Current Directions in the Auricular

Electrical stimulation of the auricular vagus nerve (aVNS) is an emerging electroceutical technology in the field of bioelectronic medicine with applications in therapy. Artificial modulation of the afferent vagus nerve – a powerful entrance to the brain – affects a large number of physiological processes implicating interactions between the brain and body. Engineering aspects of aVNS determine its efficiency in application. The relevant safety and regulatory issues need to be appropriately addressed. In particular, in silico modeling acts as a tool for aVNS optimization. The evolution of personalized electroceuticals using novel architectures of the closed-loop aVNS paradigms with biofeedback can be expected to optimally meet therapy needs. For the first time, two international workshops on aVNS have been held in Warsaw and Vienna in 2017 within the scope of EU COST Action “European network for innovative uses of EMFs in biomedical applications (BM1309).” Both workshops focused critically on the driving physiological mechanisms of aVNS, its experimental and clinical studies in animals and humans, in silico aVNS studies, technological advancements, and regulatory barriers. The results of the workshops are covered in two reviews, covering physiological and engineering aspects. The present review summarizes on engineering aspects – a discussion of physiological aspects is provided by our accompanying article (Kaniusas et al., 2019). Both reviews build a reasonable bridge from the rationale of aVNS as a therapeutic tool to current research lines, all of them being highly relevant for the promising aVNS technology to reach the patient.European Cooperation in Science and TechnologyThe Austrian Research Promotion Agenc

Multiplicity dependence of light (anti-)nuclei production in p–Pb collisions at sNN=5.02 TeV

The measurement of the deuteron and anti-deuteron production in the rapidity range −1 < y < 0 as a function of transverse momentum and event multiplicity in p–Pb collisions at √sNN = 5.02 TeV is presented. (Anti-)deuterons are identified via their specific energy loss dE/dx and via their time-of- flight. Their production in p–Pb collisions is compared to pp and Pb–Pb collisions and is discussed within the context of thermal and coalescence models. The ratio of integrated yields of deuterons to protons (d/p) shows a significant increase as a function of the charged-particle multiplicity of the event starting from values similar to those observed in pp collisions at low multiplicities and approaching those observed in Pb–Pb collisions at high multiplicities. The mean transverse particle momenta are extracted from the deuteron spectra and the values are similar to those obtained for p and particles. Thus, deuteron spectra do not follow mass ordering. This behaviour is in contrast to the trend observed for non-composite particles in p–Pb collisions. In addition, the production of the rare 3He and 3He nuclei has been studied. The spectrum corresponding to all non-single diffractive p-Pb collisions is obtained in the rapidity window −1 < y < 0 and the pT-integrated yield dN/dy is extracted. It is found that the yields of protons, deuterons, and 3He, normalised by the spin degeneracy factor, follow an exponential decrease with mass number

K∗(892)0\mathrm{K}^{*}(\mathrm{892})^{0} and ϕ(1020)\mathrm{\phi(1020)} production in p-Pb collisions at sNN\sqrt{s_{\rm NN}} = 8.16 TeV

The production of $\mathrm{K}^{*}(\mathrm{892})^{0}$ and $\mathrm{\phi(1020)}$ resonances has been measured in p-Pb collisions at $\sqrt{s_{\rm NN}}$ = 8.16 TeV using the ALICE detector. Resonances are reconstructed via their hadronic decay channels in the rapidity interval $-$0.5 $$ 8 GeV/$c$), the $R_{\rm pPb}$ values of all hadrons are consistent with unity within uncertainties. The $R_{\rm pPb}$ of $\mathrm{K}^{*}(\mathrm{892})^{0}$ and $\mathrm{\phi(1020)}$ at $\sqrt{s_{\rm NN}}$ = 8.16 and 5.02 TeV show no significant energy dependence

Data-driven precision determination of the material budget in ALICE

International audienceThe knowledge of the material budget with a high precision is fundamental for measurements of direct photon production using the photon conversion method due to its direct impact on the total systematic uncertainty. Moreover, it influences many aspects of the charged-particle reconstruction performance. In this article, two procedures to determine data-driven corrections to the material-budget description in ALICE simulation software are developed. One is based on the precise knowledge of the gas composition in the Time Projection Chamber. The other is based on the robustness of the ratio between the produced number of photons and charged particles, to a large extent due to the approximate isospin symmetry in the number of produced neutral and charged pions. Both methods are applied to ALICE data allowing for a reduction of the overall material budget systematic uncertainty from 4.5% down to 2.5%. Using these methods, a locally correct material budget is also achieved. The two proposed methods are generic and can be applied to any experiment in a similar fashion

