Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector

Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02  TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1  μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos⁡2Δϕ modulation for all ΣETPb ranges and particle pT

Observation of Associated Near-Side and Away-Side Long-Range Correlations in sqrt[s_{NN}]=5.02 TeV Proton-Lead Collisions with the ATLAS Detector.

Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in sqrt[s_{NN}]=5.02  TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1  μb^{-1} of data as a function of transverse momentum (p_{T}) and the transverse energy (ΣE_{T}^{Pb}) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) "near-side" (Δϕ∼0) correlation that grows rapidly with increasing ΣE_{T}^{Pb}. A long-range "away-side" (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣE_{T}^{Pb}, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣE_{T}^{Pb} dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos⁡2Δϕ modulation for all ΣE_{T}^{Pb} ranges and particle p_{T}

Successful low-dose azathioprine for myasthenia gravis despite hepatopathy from primary sclerosing cholangitis: a case report

<p>Abstract</p> <p>Introduction</p> <p>Although myasthenia gravis is frequently associated with other disorders, it has not been reported together with primary sclerosing cholangitis, complicating the administration of liver-toxic immunosuppressive therapy.</p> <p>Case presentation</p> <p>A 73-year-old Caucasian woman with a history of arterial hypertension, thyroid dysfunction, glaucoma, right-sided ptosis and later generalized weakness, was diagnosed with myasthenia gravis. Additionally, primary sclerosing cholangitis was detected, initially prohibiting the administration of immunosuppressants. Despite treatment with steroids and pyridostigmine she repeatedly experienced myasthenic crises. After the fifth crisis and after antibody titers had reached levels > 100 nmol/L during two years of follow-up, it was decided to restart azathioprine. Interestingly, low-dose azathioprine (1.5 mg/kg/day) was well tolerated, had a positive clinical and immunological effect and did not worsen primary sclerosing cholangitis.</p> <p>Conclusion</p> <p>Myasthenia gravis may occur together with primary sclerosing cholangitis in the same patient. Mild immunosuppression with azathioprine is feasible and effective in such a patient, without worsening myasthenia gravis or primary sclerosing cholangitis.</p

Systemic sclerosis

True comorbidity is the independent occurrence of more than one disease in a patient. In a disease like systemic sclerosis (SSc) which involves almost all organs, it is problematic to define comorbidity. A good example is SSc and primary Sjögren's disease. Figures as high as 80% comorbidity have been published, but in the majority it may be caused by fibrosis and not inflammation and thus should be interpreted as manifestation of SSc. The real comorbidity figure may be around 14%. A further illustration is the frequent uncertainty regarding the cause of death at a time when less than 10% of patients even in trials of novel therapy undergo postmortem examination. This review examines associations with malignancy, autoimmune overlap conditions, liver disease, cardiovascular disease, myasthenia gravis, depression, and osteoporosis. Malignancy occurs either concomitant with onset or years after the onset of SSc. This is related to the kind of SSc-associated autoantibodies. A rare single gene mutation links some anti-RNA polymerase III positive SSc patients' malignancy to a mutation in the POLR3 region, indicating a pathogenic correlation. Several vascular features affecting endothelial function in SSc contribute to an increased prevalence of cardiovascular disease and contribute to comorbidity with vascular disease. Impaired quality of life could be a reasonable explanation for increased prevalence of depression and risk of suicide