients. One-year survival was calculated with Kaplan-Meier curves. Results: We found significant differences between responders and non-responders for AP (P 20ml/100ml/min had a significantly (P = 0.01) higher 1-year survival, whereas an aHU value >55 HU did not discriminate survival (P = 0.12). The Cox proportional hazard model revealed AP as the only significant (P = 0.02) independent predictor of survival. Conclusion: Compared to arterial and portal venous enhancement and the 99mTc-MAA uptake ratio of liver metastases, the AP from perfusion CT is the best predictor of morphologic response to and 1-year survival with RE. Key Points : • Perfusion CT allows for calculation of the liver arterial perfusion. • Arterial perfusion of liver metastases differs between responders and non-responders to RE. • Arterial perfusion can be used to select patients responding to RE

SDSS-IV MaNGA: the spatial distribution of star formation and its dependence on mass, structure, and environment

We study the spatially resolved star formation of 1494 galaxies in the SDSS-IV MaNGA Survey. Star formation rates (SFRs) are calculated using a two-step process, using H α in star-forming regions and Dn4000 in regions identified as active galactic nucleus/low-ionization (nuclear) emission region [AGN/LI(N)ER] or lineless. The roles of secular and environmental quenching processes are investigated by studying the dependence of the radial profiles of specific star formation rate on stellar mass, galaxy structure, and environment. We report on the existence of ‘centrally suppressed’ galaxies, which have suppressed Specific Star Formation Rate (SSFR) in their cores compared to their discs. The profiles of centrally suppressed and unsuppressed galaxies are distributed in a bimodal way. Galaxies with high stellar mass and core velocity dispersion are found to be much more likely to be centrally suppressed than low-mass galaxies, and we show that this is related to morphology and the presence of AGN/LI(N)ER like emission. Centrally suppressed galaxies also display lower star formation at all radii compared to unsuppressed galaxies. The profiles of central and satellite galaxies are also compared, and we find that satellite galaxies experience lower specific star formation rates at all radii than central galaxies. This uniform suppression could be a signal of the stripping of hot halo gas in the process known as strangulation. We find that satellites are not more likely to be suppressed in their cores than centrals, indicating that the core suppression is an entirely internal process. We find no correlation between the local environment density and the profiles of star formation rate surface density

Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19

The high incidence of thrombotic events suggests a possible role of the contact system pathway in COVID-19 pathology. Here, we demonstrate altered levels of factor XII (FXII) and its activation products in critically ill COVID-19 patients in comparison to patients with severe acute respiratory distress syndrome due to influenza virus (ARDS-influenza). Compatible with this data, we report rapid consumption of FXII in COVID-19, but not in ARDS-influenza, plasma. Interestingly, the lag phase in fibrin formation, triggered by the FXII activator kaolin, was not prolonged in COVID-19 as opposed to ARDS-influenza. Using confocal and electron microscopy, we showed that increased FXII activation rate, in conjunction with elevated fibrinogen levels, triggers formation of fibrinolysis-resistant, compact clots with thin fibers and small pores in COVID-19. Accordingly, clot lysis was markedly impaired in COVID-19 as opposed to ARDS-infleunza subjects. Dysregulatated fibrinolytic system, as evidenced by elevated levels of thrombin-activatable fibrinolysis inhibitor, tissue-plasminogen activator, and plasminogen activator inhibitor-1 in COVID-19 potentiated this effect. Analysis of lung tissue sections revealed wide-spread extra- and intra-vascular compact fibrin deposits in COVID-19 patients. Together, compact fibrin network structure and dysregulated fibrinolysis may collectively contribute to high incidence of thrombotic events in COVID-19