How Do Swine Producers and Veterinarians Expect the VFD to Affect Their Business?

ANTIBIOTIC USE in livestock production is a controversial subject in the public eye. Concerns over perceived over-use of antibiotics and antimicrobial resistance has prompted public policy debates. In response, the United States Food and Drug Administration has created new antibiotic-use guidelines in livestock. The new guidelines are: ( a ) Guidance 209: Judicious Use of Medically Important Antimicrobial Drugs in Food Producing Animals; ( b ) Guidance 213: Implementation Principles for Guidance 209; and, ( c ) Veterinary Feed Directive (VFD): Final Rule. The VFD fina l rule went into effect on October 1, 2015, and label changes requested in Guidance Documents 209 and 213 took effect on January 1, 2017 (US Department of Health and Human Services 2012, 2013; Federal Registrar 2015). These guidelines direct the use of medically important antibiotics (deemed to be important for human medicine) in livestock for therapeutic purposes (prevention, control, and treatment) only, thereby eliminating medically important antibiotics for growth promotion purposes. Medically important antibiotics can continue to be used for therapeutic purposes, but only under the guidance of a veterinarian with a valid veterinary-client-patient relationship (VCPR). These rules also eliminate over-the-counter purchases of medically important antibiotics for administration in feed and water

From genome to toxicity: a combinatory approach highlights the complexity of enterotoxin production in Bacillus cereus

In recent years Bacillus cereus has gained increasing importance as a food poisoning pathogen. It is the eponymous member of the Bacillus cereus sensu lato group that consists of eight closely related species showing impressive diversity of their pathogenicity. The high variability of cytotoxicity and the complex regulatory network of enterotoxin expression have complicated efforts to predict the toxic potential of new Bacillus cereus isolates. In this study, comprehensive analyses of enterotoxin gene sequences, transcription, toxin secretion and cytotoxicity were performed. For the first time, these parameters were compared in a whole set of Bacillus cereus strains representing isolates of different origin (food or food poisoning outbreaks) and of different toxic potential (enteropathogenic and apathogenic) to elucidate potential starting points of strain-specific differential toxicity. While toxin gene sequences were highly conserved and did not allow for differentiation between high and low toxicity strains, comparison of nheB and hblD enterotoxin gene transcription and Nhe and Hbl protein titers revealed not only strain-specific differences but also incongruence between toxin gene transcripts and toxin protein levels. With one exception all strains showed comparable capability of protein secretion and so far, no secretion patterns specific for high and low toxicity strains were identified. These results indicate that enterotoxin expression is more complex than expected, possibly involving the orchestrated interplay of different transcriptional regulator proteins, as well as posttranscriptional and posttranslational regulatory mechanisms plus additional influences of environmental conditions

A future agenda for research on climate change and human mobility

In the past 15 years, research activities focusing on the interlinkages between climate change and human mobility have intensified. At the same time, an increasing number of actors and processes have sought to address human mobility in the context of climate change from a policy perspective. Hitherto, research has been limited in terms of geographical preferences as well as conceptual and methodological focus areas. This paper argues that to address the evolving policy space, future research on climate change in the context of human mobility needs to become more differentiated, integrated and generalized. This includes concerted efforts to better integrate researchers from the global South, improved cross‐linkages between different datasets, approaches and disciplines, more longitudinal and comparative studies and development of innovative qualitative and quantitative methods

A future agenda for research on climate change and human mobility

In the past 15 years, research activities focusing on the interlinkages between climate change and human mobility have intensified. At the same time, an increasing number of actors and processes have sought to address human mobility in the context of climate change from a policy perspective. Hitherto, research has been limited in terms of geographical preferences as well as conceptual and methodological focus areas. This paper argues that to address the evolving policy space, future research on climate change in the context of human mobility needs to become more differentiated, integrated and generalized. This includes concerted efforts to better integrate researchers from the global South, improved cross-linkages between different datasets, approaches and disciplines, more longitudinal and comparative studies and development of innovative qualitative and quantitative methods.</p

Retos e incertidumbres en la protección jurídica internacional de las migraciones ambientales

La indefinici&oacute;n jur&iacute;dica internacional actualmente existente delfen&oacute;meno de la &ldquo;migraci&oacute;n ambiental&rdquo;, no hace m&aacute;s que acrecentar lasituaci&oacute;n de vulnerabilidad y de inseguridad de las personas que migranpor modificaciones ambientales. La dificultad de aislar el deterioroambiental de otras variables que influyen en la migraci&oacute;n, como laecon&oacute;mica, pero tambi&eacute;n la protecci&oacute;n fragmentada y sectorializada delmedio ambiente ajena a las consecuencias del deterioro ambiental sobrelos derechos humanos han sido algunos de los principales obst&aacute;culos. Laurgencia y la necesidad de una respuesta adecuada exigen voluntadpol&iacute;tica y una cooperaci&oacute;n jur&iacute;dica internacional reforzada para procuraruna protecci&oacute;n efectiva a los migrantes v&iacute;ctimas del deterioro ambientaly responsabilizar a sus causantes. El presente art&iacute;culo aporta un an&aacute;lisisminucioso y actualizado de los principales avances producidos en laprotecci&oacute;n jur&iacute;dica internacional de la migraci&oacute;n ambiental, as&iacute; como delos retos e incertidumbres, que persisten en su determinaci&oacute;n.&nbsp;&nbsp

