104 research outputs found

    The Zero Resource Speech Challenge 2021: Spoken language modelling

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    Submitted to Interspeech 2021. arXiv admin note: text overlap with arXiv:2011.11588International audienceWe present the Zero Resource Speech Challenge 2021, which asks participants to learn a language model directly from audio, without any text or labels. The challenge is based on the Libri-light dataset, which provides up to 60k hours of audio from English audio books without any associated text. We provide a pipeline baseline system consisting on an encoder based on contrastive predictive coding (CPC), a quantizer (kk-means) and a standard language model (BERT or LSTM). The metrics evaluate the learned representations at the acoustic (ABX discrimination), lexical (spot-the-word), syntactic (acceptability judgment) and semantic levels (similarity judgment). We present an overview of the eight submitted systems from four groups and discuss the main results

    Clinical reappraisal of SHORT syndrome with PIK3R1 mutations: towards recommendation for molecular testing and management

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    International audienceSHORT syndrome has historically been defined by its acronym: short stature (S), hyperextensibility of joints and/or inguinal hernia (H), ocular depression (O), Rieger abnormality (R) and teething delay (T). More recently several research groups have identified PIK3R1 mutations as responsible for SHORT syndrome. Knowledge of the molecular etiology of SHORT syndrome has permitted a reassessment of the clinical phenotype. The detailed phenotypes of 32 individuals with SHORT syndrome and PIK3R1 mutation, including eight newly ascertained individuals, were studied to fully define the syndrome and the indications for PIK3R1 testing. The major features described in the SHORT acronym were not universally seen and only half (52%) had 4 or more of the classic features. The commonly observed clinical features of SHORT syndrome seen in the cohort included IUGR \textless 10(th) percentile, postnatal growth restriction, lipoatrophy and the characteristic facial gestalt. Anterior chamber defects and insulin resistance or diabetes were also observed but were not as prevalent. The less specific, or minor features of SHORT syndrome include teething delay, thin wrinkled skin, speech delay, sensorineural deafness, hyperextensibility of joints and inguinal hernia. Given the high risk of diabetes mellitus, regular monitoring of glucose metabolism is warranted. An echocardiogram, ophthalmological and hearing assessments are also recommended

    A search for time dependent neutrino emission from microquasars with the ANTARES telescope

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    Results are presented on a search for neutrino emission from a sample of six microquasars, based on the data collected by the ANTARES neutrino telescope between 2007 and 2010. By means of appropriate time cuts, the neutrino search has been restricted to the periods when the acceleration of relativistic jets was taking place at the microquasars under study. The time cuts have been chosen using the information from the X-ray telescopes RXTE/ASM and Swift/BAT, and, in one case, the gamma-ray telescope Fermi/LAT. No statistically significant excess has been observed, thus upper limits on the neutrino fluences have been derived and compared to the predictions by models. Constraints have been put on the ratio of proton to electron luminosity in the jets

    Work-related mental distress in primary care. Study of prevalence and associated factors

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    Le médecin généraliste (MG), est souvent confronté à des patients avec des problèmes de santé psychique en lien avec le travail. L’objectif de cette thèse est de déterminer la prévalence de la souffrance psychique en lien avec le travail chez les patients consultant leur MG et d’étudier l’association entre la souffrance psychique et les facteurs psychosociaux au travail. Ce travail est basé sur l’étude Héraclès menée auprès de 2 027 patients en activité ayant consulté leur MG dans Nord – Pas-de-Calais. La souffrance psychique a été évaluée par : le MINI International Neuropsychiatric Interview, la déclaration du patient et le diagnostic du MG. L’association entre la souffrance psychique objectivée par le MINI et les facteurs psychosociaux au travail a été étudiée en utilisant un modèle de régression de Poisson ou un modèle de régression logistique. La prévalence de la souffrance psychique en lien avec le travail objectivée par le MINI était de 25,6%, 24,5% pour la souffrance rapportée par le patient et 25,8% pour la souffrance diagnostiquée par le médecin. L’analyse multivariée a rapporté une association significative entre dépression/anxiété et l’intensité et temps de travail, l’exigence émotionnelle et les relations sociales au travail. La consommation excessive d’alcool était associée avec les relations sociales au travail et l’autonomie. La suicidalité était associée avec l’intensité et le temps de travail chez les hommes et l’exigence émotionnelle chez les femmes. Ces résultats démontrent le rôle majeur du MG dans la prise en charge de ces patients ainsi que le poids des facteurs du travail dans la présence de troubles psychiques.The general practitioner (GP) is often confronted with patients with mental health problems related to work. The objective of this study is to determine the prevalence of work related mental distress in patients consulting their GP and to study the association between mental distress and psychosocial factors at work. This work is based on the Héraclès study conducted among 2,027 patients in professional activity consulting their GP in the Nord - Pas-de-Calais. Mental distress was evaluated with the MINI International Neuropsychiatric Interview, by the patient's statement and the GP’s diagnosis. The association between mental distress objectified by the MINI and psychosocial factors at work was studied using a Poisson regression or a logistic regression model. The prevalence of work related mental distress objectified by the MINI was 25.6%, 24.5% for mental distress reported by the patient and 25.8% for mental distress diagnosed by the GP. In the multivariable analyses significant association was found for depression/anxiety and work intensity, emotional demands and social relations at work. Excessive alcohol consumption was associated with social relations at work and autonomy. For suicidality, there was an association with work intensity in men and emotional demands in women. The prevalence of work related mental distress found in our study was high and emphasize the major role of GPs in the management of these patients. Several psychosocial factors at work were associated with mental distress which shows the impact of those work characteristics on the presence of mental distress

    Simulation du comportement thermique d'un milieu continu équivalent par méthode des éléments discrets

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    International audienceLa méthode des éléments discrets est largement utilisée pour représenter non seulement le comportement mécanique de milieux hétérogènes et discontinus tels que les milieux divisés (grains, sols, maçonneries) mais aussi leur comportement thermique. Toutefois, lorsqu'elle est utilisée pour représenter un milieu continu équivalent, les approches thermo-mécaniques au sens discret ne sont plus utilisables en tant que telles. Ce travail a pour objectif d'étendre la méthode des éléments discrets afin de modéliser le transfert de chaleur par conduction dans un milieu continu équivalent. L'influence de l'arrangement spatial des éléments est étudiée afin que l'évolution de la température du système ne dépende pas de cette discrétisation. Les résultats sont comparés à une approche continue de type éléments finis. Pour conclure, le cas d'un milieu endommagé est traité afin de pouvoir effectuer une transition entre milieux continu et discret
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