Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Livedoid vasculopathy: fast involution after anticoagulant and hyperbaric oxygen therapy

The livedoid vasculopathy is a rare condition characterized by the presence of recurrent painful ulcers in distal extremities of lower limbs. Histologically there is thickness of dermal vessels, occlusion of its light by fibrin thrombi associated with minimal inflammatory infiltrate. It might occur as an isolated condition or be associated with an underlying systemic disease, including coagulation and collagen disorders, or neoplasms. Because it is a rare disease there is no consensus for its treatment. We report a case of a 41-year-old man with painful ulcers in the lower extremities. We did not find any associated diseases. The lesions improved dramatically after treatment with anticoagulant and hyperbaric therapy. We concluded that anticoagulation associated with hyperbaric oxygenation may be benefit for the treatment of patients with livedoid vasculopathy. However, further studies should be done with a larger population to confirm our results

Cobalt Tetrasulphonated Phthalocyanine Immobilized On Poly-l-lysine Film Onto Glassy Carbon Electrode As Amperometric Sensor For Cysteine.

The present work describes the development of a simple and efficient method for the amperometric determination of cysteine (CySH) in wild medium at an applied potential of 0.150 V versus Ag/AgCl. In this sense, the electrocatalytic oxidation of cysteine (CySH) was carried out on a glassy carbon electrode modified with cobalt tetrasulphonated phthalocyanine (CoTSPc) and poly-L-lysine (PLL) film. The immobilization of CoTSPc in PLL film was performed by a simple evaporation of the solvent. The CoTSPc/PLL film, formed on the GC electrode showed an electrocatalytic activity to the CySH oxidation. The sensor presented its best performance in 0.1 mol l(-1) Pipes at pH 7.5. Under optimized operational conditions, the sensor provided a wide linear response range for CySH from 0.50 up to 216.0 micromol l(-1) with a sensitivity and detection limit of 157 nA cm(-2) l micromol(-1) and 150 nmol l(-1), respectively. The proposed sensor presented higher sensitivity when compared to the other modified electrodes described in the literature and showed a stable response for at least 200 successive determinations. The repeatability of the measurements with the same sensor and different sensors, evaluated in term of relative standard deviation, were 4.1 and 5.2%, respectively, for n=10. The developed sensor was applied for the CySH determination in food supplement samples and the results were statistically the same to those obtained by a comparative method described in the literature at a confidence level of 95%.42184-9

Electrocatalytic Determination Of Reduced Glutathione In Human Erythrocytes.

The determination of reduced glutathione (GSH) in human erythrocytes using a simple, fast and sensitive method employing a glassy carbon electrode modified with cobalt tetrasulfonated phthalocyanine (CoTSPc) immobilized in poly(L: -lysine) (PLL) film was investigated. This modified electrode showed very efficient electrocatalytic activity for anodic oxidation of GSH, decreasing substantially the anodic overpotentials for 0.2 V versus Ag/AgCl. The modified electrode presented better performance in 0.1 mol l(-1) piperazine-N,N'-bis(2-ethanesulfonic acid) buffer at pH 7.4. The other experimental parameters, such as the concentration of CoTSPc and PLL in the membrane preparation, pH, type of buffer solution and applied potential, were optimized. Under optimized operational conditions, a linear response from 50 to 2,160 nmol l(-1) was obtained with a high sensitivity of 1.5 nA l nmol(-1) cm(-2). The detection limit for GSH determination was 15 nmol l(-1). The proposed sensor presented good repeatability, evaluated in terms of the relative standard deviation (1.5%) for n = 10. The modified electrode was applied for determination of GSH in erythrocyte samples and the results were in agreement with those obtained by a comparative method described in the literature The average recovery for these fortified samples was 100 +/- 1)%. Applying a paired Student's-t test to compare these methods, we could observe that, at the 95% confidence level, there was no statistical difference between the reference and the proposed methods.3871891-

The study of minimal residual disease in breast cancer patients: a review

The term minimal residual disease or micrometastasis refers to thepresence of some tumor cells in normal tissues that cannot be detectedby conventional methods, such as clinical examination, imagingmethods, or routine laboratory analyses. Investigation of minimalresidual disease in patients with breast cancer is currently done byassessment of the bone marrow or peripheral blood of these patientsin search of epithelial cells by immunocytochemical or moleculartechniques, such as RT-PCR. Cytogenetic and molecular studies havedemonstrated that these cells also harbor chromosome changessimilar to tumors present in patients and its consistent associationwith a worse prognosis in breast cancer patients reinforces itsimportance in the metastatic process. It will be briefly discussed thetheoretical bases for detection of minimal residual disease and therecent studies that allow to know some of the molecular and cellularcharacteristics of these disseminated malignant cells. This articlewill be finalized with a discussion on the most recent studies onthe prognostic value of minimal residual disease detection in breastcancer patients and future directions for research in this area