Design of trials for interrupting the transmission of endemic pathogens

Many interventions against infectious diseases have geographically diffuse effects. This leads to contamination between arms in cluster-randomized trials (CRTs). Pathogen elimination is the goal of many intervention programs against infectious agents, but contamination means that standard CRT designs and analyses do not provide inferences about the potential of interventions to interrupt pathogen transmission at maximum scale-up.; A generic model of disease transmission was used to simulate infections in stepped wedge cluster-randomized trials (SWCRTs) of a transmission-reducing intervention, where the intervention has spatially diffuse effects. Simulations of such trials were then used to examine the potential of such designs for providing generalizable causal inferences about the impact of such interventions, including measurements of the contamination effects. The simulations were applied to the geography of Rusinga Island, Lake Victoria, Kenya, the site of the SolarMal trial on the use of odor-baited mosquito traps to eliminate Plasmodium falciparum malaria. These were used to compare variants in the proposed SWCRT designs for the SolarMal trial.; Measures of contamination effects were found that could be assessed in the simulated trials. Inspired by analyses of trials of insecticide-treated nets against malaria when applied to the geography of the SolarMal trial, these measures were found to be robust to different variants of SWCRT design. Analyses of the likely extent of contamination effects supported the choice of cluster size for the trial.; The SWCRT is an appropriate design for trials that assess the feasibility of local elimination of a pathogen. The effects of incomplete coverage can be estimated by analyzing the extent of contamination between arms in such trials, and the estimates also support inferences about causality. The SolarMal example illustrates how generic transmission models incorporating spatial smoothing can be used to simulate such trials for a power calculation and optimization of cluster size and randomization strategies. The approach is applicable to a range of infectious diseases transmitted via environmental reservoirs or via arthropod vectors

Spring Dispersal Patterns of Red-winged Blackbirds, \u3ci\u3eAgelaius phoeniceus\u3c/i\u3e, staging in Eastern South Dakota

Red-winged Blackbirds (Agelaius phoeniceus) are very abundant summer residents throughout the Prairie Pothole Region of central Norht America. In late summer they assemble in post-breeding flocks that cause significant amounts of agricultural damage, particularly in sunflower fields near natal sites. In April 2001, we aerially color-marked ~370,000 Red-winged Blackbirds near Badger, South Dakota (44°48\u27N, 97°21\u27W), to determine if migrants staging here were summer residents in sunflower production areas ~350 km to the northwest. We measured patterns of migratory dispersal by collecting birds in 54 randomly selected blocks in the north central U.S. and the Prairie Provinces of Canada. The marked specimens (n =33) were categorized into three polygons based on analyses of banding and re-sighting data and proximity to concentrated sunflower production. We estimated that 82% of the migrants that had staged in eastern South Dakota resided within or on the periphery of the sunflower growing area. These birds probably stay near their breeding territories until at least late August and cause early damage to sunflower, which comprises the majority of damage. Resident birds in Alberta and most of Saskatchewan (18%) might arrive too late in the damage season to impact the sunflower crop significantly

Relationship between Color and Translucency of Multishaded Dental Composite Resins

The aim of the present study was to compare the translucency of different shades of two highly aesthetic multilayered restorative composite resins. In total nine shades from Esthet.X and ten shades from Filtek Supreme composite resins were chosen. Discs of each shade were prepared (N = 3) and light-cured. Total and diffuse transmittance values for each sample were measured. Statistical analysis showed that the opaque dentine shades of both composites were the least translucent and the enamel shades had the highest translucency. There was a significant decrease in translucency from A2 to C2 of regular body shades and also from A4 to C4 of opaque dentine shades of Esthet.X composite resin. Grey enamel shade had a significantly higher diffuse translucency compared to clear and yellow enamel shades. There was a significant decrease in translucency from A2B to D2B and also in diffuse translucency from A4D to C6D shades of Filtek Supreme composite resin. It can be concluded that the color of the composite resins tested in this study had a significant effect on their translucency. Information on the translucency of different shades of composite resins can be very useful for the clinicians in achieving optimal esthetic restorative outcome

A comprehensive model for battery State of Charge prediction

In this paper the relatively simple model for State of Charge prediction, based on energy conservation, introduced in [1] is improved and verified. The model as introduced in [1] is verified for Pb-acid, Li-ion and Seasalt batteries. The model is further improved to accommodate the rate capacity effect and the capacity recovery effect, the improvements are verified with lead-acid batteries. For further verification the model is applied on a realistic situation and compared to measurements on the behavior of a real battery in that situation. Furthermore the results are compared to results of the well-established KiBaM model. Predictions on the SoC over time done using the proposed model closely follow the SoC over time calculated from measured data. The resulting improved model is both simple and effective, making it specially useful as part of smart control, and energy usage simulations

Calendar Year 2007 Program Benefits for ENERGY STAR Labeled Products

ENERGY STAR is a voluntary energy efficiency-labeling program operated jointly by the United States Department of Energy and the United States Environmental Protection Agency (US EPA). Since the program inception in 1992, ENERGY STAR has become a leading international brand for energy efficient products. ENERGY STAR's central role in the development of regional, national, and international energy programs necessitates an open process whereby its program achievements to date as well as projected future savings are shared with committed stakeholders. Through 2007, the program saved 7.1 Quads of primary energy and avoided 128 MtC equivalent. The forecast shows that the program is expected to save 21.2 Quads of primary energy and avoid 375 MtC equivalent over the period 2008-2015. The sensitivity analysis bounds the best estimate of carbon avoided between 84 MtC and 172 MtC (1993 to 2007) and between 243 MtC and 519 MtC (2008 to 2015)

Calendar Year 2009 Program Benefits for ENERGY STAR Labeled Products

ENERGY STAR is a voluntary energy efficiency labeling program operated jointly by the Environmental Protection Agency (US EPA) and the U.S. Department of Energy (US DOE), designed to identify and promote energy-efficient products, buildings and practices. Since the program inception in 1992, ENERGY STAR has become a leading international brand for energy efficient products, and currently labels more than thirty products, spanning office equipment, heating, cooling and ventilation equipment, commercial and residential lighting, home electronics, and major appliances. ENERGY STAR's central role in the development of regional, national and international energy programs necessitates an open process whereby its program achievements to date as well as projected future savings are shared with stakeholders. This report presents savings estimates from the use ENERGY STAR labeled products. We present estimates of energy, dollar, and carbon savings achieved by the program in the year 2009, annual forecasts for 2010 and 2011, and cumulative savings estimates for the period 1993 through 2009 and cumulative forecasts for the period 2010 through 2015. Through 2009 the program saved 9.5 Quads of primary energy and avoided the equivalent of 170 million metric tons carbon (MMTC). The forecast for the period 2009-2015 is 11.5 Quads or primary energy saved and 202 MMTC emissions avoided. The sensitivity analysis bounds the best estimate of carbon avoided between 110 MMTC and 231 MMTC (1993 to 2009) and between 130 MMTC and 285 MMTC (2010 to 2015)

Combined ultrasound and photoacoustic imaging of metal objects

Methods of combined ultrasound and photoacoustic imaging are provided. In some embodiments, the methods may be used to determine the location or positioning of a metal object in a sample. In other embodiments, the methods may be used to determine the composition of a sample surrounding a metal object. Other methods are also provided.Board of Regents, University of Texas Syste

Harnessing demographic differences in organizations:what moderates the effects of workplace diversity?

To account for the double-edged nature of demographic workplace diversity (i.e,. relational demography, work group diversity, and organizational diversity) effects on social integration, performance, and well-being related variables, research has moved away from simple main effect approaches and started examining variables that moderate these effects. While there is no shortage of primary studies of the conditions under which diversity leads to positive or negative outcomes, it remains unclear which contingency factors make it work. Using the Categorization-Elaboration Model as our theoretical lens, we review variables moderating the effects of workplace diversity on social integration, performance, and well-being outcomes, focusing on factors that organizations and managers have control over (i.e., strategy, unit design, human resource, leadership, climate/culture, and individual differences). We point out avenues for future research and conclude with practical implications

Erratic Jet Wobbling in the BL Lacertae Object OJ287 Revealed by Sixteen Years of 7mm VLBA Observations

We present the results from an ultra-high-resolution 7mm Very Long Baseline Array (VLBA) study of the relativistic jet in the BL Lacertae object OJ287 from 1995 to 2011 containing 136 total intensity images. Analysis of the image sequence reveals a sharp jet-position-angle swing by >100 deg. during [2004,2006], as viewed in the plane of the sky, that we interpret as the crossing of the jet from one side of the line of sight to the other during a softer and longer term swing of the inner jet. Modulating such long term swing, our images also show for the first time a prominent erratic wobbling behavior of the innermost ~0.4mas of the jet with fluctuations in position angle of up to ~40 deg. over time scales ~2yr. This is accompanied by highly superluminal motions along non-radial trajectories, which reflect the remarkable non-ballistic nature of the jet plasma on these scales. The erratic nature and short time scales of the observed behavior rules out scenarios such as binary black hole systems, accretion disk precession, and interaction with the ambient medium as possible origins of the phenomenon on the scales probed by our observations, although such processes may cause longer-term modulation of the jet direction. We propose that variable asymmetric injection of the jet flow; perhaps related to turbulence in the accretion disk; coupled with hydrodynamic instabilities, leads to the non-ballistic dynamics that cause the observed non-periodic changes in the direction of the inner jet.Comment: Accepted for Publication in The Astrophysical Journal. 11 pages, 6 figures, 4 tables. High resolution images on figure 1 and complete tables 1 and 2 may be provided on reques

Savings estimates for the United States Environmental Protection Agency?s ENERGY STAR voluntary product labeling program

ENERGY STAR is a voluntary energy efficiency-labeling program operated jointly by the United States Department of Energy and the United States Environmental Protection Agency (US EPA). Since the program inception in 1992, ENERGY STAR has become a leading international brand for energy efficient products. ENERGY STAR's central role in the development of regional, national, and international energy programs necessitates an open process whereby its program achievements to date as well as projected future savings are shared with committed stakeholders. Through 2006, US EPA?S ENERGY STAR labeled products saved 4.8 EJ of primary energy and avoided 82 Tg C equivalent. We project that US EPA?S ENERGY STAR labeled products will save 12.8 EJ and avoid 203 Tg C equivalent over the period 2007-2015. A sensitivity analysis examining two key inputs (carbon factor and ENERGY STAR unit sales) bounds the best estimate of carbon avoided between 54 Tg C and 107 Tg C (1993 to 2006) and between 132 Tg C and 278 Tg C (2007 to 2015)