Vilwapanchanga Ghrita in the Management of Pediatric Intractable Epilepsy: A Preliminary Clinical Study

Background: Drug-resistant epilepsy (DRE) in children remains a major clinical challenge, with limited efficacy of current pharmacological and non-pharmacological interventions. In Ayurveda, Apasmara is described as a condition analogous to epilepsy, with classical texts recommending Vilwapanchanga Ghrita as a key therapeutic formulation. Materials and Methods: An open-label clinical study was conducted in 10 pediatric patients (2–12 years) diagnosed with intractable epilepsy. Vilwapanchanga Ghrita, prepared as per Arogyakalpadruma, was administered for two months, with a subsequent two-month follow-up. Outcome measures included seizure severity (Hague Seizure Severity Scale), frequency of impairment of consciousness, frequency of jerks or cramps, seizure duration, and safety profile. Statistical analyses were performed using paired t-test and Wilcoxon signed-rank test. Results: A significant reduction in seizure severity was observed, with mean scores decreasing from 43.0 ± 2.58 at baseline to 32.5 ± 1.84 post-treatment (p<0.001), and sustained during follow-up. Frequency of impairment of consciousness and jerks/cramps also improved significantly (p < 0.01). Median seizure duration reduced from 300 seconds (IQR 226.25–510.00) at baseline to 120 seconds post-treatment, and further to 47.5 seconds at follow-up (p=0.005). No adverse effects were reported; instead, caregivers noted improvements in digestion and reduction in recurrent respiratory infections. Conclusion: Vilwapanchanga Ghrita demonstrated significant and sustained efficacy in reducing seizure severity, frequency, and duration in pediatric intractable epilepsy, with an excellent safety profile. These findings provide preliminary clinical validation for its classical use in Apasmara management and suggest potential as an adjunctive therapy. Larger randomized controlled trials are warranted

A Clinical Trial on the Effect of Guduci (Tinospora Cordifolia (Willd) Miers) Satva along with Ksheera in Perimenopausal Symptoms

Perimenopause refers to the period around menopause. In Ayurveda it is considered as Rajakshaya, the transition period of body from predominance of Pitta dosha to Vatadosha which is characterized by aggravation of Vata, alteration of Pitta and Kaphadosha. It is included as a Swabhavikavyadhi in Ayurveda. Management of Dhatukshaya, Rasayana, Balya and Rasa- Raktha Prasadana treatments are seen beneficial in this condition. Guduci is one among Rasayana drugs mentioned in Ayurveda. The drug Guducisatva taken for the study is from the classic Yogaratnakara and has Dhatukrith and Vayastapana property. The objective of the study was to evaluate the effect of 1g Guduci Satva along with Ksheera (25ml boiled and lukewarm) in perimenopausal symptoms. Females in the age group 40-50 years with perimenopausal symptoms were selected for the study from the OPD of Prasutitantra-striroga, GAVC Hospital, Tripunithura as per the inclusion criteria. Study tools are clinical case proforma and Greene Climacteric scale score above 30. Drug was given orally in the dose of 1g twice along with 25ml Ksheera one hour before food. Duration of administration was 30 days and assessment was taken on 0th day, 31st day and 60th day. Results were analysed statistically by Wilcoxon's signed rank test and Friedman’s test. The study result is highly significant after treatment with P value <0.001 during treatment and during follow up and is found effective in reducing the symptoms in perimenopause

Effectiveness of Multimodal Ayurvedic Treatment in Vataja Pandu w.s.r Nutritional Deficiency Anemia - A Case Report

Panduroga is a condition where in Pitta Pradhana Tridoshas affect the Dhathus causing deterioration of Varna and Bala, leading to Twak Vaivarnyatha or Pandutha. In present day medical science, symptoms of Pandu are alike to that of anaemia. Anemia is a condition presenting with a depletion of hemoglobin concentration below normal values, or Hematocrit or Red blood cells in the blood. On an average, about 30% or nearly one third of world’s population is claimed to be affected by anemia because of numerous causes. In India prevalence is extremely high compared to world prevalence, close to 51%. Nutritional macrocytic anemia (NMA) in prevailing population and in pregnancy, commonly seen in India, most likely represents combined deficiency of iron, folic acid and vitamin B12. A 45 years old female presented with complaints of Panduta (Pallor of skin), Daurbalya (weakness), Aruchi (loss of appetite), Padashopha (pedal oedema), Pindikodweshtana (leg cramps), Shrama Shwasa (exertional dyspnoea) and Hriddrava (palpitation) with haemoglobin concentration 3.7gm% visited OPD of SJIIM, GAMC, Bengaluru. Initially she was started with oral medications followed by admission to in-patient ward on the succeeding visit. The present case study is intended to understand the accuracy of multimodal Ayurvedic approach consisting of oral medications and Matra Basti with Dadimadya Ghrita, in the management of Panduroga and is found to be effective in overcoming Vataja Pand

