Reconstructing Orbits of Galaxies in Extreme Regions (ROGER) III: galaxy evolution patterns in projected phase space around massive X-ray clusters

We use the ROGER code by de los Rios et al. to classify galaxies around a sample of X-ray clusters into five classes according to their positions in the projected phase space diagram: cluster galaxies, backsplash galaxies, recent infallers, infalling galaxies, and interlopers. To understand the effects of the cluster environment to the evolution of galaxies, we compare across the five classes: stellar mass, specific star formation rate, size, and morphology. Following the guidelines of Coenda et al., a separate analysis is carried out for red and blue galaxies. For red galaxies, cluster galaxies differ from the other classes, having a suppressed specific star formation rate, smaller sizes, and are more likely to be classified as ellipticals. Differences are smaller between the other classes, however backsplash galaxies have significantly lower specific star formation rates than early or recent infalling galaxies. For blue galaxies, we find evidence that recent infallers are smaller than infalling galaxies and interlopers, while the latter two are comparable in size. Our results provide evidence that, after a single passage, the cluster environment can diminish a galaxy's star formation, modify its morphology, and can also reduce in size blue galaxies. We find evidence that quenching occurs faster than morphological transformation from spirals to ellipticals for all classes. While quenching is evidently enhanced as soon as galaxies get into clusters, significant morphological transformations require galaxies to experience the action of the physical mechanisms of the cluster for longer timescales.Comment: Accepted in MNRAS, 11 pages, 7 figure

How do galaxies populate haloes in high-density environments? An analysis of the Halo Occupation Distribution in future virialized structures

There are hints suggesting that properties of galaxy populations in dark matter haloes may depend on their large-scale environment. Recent works point out that very low-density environments influence halo occupation distribution (HOD), however there is not a similar analysis focused on high-density environments. Here we use a simulated set of future virialized superstructures (FVS) to analyse the occupation of galaxies in haloes within these high globally dense regions. We use a publicly available simulated galaxy set constructed with a semi-analytical model to identify FVS in the simulation. Then, we computed the HOD within these superstructures for different absolute magnitude thresholds and make several analysis including the comparison to the global HOD results. We study the dependence on the results on properties of the FVS such as density and volume as well as consider the morphology of galaxies. We also analysed the properties of the stellar content of galaxies and the formation time of the haloes inside FVS. We find a significant increase in the HOD inside FVS. This result is present for all absolute magnitude thresholds explored. The effect is larger in the densest regions of FVS, but does not depend on the volume of the superstructure. We also find that the stellar-mass content of galaxies considerably differs inside the superstructures. Low mass haloes have their central and satellite galaxies with a higher stellar mass content (50%), and exhibit mean star ages (20%) older than average. For massive haloes in FVS we find that only the stellar mass of satellite galaxies varies considerably corresponding to a decrease of 50%. We find a significant statistical difference between the formation times of haloes in FVS and the average population. Haloes residing in superstructures formed earlier, a fact that leads to several changes in the HOD and their member galaxy properties.Comment: 12 pages, 14 figures, the paper has been accepted to be published by the A&

Guess the cheese flavour by the size of its holes: A cosmological test using the abundance of Popcorn voids

We present a new definition of cosmic void and a publicly available code with the algorithm that implements it. Underdense regions are defined as free-form objects, called popcorn voids, made from the union of spheres of maximum volume with a given joint integrated underdensity contrast.The method is inspired by the excursion-set theory and consequently no rescaling processing is needed, the removal of overlapping voids and objects with sizes below the shot noise threshold is inherent in the algorithm. The abundance of popcorn voids in the matter field can be fitted using the excursion-set theory provided the relationship between the linear density contrast of the barrier and the threshold used in void identification is modified relative to the spherical evolution model. We also analysed the abundance of voids in biased tracer samples in redshift space. We show how the void abundance can be used to measure the geometric distortions due to the assumed fiducial cosmology, in a test similar to an Alcock-Paczy\'nski test. Using the formalism derived from previous works, we show how to correct the abundance of popcorn voids for redshift-space distortion effects. Using this treatment, in combination with the excursion-set theory, we demonstrate the feasibility of void abundance measurements as cosmological probes. We obtain unbiased estimates of the target parameters, albeit with large degeneracies in the parameter space. Therefore, we conclude that the proposed test in combination with other cosmological probes has potential to improve current cosmological parameter constraints.Comment: Updated manuscript sent to the MNRAS after referee report: 16 pages, 8 figures. Corrections were made to Fig. 4, some related conclusions were modified. The main conclusions remain unchange

Evidencias de actividad glaciar durante el Dryas reciente (12, 9-11, 7 ka BP) en la Península Ibérica

