The problem of exploitation in advanced capitalism : are there feasible alternatives alleviating exploitation?

Le concept de l’exploitation est au cœur de la philosophie du travail et constitue l'une des tensions les plus fondamentales au sein des sociétés capitalistes modernes. Depuis Thomas Aquinas, jusqu’aux philosophes plus modernes tels John Locke, Adam Smith, Karl Marx ainsi que ceux plus contemporains tels John Rawls et G.A Cohen, l’exploitation est un enjeu qui fut longuement discuté en philosophie politique. Néanmoins, il semblerait que nous soyons toujours confrontés à la question de savoir ce que signifie d’être exploité. Solliciter l’avis d’un libertarien et d’un socialiste afin de décortiquer le concept de l’exploitation laisserait place à un débat perpétuel en l’absence d’une base commune qui permettrait d’élaborer sur le sujet. Toutefois, il ne suffit pas de considérer uniquement la perspective qui repose sur la définition pour comprendre l’exploitation. Cela dit, ce projet se concentre sur deux approches distinctes du problème de l'exploitation afin de parvenir à ériger des solutions réalistes vis-à-vis un problème aussi vieux que le travail lui-même. En explorant d'abord la façon dont la philosophie définit l'exploitation, nous pourrons situer un fondement théorique au problème. Une fois qu'une compréhension théorique est développée et que notre propre définition de l'exploitation est proposée, la discussion transige vers une exploration empirique de l'exploitation et de sa liaison étroite aux relations de pouvoir asymétriques du modèle capitaliste. Pour mettre en évidence l'asymétrie de pouvoir entre employeur et employé dans le capitalisme moderne, une étude de cas qui porte sur la fermeture de la succursale de Wal-Mart à Jonquière démontrera la partie empirique de notre étude ainsi que l'étendue de la vulnérabilité des travailleurs au sein du capitalisme avancé. Cette combinaison de l'exploration théorique et de la réalisation empirique nous permettra d'isoler les facteurs qui contribuent à la problématique de l'exploitation dans le capitalisme avancé ainsi que de formuler des solutions viables et réalistes. À travers ces solutions, ce projet cherche à comprendre comment nous pouvons rendre le capitalisme un meilleur système pour les travailleurs à l’aide la diminution graduelle de l'exploitation obtenue grâce à l'intégration des principes socialistes dans le capitalisme avancé lui-même.Exploitation as a concept sits at the heart of the philosophy of labour and constitutes one of the most fundamental tensions within modern capitalist societies. From as early as Thomas Aquinas, to more modern philosophers like John Locke, Adam Smith, Karl Marx, and even more contemporary, John Rawls and G.A Cohen, exploitation is a topic that has been discussed at lengths in political philosophy. However, it would seem that we are still met with the question of what it means to be exploited. Asking a libertarian and a socialist what constitutes exploitation would yield an endless debate that requires a steady ground to understand what it means to be exploited. However, it is not merely enough to understand from a definitional perspective what exploitation is. As such, this project focuses on two distinct approaches to the problem of exploitation in order to arrive at feasible solutions to a problem as old as labor itself. In first exploring what the cannon of philosophy defines exploitation as, we will be able to situate a theoretic underpinning of the problem. Once a theoretic understanding is developed and our own working definition of exploitation is put forward, the discussion will transition into an empiric exploration of exploitation and its connection to asymmetric power relations in capitalism. A case study surrounding the store closure of Wal-Mart’s Jonquière branch will highlight the asymmetry of power between employer and employee and subsequently showcase the extent of the vulnerability of workers within advanced capitalism. This coupling of theoretic exploration and empiric realisation will allow us to isolate what factors contribute to the problem of exploitation in advanced capitalism and posit feasible solutions to the problem of exploitation. In putting forward these solutions this project seeks to understand ways in which we can render capitalism a better system for workers through the gradual diminishment of exploitation achieved through the integration of socialist principles within advanced capitalism itself

Un sistema informativo di supporto ad una pianificazione innovativa della sicurezza stradale

Il Safety Manager è un sistema informativo che si basa sull'informatizzazione del processo di analisi e di pianificazione e cerca di migliorare le capacità decisionali dei progettisti durante l'identificazione delle possibili cause di incidentalità e durante la scelta degli interventi più efficaci per uno specifico sito, in base al minor rapporto costi/benefici

A preliminary analysis of in-depth accident data for powered two-wheelers and bicycles in Europe

Despite progress from scientific and technological advancements, road safety remains a major issue worldwide. Road accident impacts such as fatalities, injuries and property damage consist considerable costs borne not only by involved people but society as well. This study aims to present preliminary findings of in-depth accident analysis for two-wheelers (bicycles and powered two wheelers – PTWs) across six countries in Europe. Data regarding the conditions underlying accident occurrence are presented, including time and date, weather, vehicle and road conditions and rider-related parameters such as age, intoxication and use of protective equipment. In addition, a Two Step Cluster Analysis is implemented in order to explore any possible classification of the analysed cases. It appears that two clusters are formed: the first includes more favourable conditions (“no wind, no drugs, good lighting”) while the second consists of less favourable conditions for road safety (“windy, lighting, unknown DUI condition”). This hints at a meaningful separation of the examination of two-wheeler accidents when the influence of outside factors is considerable. The inclusion of different but representative areas across Europe offers robustness and transferability to the data and respective results

Toxoplasma gondii Syntaxin 6 is required for vesicular transport between endosomal-like compartments and the Golgi Complex

Apicomplexans are obligate intracellular parasites that invade the host cell in an active process that relies on unique secretory organelles (micronemes, rhoptries and dense granules) localized at the apical tip of these highly polarized eukaryotes. In order for the contents of these specialized organelles to reach their final destination, these proteins are sorted post-Golgi and it has been speculated that they pass through endosomal-like compartments (ELCs), where they undergo maturation. Here, we characterize a Toxoplasma gondii homologue of Syntaxin 6 (TgStx6), a well-established marker for the early endosomes and trans Golgi network (TGN) in diverse eukaryotes. Indeed, TgStx6 appears to have a role in the retrograde transport between ELCs, the TGN and the Golgi, because overexpression of TgStx6 results in the development of abnormally shaped parasites with expanded ELCs, a fragmented Golgi and a defect in inner membrane complex maturation. Interestingly, other organelles such as the micronemes, rhoptries and the apicoplast are not affected, establishing the TGN as a major sorting compartment where several transport pathways intersect. It therefore appears thatToxoplasma has retained a plant-like secretory pathway

SaferWheels study on powered two-wheeler and bicycle accidents in the EU - Annex 6 case summaries

SaferWheels study on powered two-wheeler and bicycle accidents in the EU - Annex 6 case summarie

SaferWheels study on powered two-wheeler and bicycle accidents in the EU - Final report

Road Safety remains a major societal issue within the European Union. In 2014, some 26,000 people died and more than 203,500 were seriously injured on the roads of Europe, i.e. the equivalent of a medium town. However, although there are variations between Member States, road fatalities have been falling throughout the EU. Over the last 20 years, most Member States have achieved an overall reduction, some more than 50%. During this period, research on road safety and accident prevention has predominantly focused on protecting car occupants, with significant results. However, at the same time the number of fatalities and injuries among other categories of road users has not fallen to the same extent, indeed, in some cases, they have risen. The “Vulnerable Road Users” (VRUs) in particular are a priority and represent a real challenge for researchers working on road safety and accident prevention. Accidents involving VRUs comprised approximately 48% of all fatalities in the EU during 2014, with Powered Two-Wheelers (PTWs) comprising 18% and cyclists comprising 8% of the total numbers of fatalities. The Commission adopted in July 2010 its Policy Orientations on Road Safety for 2010-2020. One of the strategic objectifies identified by the Commission is to improve the safety of Vulnerable Road Users. With this category of road users, motorcycle and moped users require specific attention given the trend in the number of accidents involving them and their important share of fatalities and serious injuries. The SaferWheels study was therefore conducted to investigate accident causation for traffic accidents involving powered two-wheelers and bicycles in the European Union. The objective of the study was to gather PTW and bicycle accident data from in-depth crash investigations, obtain accident causation and medical data for those crashes, and to store the information according to an appropriate and efficient protocol enabling a causation-oriented analysis. The expected outcomes were: - Collection of accident data for at least 500 accidents of which approximately 80% would involve Powered Two–Wheelers and the remainder bicycles. Equal numbers of cases were to be gathered in six countries; France, Greece, Italy, the Netherlands, Poland and the UK. - In-depth investigation and reporting for each of the accidents on the basis of the data collected. - Description of the main accident typologies and accident factors. - Proposal of most cost-effective measures to prevent PTW and bicycle accidents

Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii

Regulated exocytosis allows the timely delivery of proteins and other macromolecules precisely when they are needed to fulfil their functions. The intracellular parasite Toxoplasma gondii has one of the most extensive regulated exocytic systems among all unicellular organisms, yet the basis of protein trafficking and proteolytic modification in this system is poorly understood. We demonstrate that a parasite cathepsin protease, TgCPL, occupies a newly recognized va cuolar c ompartment (VAC) that undergoes dynamic fragmentation during T. gondii replication. We also provide evidence that within the VAC or late endosome this protease mediates the proteolytic maturation of proproteins targeted to micronemes, regulated secretory organelles that deliver adhesive proteins to the parasite surface during cell invasion. Our findings suggest that processing of microneme precursors occurs within intermediate endocytic compartments within the exocytic system, indicating an extensive convergence of the endocytic and exocytic pathways in this human parasite.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79312/1/j.1365-2958.2010.07181.x.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/79312/2/MMI_7181_sm_FigS1-8.pd

Deficiency of a Niemann-Pick, Type C1-related Protein in Toxoplasma Is Associated with Multiple Lipidoses and Increased Pathogenicity

Several proteins that play key roles in cholesterol synthesis, regulation, trafficking and signaling are united by sharing the phylogenetically conserved ‘sterol-sensing domain’ (SSD). The intracellular parasite Toxoplasma possesses at least one gene coding for a protein containing the canonical SSD. We investigated the role of this protein to provide information on lipid regulatory mechanisms in the parasite. The protein sequence predicts an uncharacterized Niemann-Pick, type C1-related protein (NPC1) with significant identity to human NPC1, and it contains many residues implicated in human NPC disease. We named this NPC1-related protein, TgNCR1. Mammalian NPC1 localizes to endo-lysosomes and promotes the movement of sterols and sphingolipids across the membranes of these organelles. Miscoding patient mutations in NPC1 cause overloading of these lipids in endo-lysosomes. TgNCR1, however, lacks endosomal targeting signals, and localizes to flattened vesicles beneath the plasma membrane of Toxoplasma. When expressed in mammalian NPC1 mutant cells and properly addressed to endo-lysosomes, TgNCR1 restores cholesterol and GM1 clearance from these organelles. To clarify the role of TgNCR1 in the parasite, we genetically disrupted NCR1; mutant parasites were viable. Quantitative lipidomic analyses on the ΔNCR1 strain reveal normal cholesterol levels but an overaccumulation of several species of cholesteryl esters, sphingomyelins and ceramides. ΔNCR1 parasites are also characterized by abundant storage lipid bodies and long membranous tubules derived from their parasitophorous vacuoles. Interestingly, these mutants can generate multiple daughters per single mother cell at high frequencies, allowing fast replication in vitro, and they are slightly more virulent in mice than the parental strain. These data suggest that the ΔNCR1 strain has lost the ability to control the intracellular levels of several lipids, which subsequently results in the stimulation of lipid storage, membrane biosynthesis and parasite division. Based on these observations, we ascribe a role for TgNCR1 in lipid homeostasis in Toxoplasma

Resolving the homology-function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology

With advances in DNA sequencing technology, it is increasingly common and tractable to informatically look for genes of interest in the genomic databases of parasitic organisms and infer cellular states. Assignment of a putative gene function based on homology to functionally characterized genes in other organisms, though powerful, relies on the implicit assumption of functional homology, i.e. that orthology indicates conserved function. Eukaryotes reveal a dazzling array of cellular features and structural organization, suggesting a concomitant diversity in their underlying molecular machinery. Significantly, examples of novel functions for pre-existing or new paralogues are not uncommon. Do these examples undermine the basic assumption of functional homology, especially in parasitic protists, which are often highly derived? Here we examine the extent to which functional homology exists between organisms spanning the eukaryotic lineage. By comparing membrane trafficking proteins between parasitic protists and traditional model organisms, where direct functional evidence is available, we find that function is indeed largely conserved between orthologues, albeit with significant adaptation arising from the unique biological features within each lineage