Study of the p−-p−-K+^+ and p−-p−-K−^- dynamics using the femtoscopy technique

International audienceThe interactions of kaons (K) and antikaons ($\mathrm{\overline{K}}$) with few nucleons (N) were studied so far using kaonic atom data and measurements of kaon production and interaction yields in nuclei. Some details of the three-body KNN and $\mathrm{\overline{K}}$NN dynamics are still not well understood, mainly due to the overlap with multi-nucleon interactions in nuclei. An alternative method to probe the dynamics of three-body systems with kaons is to study the final state interaction within triplet of particles emitted in pp collisions at the Large Hadron Collider, which are free from effects due to the presence of bound nucleons. This Letter reports the first femtoscopic study of p$-$p$-$K$^+$ and p$-$p$-$K$^-$ correlations measured in high-multiplicity pp collisions at $\sqrt{s}$ = 13 TeV by the ALICE Collaboration. The analysis shows that the measured p$-$p$-$K$^+$ and p$-$p$-$K$^-$ correlation functions can be interpreted in terms of pairwise interactions in the triplets, indicating that the dynamics of such systems is dominated by the two-body interactions without significant contributions from three-body effects or bound states

Study of the Λ\Lambda-Λ\Lambda interaction with femtoscopy correlations in pp and p-Pb collisions at the LHCC

This work presents new constraints on the existence and the binding energy of a possible $\Lambda$-$\Lambda$ bound state, the H-dibaryon, derived from $\Lambda$-$\Lambda$ femtoscopic measurements by the ALICE collaboration. The results are obtained from a new measurement using the femtoscopy technique in pp collisions at $\sqrt{s}=13$ TeV and p-Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV, combined with previously published results from pp collisions at $\sqrt{s}=7$ TeV. The $\Lambda$-$\Lambda$ scattering parameter space, spanned by the inverse scattering length $f_0^{-1}$ and the effective range $d_0$, is constrained by comparing the measured $\Lambda$-$\Lambda$ correlation function with calculations obtained within the Lednicky model. The data are compatible with hypernuclei results and lattice computations, both predicting a shallow attractive interaction, and permit to test different theoretical approaches describing the $\Lambda$-$\Lambda$ interaction. The region in the $(f_0^{-1},d_0)$ plane which would accommodate a $\Lambda$-$\Lambda$ bound state is substantially restricted compared to previous studies. The binding energy of the possible $\Lambda$-$\Lambda$ bound state is estimated within an effective-range expansion approach and is found to be $B_{\Lambda\Lambda}=3.2^{+1.6}_{-2.4}\rm{(stat)}^{+1.8}_{-1.0}\rm{(syst)}$ MeV.This work presents new constraints on the existence and the binding energy of a possible Λ–Λ bound state, the H-dibaryon, derived from Λ–Λ femtoscopic measurements by the ALICE collaboration. The results are obtained from a new measurement using the femtoscopy technique in Image 1 collisions at s=13 TeV and p–Pb collisions at sNN=5.02 TeV, combined with previously published results from Image 1 collisions at s=7 TeV. The Λ–Λ scattering parameter space, spanned by the inverse scattering length f0−1 and the effective range d0 , is constrained by comparing the measured Λ–Λ correlation function with calculations obtained within the Lednický model. The data are compatible with hypernuclei results and lattice computations, both predicting a shallow attractive interaction, and permit to test different theoretical approaches describing the Λ–Λ interaction. The region in the (f0−1,d0) plane which would accommodate a Λ–Λ bound state is substantially restricted compared to previous studies. The binding energy of the possible Λ–Λ bound state is estimated within an effective-range expansion approach and is found to be BΛΛ=3.2−2.4+1.6(stat)−1.0+1.8(syst) MeV.This work presents new constraints on the existence and the binding energy of a possible $\Lambda$-$\Lambda$ bound state, the H-dibaryon, derived from $\Lambda$-$\Lambda$ femtoscopic measurements by the ALICE collaboration. The results are obtained from a new measurement using the femtoscopy technique in pp collisions at $\sqrt{s}=13$ TeV and p-Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV, combined with previously published results from p-Pb collisions at $\sqrt{s}=7$ TeV. The $\Lambda$-$\Lambda$ scattering parameter space, spanned by the inverse scattering length $f_0^{-1}$ and the effective range $d_0$, is constrained by comparing the measured $\Lambda$-$\Lambda$ correlation function with calculations obtained within the Lednicky model. The data are compatible with hypernuclei results and lattice computations, both predicting a shallow attractive interaction, and permit to test different theoretical approaches describing the $\Lambda$-$\Lambda$ interaction. The region in the $(f_0^{-1},d_0)$ plane which would accommodate a $\Lambda$-$\Lambda$ bound state is substantially restricted compared to previous studies. The binding energy of the possible $\Lambda$-$\Lambda$ bound state is estimated within an effective-range expansion approach and is found to be $B_{\Lambda\Lambda}=3.2^{+1.6}_{-2.4}\mathrm{(stat)}^{+1.8}_{-1.0}\mathrm{(syst)}$ MeV

Investigations of Anisotropic Flow Using Multiparticle Azimuthal Correlations in pppp, p−Pbp-Pb, Xe-Xe, and Pb-Pb Collisions at the LHC

