51 research outputs found
Etude du support publicitaire, des critĂšres de choix et de la satisfaction des patients de deux centres dentaires
Le propos gĂ©nĂ©ral de ce mĂ©moire est de dĂ©terminer pourquoi un nouveau patient choisit de prendre rendez-vous dans un centre dentaire et d'Ă©valuer son niveau de satisfaction. L'Ă©tude est basĂ©e sur un questionnaire distribuĂ© lors du premier rendez-vous des nouveaux patients. Il est constituĂ© de trois sections (socio-dĂ©mographie, critĂšres de choix, satisfaction) et est complĂ©tĂ© par le patient en deux phases, les parties socio-dĂ©mographiques et critĂšres de choix avant le traitement par le dentiste et la partie satisfaction aprĂšs le traitement. L'Ă©chantillon de patients provient de deux centres dentaires ayant les mĂȘmes exigences en termes d'accueil et de qualitĂ© des soins, l'un Ă©tant situĂ© dans le canton de Zurich et l'autre dans le canton de Fribourg. [...] [Extrait p. 4]]]>
Group Practice, Dental ; Patient Satisfaction ; Advertising as Topic ; Choice Behavior ; Questionnaires
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Understanding Populist Party Organization : The Radical Right in Western Europe
info:doi:10.1057/978-1-137-58197-6
info:eu-repo/semantics/altIdentifier/doi/10.1057/978-1-137-58197-6
urn:isbn:978-1-137-58196-9
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urn:isbn:978-1-137-58197-6
info:eu-repo/semantics/altIdentifier/isbn/978-1-137-58197-6
http://www.palgrave.com/jp/book/9781137581969
Heinisch, Reinhard
Mazzoleni, Oscar
info:eu-repo/semantics/book
book
2016-11-11
eng
X2074055640/61
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2022-05-11T11:44:09Z
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oai:serval.unil.ch:BIB_E92000305FEF
2022-05-07T01:29:17Z
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https://serval.unil.ch/notice/serval:BIB_E92000305FEF
Validation des SCORES cliniques: notions théoriques et pratiques de base. [Validation of clinical scores: theoretical and practical basic notions].
info:eu-repo/semantics/altIdentifier/pmid/20964015
Guessous, Idris
Durieux-Paillard, Sophie
info:eu-repo/semantics/article
article
2010
Revue MĂ©dicale Suisse, vol. 6, no. 264, pp. 1798-1802
info:eu-repo/semantics/altIdentifier/pissn/1660-9379[print], 1660-9379[linking]
<![CDATA[Chaque jour, le médecin utilise dans sa pratique des scores cliniques. Ces scores sont souvent des aides à la décision médicale. Les étapes de validation des scores cliniques sont par contre souvent méconnues du médecin. Cette revue rappelle les bases théoriques de la validation d'un score clinique et propose des exercices pratiques.
[Abstract] Physicians are using clinical scores on a regular basis. These scores are generally helpful in making medical decisions. However, the process of validation of clinical scores is often unknown to the physicians. This paper reviews the theory of validation of clinical scores and proposes practical exercises
LâintĂ©gration dâun Ă©lĂšve avec une dĂ©ficience intellectuelle dans les degrĂ©s 1H-2H
Nous avons choisi la thĂ©matique de lâintĂ©gration scolaire au cycle 1 pour notre mĂ©moire professionnel. Nous dĂ©sirions dĂ©couvrir les moyens mis en place afin de faciliter lâintĂ©gration dâun Ă©lĂšve avec une dĂ©ficience intellectuelle dans une classe 1H-2H. Nous souhaitions Ă©galement connaĂźtre les buts, les bĂ©nĂ©fices, les difficultĂ©s que peut provoquer une intĂ©gration scolaire. Pour dĂ©buter notre travail, nous nous sommes renseignĂ©es sur des aspects historiques concernant le handicap en Suisse afin dâen connaĂźtre son Ă©volution et comprendre ce quâil se passe actuellement lorsquâun enseignant intĂšgre un enfant en situation de handicap au sein de sa classe. En effet, nous savions que cette thĂ©matique de lâintĂ©gration Ă©tait dâactualitĂ© et quâelle Ă©tait en plein changement. Il nous semblait Ă©galement essentiel de nous familiariser avec les textes de la loi scolaire pour le canton du Jura afin de savoir quelle Ă©tait la place de lâintĂ©gration au niveau politique. Nous avons ensuite dĂ©fini le concept de handicap et celui dâintĂ©gration. Nous avons pris connaissance des diffĂ©rentes maniĂšres dâintĂ©grer afin de discerner le modĂšle dâintĂ©gration employĂ© dans le canton du Jura. AprĂšs nous ĂȘtre imprĂ©gnĂ©es de la