ICAR: endoscopic skull‐base surgery

n/

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access

Trends and evolution of drug use in adolescents of Mexico City: 1989-1997. Community Epidemiology Work Group. National Institute of Drug Abuse.

Artícul

Alcohol and Drug Consumption among Students from Pachuca, Hidalgo

OBJECTIVE. To determine the prevalence of alcohol and drug consumption and its relationship to sociodemographic variables, leisure activities, antisocial behavior, family norms and conflicts, among others. MATERIAL AND METHODS. Data derive from a representative survey of 1 929 students of junior high and high school, conducted in 1996 in the city of Pachuca, Hidalgo, Mexico. Of these, 44.9% were boys and 52.5% were girls; mean age was 14. A self-applied questionnaire, prepared by the WHO together with some countries, among them Mexico, was completed by the studied subjects, and included indicators of alcohol and drug consumption. RESULTS. Of the total sample, 47.9% had tried alcohol, and 12.6% had drunk large quantities -5 drinks or more per sitting- during the month previous to the survey. Preferred drinks are beer and coolers , which they buy at shops where no identification is required and drink at home or at friend\u27s homes. With respect to drugs, 5.1% had tried illegal or medical drugs without prescription, in particular inhalants, marihuana and tranquilizers. More boys consumed illegal drugs, and more girls medical drugs without prescription. Boys, who are also older, more frequently consumed alcohol and drugs and were more often employed during the previous year at part-time jobs. High alcohol level and drug consumers were characterized by their frequent report of being bored in their free time, drinking with friends and enrolling in antisocial behavior. With respect to family norms, they follow them less and show less interest in doing so. An elevated percentage informed that their parents fight frequently, that they have sought help for this reason and have intended separation. CONCLUSIONS. Groups who drink more alcohol and use other drugs, in contrast with non-users, presented more behavioral problems, more outdoors activities that included drinking with friends, more antisocial behavior, had a distant relationship with their families sharing few activities with them, an showed little interest in following family rules and perceiving conflicts within their families

Consumo de alcohol y drogas en estudiantes de Pachuca, Hidalgo. [Alcohol and drug use students from Pachuca, Hidalgo]