International audienceMeasurements of anisotropic flow coefficients (vn) and their cross-correlations using two- and multiparticle cumulant methods are reported in collisions of pp at s=13  TeV, p-Pb at a center-of-mass energy per nucleon pair sNN=5.02  TeV, Xe-Xe at sNN=5.44  TeV, and Pb-Pb at sNN=5.02  TeV recorded with the ALICE detector. The multiplicity dependence of vn is studied in a very wide range from 20 to 3000 particles produced in the midrapidity region |η|v3>v4 is found in pp and p-Pb collisions, similar to that seen in large collision systems, while a weak v2 multiplicity dependence is observed relative to nucleus-nucleus collisions in the same multiplicity range. Using a novel subevent method, v2 measured with four-particle cumulants is found to be compatible with that from six-particle cumulants in pp and p-Pb collisions. The magnitude of the correlation between vn2 and vm2, evaluated with the symmetric cumulants SC(m,n) is observed to be positive at all multiplicities for v2 and v4, while for v2 and v3 it is negative and changes sign for multiplicities below 100, which may indicate a different vn fluctuation pattern in this multiplicity range. The observed long-range multiparticle azimuthal correlations in high multiplicity pp and p-Pb collisions can neither be described by pythia 8 nor by impact-parameter-Glasma, music, and ultrarelativistic quantum molecular dynamics model calculations, and hence, provide new insights into the understanding of collective effects in small collision systems

Global polarization of Λ and Λ hyperons in Pb-Pb collisions at √ s N N = 2.76 and 5.02 TeV

The global polarization of Λ and Λ hyperons is measured for Pb-Pb collisions at √sNN = 2.76 and 5.02 TeV recorded with the ALICE at the Large Hadron Collider (LHC). The results are reported differentially as a function of collision centrality and hyperon’s transverse momentum (pT ) for the range of centrality 5–50%, 0.5 < pT < 5 GeV/c, and rapidity |y| < 0.5. The hyperon global polarization averaged for Pb-Pb collisions at √sNN = 2.76 and 5.02 TeV is found to be consistent with zero, ⟨PH⟩(%)≈0.01±0.06(stat.)±0.03(syst.) in the collision centrality range 15–50%, where the largest signal is expected. The results are compatible with expectations based on an extrapolation from measurements at lower collision energies at the Relativistic Heavy Ion Collider, hydrodynamical model calculations, and empirical estimates based on collision energy dependence of directed flow, all of which predict the global polarization values at LHC energies of the order of 0.01%

Experimental Evidence for an Attractive p-ϕ\phi Interaction

This Letter presents the first experimental evidence of the attractive strong interaction between a proton and a ϕ meson. The result is obtained from two-particle correlations of combined $p$-ϕ⊕ $\bar{p}$-ϕ pairs measured in high-multiplicity pp collisions at $\sqrt{s}$ = 13 TeV by the ALICE Collaboration. The spin-averaged scattering length and effective range of the p-ϕ interaction are extracted from the fully corrected correlation function employing the Lednický-Lyuboshits approach. In particular, the imaginary part of the scattering length vanishes within uncertainties, indicating that inelastic processes do not play a prominent role for the p-ϕ interaction. These data demonstrate that the interaction is dominated by elastic p-ϕ scattering. Furthermore, an analysis employing phenomenological Gaussian- and Yukawa-type potentials is conducted. Under the assumption of the latter, the N-ϕ coupling constant is found to be $g_{N-ϕ}$ = 0.14 ± 0.03(stat) ± 0.02(syst). This work provides valuable experimental input to accomplish a self-consistent description of the N-ϕ interaction, which is particularly relevant for the more fundamental studies on partial restoration of chiral symmetry in nuclear medium

Kaon–proton strong interaction at low relative momentum via femtoscopy in Pb–Pb collisions at the LHC

In quantum scattering processes between two particles, aspects characterizing the strong and Coulomb forces can be observed in kinematic distributions of the particle pairs. The sensitivity to the interaction potential reaches a maximum at low relative momentum and vanishing distance between the two particles. Ultrarelativistic heavy-ion collisions at the LHC provide an abundant source of many hadron species and can be employed as a measurement method of scattering parameters that is complementary to scattering experiments. This study confirms that momentum correlations of particles produced in Pb–Pb collisions at the LHC provide an accurate measurement of kaon–proton scattering parameters at low relative momentum, allowing precise access to the $K^- p \to K^- p$ process. This work also validates the femtoscopic measurement in ultrarelativistic heavy-ion collisions as an alternative to scattering experiments and a complementary tool to the study of exotic atoms with comparable precision. In this work, the first femtoscopic measurement of momentum correlations of $K^- p(K^- \overline{p})$ and $K^+p(K^-\overline{p})$ pairs in Pb–Pb collisions at centre-of-mass energy per nucleon pair of $\sqrt{s_{NN}}$=5.02 TeV registered by the ALICE experiment is reported. The components of the $K^-p$ complex scattering length are extracted and found to be $\Re f_0=-0.91 \pm 0.03 \textrm{(stat)}^{+0.17}_{-0.03} \textrm{(syst)}$ and $\Im f_0=0.92 \pm 0.05 \textrm{(stat)}_{-0.33}^{+0.12} \textrm{(syst)}$. The results are compared with chiral effective field theory predictions as well as with existing data from dedicated scattering and exotic kaonic atom experiments