AYURVEDIC MANAGEMENT OF SYSTEMIC SCLEROSIS - A SINGLE CASE STUDY

Systemic sclerosis (SSc) is a multisystem autoimmune disorder caused by unknown factors. Which results in fibrosis of the skin, blood vessels, and visceral organs, including the gastrointestinal tract, lungs, heart, and kidneys. One among subset is referred to as diffuse cutaneous scleroderma and characterized by the rapid development of symmetric skin thickening of proximal and distal extremity, face, and trunk. When it affects on musculoskeletal system, the synovium in patients with arthritis is similar to that seen in early rheumatoid arthritis and shows edema with infiltration of lymphocytes and plasma cells. A 35-year-old house wife with this diagnosis came to OPD, which is managed by the principle of Amavata (diseases of connective tissue in Ayurveda) line of treatment. Vaitarana basti and Valuka sweda has done for 7 days with oral medication Vaishwanara churna ½ teaspoon with first morsal of food for 3 times. The QOL (quality of life) has been improved with in 7 days of treatment

CRITIQUE ON THE CONCEPT OF PSYCHONEUROIMMUNOLOGY (PNI) IN AYURVEDA AND YOGA w.s.r. TO COVID-19 PANDEMIC

The COVID-19 outbreak has prompted significant levels of psychological distress and critical effect on emotional wellness as well as challenged health care systems across the globe. Such distress is accompanied with alterations in immune function including expanded danger of viral respiratory tract infections. It has shaken the entire world with this worldwide crisis. The panic situation created by the disease along with the unfamiliar way of conduct imposed several psychological impacts on human life. Many can’t cope up with the situation on their own and are in need of an intervention such as Psychological First Aid. Fear, anxiety, future concerns, interpersonal relationships issues, behavioral issues, domestic abuses, separation anxiety are a few among the psychological issues reported. It is basic to comprehend that these depend on a more profound comprehension of how choice less mindfulness coordinates the neurological, immune and metabolic frameworks with psychological processes to work overall. In this review article, an attempt has been made to critically enlighten the ancient and recent development of the Psychoneuroimmuology (PNI) in Ayurveda and Yoga in concern with Covid-19 Pandemic

EFFECTIVE MANAGEMENT OF ARTAVA KSHAYA BY AYURVEDA: A CASE REPORT

A female patient of 25 years of age came to OPD of National Institute of Ayurveda, Jaipur on 22 September, 2020 with chief complaint of delayed menstruation with scanty flow since 4.5 years. Methodology: Detailed history with all necessary clinical, physical examination and laboratory investigations were carried out. No gross physical and chemical abnormality was found. All the laboratory investigations (including USG and hormonal analysis) were found to be normal. So the treatment was planned according to the symptoms. Diagnosis was made on the basis on the basis of presenting complaints was Artava kshaya. Patient was treated with Tilashelukaravi kwatha for 2 consecutive cycles. Patient was kept on follow up for 1 cycle after cessation of Tilashelukaravi kwatha. Result: Patient had got her menstruation regularly with normal duration while taking medicine. Also the amount of flow was also improved and intensity of pain was reduced effectively from moderate to mild. Even after cessation of medicine she got her menstruation in 30 days with normal amount of flow

ROLE OF BASE PLATFORM TO PREPARE PARPATI KALPANA W.S.R. TO RASA PARPATI

Parpati Kalpana is one of the famous Kalpanas of Rasashastra which is widely used and considered as a boon for digestive disorders. The Parpati name is given to this Kalpana as per its Papad or Parpata – thin flake – like appearance. Parpati Kalpana is mainly divided into Sagandha and Nirgandha Parpati Kalpana. Rasa Parpati is the type of Sagandha Parpati Kalpana. To prepare Parpati kalpana, at least one ingredient should get liquefied at normal heating and should get solidified when it gets cooled down, not only that, to get the thin flake like structure specific pressure needs to be applied. In present study Rasa Parpati was prepared by using Samaguna Kajjali (Equal quantity of Parada and Gandhaka) and to check the cooling effect and the role of base platform; here three different platforms were made i.e. cow dung and wet clay mixed platform, only wet clay platform (Earthen platform) and ice block platform. Total nine samples of Rasa Parpati were prepared, three on each platform to check which platform is convenient to prepare Rasa Parpati. The average thickness of Rasa Parpati was found minimum (2.83 mm) on cow dung and wet clay mixed platform whereas the maximum (4 mm) on ice block platform i.e. 4 mm. Average thickness of Rasa Parpati made on earthen platform was 3.57 mm which is thicker than the Cow dung and wet clay mixed platform and thinner than the ice cube platform. Which indicates the best platform to make thinnest Parpati is cow dung and wet clay mixed platform