Developing a holistic approach to the analysis of farmer decision-making: implications for adaptation policy and practice in developing countries

Smallholder farmers operate within a risky and uncertain context. In addition to climate variability and climate change, social, environmental, institutional, and market-related dynamics affect their agricultural decisions and ability to cope and adapt. In this paper, we develop and apply a set of framing questions to investigate the factors shaping farmer decision-making and how these are situated in pathways of response. Drawing on a literature review of decision-making for risk management, four questions are posed to frame enquiry: who makes livelihood decisions, why they are made, and how and when they are made. This approach conceptualises and explores household decision-making in a holistic manner, moving beyond previous studies that examine smallholder decisions through disciplinary boundaries (e.g. psychology, economics, risk management) or particular theoretical approaches (e.g. bounded rationality, theory of planned behaviour). The framing questions are used to design and interpret empirical evidence from Pratapgarh, a tribal-dominated rainfed district in southeast Rajasthan, India. The findings suggest that while resource ownership and access are the main drivers of decision-making, socio-cognitive factors such as perceived adaptive capacity and perceived efficacy to carry out adaptive actions are equally important factors mediating farmer responses. We also find that the holistic approach helps explain how personal motivations and individual perceptions of adaptive capacity interact with socioeconomic, climatic, and agro-ecological dynamics at local and regional scales to mediate risk perception and inform response behaviour. Making a case for mixed methods to investigate farmer decision-making holistically, this paper provides an approach that reflects the complex and iterative nature of real farmer decision-making and can be used by researchers, policymakers, and practitioners to better understand and describe decision making and to develop informed policies and interventions

Supramolecular organization of dye molecules in zeolite L channels: synthesis, properties, and composite materials

Sequential insertion of different dyes into the 1D channels of zeolite L (ZL) leads to supramolecular sandwich structures and allows the formation of sophisticated antenna composites for light harvesting, transport, and trapping. The synthesis and properties of dye molecules, host materials, composites, and composites embedded in polymer matrices, including two- and three-color antenna systems, are described. Perylene diimide (PDI) dyes are an important class of chromophores and are of great interest for the synthesis of artificial antenna systems. They are especially well suited to advancing our understanding of the structure–transport relationship in ZL because their core fits tightly through the 12-ring channel opening. The substituents at both ends of the PDIs can be varied to a large extent without influencing their electronic absorption and fluorescence spectra. The intercalation/insertion of 17 PDIs, 2 terrylenes, and 1 quaterrylene into ZL are compared and their interactions with the inner surface of the ZL nanochannels discussed. ZL crystals of about 500 nm in size have been used because they meet the criteria that must be respected for the preparation of antenna composites for light harvesting, transport, and trapping. The photostability of dyes is considerably improved by inserting them into the ZL channels because the guests are protected by being confined. Plugging the channel entrances, so that the guests cannot escape into the environment is a prerequisite for achieving long-term stability of composites embedded in an organic matrix. Successful methods to achieve this goal are described. Finally, the embedding of dye–ZL composites in polymer matrices, while maintaining optical transparency, is reported. These results facilitate the rational design of advanced dye–zeolite composite materials and provide powerful tools for further developing and understanding artificial antenna systems, which are among the most fascinating subjects of current photochemistry and photophysics

Managing risk, changing aspirations and household dynamics: implications for wellbeing and adaptation in semi-arid Africa and India

Semi-arid regions across Africa and Asia are characterized by rapidly changing biophysical regimes, structural vulnerabilities, and increasing livelihood precarity. Gender, class, and caste/ethnic identities and relationships, and the specific social, economic and political power, roles and responsibilities they entail, shape the choices and decisions open to individuals and households in managing the risks they face. Unpacking the multiple, intersecting inequalities confronting rural populations in these climate hotspots is therefore vital to understand how risk can be managed in a way that supports effective, inclusive, and sustainable local adaptation. Drawing on empirical evidence from six countries, generated through a mixed methods approach, we examine how changes in household dynamics, structure, and aspirations, shape risk management with implications for household well-being, adaptive capacity, and ultimately sustainable development. The ability of individuals within households, differentiated by age, marital status, or education, to manipulate the very structure of the household and the material and social resources it offers, differentiates risk management strategies such as livelihood diversification, migration, changing agricultural practices and leveraging social support. Our evidence suggests that while greater risks can drive conflictive behavior within households, with women often reporting lower subjective wellbeing, new forms of cooperative behavior are also emerging, especially in peri-urban spaces. Through this study, we identify entry points into enabling sustainable and inclusive adaptation behavior, emphasizing that interventions should work for both women and men by challenging inequitable social and gender norms and renegotiating the domains of work and cooperation to maintain overall household wellbeing