Reproductive Failure in UK Harbour Porpoises Phocoena phocoena : Legacy of Pollutant Exposure?

This research was supported by a Marie Curie International Outgoing Fellowship within the Seventh European Community Framework Programme (Project Cetacean-stressors, PIOF-GA-2010-276145 to PDJ and SM). Additional funding was provided through the Agreement on the Conservation of Small Cetaceans of the Baltic, North East Atlantic, Irish and North Seas (ASCOBANS) (Grants SSFA/2008 and SSFA / ASCOBANS / 2010 / 5 to SM). Analysis of Scottish reproductive and teeth samples was funded by the EC-funded BIOCET project (BIOaccumulation of persistent organic pollutants in small CETaceans in European waters: transport pathways and impact on reproduction, grant EVK3-2000-00027 to GJP), and Marine Scotland (GJP). Samples examined in this research were collected under the collaborative Cetacean Strandings Investigation Programme (http://ukstrandings.org/), which is funded by the Department for Environment, Food and Rural Affairs (Defra) and the UK’s Devolved Administrations in Scotland and Wales (http://sciencesearch.defra.gov.uk/Defaul​t.aspx?Menu=Menu&Module=More&Location=No​ne&Completed=0&ProjectID=15331) (grants to PDJ, RD). UK Defra also funded the chemical analysis under a service-level agreement with the Centre for Environment, Fisheries and Aquaculture Science (grants to RJL, JB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Tectonic Transport Directions, Shear Senses and Deformation Temperatures Indicated by Quartz c‐Axis Fabrics and Microstructures in a NW‐SE Transect across the Moine and Sgurr Beag Thrust Sheets, Caledonian Orogen of Northern Scotland

Moine metasedimentary rocks of northern Scotland are characterized by arcuate map patterns of mineral lineations that swing progressively clockwise from orogen‐perpendicular E‐trend-ing lineations in greenschist facies mylonites above the Moine thrust on the foreland edge of the Caledonian Orogen, to S‐trending lineations at higher structural levels and metamorphic grades in the hinterland. Quartz c‐axis fabrics measured on a west to east coast transect demonstrate that the lineations developed parallel to the maximum principal extension direction and therefore track the local tectonic transport direction. Microstructures and c‐axis fabrics document a progressive change from top to the N shearing in the hinterland to top to the W shearing on the foreland edge. Field relationships indicate that the domain of top to the N shearing was at least 55 km wide before later horizontal shortening on km‐scale W‐vergent folds that detach on the underlying Moine thrust. Previously published data from the Moine thrust mylonites demonstrate that top to the W shearing had largely ceased by 430 Ma, while preliminary isotopic age data suggest top to the N shearing occurred at ~470–450 Ma. In addition, data from the east coast end of our transect indicate normal-sense top down‐SE shearing at close to peak temperatures at ~420 Ma that may be related to the closing stages of Scandian deformation, metamorphism and cooling/exhumation

Searching for transits in the Wide Field Camera Transit Survey with difference-imaging light curves

The Wide Field Camera Transit Survey is a pioneer program aiming at for searching extra-solar planets in the near-infrared. The images from the survey are processed by a data reduction pipeline, which uses aperture photometry to construct the light curves. We produce an alternative set of light curves using the difference-imaging method for the most complete field in the survey and carry out a quantitative comparison between the photometric precision achieved with both methods. The results show that differencephotometry light curves present an important improvement for stars with J > 16. We report an implementation on the box-fitting transit detection algorithm, which performs a trapezoid-fit to the folded light curve, providing more accurate results than the boxfitting model. We describe and optimize a set of selection criteria to search for transit candidates, including the V-shape parameter calculated by our detection algorithm. The optimized selection criteria are applied to the aperture photometry and difference-imaging light curves, resulting in the automatic detection of the best 200 transit candidates from a sample of ~475 000 sources. We carry out a detailed analysis in the 18 best detections and classify them as transiting planet and eclipsing binary candidates. We present one planet candidate orbiting a late G-type star. No planet candidate around M-stars has been found, confirming the null detection hypothesis and upper limits on the occurrence rate of short-period giant planets around M-dwarfs presented in a prior study. We extend the search for transiting planets to stars with J ≤ 18, which enables us to set a stricter upper limit of 1.1%. Furthermore, we present the detection of five faint extremely-short period eclipsing binaries and three M-dwarf/M-dwarf binary candidates. The detections demonstrate the benefits of using the difference-imaging light curves, especially when going to fainter magnitudes.Peer reviewe

The economic impacts of ocean acidification on shellfish fisheries and aquaculture in the United Kingdom