OBJETIVO. Determinar la prevalencia del consumo de drogas y bebidas alcohólicas entre estudiantes, así como la relación de este consumo con variables sociodemográficas, tiempo libre, actos antisociales, normas y conflictos familiares, entre otras. MATERIAL Y MÉTODOS. Los datos se derivan de una encuesta representativa de 1 929 estudiantes de enseñanza media y media superior de la ciudad de Pachuca, estado de Hidalgo, México, levantada en 1996, de los cuales 44.9% son hombres y 52.5% mujeres, con una media de edad de 14 años. Se utilizó un cuestionario autoaplicable, que incluye indicadores de consumo de drogas y alcohol elaborados por algunos países, entre ellos México, con la Organización Mundial de la Salud. RESULTADOS. El 47.9% ha probado bebidas alcohólicas; 12.6% bebieron cantidades considerables -cinco copas o más por ocasión- durante el mes anterior a la encuesta. Las bebidas preferidas son la cerveza y los coolers; el alcohol lo compraron principalmente en tiendas donde no les piden identificación y lo consumen en su casa o en la de otras personas. El 5.1% ha consumido drogas, sobre todo inhalables, mariguana y tranquilizantes. Una cifra mayor de varones consume drogas ilegales, y las mujeres, medicamentos sin prescripción. Un número superior de hombres toma más cantidades de alcohol y consume drogas, tienen mayor edad y trabajaron de medio tiempo durante el año anterior a la encuesta. Los consumidores de drogas y de altas cantidades de alcohol se distinguieron porque un número considerable informó que se aburría en su tiempo libre, se va a beber con sus amigos o ha cometido actos antisociales. Respecto a la familia, manifiestan cumplir menos con las normas parentales y muestran menor interés en hacerlo. Asimismo, un porcentaje más elevado informó que sus padres pelean con frecuencia, han pedido ayuda por esa razón y han intentado separarse. CONCLUSIONES. Los estudiantes que beben cantidades elevadas de alcohol y los consumidores de otras drogas, a diferencia de lo que sucede con los abstemios, presentaron más problemas al destinar su tiempo libre a actividades como irse a beber con amigos, exhibir más conductas antisociales y tener un distanciamiento de la familia que se refleja en la baja participación en actividades compartidas, en el desinterés por cumplir con sus normas y en la percepción de conflictos al interior de la misma.OBJECTIVE. To determine the prevalence of alcohol and drug consumption and its relationship to sociodemographic variables, leisure activities, antisocial behavior, family norms and conflicts, among others. MATERIAL AND METHODS. Data derive from a representative survey of 1 929 students of junior high and high school, conducted in 1996 in the city of Pachuca, Hidalgo, Mexico. Of these, 44.9% were boys and 52.5% were girls; mean age was 14. A self-applied questionnaire, prepared by the WHO together with some countries, among them Mexico, was completed by the studied subjects, and included indicators of alcohol and drug consumption. RESULTS. Of the total sample, 47.9% had tried alcohol, and 12.6% had drunk large quantities -5 drinks or more per sitting- during the month previous to the survey. Preferred drinks are beer and "coolers", which they buy at shops where no identification is required and drink at home or at friend's homes. With respect to drugs, 5.1% had tried illegal or medical drugs without prescription, in particular inhalants, marihuana and tranquilizers. More boys consumed illegal drugs, and more girls medical drugs without prescription. Boys, who are also older, more frequently consumed alcohol and drugs and were more often employed during the previous year at part-time jobs. High alcohol level and drug consumers were characterized by their frequent report of being bored in their free time, drinking with friends and enrolling in antisocial behavior. With respect to family norms, they follow them less and show less interest in doing so. An elevated percentage informed that their parents fight frequently, that they have sought help for this reason and have intended separation. CONCLUSIONS. Groups who drink more alcohol and use other drugs, in contrast with non-users, presented more behavioral problems, more outdoors activities that included drinking with friends, more antisocial behavior, had a distant relationship with their families sharing few activities with them, an showed little interest in following family rules and perceiving conflicts within their families

Associação entre comportamentos de risco à saúde de pais e adolescentes em escolares de zona rural de um município do Sul do Brasil Association between health risk behaviors in parents and adolescents in a rural area in southern Brazil

Objetivou-se avaliar a associação entre comportamentos de risco à saúde dos pais e adolescentes escolares de zona rural. Participaram 377 escolares entre 10 e 18 anos e 338 pais. Foram analisados: nível de atividade física no lazer e deslocamento, hábitos de alimentação inadequados, excesso de peso, uso de cigarros e consumo de bebidas alcoólicas. A prevalência de relato de uso de cigarro e álcool nos últimos 30 dias entre os jovens foi de 6,7% e 27%, respectivamente. Quarenta e cinco por cento dos adolescentes não atingiram o escore de atividade física. A adesão aos passos para uma alimentação saudável foi baixa. A atividade física dos adolescentes esteve relacionada de forma positiva com a dos pais, e o consumo de álcool da mãe se associou de forma positiva com o consumo do adolescente. Para os outros comportamentos, não houve associação significativa. Na análise estratificada por sexo, o nível de atividade física do pai se associou ao nível de atividade física das meninas. O comportamento de risco à saúde dos pais associa-se ao mesmo comportamento dos adolescentes de zona rural.<br>This article aimed to assess the association between health risk behaviors in parents and adolescents in a rural area. The sample included 377 schoolchildren 10 to 18 years of age and 338 parents. The following variables were analyzed: level of leisure-time and commuting physical activity, inadequate eating habits, overweight/obesity, smoking, and alcohol consumption. Prevalence rates for smoking and alcohol consumption by adolescents in the previous 30 days were 6.7% and 27%, respectively. Forty-five percent of adolescents failed to reach the target physical activity score. Adherence to steps to healthy eating was low. Physical activity in adolescents was positively associated with that of parents, and adolescent drinking was associated with maternal alcohol consumption. There was no significant association for other behaviors. In the analysis stratified by gender, level of physical exercise in female adolescents was associated with that of fathers. Parental health risk behaviors were associated with the behaviors in the adolescent children in this rural area

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease