Prévalence des critères échocardiographiques de non-compaction du ventricule gauche au sein d'une population non sélectionnée d'un laboratoire d'échocardiographie

DIJON-BU Médecine Pharmacie (212312103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

In Situ Determination of the Structural Properties of Initially Deposited Polyelectrolyte Multilayers

International audienc

Optimized and controlled provisioning of encrypted outsourced data

International audienceRecent advances in encrypted outsourced databases support the direct processing of queries on encrypted data. Depending on functionality (i.e. operators) required in the queries the database has to use different encryption schemes with different security properties. Next to these functional requirements a security administrator may have to address security policies that may equally determine the used encryption schemes. We present an algorithm and tool set that determines an optimal balance between security and functionality as well as helps to identify and resolve possible conflicts. We test our solution on a database benchmark and business-driven security policies

Plant pathogens as agroterrorist weapons: assessment of the threat for European agriculture and forestry

Agroterrorism, Anti-crop bioweapons, Crop biosecurity, Foresight, Plant pathogens, Risk assessment,

Microrefugia, Climate Change, and Conservation of Cedrus atlantica in the Rif Mountains, Morocco

International audienceThis study reconstructs and interprets the changing range of Atlas cedar in northern Morocco over the last 9,000 years. A synthesis of fossil pollen records indicated that Atlas cedars occupied a wider range at lower elevations during the mid-Holocene than today. The mid-Holocene geographical expansion reflected low winter temperatures and higher water availability over the whole range of the Rif Mountains relative to modern conditions. A trend of increasing aridity observed after 6,000 years BP progressively reduced the range of Atlas cedar and prompted its migration toward elevations above 1,400 masl. To assess the impact of climate change on cedar populations over the last decades, we performed a transient model simulation for the period between 1960 and 2010. Our simulation showed that the range of Atlas cedar decreased by about 75% over the last 50 years and that the eastern populations of the range in the Rif Mountains were even more threatened by the overall lack of water availability than the western ones. Today, Atlas cedar populations in the Rif Mountains are persisting in restricted and isolated areas (Jbel Kelti, Talassemtane, Jbel Tiziren, Oursane, Tidighine) that we consider to be modern microrefugia. Conservation of these isolated populations is essential for the future survival of the species, preserving polymorphisms and the potential for population recovery under different climatic conditions

The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification.

The PAR-domain basic leucine zipper (PAR bZip) transcription factors DBP, TEF, and HLF accumulate in a highly circadian manner in several peripheral tissues, including liver and kidney. Mice devoid of all three of these proteins are born at expected Mendelian ratios, but are epilepsy prone, age at an accelerated rate, and die prematurely. In the hope of identifying PAR bZip target genes whose altered expression might contribute to the high morbidity and mortality of PAR bZip triple knockout mice, we compared the liver and kidney transcriptomes of these animals to those of wild-type or heterozygous mutant mice. These experiments revealed that PAR bZip proteins control the expression of many enzymes and regulators involved in detoxification and drug metabolism, such as cytochrome P450 enzymes, carboxylesterases, and constitutive androstane receptor (CAR). Indeed, PAR bZip triple knockout mice are hypersensitive to xenobiotic compounds, and the deficiency in detoxification may contribute to their early aging

Fractional Flow Reserve to Guide Treatment of Patients With Multivessel Coronary Artery Disease

International audienc