Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

All-Russian Scientific and Methodological Workshop The Virtual Reconstruction of the Objects of Historical and Cultural Heritage in the Format of the Scientific Research and Educational Process

The article gives an overview of reports presented at the All-Russian scientific and methodological workshop which was organized by the Association History and Computers and the Institute for the Humanities of Siberian Federal University in Krasnoyarsk on April 22-23, 2011. The workshop allowed to summarize and analyze the experience of preserving the objects of historical and cultural heritage by means of computer technologies, in particular the experience of creating virtual historical reconstructions. The participants discussed prospects of using virtual reconstructions in research activities; issues connected with the quality of references and resources, criteria of the scientific rationale, necessities of interdisciplinary study in the process of creating virtual reconstructions. Special attention was paid to implementation of computer reconstructions in the educational process, as well as to opportunities of using virtual reconstructions in research and educational activities of museums, educational centres and other institutions of culture and education.В статье дается обзор докладов, представленных на Всероссийском научно-методическом семинаре, проведенном 22-23 апреля 2011 года в Красноярске Ассоциацией «История и компьютер» и Гуманитарным институтом Сибирского федерального университета. На семинаре был обобщен и проанализирован опыт сохранения объектов историко-культурного наследия средствами компьютерных технологий, в частности опыт построения виртуальных исторических реконструкций. Обсуждались перспективы использования виртуальных реконструкций в научно-исследовательской деятельности: вопросы, связанные с качеством источниковой базы, критериями научного обоснования, необходимостью междисциплинарного исследования в процессе создания виртуальных реконструкций. Особенное внимание уделялось применению технологий компьютерной реконструкции в образовательном процессе, а также возможностям использования виртуальных реконструкций в научно-просветительской деятельности музеев, образовательных центров и иных учреждений культуры и образования

Electron-positron annihilation processes in MCSANCee

The Monte Carlo even generator MCSANCee is used to estimate the significance of polarization effects in one-loop electroweak radiative corrections. The electron-positron annihilation processes $e^+e^- → µ^−µ^+$ ($τ^−τ^+$, ZH) were considered taking into account conditions of future colliders

All-Russian Scientific and Methodological Workshop The Virtual Reconstruction of the Objects of Historical and Cultural Heritage in the Format of the Scientific Research and Educational Process

The article gives an overview of reports presented at the All-Russian scientific and methodological workshop which was organized by the Association History and Computers and the Institute for the Humanities of Siberian Federal University in Krasnoyarsk on April 22-23, 2011. The workshop allowed to summarize and analyze the experience of preserving the objects of historical and cultural heritage by means of computer technologies, in particular the experience of creating virtual historical reconstructions. The participants discussed prospects of using virtual reconstructions in research activities; issues connected with the quality of references and resources, criteria of the scientific rationale, necessities of interdisciplinary study in the process of creating virtual reconstructions. Special attention was paid to implementation of computer reconstructions in the educational process, as well as to opportunities of using virtual reconstructions in research and educational activities of museums, educational centres and other institutions of culture and education.В статье дается обзор докладов, представленных на Всероссийском научно-методическом семинаре, проведенном 22-23 апреля 2011 года в Красноярске Ассоциацией «История и компьютер» и Гуманитарным институтом Сибирского федерального университета. На семинаре был обобщен и проанализирован опыт сохранения объектов историко-культурного наследия средствами компьютерных технологий, в частности опыт построения виртуальных исторических реконструкций. Обсуждались перспективы использования виртуальных реконструкций в научно-исследовательской деятельности: вопросы, связанные с качеством источниковой базы, критериями научного обоснования, необходимостью междисциплинарного исследования в процессе создания виртуальных реконструкций. Особенное внимание уделялось применению технологий компьютерной реконструкции в образовательном процессе, а также возможностям использования виртуальных реконструкций в научно-просветительской деятельности музеев, образовательных центров и иных учреждений культуры и образования