NEURO-ENDOCRINE-IMMUNE MODULATION BY AYURVEDIC RASAYANA DRUGS

Ayurveda which literally means “the science of life” is the ancient Indian system of medicine. Rasayana is a specialized branch of Ayurveda. The drugs attributed with Rasayana properties are mentioned to delay the process of ageing, enhance the mental and cognitive functions and deliver freedom from a number of diseases including those caused by infectious organisms. All these activities of Rasayana drugs seem to be associated with neuro-endocrine-immune systems. In this study we have reviewed the growing inter-relationship between the neuro-endocrine-immune systems and stress as a neuro-endocrine-immune phenomenon. Some important Ayurvedic Rasayana drugs including Aswagandha (Withania somnifera), Tulsi (Ocimum sanctum), Guduchi (Tinospora cordifolia), Shilajit (Asphalt), Brahmi (Bacopa monnieri) and few others along with their pharmacological actions on the above three systems and stress as well have also been reviewed. It has been observed that most of them tend to exhibit their activities by modulating the neuro-endocrine-immune systems along with anti-stress/adaptogenic capability. The scientific inter-relationship between the three systems has been taken as the model reference. Similar actions are expected from other Rasayana drugs too. Therefore Rasayana drugs in Ayurveda can be evaluated and used as neuro-endocrine-immune modulators

EVALUATION OF THE TREATMENT OF SHWITRA WITH AYURVEDA MODALITIES: A CASE STUDY

In Ayurveda most of the skin diseases are explained under the term Kushtha. Shwitra is considered as one of the varieties of Kushtha in the Ayurvedic Classics, caused vitiation of Tridoshas and Dhatus like Rakta, Mamsa and Meda. The references of Shwitra are found in almost all the Samhitas like Bruhatrayees and Laghutrayees. Partial or complete loss of skin pigmentation giving rise to white patch on any part of the body is called as leucoderma or vitiligo and in Ayurveda it is called as Shwitra. This depigmentation results due to destruction of melanocytes, which may be unknown in origin or due to autoimmune endocrinopathies selective IgA deficiency. A female patient, aged 20 year suffering from white patches in neck region since 4 year was treated with both Shaman Chikitsa and Sodhan Chikitsa for a period to 4 months with follow up at every 30 days in between, Relief from the complaints was assessed by noting the changes in the size of patch. After 4 months of treatment the size of patch was reduced. The present case study revealed the efficacy of Ayurveda therapy both internal and external for duration of 4 months in the management of Shwitra

IN VITRO ANTIBACTERIAL EFFECT OF AQUEOUS EXTRACT OF SIDDHARTAKA SNANA USED IN TREATMENT OF VICARCHIKA (ECZEMA)

Vicarchika is a type of Kushta Roga (skin disease). It can be correlated with eczema. Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa are some of the bacteria which cause skin diseases. Siddhartaka Snana is a herbal bath that is described in Charaka Samhita as a treatment for Kushta Roga. Siddhartaka Snana is a herbal preparation which consists ten herbs namely; Cyperus rotundus, Catunaregum spinosa, Phyllanthus emblica, Terminalia chebula, Terminalia bellarica, Cassia fistula, Pongamia pinnata, Holarrhena antidysentrica, Alastonia scholaris and Coscinum fenestratum. Antibacterial effect of Siddhartaka Snana against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa that are responsible for skin diseases was studied using disc diffusion method and well diffusion methods. In disc diffusion method, no inhibition zone was observed with any of the tested bacteria. However, an inhibition zone of 9.67mm was observed against Staphylococcus aureus in well diffusion method with Siddhartaka Snana. Minimum Inhibitory Concentration (MIC) of Siddhartaka Snana against Staphylococcus aureus was 0.9225 mg/1ml. Ingredients of Siddhartaka Snana contain tannins, phenols and flavonoids, all of which possess antibacterial properties. Antibacterial effect of Siddhartaka Snana may have been exhibited due to actions of these phytochemicals. It was concluded that Siddhartaka Snana has an antibacterial effect against Staphylococcus aureus