El Dryas Reciente (Younger Dryas) (GS-1, entre 12, 9 y 11, 7 ka BP) se caracterizó por un marcado descenso de la temperatura a escala global. La consecuencia fue un re avance de los glaciares que afectó también a las cordilleras más importantes de la Península Ibérica. Este trabajo revisa la información disponible sobre la localización, evolución y extensión de tales glaciares. La actividad geomorfológica durante el Dryas Reciente en la Península Ibérica se ha identificado mediante depósitos morrénicos, umbrales rocosos pulidos por el hielo, y glaciares rocosos, datados en la mayor parte de los casos mediante métodos cosmogénicos. Los mejores ejemplos de morrenas del Dryas Reciente se localizan en los Pirineos, donde se desarrollaron cortas lenguas glaciares de hasta 4 km de longitud en los macizos más elevados y numerosos glaciares de circo. También hay evidencias de pequeños glaciares de circo y glaciares rocosos en la Cordillera Cantábrica y en el Sistema Central (sierras de Gredos y Guadarrama), como indican umbrales rocosos y depósitos morrénicos en el frente de circos glaciares. En cambio, en Sierra Nevada, en el extremo meridional de la Península Ibérica, las únicas evidencias del Younger Dryas son glaciares rocosos que se desarrollaron durante el Dryas Antiguo y estuvieron funcionales durante todo el Dryas reciente. The Younger Dryas (GS-1, entre 12, 9 y 11, 7 ka BP) was characterized by a remarkable declining in temperature at a global scale. The consequence was a moderate re-advance of glaciers that also affected the main ranges of the Iberian Peninsula. This paper reviews the available information on the location, evolution and extent of such glaciers. The geomorphological activity during the Younger Dryas in the Iberian Peninsula has been identified throughout the presence of morainic deposits (dated in most cases with cosmogenic exposure ages), rocky thresholds polished by the ice, and rock glaciers. The best examples of Younger Dryas moraines were found in the Central Pyrenees, with short ice tongues of up to 4 km in length in the highest massifs and a number of glacial cirques. There is also evidence of small cirque glaciers in the Cantabrian Range and the Central System Range (Gredos and Guadarrama sierras), as deduced by rocky thresholds and morainic deposits close to cirque headwalls. Conversely, in Sierra Nevada (southernmost sector of the Iberian Peninsula) the only evidence of the Younger Dryas is the presence of rock glaciers that were developed during the Oldest Dryas and survived during the Younger Dryas

Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand.

OBJECTIVE: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. DESIGN: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. METHODS: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1-10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. RESULTS: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and -1.2 (IQR: -2.3 to -0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20-0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than -1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least -1, there was no association with age. Girls and boys who initiated ART with HAZ at least -1 maintained a similar height to the WHO reference mean. CONCLUSION: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least -1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age

Structural and Biochemical Characterization of SrcA, a Multi-Cargo Type III Secretion Chaperone in Salmonella Required for Pathogenic Association with a Host

Many Gram-negative bacteria colonize and exploit host niches using a protein apparatus called a type III secretion system (T3SS) that translocates bacterial effector proteins into host cells where their functions are essential for pathogenesis. A suite of T3SS-associated chaperone proteins bind cargo in the bacterial cytosol, establishing protein interaction networks needed for effector translocation into host cells. In Salmonella enterica serovar Typhimurium, a T3SS encoded in a large genomic island (SPI-2) is required for intracellular infection, but the chaperone complement required for effector translocation by this system is not known. Using a reverse genetics approach, we identified a multi-cargo secretion chaperone that is functionally integrated with the SPI-2-encoded T3SS and required for systemic infection in mice. Crystallographic analysis of SrcA at a resolution of 2.5 Å revealed a dimer similar to the CesT chaperone from enteropathogenic E. coli but lacking a 17-amino acid extension at the carboxyl terminus. Further biochemical and quantitative proteomics data revealed three protein interactions with SrcA, including two effector cargos (SseL and PipB2) and the type III-associated ATPase, SsaN, that increases the efficiency of effector translocation. Using competitive infections in mice we show that SrcA increases bacterial fitness during host infection, highlighting the in vivo importance of effector chaperones for the SPI-2 T3SS

The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala

In rodents, the medial nucleus of the amygdala receives direct inputs from the accessory olfactory bulbs and is mainly implicated in pheromone-mediated reproductive and defensive behaviors. The principal neurons of the medial amygdala are GABAergic neurons generated principally in the caudo-ventral medial ganglionic eminence and preoptic area. Beside GABAergic neurons, the medial amygdala also contains glutamatergic Otp-expressing neurons cells generated in the lateral hypothalamic neuroepithelium and a non-well characterized Pax6-positive population. In the present work, we describe a novel glutamatergic Ebf3-expressing neuronal subpopulation distributed within the periphery of the postero-ventral medial amygdala. These neurons are generated in a pallial domain characterized by high expression of Gdf10. This territory is topologically the most caudal tier of the ventral pallium and accordingly, we named it Caudo-Ventral Pallium (CVP). In the absence of Pax6, the CVP is disrupted and Ebf3-expressing neurons fail to be generated. Overall, this work proposes a novel model of the neuronal composition of the medial amygdala and unravels for the first time a new novel pallial subpopulation originating from the CVP and expressing the transcription factor Ebf3.This work was supported by Grants of the French National Research Agency (Agence Nationale de la Recherche; ANR) [ANR-13-BSV4-0011] and by the French Government through the ‘Investments for the Future’ LABEX SIGNALIFE [ANR-11-LABX-0028-01] to M.S., by the Spanish Government (BFU2007-60263 and BFU2010-17305) to A.F, and by the Medical Research Council (MR/K013750/1) to T.T. N.R.-R. is funded by a postdoctoral fellowship from the Ville de Nice, France (“Aide Individuelle aux Jeunes Chercheurs 2016”).Peer reviewe

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London