littĂ©rature concernant lâintĂ©gration scolaire, nous avons Ă©laborĂ© un guide dâentretien qui nous a permis de questionner dix enseignantes jurassiennes des classes 1H -2H sur leur expĂ©rience concernant lâintĂ©gration. Par ce procĂ©dĂ©, nous dĂ©sirions prendre connaissance de ce quâimplique une intĂ©gration scolaire pour lâenseignant. Nous exposons trois Ă©lĂ©ments qui ressortent de notre analyse. Le premier est lâimportance de la collaboration entre les diffĂ©rents protagonistes (lâaide externe, les parents de lâenfant intĂ©grĂ©) lors dâune intĂ©gration. Le deuxiĂšme Ă©lĂ©ment concerne lâaide externe qui est prĂ©sente dans la classe lors de lâintĂ©gration de lâenfant avec une dĂ©ficience intellectuelle et qui est essentielle au bon fonctionnement de ce processus. Pour terminer, le troisiĂšme Ă©lĂ©ment traite de lâorganisation nĂ©cessaire pour accueillir un Ă©lĂšve en situation de handicap
Identification of Plastoglobules as a Site of Carotenoid Cleavage
Carotenoids play an essential role in light harvesting and protection from excess light. During chloroplast senescence carotenoids are released from their binding proteins and are eventually metabolized. Carotenoid cleavage dioxygenase 4 (CCD4) is involved in carotenoid breakdown in senescing leaf and desiccating seed, and is part of the proteome of plastoglobules (PG), which are thylakoid-associated lipid droplets. Here, we demonstrate that CCD4 is functionally active in PG. Leaves of Arabidopsis thaliana ccd4 mutants constitutively expressing CCD4 fused to yellow fluorescent protein showed strong fluorescence in PG and reduced carotenoid levels upon dark- induced senescence. Lipidome-wide analysis indicated that Ă-carotene, lutein, and violaxanthin were the principle substrates of CCD4 in vivo and were cleaved in senescing chloroplasts. Moreover, carotenoids were shown to accumulate in PG of ccd4 mutant plants during senescence, indicating translocation of carotenoids to PG prior to degradation
Characterisation of Hybrid Polymersome Vesicles Containing the Efflux Pumps NaAtm1 or P-Glycoprotein
Investigative systems for purified membrane transporters are almost exclusively reliant on the use of phospholipid vesicles or liposomes. Liposomes provide an environment to support protein function; however, they also have numerous drawbacks and should not be considered as a âone-size fits allâ system. The use of artificial vesicles comprising block co-polymers (polymersomes) offers considerable advantages in terms of structural stability; provision of sufficient lateral pressure; and low passive permeability, which is a particular issue for transport assays using hydrophobic compounds. The present investigation demonstrates strategies to reconstitute ATP binding cassette (ABC) transporters into hybrid vesicles combining phospholipids and the block co-polymer poly (butadiene)-poly (ethylene oxide). Two efflux pumps were chosen; namely the Novosphingobium aromaticivorans Atm1 protein and human P-glycoprotein (Pgp). Polymersomes were generated with one of two lipid partners, either purified palmitoyl-oleoyl-phosphatidylcholine, or a mixture of crude E. coli lipid extract and cholesterol. Hybrid polymersomes were characterised for size, structural homogeneity, stability to detergents, and permeability. Two transporters, NaAtm1 and P-gp, were successfully reconstituted into pre-formed and surfactant-destabilised hybrid polymersomes using a detergent adsorption strategy. Reconstitution of both proteins was confirmed by density gradient centrifugation and the hybrid polymersomes supported substrate dependent ATPase activity of both transporters. The hybrid polymersomes also displayed low passive permeability to a fluorescent probe (calcein acetomethoxyl-ester (C-AM)) and offer the potential for quantitative measurements of transport activity for hydrophobic compounds
The Specialized Roles in Carotenogenesis and Apocarotenogenesis of the Phytoene Synthase Gene Family in Saffron
Crocus sativus stigmas are the main source of crocins, which are glucosylated
apocarotenoids derived from zeaxanthin cleavage that give saffron its red color.
Phytoene synthase (PSY) mediates the first committed step in carotenoid biosynthesis
in plants. Four PSY genes encoding functional enzymes were isolated from saffron.
