Structural response of concrete-filled elliptical steel hollow sections under eccentric compression

The purpose of this research is to examine the behaviour of elliptical concrete-filled steel tubular stub columns under a combination of axial force and bending moment. Most of the research carried out to date involving concrete-filled steel sections has focussed on circular and rectangular tubes, with each shape exhibiting distinct behaviour. The degree of concrete confinement provided by the hollow section wall has been studied under pure compression but remains ambiguous for combined compressive and bending loads, with no current design provision for this loading combination. To explore the structural behaviour, laboratory tests were carried out using eight stub columns of two different tube wall thicknesses and applying axial compression under various eccentricities. Moment-rotation relationships were produced for each specimen to establish the influence of cross-section dimension and axis of bending on overall response. Full 3D finite element models were developed, comparing the effect of different material constitutive models, until good agreement was found. Finally, analytical interaction curves were generated assuming plastic behaviour and compared with the experimental and finite element results. Ground work provided from these tests paves the way for the development of future design guidelines on the member level

Adaptive diffusion schemes for heterogeneous networks

In this paper, we deal with distributed estimation problems in diffusion networks with heterogeneous nodes, i.e., nodes that either implement different adaptive rules or differ in some other aspect such as the filter structure or length, or step size. Although such heterogeneous networks have been considered from the first works on diffusion networks, obtaining practical and robust schemes to adaptively adjust the combiners in different scenarios is still an open problem. In this paper, we study a diffusion strategy specially designed and suited to heterogeneous networks. Our approach is based on two key ingredients: 1) the adaptation and combination phases are completely decoupled, so that network nodes keep purely local estimations at all times and 2) combiners are adapted to minimize estimates of the network mean-square-error. Our scheme is compared with the standard adapt-Then-combine scheme and theoretically analyzed using energy conservation arguments. Several experiments involving networks with heterogeneous nodes show that the proposed decoupled adapt-Then-combine approach with adaptive combiners outperforms other state-of-The-Art techniques, becoming a competitive approach in these scenarios

Pd-(L)1 inhibitors as monotherapy for the first-line treatment of non-small-cell lung cancer patients with high pd-l1 expression : A network meta-analysis

Altres ajuts: RocheProgrammed cell death-ligand 1 (PD-L1) has emerged as a potential biomarker for selec-tion of patients more likely to respond to immunotherapy and as a prognostic factor in non-small cell lung cancer (NSCLC). In this network meta-analysis, we aimed to evaluate the efficacy of first-line anti-PD-(L)1 monotherapy in advanced NSCLC patients with high PD-L1 expression (≥50%) compared to platinum-based chemotherapy. We also evaluated efficacy outcomes according to tumor mutational burden (TMB). To that end, we conducted a systematic review. Six clinical trials with 2111 patients were included. In head-to-head comparisons, immunotherapy showed a significant improvement in progression-free survival (PFS: HRpooled = 0.69, 95% CI: 0.52-0.90, p = 0.007), overall survival (OS: HRpooled = 0.69, 95% CI: 0.61-0.78; p < 0.001) and overall response rate (ORR) (Risk ratio (RR)pooled = 1.354, 95% CI: 1.04-1.762, p = 0.024). In the assessment of relative efficacy for PFS through indirect comparisons, pembrolizumab (results from KEYNOTE-024) ranked highest followed by cemiplimab and atezolizumab, with statistical significance determined for some of the drugs. In terms of OS, cemiplimab ranked highest followed by atezolizumab and pembrolizumab, although non-significant OS was determined for these drugs. In conclusion, PD-(L)1 inhibitor mon-otherapy improves efficacy outcomes in the first line setting of advanced NSCLC patients with high PD-L1 expression. Evaluations with longer follow up are still needed to determine the superiority of any specific drug

Constraining Very Heavy Dark Matter Using Diffuse Backgrounds of Neutrinos and Cascaded Gamma Rays

