ANTIOXIDANT AND ANTI-INFLAMMATORY EFFECT OF SUNTHI IN PRANVAHA SROTAS

Ginger, (Zingiber officinale Roscoe) is one of the important medicinal plants which is being used in Ayurveda from the ancient time. Zingiber officinale is well known as a health promoting. It has been an important ingredient in Ayurvedic, Chinese, and Tibb-Unani herbal medicines. In ancient culture medical practitioners focused on herbals for the promoting the immune system of body. Ginger has been identified as prostaglandin synthesis suppressor through inhibition of cyclooxygenase-1 and cyclooxygenase-2 and apart from its medicinal properties ginger can also be used as an antioxidant supplement. It has also anti-oxidant, anti-inflammatory, anti bacterial, immune modulator, anticancer, anti-diabetic and several properties. It has a rich phytochemical compound like Gingeral, Shogaol, Zingerene. In Pranavaha srotas anti-inflammatory effect is very useful to treat the disease Ginger inhibits the production of free radicals like ketone body{H+,OH-}, Lactic acid, uric acid intermediated product which is leading cause of DNA damage and various disease. Ethenol extract of Z.officinale alone with vit-E induced the nephro toxicity and Acetaminophen induced liver cell damage. Studies have shown that, the long term dietary intake of ginger has hypoglycaemic and hypolipidaemic effect It can reduced the muscle pain after physical activity, valuable ingredients which can prevent various cancer’s angiogenesis and metastasis induction of apoptosis and inhibit of cell-cycle progression and used in the cardiovascular system, Diabetes mellitus and Gastrointestinal rheumatism, cough, corhyza and bronchitis disease. Aim of this article to provide knowledge about Anti-oxidant and Anti-inflammatory properties of Zingiber officinalis

EFFECT OF RASONADI KWATH IN THE MANAGEMENT OF RHEUMATOID ARTHRITIS: A REVIEW

Rheumatoid arthritis is a most common persistent inflammatory arthritis of unknown etiology marked by symmetric, peripheral poly arthritis and often result in joint damage and physical disability. Arthritis is always associated with arthralgia. It is 1.0-1.5% with a female to male ratio of 3:1 functional capacity decrease most rapidly at the beginning of disease and the function state of patients in their first year. R.A. Etiology like Immunological factor (HLA-DRB1), Hormonal factor, contraceptives pills, is also associated with a worse disease outcome in R.A. Particularly in genetically predisposed individuals, some environmental antigen trigger, probably a virus, stimulates the production of autoantibodies (IgM rheumatoid factor) against the body, own IgM immunologlobins. This process can become self perpetuating. The prominent feature is the formation of immune complexes. within the joint resulting from tissue damage. These complex activate complement and attract neutrophils. Phagocytosis of immune complexes by neutrophils leads to release of chemical mediators of inflammation. Continued inflammation stimulates the formation of a proliferative synovitis. This hypertrophic granulation tissue is called pannus. This process is responsible for the causing joint erosions. In Ayurveda it is clinically correlated with Aamvata. According to Bhavprakash Beautiful composition is given in Aamvata chikitsa 26th chapter Rasonadi Kwath. Conceptually it is play very effective role because of its Sothhara, Vedna-sthapana, Kapha-vatashamak, Deepan-Pachan, Anuloman, Shoola-prashman, and also Shunthi is Uttam Aama pachak. The aim of this article is to provide a management for RA by Rasonadi Kwath

Measurement of Bottom versus Charm as a Function of Transverse Momentum with Electron-Hadron Correlations in p+p Collisions at sqrt(s)=200 GeV

The momentum distribution of electrons from semi-leptonic decays of charm and bottom for mid-rapidity |y|<0.35 in p+p collisions at sqrt(s)=200 GeV is measured by the PHENIX experiment at the Relativistic Heavy Ion Collider (RHIC) over the transverse momentum range 2 < p_T < 7 GeV/c. The ratio of the yield of electrons from bottom to that from charm is presented. The ratio is determined using partial D/D^bar --> e^{+/-} K^{-/+} X (K unidentified) reconstruction. It is found that the yield of electrons from bottom becomes significant above 4 GeV/c in p_T. A fixed-order-plus-next-to-leading-log (FONLL) perturbative quantum chromodynamics (pQCD) calculation agrees with the data within the theoretical and experimental uncertainties. The extracted total bottom production cross section at this energy is \sigma_{b\b^bar}= 3.2 ^{+1.2}_{-1.1}(stat) ^{+1.4}_{-1.3}(syst) micro b.Comment: 432 authors, 6 pages text, 3 figures. Submitted to Phys. Rev. Lett. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

