Swim test for joint angles dispersion analysis during hind limb motor function assessment in SCI models

In the most of functional studies, various stress tests are used to assess functional improvement following spinal cord injury in animal models. However, available methods of motor function evaluation are not always accurate and unbiased. The main objective of the study was to create a new method of motor activity assessment in minor animal models of spinal cord injury. This method should provide an objective and accurate evaluation of limb motor function in models having severe neurological disorders following contusion spinal cord injury. The swimming test was used as the key behavioral test. To assess the motor function of swimming animals’ hind limbs, we measured angles of hind limbs movements adjusted to the motion direction axis. Then we calculated individual angles dispersion for each joint and limb using the parameters of angles sample dispersion and amplitude-depending dispersion. The current study included two groups of Sprague-Dawley rats: control group and a group of animals having moderate thoracic spinal cord contusion injury. Control animals demonstrated stable dispersion indicators for 6 weeks of follow-up. In the experimental group, a tendency to the improvement of motor function in hind limbs between 1 and 3 weeks was revealed followed by stabilization and preservation of both indicators between 3 and 6 weeks. Provided method based on the measurement of joint angles adjusted to the movement direction axis followed by calculation of indicators of variance of a random variable and amplitude-depending variance can be an effective and objective alternative for motor function evaluation

Using the Hottest Particles in the Universe to Probe Icy Solar System Worlds

We present results of our Phase 1 NIAC Study to determine the feasibility of developing a competitive, low cost, low power, low mass passive instrument to measure ice depth on outer planet ice moons, such as Europa, Ganymede, Callisto, and Enceladus. Indirect measurements indicate that liquid water oceans are likely present beneath the icy shells of such moons (see e.g.,the JPL press release "The Solar System and Beyond is Awash in Water"), which has important astrobiological implications. Determining the thickness of these ice shells is challenging given spacecraft SWaP (Size, Weight and Power) resources. The current approach uses a suite of instruments, including a high power, massive ice penetrating radar. The instrument under study, called PRIDE (Passive Radio Ice Depth Experiment) exploits a remarkable confluence between methods from the high energy particle physics and the search for extraterrestrial life within the solar system. PRIDE is a passive receiver of a naturally occurring radio frequency (RF) signal generated by interactions of deep penetrating Extremely High Energy (> 10^18 eV) cosmic ray neutrinos. It could measure ice thickness directly, and at a significant savings to spacecraft resources. At RF frequencies the transparency of modeled Europan ice is up to many km, so an RF sensor in orbit can observe neutrino interactions to great depths, and thereby probe the thickness of the ice layer

Complex temporal patterns in molecular dynamics:a direct measure of the phase-space exploration by the trajectory at macroscopic time scales

Computer simulated trajectories of bulk water molecules form complex spatiotemporal structures at the picosecond time scale. This intrinsic complexity, which underlies the formation of molecular structures at longer time scales, has been quantified using a measure of statistical complexity. The method estimates the information contained in the molecular trajectory by detecting and quantifying temporal patterns present in the simulated data (velocity time series). Two types of temporal patterns are found. The first, defined by the short-time correlations corresponding to the velocity autocorrelation decay times (â‰0.1â€ps), remains asymptotically stable for time intervals longer than several tens of nanoseconds. The second is caused by previously unknown longer-time correlations (found at longer than the nanoseconds time scales) leading to a value of statistical complexity that slowly increases with time. A direct measure based on the notion of statistical complexity that describes how the trajectory explores the phase space and independent from the particular molecular signal used as the observed time series is introduced

Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter.Comment: 15 pages, 11 figures. Published in European Physical Journal

Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

Peer reviewe

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation