Proceso de implementación de un sistema de producción más limpia en una empacadora de camarones

Producción más limpia (PML) significa aplicar una estrategia preventiva integral a los procesos, productos y servicios para incrementar la eficiencia y reducir los riesgos para las personas y el ambiente. Para la implementación se debió primeramente establecer un equipo de trabajo, luego se hizo un reconocimiento completo del proceso, seguido de un balance de materia y energía en el área de Shell On. Para identificar oportunidades de PML, se procedió a utilizar una matriz de impactos ambientales donde se analiza la severidad de los impactos, la probabilidad de contaminación y medidas para la reducción de los impactos, determinando la prioridad de las medidas y actuaciones a tomar por la empresa. Una vez determinada la prioridad de los casos se hace un estudio detallado de casos problema en este estudio se incluye identificación de los principales indicadores, análisis económicos y beneficios ambientales. Finalmente se establecen las conclusiones y recomendaciones

Potentialities and challenges of the Tourism and ecoturismo in the state of San Luis Potosí, Mexico: challenges and expectations to reach the regional development

El objetivo del trabajo es analizar la presencia de diversos actores y componentes en el estado de San Luis Potosí, México que pueden potenciar y que a la vez también que pueden ser vistos como obstáculos para que el turismo y ecoturismo logren convertirse en actividades que promuevan el bienestar económico y el desarrollo de cada una de las 4 regiones que conforman el estado. La investigación se sustenta en trabajo de campo, entrevistas con funcionarios municipales relacionados con el turismo, delegados regionales de la secretaria de turismo en las regiones Media, Altiplano y Huasteca del estado y con prestadores de servicios.The objective of the work is analyze the presence of diverse actors and components in the state of San Luis Potosí, Mexico that can harness and that simultaneously also that can be seen like obstacles so that the tourism and ecoturismo manage to become activities that promote the economic well-being and the development of each one of the regions of the State. The investigation is sustained in work of field, interviews with municipal civil employees related to the tourism, regional delegates of the secretary of tourism in the regions Media, Altiplano and Huasteca of the serve with lenders

Development of a variable stocking rate allocation model (VSRAM) in southern Patagonia

El ajuste de la carga animal es un aspecto clave en el manejo del pastoreo extensivo y en Santa Cruz, Argentina se realiza tradicionalmente utilizando una asignación fija de forraje (AFF) por animal, indistintamente si un potrero se utiliza continuamente durante el año o se usa estacionalmente durante el invierno. En este trabajo se generó un modelo para asignación variable de carga (MAVC) que contempla aspectos biológicos de balance de biomasa y calidad del pastizal relacionado con distintas variables del animal. El modelo se generó para 6 áreas ecológicas de Patagonia Sur: Pastizal Subandino, Matorral de Mata Negra, Estepa Magallánica Seca, Estepa Magallánica Húmeda, Complejo Andino y Ecotono Fueguino y puede ser utilizado en campos con uso continuo o estacional.El análisis de sensibilidad mostró que la variable porcentaje en dieta de forraje (variable que estima el consumo del animal) fue la más influyente en la respuesta del modelo. La variable de respuesta Residuo Forrajero Estimado por el modelo fue explicada satisfactoriamente por sus variables predictoras (Carga Animal Previa, Carga Animal Propuesta y Disponibilidad Forrajera) y resultó acorde con los datos de residuos forrajeros obtenidos durante los chequeos a campo (R2==0.91; p<0.01). Los resultados indican que el MAVC arroja valores similares a los cálculos realizados mediante AFF cuando los campos son utilizados anualmente. Por el contrario, cuando se evalúa el uso invernal, el modelo propone menores valores de carga animal que el método tradicional. El modelo MACV desarrollado en el presente trabajo ha logrado un balance entre complejidad y practicidad en la estimación de la capacidad de carga animal, lo cual sugiere que es una herramienta importante que puede ser utilizada en el manejo de los sistemas ganaderos en los pastizales de Patagonia Sur.Stocking rate adjustment is a key aspect in extensive grazing management. In Santa Cruz, Argentina, sheep carrying capacity is estimated through a fixed forage allowance (FFA) regardless of paddock use. In this work, we developed a variable stocking rate allocation model (VSRAM) based on the simulation of forage biomass and quality dynamics and the setting of critical residue targets at the end of the grazing period. The model was generated for 6 ecological areas of southern Patagonia and it can be used in paddocks with continuous or seasonal use. Model sensitivity analysis showed that the diet was the most sensitive variable for stocking rate estimations. We found a significant lineal correlation between values estimated by VSRAM and data observed in the field (R2=0.91; p<0.01). The results indicated that stocking rate estimation from the model and FFA had similar values when paddocks were used on an annual basis. However, when paddocks are used for short periods in winter, the model predicted lower stocking rate values than the traditional method. The VSRAM model achieved a balance between complexity and practicability for sheep carrying capacity determination. Our results suggest that this model is an important tool that can be used in the management of livestock systems in grasslands of South Patagonia.Fil: Andrade, Miguel Alberto. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional.patagonia Sur. Estacion Experimental Agropecuaria Santa Cruz.; Argentina. Universidad Nacional de la Patagonia Austral. Unidad Académica Río Gallegos; ArgentinaFil: Suarez, Diego D.. No especifíca;Fil: Peri, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Patagonia Austral. Unidad Académica Río Gallegos; Argentina. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional.patagonia Sur. Estacion Experimental Agropecuaria Santa Cruz.; ArgentinaFil: Borrelli, Nicolas Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. OVIS 21; ArgentinaFil: Ormaechea, Sebastián Gabriel. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional.patagonia Sur. Estacion Experimental Agropecuaria Santa Cruz.; ArgentinaFil: Ferrante, Daniela. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional.patagonia Sur. Estacion Experimental Agropecuaria Santa Cruz.; Argentina. Universidad Nacional de la Patagonia Austral. Unidad Académica Río Gallegos; ArgentinaFil: Rivera, Emilio H.. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional.patagonia Sur. Estacion Experimental Agropecuaria Santa Cruz.; ArgentinaFil: Sturzenbaum, María Virginia. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional.patagonia Sur. Estacion Experimental Agropecuaria Santa Cruz.; Argentin