Ocean acidification may pose a major threat to commercial fisheries, especially those for calcifying shellfish species. This study was undertaken to estimate the potential economic costs resulting from ocean acidification on UK wild capture and aquaculture shellfish production. Applying the net present value (NPV) and partial equilibrium (PE) models, we estimate both direct and economy-wide economic losses of shellfish production by 2100. Estimates using the NPV method show that the direct potential losses due to reduced shellfish production range from 14% to 28% of fishery NPV. This equates to annual economic losses of between o3 and o6 billion of the UK's GDP in 2013, for medium and high emission scenarios. Results using the PE model showed the total loss to the UK economy from shellfish production and consumption ranging from o23-o88 million. The results from both the direct valuation and predicted estimate for the economic losses on shellfish harvest indicate that there are regional variations due to different patterns of shellfish wild-capture and aquaculture, and the exploitation of species with differing sensitivities to ocean acidification. These results suggest that the potential economic losses vary depending on the chosen valuation method. This analysis is also partial as it did not include a wider group of species in early-life-stages or predator-prey effects. Nevertheless, findings show that the economic losses to the UK and its devolved administrations due to ocean acidification could be substantial. We conclude that addressing ocean acidification with the aim of preserving commercially valuable shellfish resources will require regional, national or international solutions using a combined approach to reduce atmospheric CO2 emissions and shift in focus to exploit species that are less vulnerable to ocean acidification

Mass models of the Milky Way

We present a simple method for fitting parametrized mass models of the Milky Way to observational constraints. We take a Bayesian approach which allows us to take into account input from photometric and kinematic data, and expectations from theoretical modelling. This provides us with a best-fitting model, which is a suitable starting point for dynamical modelling. We also determine a probability density function on the properties of the model, which demonstrates that the mass distribution of the Galaxy remains very uncertain. For our choices of parametrization and constraints, we find disc scale lengths of 3.00 \pm 0.22 kpc and 3.29 \pm 0.56 kpc for the thin and thick discs respectively; a Solar radius of 8.29 \pm 0.16 kpc and a circular speed at the Sun of 239 \pm 5 km/s; a total stellar mass of 6.43 \pm 0.63 * 10^10 M_sun; a virial mass of 1.26 \pm 0.24 * 10^12 M_sun and a local dark matter density of 0.40 \pm 0.04 GeV/cm^3. We find some correlations between the best-fitting parameters of our models (for example, between the disk scale lengths and the Solar radius), which we discuss. The chosen disc scale-heights are shown to have little effect on the key properties of the model.Comment: 13 pages, 5 figures, 4 tables. Accepted by MNRA

Antlia Dwarf Galaxy: Distance, quantitative morphology and recent formation history via statistical field correction

We apply a statistical field correction technique originally designed to determine membership of high redshift galaxy clusters to Hubble Space Telescope imaging of the Antlia Dwarf Galaxy; a galaxy at the very edge of the Local Group. Using the tip of the red giant branch standard candle method coupled with a simple Sobel edge detection filter we find a new distance to Antlia of 1.31 +/- 0.03 Mpc. For the first time for a Local Group Member, we compute the concentration, asymmetry and clumpiness (CAS) quantitative morphology parameters for Antlia from the distribution of resolved stars in the HST/ACS field, corrected with a new method for contaminants and complement these parameters with the Gini coefficient (G) and the second order moment of the brightest 20 per cent of the flux (M_20). We show that it is a classic dwarf elliptical (C = 2.0, A = 0.063, S = 0.077, G = 0.39 and M_20 = -1.17 in the F814W band), but has an appreciable blue stellar population at its core, confirming on-going star-formation. The values of asymmetry and clumpiness, as well as Gini and M_20 are consistent with an undisturbed galaxy. Although our analysis suggests that Antlia may not be tidally influenced by NGC 3109 it does not necessarily preclude such interaction.Comment: Accepted for publication in MNRA

Blood eosinophil-guided oral prednisolone for COPD exacerbations in primary care in the UK (STARR2): A non-inferiority, multicentre, double-blind, placebo-controlled, randomised controlled trial