Autoimmune Effect of Antibodies against the SARS-CoV-2 Nucleoprotein

COVID-19 caused by SARS-CoV-2 is continuing to spread around the world and drastically affect our daily life. New strains appear, and the severity of the course of the disease itself seems to be decreasing, but even people who have been ill on an outpatient basis suffer post-COVID consequences. Partly, it is associated with the autoimmune reactions, so debates about the development of new vaccines and the need for vaccination/revaccination continue. In this study we performed an analysis of the antibody response of patients with COVID-19 to linear and conformational epitopes of viral proteins using ELISA, chip array and western blot with analysis of correlations between antibody titer, disease severity, and complications. We have shown that the presence of IgG antibodies to the nucleoprotein can deteriorate the course of the disease, induce multiple direct COVID-19 symptoms, and contribute to long-term post-covid symptoms. We analyzed the cross reactivity of antibodies to SARS-CoV-2 with own human proteins and showed that antibodies to the nucleocapsid protein can bind to human proteins. In accordance with the possibility of HLA presentation, the main possible targets of the autoantibodies were identified. People with HLA alleles A01:01; A26:01; B39:01; B15:01 are most susceptible to the development of autoimmune processes after COVID-19

Optical Studies and Transmission Electron Microscopy of HgCdTe Quantum Well Heterostructures for Very Long Wavelength Lasers

International audienceHgTe/CdHgTe quantum well (QW) heterostructures have attracted a lot of interest recently due to insights they provided towards the physics of topological insulators and massless Dirac fermions. Our work focuses on HgCdTe QWs with the energy spectrum close to the graphenelike relativistic dispersion that is supposed to suppress the non-radiative Auger recombination. We combine various methods such as photoconductivity, photoluminescence and magneto-optical measurements as well as transmission electron microscopy to retrofit growth parameters in multi-QW waveguide structures, designed for long wavelengths lasing in the range of 10–22 \mum. The results reveal that the attainable operating temperatures and wavelengths are strongly dependent on Cd content in the QW, since it alters the dominating recombination mechanism of the carriers

Relation between genomic dna breakpoints in mll gene and treatment outcome in infants with acute leukemia

Цель: Оценить влияние локализации точки разрыва в геномной ДНК гена MLL на прогноз острых лейкозов (ОЛ) у детей первого года жизни. Методы: В исследование было включено 68 детей первого года жизни (29 мальчиков и 39 девочек с медианой возраста 4,8 мес.) с MLL-позитивными острым лимфобластным лейкозом (ОЛЛ) (n = 46), острым миелоидным лейкозом (ОМЛ) (n = 20) и ОЛ смешанной линейности (n = 2). Результаты: 5-летняя бессобытийная выживаемость (БСВ) детей первого года жизни с ОЛЛ, включенных в исследование MLL-Baby, с точкой разрыва в интроне 11 ДНК гена MLL (n = 29) была статистически значимо ниже, чем у пациентов c локализацией точек разрыва, начиная с интрона 7 по экзон 11 (n = 17; 0,16 ± 0,07 и 0,38 ± 0,14; p = 0,039), а кумулятивная вероятность развития рецидива была значительно выше в группе с точкой разрыва в интроне 11 (0,74 ± 0,09 и 0,52 ± 0,17; p = 0,045). В то же время многофакторный анализ показал, что единственным значимым фактором, связанным с неблагоприятным прогнозом, остается сохранение минимальной остаточной болезни (МОБ) в точке наблюдения 4 протокола MLL-Baby (отношение опасности 5,994; 95%-й доверительный интервал 2,209–16,263; p < 0,001). У 22 пациентов с ОМЛ связи между прогнозом и локализацией точки разрыва в ДНК гена MLL не выявлено. Заключение: Наличие точки разрыва в интроне 11 гена MLL у детей первого года жизни с ОЛЛ, получавших лечение по протоколу MLL-Baby, вело к статистически значимо более низким показателям БСВ и более высокой кумулятивной вероятности развития рецидива. Однако в многофакторной модели риска это нивелировалось сохранением МОБ в точке наблюдения 4. У детей первого года жизни с ОМЛ взаимосвязи между локализацией точки разрыва в ДНК гена MLL и прогнозом не выявлено.Aim: To evaluate the relation between genomic DNA breakpoints in MLL and translocation partner genes (TPG) and clinical parameters of infant AL. Methods: 68 infants (29 boys and 39 girls with median age of 4.8 mo) with MLL-rearranged acute lymphoblastic leukemia (ALL) (n = 46), acute myeloid leukemia (AML) (n = 20) and mixed phenotype acute leukemia (MPAL) (n = 2) were included in the current study. Results: 5-year EFS was significantly lower in patients with breakpoints in intron 11 (n = 29) in comparison to patients with breakpoint localized from intron 7 to exon 11 (n = 17) (0.16 ± 0.07 vs 0.38 ± 0.14, p = 0.039). While cumulative incidence of relapse was remarkably higher in the first group of patients (0.74 ± 0.09 vs 0.52 ± 0.17, p = 0.045). Although in Cox regression model including breakpoint location in intron 11 together with age, immunophenotype, initial white blood cell count, initial CNS involvement, type of MLL rearrangements, absolute blast number at day 8 of dexamethasone profase, minimal residual disease (MRD) at time point 4 (TP4) of MLL-Baby protocol, the only significant covariate was the presence of MRD at TP4 (HR 5.994, 95% CI 2.209–16.263, p < 0.001). In 22 AML patients there was not any correlation between breakpoint location and treatment outcome. Conclusion: Breakpoints in intron 11 of MLL gene led to significantly worse outcome in infants with ALL, treated by MLL-Baby protocol, although this parameter was overcome by MRD-positivity at TP4. The latter was the only independent covariate in multivariate analysis. Our data provide additional information of molecular genetic features of MLL-rearranged infant AL

