Progettare e condurre l\u27apprendimento in rete: un corso blended per futuri insegnanti

What are the main issues connected with the design and development of distance learning courses? How to plan effective courses taking into account the context requirements, the contents to be delivered, the learning needs, the resources available? This paper analyses the instructional design decisions and the delivery strategies of a blended course in Educational Technology, run by ITD-CNR for the local Postgraduate School for Secondary Teaching. The course designers developed criteria for harmonising and integrating the face-to-face and the online course components, with the aim to take advantage of their specific features. These criteria derive from a model that comprises four dimensions: the cognitive dimension, focused on the course themes and contents; the teaching dimension, focused on the teaching and learning strategies; the social dimension, focused on the interaction among participants, and the meta-cognitive dimension, focused on the reflection on the learning path and the teaching profession.Quali sono le problematiche che emergono nella progettazione e nella conduzione di iniziative di formazione in rete? Come riuscire a tener conto delle caratteristiche del contesto di formazione e della popolazione obiettivo, dei contenuti e degli obiettivi didattici per proporre interventi efficaci? In questo contributo si mettono a fuoco i principali criteri che sono stati seguiti nella progettazione e conduzione di un corso blended erogato dall\u27ITD-CNR nell\u27ambito della Scuola di Specializzazione per l\u27Insegnamento Secondario dell\u27Universit? degli Studi di Genova. Particolare attenzione ? dedicata agli aspetti che hanno contribuito a creare o rinsaldare i legami tra le attivit? svolte in presenza e quelle effettuate online. La presentazione ? organizzata intorno a quattro aspetti: a livello cognitivo, sui temi e i contenuti oggetto del corso; a livello didattico, sulle strategie di insegnamento che sono state messe in atto al fine di facilitare i processi di apprendimento; a livello sociale, sulle interazioni tra i partecipanti e sulla costituzione della comunit? di apprendimento; e, infine, a livello metacognitivo, sulla riflessione inerente il percorso di apprendimento e la professione dell\u27insegnante

Online learning: attitudes, expectations and prejudices of adult novices

The main attitudes, expectations and misconceptions of adult novices towards online learning have been investigated through a survey carried out within two different web-based courses. The data emerged from the two contexts showed several similarities: the reasons for the choice of the online approach, a positive perception of the method, a negative perception of the heavy commitment required, some resistance due to logistic and cultural difficulties. The main misconceptions include the tendency to overestimate the time flexibility offered by the collaborative approach and the inclination to underestimate the commitment required and the educational potential of written communication

Cardiovascular mitochondrial dysfunction induced by cocaine: biomarkers and possible beneficial effects of modulators of oxidative stress

Cocaine abuse has long been known to cause morbidity and mortality due to its cardiovascular toxic effects. The pathogenesis of the cardiovascular toxicity of cocaine use has been largely reviewed, and the most recent data indicate a fundamental role of oxidative stress in cocaine-induced cardiovascular toxicity, indicating that mitochondrial dysfunction is involved in the mechanisms of oxidative stress. The comprehension of the mechanisms involving mitochondrial dysfunction could help in selecting the most appropriate mitochondria injury biological marker, such as superoxide dismutase-2 activity and glutathionylated hemoglobin. The potential use of modulators of oxidative stress (mitoubiquinone, the short-chain quinone idebenone, and allopurinol) in the treatment of cocaine cardiotoxic effects is also suggested to promote further investigations on these potential mitochondria-targeted antioxidant strategies

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours

Enhancement of cellular senescence in tumours triggers a stable cell growth arrest and activation of an antitumour immune response that can be exploited for cancer therapy. Currently, there are only a limited number of targeted therapies that act by increasing senescence in cancers, but the majority of them are not selective and also target healthy cells. Here we developed a chemogenomic screening to identify compounds that enhance senescence in PTEN-deficient cells without affecting normal cells. By using this approach, we identified casein kinase 2 (CK2) as a pro-senescent target. Mechanistically, we show that Pten loss increases CK2 levels by activating STAT3. CK2 upregulation in Pten null tumours affects the stability of Pml, an essential regulator of senescence. However, CK2 inhibition stabilizes Pml levels enhancing senescence in Pten null tumours. Taken together, our screening strategy has identified a novel STAT3-CK2-PML network that can be targeted for pro-senescence therapy for cancer

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

EVALITA Evaluation of NLP and Speech Tools for Italian - December 17th, 2020

Welcome to EVALITA 2020! EVALITA is the evaluation campaign of Natural Language Processing and Speech Tools for Italian. EVALITA is an initiative of the Italian Association for Computational Linguistics (AILC, http://www.ai-lc.it) and it is endorsed by the Italian Association for Artificial Intelligence (AIxIA, http://www.aixia.it) and the Italian Association for Speech Sciences (AISV, http://www.aisv.it)

Familles laborieuses. Rémunération, transmission et apprentissage dans les ateliers familiaux de la fin du Moyen Âge à l’époque contemporaine en Europe

International audienc

What is work? Gender at the Crossroads between Home, Family and Business from the Early Modern Era to the Present. Introduction

International audienc