All the proteins were localized in plastids, but the expression patterns of each gene,
CsPSY1a, CsPSY1b, CsPSY2, and CsPSY3, in different saffron tissues and during the
development of the stigma showed different tissue specialization. The CsPSY2 transcript
was primarily detected in the stigmas where it activates and stimulates the accumulation
of crocins, while its expression was very low in other tissues. In contrast, CsPSY1a
and CsPSY1b were mainly expressed in the leaves, but only CsPSY1b showed stresslight
regulation. Interestingly, CsPSY1b showed differential expression of two alternative
splice variants, which differ in the intron retention at their 50 UTRs, resulting in a reduction
in their expression levels. In addition, the CsPSY1a and CsPSY1b transcripts, together
with the CsPSY3 transcript, were induced in roots under different stress conditions.
The CsPSY3 expression was high in the root tip, and its expression was associated
with mycorrhizal colonization and strigolactone production. CsPSY3 formed a separate
branch to the stress-specific Poaceae homologs but was closely related to the dicot
PSY3 enzymes
Overexpression of the chloroplastic 2-oxoglutarate/malate transporter disturbs carbon and nitrogen homeostasis in rice
The chloroplastic 2-oxaloacetate (OAA)/malate transporter (OMT1 or DiT1) takes part in the malate valve that protects chloroplasts from excessive redox poise through export of malate and import of OAA. Together with the glutamate/malate transporter (DCT1 or DiT2), it connects carbon with nitrogen assimilation, by providing 2-oxoglutarate for the GS/GOGAT (glutamine synthetase/glutamate synthase) reaction and exporting glutamate to the cytoplasm. OMT1 further plays a prominent role in C4 photosynthesis: OAA resulting from phosphoenolpyruvate carboxylation is imported into the chloroplast, reduced to malate by plastidic NADP-malate dehydrogenase, and then exported for transport to bundle sheath cells. Both transport steps are catalyzed by OMT1, at the rate of net carbon assimilation. To engineer C4 photosynthesis into C3 crops, OMT1 must be expressed in high amounts on top of core C4 metabolic enzymes. We report here high-level expression of ZmOMT1 from maize in rice (Oryza sativa ssp. indica IR64). Increased activity of the transporter in transgenic rice was confirmed by reconstitution of transporter activity into proteoliposomes. Unexpectedly, overexpression of ZmOMT1 in rice negatively affected growth, CO2 assimilation rate, total free amino acid content, tricarboxylic acid cycle metabolites, as well as sucrose and starch contents. Accumulation of high amounts of aspartate and the impaired growth phenotype of OMT1 rice lines could be suppressed by simultaneous overexpression of ZmDiT2. Implications for engineering C4 rice are discussed
Interaction of Copper-Based Nanoparticles to Soil, Terrestrial, and Aquatic Systems: Critical Review of the State of the Science and Future Perspectives
In the past two decades, increased production and usage of metallic nanoparticles (NPs) has inevitably increased their discharge into the different compartments of the environment, which ultimately paved the way for their uptake and accumulation in various trophic levels of the food chain. Due to these issues, several questions have been raised on the usage of NPs in everyday life and has become a matter of public health concern. Among the metallic NPs, Cu-based NPs have gained popularity due to their cost-effectiveness and multifarious promising uses. Several studies in the past represented the phytotoxicity of Cu-based NPs on plants. However, comprehensive knowledge is still lacking. Additionally, the impact of Cu-based NPs on soil organisms such as agriculturally important microbes, fungi, mycorrhiza, nematode, and earthworms are poorly studied. This review article critically analyses the literature data to achieve a more comprehensive knowledge on the toxicological profile of Cu-based NPs and increase our understanding of the effects of Cu-based NPs on aquatic and terrestrial plants as well as on soil microbial communities. The underlying mechanism of biotransformation of Cu-based NPs and the process of their penetration into plants has also been discussed herein. Overall, this review could provide valuable information to design rules and regulations for the safe disposal of Cu-based NPs into a sustainable environment
Ăvolution diffĂ©rente de deux traits de contact interdialectal en français louisianais : les cas de quoi et jâavons
Abstract
Contemporary Louisiana French is a koine, the product of contact between several 18th- and 19th-century varieties of French. We will explore two variables with different outcomes in the context of dialect contact: qui vs. quoi âwhatâ, and the JâAVONS pattern (e.g. jâavons, je parlons). The interrogatives qui and quoi are both still widely attested in Louisiana French, though in different locales. We explore Byersâ (1988) hypothesis that their distribution can be attributed to settlement patterns of Acadians (quoi) and 18th-century Creoles (qui). The JâAVONS pattern, though totally unattested today, is found in a dozen late 19th- and early 20th-century sources. Strikingly, though, most of these Louisiana attestations are not 1pl. but 1sg.We argue that this can be understood as a reanalysis of JâAVONS, precipitated by contact with non-JâAVONS dialects, prior to elimination of the form altogether, and contributing to the largely leveled verb paradigm one finds in Louisiana French today
- âŠ