The role of interparticle interaction and environmental coupling in a two-particle open quantum system

The effects of bath coupling on an interacting two-particle quantum system are studied using tools from information theory. Shannon entropies of the one (reduced) and two-particle distribution functions in position, momentum and separable phase-space are examined. Results show that the presence of the bath leads to a delocalization of the distribution functions in position space, and a localization in momentum space. This can be interpreted as a loss of information in position space and a gain of information in momentum space. The entropy sum of the system, in the presence of a bath, is shown to be dependent on the strength of the interparticle potential and also on the strength of the coupling to the bath. The statistical correlation between the particles, and its dependence on the bath and interparticle potential, is examined using mutual information. A stronger repulsive potential between particles, in the presence of the bath, yields a smaller correlation between the particles positions, and a larger one between their momenta.Chemistry and Chemical Biolog

Star formation in young star cluster NGC 1893

We present a comprehensive multi-wavelength study of the star-forming region NGC 1893 to explore the effects of massive stars on low-mass star formation. Using near-infrared colours, slitless spectroscopy and narrow-band $H\alpha$ photometry in the cluster region we have identified candidate young stellar objects (YSOs) distributed in a pattern from the cluster to one of the nearby nebulae Sim 129. The $V, (V-I)$ colour-magnitude diagram of the YSOs indicates that majority of these objects have ages between 1 to 5 Myr. The spread in the ages of the YSOs may indicate a non-coeval star formation in the cluster. The slope of the KLF for the cluster is estimated to be $0.34\pm0.07$, which agrees well with the average value ($\sim 0.4$) reported for young clusters. For the entire observed mass range $0.6 < M/M_\odot \le 17.7$ the value of the slope of the initial mass function, $`\Gamma$', comes out to be $-1.27\pm0.08$, which is in agreement with the Salpeter value of -1.35 in the solar neighborhood. However, the value of $`\Gamma$' for PMS phase stars (mass range $0.6 < M/M_\odot \le 2.0$) is found to be $-0.88\pm0.09$ which is shallower than the value ($-1.71\pm0.20$) obtained for MS stars having mass range $2.5 < M/M_\odot \le 17.7$ indicating a break in the slope of the mass function at $\sim 2 M_\odot$. Estimated $`\Gamma$' values indicate an effect of mass segregation for main-sequence stars, in the sense that massive stars are preferentially located towards the cluster center. The estimated dynamical evolution time is found to be greater than the age of the cluster, therefore the observed mass segregation in the cluster may be the imprint of the star formation process. There is evidence for triggered star formation in the region, which seems to govern initial morphology of the cluster.Comment: Accepted for the publication in MNRAS, 21 pages, 26 figures, 10 table

The Gaia-ESO Survey::Properties of the intermediate age open cluster NGC 4815

Context. NGC 4815 is a populous similar to 500 Myr open cluster at R-gc similar to 7 kpc observed in the first six months of the Gaia-ESO Survey. Located in the inner Galactic disk, NGC 4815 is an important potential tracer of the abundance gradient, where relatively few intermediate age open clusters are found. Aims. The Gaia-ESO Survey data can provide an improved characterization of the cluster properties, such as age, distance, reddening, and abundance profile. Methods. We use the survey derived radial velocities, stellar atmospheric parameters, metallicity, and elemental abundances for stars targeted as potential members of this cluster to carry out an analysis of cluster properties. The radial velocity distribution of stars in the cluster field is used to define the cluster systemic velocity and derive likely cluster membership for stars observed by the Gaia-ESO Survey. We investigate the distributions of Fe and Fe-peak elements, alpha-elements, and the light elements Na and Al and characterize the cluster's internal chemical homogeneity comparing it to the properties of radial velocity non-member stars. Utilizing these cluster properties, the cluster color-magnitude diagram is analyzed and theoretical isochrones are fit to derive cluster reddening, distance, and age. Results. NGC 4815 is found to have a mean metallicity of [Fe/H] = +0.03 +/- 0.05 dex (s.d.). Elemental abundances of cluster members show typically very small internal variation, with internal dispersions of similar to 0.05 dex. The alpha-elements [Ca/Fe] and [Si/Fe] show solar ratios, but [Mg/Fe] is moderately enhanced, while [Ti/Fe] appears slightly deficient. As with many open clusters, the light elements [Na/Fe] and [Al/Fe] are enhanced, [Na/Fe] significantly so, although the role of internal mixing and the assumption of local thermodynamical equilibrium in the analysis remain to be investigated. From isochrone fits to color-magnitude diagrams, we find a cluster age of 0.5 to 0.63 Gyr, a reddening of E(B-V) = 0.59 to 0.65, and a distance modulus (m -M)(0) = 11.95 to 12.20, depending on the choice of theoretical models, leading to a Galactocentric distance of 6.9 kpc

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

Phase-Space Position-Momentum Correlation and Potentials

Solutions to the radial Schr¨odinger equation of a particle in a quantum corral are used to probe how the statistical correlation between the position, and The momentum of the particle depends on the effective potential. The analysis is done via the Wigner function and its Shannon entropy. We show by comparison to the particle-in-a-box model that the attractive potential increases the magnitude of the correlation, while a repulsive potential decreases the magnitude of this correlation. Varying the magnitude of the repulsive potential yields that the correlation decreases with a stronger repulsive potential