International comparison CCQM-K76 : sulfur dioxide in nitrogen

85 p. : il.This Key Comparison is designed to test the capabilities of the participants to measure and certify sulfur dioxide in nitrogen, and will provide supporting evidence for the CMCs of institutes for sulfur dioxide. Also, as sulfur dioxide is designated a core compound, and the 100 μmol/mol concentration is within the designated core compound concentration range, this comparison is also designed to demonstrate core capabilities of institutes which qualify under the rules of the Gas Analysis Working Group

CEPC Technical Design Report -- Accelerator

International audienceThe Circular Electron Positron Collider (CEPC) is a large scientific project initiated and hosted by China, fostered through extensive collaboration with international partners. The complex comprises four accelerators: a 30 GeV Linac, a 1.1 GeV Damping Ring, a Booster capable of achieving energies up to 180 GeV, and a Collider operating at varying energy modes (Z, W, H, and ttbar). The Linac and Damping Ring are situated on the surface, while the Booster and Collider are housed in a 100 km circumference underground tunnel, strategically accommodating future expansion with provisions for a Super Proton Proton Collider (SPPC). The CEPC primarily serves as a Higgs factory. In its baseline design with synchrotron radiation (SR) power of 30 MW per beam, it can achieve a luminosity of 5e34 /cm^2/s^1, resulting in an integrated luminosity of 13 /ab for two interaction points over a decade, producing 2.6 million Higgs bosons. Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons, facilitating precise measurements of Higgs coupling at sub-percent levels, exceeding the precision expected from the HL-LHC by an order of magnitude. This Technical Design Report (TDR) follows the Preliminary Conceptual Design Report (Pre-CDR, 2015) and the Conceptual Design Report (CDR, 2018), comprehensively detailing the machine's layout and performance, physical design and analysis, technical systems design, R&D and prototyping efforts, and associated civil engineering aspects. Additionally, it includes a cost estimate and a preliminary construction timeline, establishing a framework for forthcoming engineering design phase and site selection procedures. Construction is anticipated to begin around 2027-2028, pending government approval, with an estimated duration of 8 years. The commencement of experiments could potentially initiate in the mid-2030s