Background: Systemic glucocorticoids are recommended for use in chronic obstructive pulmonary disease (COPD) exacerbations; however, there is increased harm associated with their use. We hypothesised that the use of eosinophil biomarker-directed oral prednisolone therapy at the time of an exacerbation of COPD was effective at reducing prednisolone use without affecting adverse outcomes. Methods: The studying acute exacerbations and response (STARR2) study was a multicentre, randomised, double-blind, placebo-controlled trial conducted in 14 primary care practices in the UK. We included adults (aged ≥ 40 years), who were current or former smokers (with at least a 10 pack year smoking history) with a diagnosis of COPD, defined as a post-bronchodilator FEV1/forced vital capacity ratio of less than 0·7 previously recorded by the primary care physician, and a history of at least one exacerbation in the previous 12 months requiring systemic corticosteroids with or without antibiotics. All study staff and participants were masked to study group allocation and to treatment allocation. Participants were randomly assigned (1:1) to blood eosinophil-directed treatment (BET; to receive oral prednisolone 30 mg once daily if eosinophil count was high [ ≥ 2%] or placebo if eosinophil count was low [ \u3c 2%]) or to standard care treatment (ST; to receive prednisolone 30 mg once daily irrespective of the point-of-care eosinophil result). Treatment was prescribed for 14 days and all patients also received antibiotics. The primary outcome was the rate of treatment failure, defined as any need for re-treatment with antibiotics or steroids, hospitalisation for any cause, or death, assessed at 30 days after exacerbation in the modified intention-to-treat population. Participants were eligible for re-randomisation at further exacerbations (with a maximum of four exacerbations per participant). A safety analysis was conducted on all randomly assigned participants. Although designed as a superiority trial, after identification of an error in the randomisation code before data lock the study converted to show non-inferiority. An upper margin of 1·105 for the 95% CI was defined as the non-inferiority margin. This study was registered with EudraCT, 2017-001586-24, and is complete. Findings: Between Nov 6, 2017, and April 30, 2020, 308 participants were recruited from 14 general practices. 144 exacerbations (73 in the BET group and 71 in the ST group) from 93 participants (mean age 70 years [range 46–84] and mean percent predicted FEV1 60·9% [SD 19·4]; 52 [56%] male and 41 [44%] female; ethnicity data was not collected]) were included in the modified intention-to-treat analysis. There were 14 (19%) treatment failures at 30 days post-exacerbation in the BET group and 23 (32%) in the ST group; we found a large non-significant estimated effect between BET and ST (RR 0·60 [95% CI 0·33–1·04]; p=0·070) in reducing treatment failures after a COPD exacerbation. The non-inferiority analysis supported that BET was non-inferior to ST. Frequency of adverse events were similar between the study groups; glycosuria (2/102 [2%] in BET group and 1/101 [1%] in the ST group) and hospital admission for COPD exacerbation (2/102 [2%] in BET group and 1/101 [1%] in the ST group) were the two most common adverse events in both groups. No deaths occurred in the study. Interpretation: Blood eosinophil-directed prednisolone therapy at the time of an acute exacerbation of COPD is non-inferior to standard care and can be used to safely reduce systemic glucocorticoid use in clinical practice. Funding: National Institute for Health and Care Research

Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project

Testicular germ cell tumours (TGCT), which comprise seminoma and non-seminoma subtypes, are the most common cancers in young men. In this study, we present a comprehensive whole genome sequencing analysis of adult TGCTs. Leveraging samples from participants recruited via the UK National Health Service and data from the Genomics England 100,000 Genomes Project, our results provide an extended description of genomic elements underlying TGCT pathogenesis. This catalogue offers a comprehensive, high-resolution map of copy number alterations, structural variation, and key global genome features, including mutational signatures and analysis of extrachromosomal DNA amplification. This study establishes correlations between genomic alterations and histological diversification, revealing divergent evolutionary trajectories among TGCT subtypes. By reconstructing the chronological order of driver events, we identify a subgroup of adult TGCTs undergoing relatively late whole genome duplication. Additionally, we present evidence that human leukocyte antigen loss is a more prevalent mechanism of immune disruption in seminomas. Collectively, our findings provide valuable insights into the developmental and immune modulatory processes implicated in TGCT pathogenesis and progression

The velocity dispersion and mass function of the outer halo globular cluster Palomar 4

We obtained precise line-of-sight radial velocities of 23 member stars of the remote halo globular cluster Palomar 4 (Pal 4) using the High Resolution Echelle Spectrograph (HIRES) at the Keck I telescope. We also measured the mass function of the cluster down to a limiting magnitude of V~28 mag using archival HST/WFPC2 imaging. We derived the cluster's surface brightness profile based on the WFPC2 data and on broad-band imaging with the Low-Resolution Imaging Spectrometer (LRIS) at the Keck II telescope. We find a mean cluster velocity of 72.55+/-0.22 km/s and a velocity dispersion of 0.87+/-0.18 km/s. The global mass function of the cluster, in the mass range 0.55<=M<=0.85 M_solar, is shallower than a Kroupa mass function and the cluster is significantly depleted in low-mass stars in its center compared to its outskirts. Since the relaxation time of Pal 4 is of the order of a Hubble time, this points to primordial mass segregation in this cluster. Extrapolating the measured mass function towards lower-mass stars and including the contribution of compact remnants, we derive a total cluster mass of 29800 M_solar. For this mass, the measured velocity dispersion is consistent with the expectations of Newtonian dynamics and below the prediction of Modified Newtonian Dynamics (MOND). Pal 4 adds to the growing body of evidence that the dynamics of star clusters in the outer Galactic halo can hardly be explained by MOND.Comment: 17 pages, accepted for publication in MNRAS; Fig. 8 surface brightness/density data at github.com/matthiasjfrank/pal4_surface_brightnes