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on cellular hierarchies reminiscent of normal development but superimposed on underlying genetic aberrations. In glioblastoma (GBM), a subset of stem-like tumor-propagating cells (TPCs) appears to drive tumor progression and underlie therapeutic resistance, yet remain poorly understood. Here, we identify a core set of neurodevelopmental TFs (POU3F2, SOX2, SALL2, OLIG2) essential for GBM propagation. These TFs coordinately bind and activate TPC-specific regulatory elements, and are sufficient to fully reprogram differentiated GBM cells to ‘induced’ TPCs, recapitulating the epigenetic landscape and phenotype of native TPCs. We reconstruct a network model that highlights critical interactions and identifies novel therapeutic targets for eliminating TPCs. Our study establishes the epigenetic basis of a developmental hierarchy in GBM, provides detailed insight into underlying gene regulatory programs, and suggests attendant therapeutic strategies

A global observational analysis to understand changes in air quality during exceptionally low anthropogenic emission

This global study, which has been coordinated by the World Meteorological Organization Global Atmospheric Watch (WMO/GAW) programme, aims to understand the behaviour of key air pollutant species during the COVID-19 pandemic period of exceptionally low emissions across the globe. We investigated the effects of the differences in both emissions and regional and local meteorology in 2020 compared with the period 2015–2019. By adopting a globally consistent approach, this comprehensive observational analysis focuses on changes in air quality in and around cities across the globe for the following air pollutants PM2.5, PM10, PMC (coarse fraction of PM), NO2, SO2, NOx, CO, O3 and the total gaseous oxidant (OX = NO2 + O3) during the pre-lockdown, partial lockdown, full lockdown and two relaxation periods spanning from January to September 2020. The analysis is based on in situ ground-based air quality observations at over 540 traffic, background and rural stations, from 63 cities and covering 25 countries over seven geographical regions of the world. Anomalies in the air pollutant concentrations (increases or decreases during 2020 periods compared to equivalent 2015–2019 periods) were calculated and the possible effects of meteorological conditions were analysed by computing anomalies from ERA5 reanalyses and local observations for these periods. We observed a positive correlation between the reductions in NO2 and NOx concentrations and peoples’ mobility for most cities. A correlation between PMC and mobility changes was also seen for some Asian and South American cities. A clear signal was not observed for other pollutants, suggesting that sources besides vehicular emissions also substantially contributed to the change in air quality. As a global and regional overview of the changes in ambient concentrations of key air quality species, we observed decreases of up to about 70% in mean NO2 and between 30% and 40% in mean PM2.5 concentrations over 2020 full lockdown compared to the same period in 2015–2019. However, PM2.5 exhibited complex signals, even within the same region, with increases in some Spanish cities, attributed mainly to the long-range transport of African dust and/or biomass burning (corroborated with the analysis of NO2/CO ratio). Some Chinese cities showed similar increases in PM2.5 during the lockdown periods, but in this case, it was likely due to secondary PM formation. Changes in O3 concentrations were highly heterogeneous, with no overall change or small increases (as in the case of Europe), and positive anomalies of 25% and 30% in East Asia and South America, respectively, with Colombia showing the largest positive anomaly of ~70%. The SO2 anomalies were negative for 2020 compared to 2015–2019 (between ~25 to 60%) for all regions. For CO, negative anomalies were observed for all regions with the largest decrease for South America of up to ~40%. The NO2/CO ratio indicated that specific sites (such as those in Spanish cities) were affected by biomass burning plumes, which outweighed the NO2 decrease due to the general reduction in mobility (ratio of ~60%). Analysis of the total oxidant (OX = NO2 + O3) showed that primary NO2 emissions at urban locations were greater than the O3 production, whereas at background sites, OX was mostly driven by the regional contributions rather than local NO2 and O3 concentrations. The present study clearly highlights the importance of meteorology and episodic contributions (e.g., from dust, domestic, agricultural biomass burning and crop fertilizing) when analysing air quality in and around cities even during large emissions reductions. There is still the need to better understand how the chemical responses of secondary pollutants to emission change under complex meteorological conditions, along with climate change and socio-economic drivers may affect future air quality. The implications for regional and global policies are also significant, as our study clearly indicates that PM2.5 concentrations would not likely meet the World Health Organization guidelines in many parts of the world, despite the drastic reductions in mobility. Consequently, revisions of air quality regulation (e.g., the Gothenburg Protocol) with more ambitious targets that are specific to the different regions of the world may well be required.Peer reviewedFinal Published versio