Mapping child growth failure across low- and middle-income countries

Childhood malnutrition is associated with high morbidity and mortality globally1. Undernourished children are more likely to experience cognitive, physical, and metabolic developmental impairments that can lead to later cardiovascular disease, reduced intellectual ability and school attainment, and reduced economic productivity in adulthood2. Child growth failure (CGF), expressed as stunting, wasting, and underweight in children under five years of age (0�59 months), is a specific subset of undernutrition characterized by insufficient height or weight against age-specific growth reference standards3�5. The prevalence of stunting, wasting, or underweight in children under five is the proportion of children with a height-for-age, weight-for-height, or weight-for-age z-score, respectively, that is more than two standard deviations below the World Health Organization�s median growth reference standards for a healthy population6. Subnational estimates of CGF report substantial heterogeneity within countries, but are available primarily at the first administrative level (for example, states or provinces)7; the uneven geographical distribution of CGF has motivated further calls for assessments that can match the local scale of many public health programmes8. Building from our previous work mapping CGF in Africa9, here we provide the first, to our knowledge, mapped high-spatial-resolution estimates of CGF indicators from 2000 to 2017 across 105 low- and middle-income countries (LMICs), where 99 of affected children live1, aggregated to policy-relevant first and second (for example, districts or counties) administrative-level units and national levels. Despite remarkable declines over the study period, many LMICs remain far from the ambitious World Health Organization Global Nutrition Targets to reduce stunting by 40 and wasting to less than 5 by 2025. Large disparities in prevalence and progress exist across and within countries; our maps identify high-prevalence areas even within nations otherwise succeeding in reducing overall CGF prevalence. By highlighting where the highest-need populations reside, these geospatial estimates can support policy-makers in planning interventions that are adapted locally and in efficiently directing resources towards reducing CGF and its health implications. © 2020, The Author(s)

Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17 : analysis for the Global Burden of Disease Study 2017

Background Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. Identifying subnational regions with the highest burden and mapping associated risk factors can aid in reducing preventable childhood diarrhoea. Methods We used Bayesian model-based geostatistics and a geolocated dataset comprising 15 072 746 children younger than 5 years from 466 surveys in 94 LMICs, in combination with findings of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, to estimate posterior distributions of diarrhoea prevalence, incidence, and mortality from 2000 to 2017. From these data, we estimated the burden of diarrhoea at varying subnational levels (termed units) by spatially aggregating draws, and we investigated the drivers of subnational patterns by creating aggregated risk factor estimates. Findings The greatest declines in diarrhoeal mortality were seen in south and southeast Asia and South America, where 54·0% (95% uncertainty interval [UI] 38·1–65·8), 17·4% (7·7–28·4), and 59·5% (34·2–86·9) of units, respectively, recorded decreases in deaths from diarrhoea greater than 10%. Although children in much of Africa remain at high risk of death due to diarrhoea, regions with the most deaths were outside Africa, with the highest mortality units located in Pakistan. Indonesia showed the greatest within-country geographical inequality; some regions had mortality rates nearly four times the average country rate. Reductions in mortality were correlated to improvements in water, sanitation, and hygiene (WASH) or reductions in child growth failure (CGF). Similarly, most high-risk areas had poor WASH, high CGF, or low oral rehydration therapy coverage. Interpretation By co-analysing geospatial trends in diarrhoeal burden and its key risk factors, we could assess candidate drivers of subnational death reduction. Further, by doing a counterfactual analysis of the remaining disease burden using key risk factors, we identified potential intervention strategies for vulnerable populations. In view of the demands for limited resources in LMICs, accurately quantifying the burden of diarrhoea and its drivers is important for precision public health