1,004 research outputs found
Structural response of concrete-filled elliptical steel hollow sections under eccentric compression
The purpose of this research is to examine the behaviour of elliptical concrete-filled steel tubular stub columns under a combination of axial force and bending moment. Most of the research carried out to date involving concrete-filled steel sections has focussed on circular and rectangular tubes, with each shape exhibiting distinct behaviour. The degree of concrete confinement provided by the hollow section wall has been studied under pure compression but remains ambiguous for combined compressive and bending loads, with no current design provision for this loading combination. To explore the structural behaviour, laboratory tests were carried out using eight stub columns of two different tube wall thicknesses and applying axial compression under various eccentricities. Moment-rotation relationships were produced for each specimen to establish the influence of cross-section dimension and axis of bending on overall response. Full 3D finite element models were developed, comparing the effect of different material constitutive models, until good agreement was found. Finally, analytical interaction curves were generated assuming plastic behaviour and compared with the experimental and finite element results. Ground work provided from these tests paves the way for the development of future design guidelines on the member level
Adaptive diffusion schemes for heterogeneous networks
In this paper, we deal with distributed estimation problems in diffusion networks with heterogeneous nodes, i.e., nodes that either implement different adaptive rules or differ in some other aspect such as the filter structure or length, or step size. Although such heterogeneous networks have been considered from the first works on diffusion networks, obtaining practical and robust schemes to adaptively adjust the combiners in different scenarios is still an open problem. In this paper, we study a diffusion strategy specially designed and suited to heterogeneous networks. Our approach is based on two key ingredients: 1) the adaptation and combination phases are completely decoupled, so that network nodes keep purely local estimations at all times and 2) combiners are adapted to minimize estimates of the network mean-square-error. Our scheme is compared with the standard adapt-Then-combine scheme and theoretically analyzed using energy conservation arguments. Several experiments involving networks with heterogeneous nodes show that the proposed decoupled adapt-Then-combine approach with adaptive combiners outperforms other state-of-The-Art techniques, becoming a competitive approach in these scenarios
Sediment stress, water turbidity and sewage impacts on threatened Elkhorn Coral (Acropora palmata) Stands at Vega Baja, Puerto Rico.
Pd-(L)1 inhibitors as monotherapy for the first-line treatment of non-small-cell lung cancer patients with high pd-l1 expression : A network meta-analysis
Altres ajuts: RocheProgrammed cell death-ligand 1 (PD-L1) has emerged as a potential biomarker for selec-tion of patients more likely to respond to immunotherapy and as a prognostic factor in non-small cell lung cancer (NSCLC). In this network meta-analysis, we aimed to evaluate the efficacy of first-line anti-PD-(L)1 monotherapy in advanced NSCLC patients with high PD-L1 expression (â„50%) compared to platinum-based chemotherapy. We also evaluated efficacy outcomes according to tumor mutational burden (TMB). To that end, we conducted a systematic review. Six clinical trials with 2111 patients were included. In head-to-head comparisons, immunotherapy showed a significant improvement in progression-free survival (PFS: HRpooled = 0.69, 95% CI: 0.52-0.90, p = 0.007), overall survival (OS: HRpooled = 0.69, 95% CI: 0.61-0.78; p < 0.001) and overall response rate (ORR) (Risk ratio (RR)pooled = 1.354, 95% CI: 1.04-1.762, p = 0.024). In the assessment of relative efficacy for PFS through indirect comparisons, pembrolizumab (results from KEYNOTE-024) ranked highest followed by cemiplimab and atezolizumab, with statistical significance determined for some of the drugs. In terms of OS, cemiplimab ranked highest followed by atezolizumab and pembrolizumab, although non-significant OS was determined for these drugs. In conclusion, PD-(L)1 inhibitor mon-otherapy improves efficacy outcomes in the first line setting of advanced NSCLC patients with high PD-L1 expression. Evaluations with longer follow up are still needed to determine the superiority of any specific drug
Constraining Very Heavy Dark Matter Using Diffuse Backgrounds of Neutrinos and Cascaded Gamma Rays
We consider multi-messenger constraints on very heavy dark matter (VHDM) from
recent Fermi gamma-ray and IceCube neutrino observations of isotropic
background radiation. Fermi data on the diffuse gamma-ray background (DGB)
shows a possible unexplained feature at very high energies (VHE), which we have
called the "VHE Excess" relative to expectations for an attenuated power law
extrapolated from lower energies. We show that VHDM could explain this excess,
and that neutrino observations will be an important tool for testing this
scenario. More conservatively, we derive new constraints on the properties of
VHDM for masses of 10^3-10^10 GeV. These generic bounds follow from cosmic
energy budget constraints for gamma rays and neutrinos that we developed
elsewhere, based on detailed calculations of cosmic electromagnetic cascades
and also neutrino detection rates. We show that combining both gamma-ray and
neutrino data is essential for making the constraints on VHDM properties both
strong and robust. In the lower mass range, our constraints on VHDM
annihilation and decay are comparable to other results; however, our
constraints continue to much higher masses, where they become relatively
stronger.Comment: 33 pages, 21 figures, accepted for publication in JCA
Analysis of the lepton polarisation asymmetries of decay
In this work we will study the longitudinal polarisations of both leptons in
the decay process . This
process has all the features of the related and well investigated process
, with theoretically
comparable branching ratios. The polarised differential decay rates as well as
the single and double polarisation asymmetries are worked out, where the
sensitivity of these to possible right-handed couplings for the related radiative decay (and other generic BSM parameters) are also investigated.Comment: 13 pages, 10 figures file
Comments on Hastings' Additivity Counterexamples
Hastings recently provided a proof of the existence of channels which violate
the additivity conjecture for minimal output entropy. In this paper we present
an expanded version of Hastings' proof. In addition to a careful elucidation of
the details of the proof, we also present bounds for the minimal dimensions
needed to obtain a counterexample.Comment: 38 page
Modeling the Subsurface Structure of Sunspots
While sunspots are easily observed at the solar surface, determining their
subsurface structure is not trivial. There are two main hypotheses for the
subsurface structure of sunspots: the monolithic model and the cluster model.
Local helioseismology is the only means by which we can investigate
subphotospheric structure. However, as current linear inversion techniques do
not yet allow helioseismology to probe the internal structure with sufficient
confidence to distinguish between the monolith and cluster models, the
development of physically realistic sunspot models are a priority for
helioseismologists. This is because they are not only important indicators of
the variety of physical effects that may influence helioseismic inferences in
active regions, but they also enable detailed assessments of the validity of
helioseismic interpretations through numerical forward modeling. In this paper,
we provide a critical review of the existing sunspot models and an overview of
numerical methods employed to model wave propagation through model sunspots. We
then carry out an helioseismic analysis of the sunspot in Active Region 9787
and address the serious inconsistencies uncovered by
\citeauthor{gizonetal2009}~(\citeyear{gizonetal2009,gizonetal2009a}). We find
that this sunspot is most probably associated with a shallow, positive
wave-speed perturbation (unlike the traditional two-layer model) and that
travel-time measurements are consistent with a horizontal outflow in the
surrounding moat.Comment: 73 pages, 19 figures, accepted by Solar Physic
Model-independent search for CP violation in D0âKâK+ÏâÏ+ and D0âÏâÏ+Ï+Ïâ decays
A search for CP violation in the phase-space structures of D0 and View the MathML source decays to the final states KâK+ÏâÏ+ and ÏâÏ+Ï+Ïâ is presented. The search is carried out with a data set corresponding to an integrated luminosity of 1.0 fbâ1 collected in 2011 by the LHCb experiment in pp collisions at a centre-of-mass energy of 7 TeV. For the KâK+ÏâÏ+ final state, the four-body phase space is divided into 32 bins, each bin with approximately 1800 decays. The p-value under the hypothesis of no CP violation is 9.1%, and in no bin is a CP asymmetry greater than 6.5% observed. The phase space of the ÏâÏ+Ï+Ïâ final state is partitioned into 128 bins, each bin with approximately 2500 decays. The p-value under the hypothesis of no CP violation is 41%, and in no bin is a CP asymmetry greater than 5.5% observed. All results are consistent with the hypothesis of no CP violation at the current sensitivity
Search for the lepton-flavor-violating decays Bs0âe±Όâ and B0âe±Όâ
A search for the lepton-flavor-violating decays Bs0âe±Όâ and B0âe±Όâ is performed with a data sample, corresponding to an integrated luminosity of 1.0ââfb-1 of pp collisions at âs=7ââTeV, collected by the LHCb experiment. The observed number of Bs0âe±Όâ and B0âe±Όâ candidates is consistent with background expectations. Upper limits on the branching fractions of both decays are determined to be B(Bs0âe±Όâ)101ââTeV/c2 and MLQ(B0âe±Όâ)>126ââTeV/c2 at 95% C.L., and are a factor of 2 higher than the previous bounds
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