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

Utilization of mechanical power and associations with clinical outcomes in brain injured patients: a secondary analysis of the extubation strategies in neuro-intensive care unit patients and associations with outcome (ENIO) trial

Background: There is insufficient evidence to guide ventilatory targets in acute brain injury (ABI). Recent studies have shown associations between mechanical power (MP) and mortality in critical care populations. We aimed to describe MP in ventilated patients with ABI, and evaluate associations between MP and clinical outcomes. Methods: In this preplanned, secondary analysis of a prospective, multi-center, observational cohort study (ENIO, NCT03400904), we included adult patients with ABI (Glasgow Coma Scale ≤ 12 before intubation) who required mechanical ventilation (MV) ≥ 24&nbsp;h. Using multivariable log binomial regressions, we separately assessed associations between MP on hospital day (HD)1, HD3, HD7 and clinical outcomes: hospital mortality, need for reintubation, tracheostomy placement, and development of acute respiratory distress syndrome (ARDS). Results: We included 1217 patients (mean age 51.2&nbsp;years [SD 18.1], 66% male, mean body mass index [BMI] 26.3 [SD 5.18]) hospitalized at 62 intensive care units in 18 countries. Hospital mortality was 11% (n = 139), 44% (n = 536) were extubated by HD7 of which 20% (107/536) required reintubation, 28% (n = 340) underwent tracheostomy placement, and 9% (n = 114) developed ARDS. The median MP on HD1, HD3, and HD7 was 11.9&nbsp;J/min [IQR 9.2-15.1], 13&nbsp;J/min [IQR 10-17], and 14&nbsp;J/min [IQR 11-20], respectively. MP was overall higher in patients with ARDS, especially those with higher ARDS severity. After controlling for same-day pressure of arterial oxygen/fraction of inspired oxygen (P/F ratio), BMI, and neurological severity, MP at HD1, HD3, and HD7 was independently associated with hospital mortality, reintubation and tracheostomy placement. The adjusted relative risk (aRR) was greater at higher MP, and strongest for: mortality on HD1 (compared to the HD1 median MP 11.9&nbsp;J/min, aRR at 17&nbsp;J/min was 1.22, 95% CI 1.14-1.30) and HD3 (1.38, 95% CI 1.23-1.53), reintubation on HD1 (1.64; 95% CI 1.57-1.72), and tracheostomy on HD7 (1.53; 95%CI 1.18-1.99). MP was associated with the development of moderate-severe ARDS on HD1 (2.07; 95% CI 1.56-2.78) and HD3 (1.76; 95% CI 1.41-2.22). Conclusions: Exposure to high MP during the first week of MV is associated with poor clinical outcomes in ABI, independent of P/F ratio and neurological severity. Potential benefits of optimizing ventilator settings to limit MP warrant further investigation

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

Tumor subclasses differ according to the genotypes and phenotypes of malignant cells as well as the composition of the tumor microenvironment (TME).We dissected these influences in isocitrate dehydrogenase (IDH)-mutant gliomas by combining 14,226 single-cell RNA sequencing (RNA-seq) profiles from 16 patient samples with bulk RNA-seq profiles from 165 patient samples. Differences in bulk profiles between IDH-mutant astrocytoma and oligodendroglioma can be primarily explained by distinct TME and signature genetic events, whereas both tumor types share similar developmental hierarchies and lineages of glial differentiation. As tumor grade increases, we find enhanced proliferation of malignant cells, larger pools of undifferentiated glioma cells, and an increase in macrophage over microglia expression programs in TME. Our work provides a unifying model for IDH-mutant gliomas and a general framework for dissecting the differences among human tumor subclasses.National Cancer Institute (U.S.) (Grant P30-CA14051