We consider multi-messenger constraints on very heavy dark matter (VHDM) from recent Fermi gamma-ray and IceCube neutrino observations of isotropic background radiation. Fermi data on the diffuse gamma-ray background (DGB) shows a possible unexplained feature at very high energies (VHE), which we have called the "VHE Excess" relative to expectations for an attenuated power law extrapolated from lower energies. We show that VHDM could explain this excess, and that neutrino observations will be an important tool for testing this scenario. More conservatively, we derive new constraints on the properties of VHDM for masses of 10^3-10^10 GeV. These generic bounds follow from cosmic energy budget constraints for gamma rays and neutrinos that we developed elsewhere, based on detailed calculations of cosmic electromagnetic cascades and also neutrino detection rates. We show that combining both gamma-ray and neutrino data is essential for making the constraints on VHDM properties both strong and robust. In the lower mass range, our constraints on VHDM annihilation and decay are comparable to other results; however, our constraints continue to much higher masses, where they become relatively stronger.Comment: 33 pages, 21 figures, accepted for publication in JCA

Analysis of the lepton polarisation asymmetries of Bˉ→Kˉ2(1430) ℓ+ ℓ−{\bar B} \to {\bar K}_2(1430) \, \ell^+ \, \ell^- decay

In this work we will study the longitudinal polarisations of both leptons in the decay process ${\bar B} \to {\bar K}_2(1430)\, \ell^+ \, \ell^-$. This process has all the features of the related and well investigated process ${\bar B} \to {\bar K}^*(890) \, \ell^+ \, \ell^-$, with theoretically comparable branching ratios. The polarised differential decay rates as well as the single and double polarisation asymmetries are worked out, where the sensitivity of these to possible right-handed couplings for the related $b \to s$ radiative decay (and other generic BSM parameters) are also investigated.Comment: 13 pages, 10 figures file

Comments on Hastings' Additivity Counterexamples

Hastings recently provided a proof of the existence of channels which violate the additivity conjecture for minimal output entropy. In this paper we present an expanded version of Hastings' proof. In addition to a careful elucidation of the details of the proof, we also present bounds for the minimal dimensions needed to obtain a counterexample.Comment: 38 page

Modeling the Subsurface Structure of Sunspots

While sunspots are easily observed at the solar surface, determining their subsurface structure is not trivial. There are two main hypotheses for the subsurface structure of sunspots: the monolithic model and the cluster model. Local helioseismology is the only means by which we can investigate subphotospheric structure. However, as current linear inversion techniques do not yet allow helioseismology to probe the internal structure with sufficient confidence to distinguish between the monolith and cluster models, the development of physically realistic sunspot models are a priority for helioseismologists. This is because they are not only important indicators of the variety of physical effects that may influence helioseismic inferences in active regions, but they also enable detailed assessments of the validity of helioseismic interpretations through numerical forward modeling. In this paper, we provide a critical review of the existing sunspot models and an overview of numerical methods employed to model wave propagation through model sunspots. We then carry out an helioseismic analysis of the sunspot in Active Region 9787 and address the serious inconsistencies uncovered by \citeauthor{gizonetal2009}~(\citeyear{gizonetal2009,gizonetal2009a}). We find that this sunspot is most probably associated with a shallow, positive wave-speed perturbation (unlike the traditional two-layer model) and that travel-time measurements are consistent with a horizontal outflow in the surrounding moat.Comment: 73 pages, 19 figures, accepted by Solar Physic

Model-independent search for CP violation in D0→K−K+π−π+ and D0→π−π+π+π− decays

A search for CP violation in the phase-space structures of D0 and View the MathML source decays to the final states K−K+π−π+ and π−π+π+π− is presented. The search is carried out with a data set corresponding to an integrated luminosity of 1.0 fb−1 collected in 2011 by the LHCb experiment in pp collisions at a centre-of-mass energy of 7 TeV. For the K−K+π−π+ final state, the four-body phase space is divided into 32 bins, each bin with approximately 1800 decays. The p-value under the hypothesis of no CP violation is 9.1%, and in no bin is a CP asymmetry greater than 6.5% observed. The phase space of the π−π+π+π− final state is partitioned into 128 bins, each bin with approximately 2500 decays. The p-value under the hypothesis of no CP violation is 41%, and in no bin is a CP asymmetry greater than 5.5% observed. All results are consistent with the hypothesis of no CP violation at the current sensitivity

Search for the lepton-flavor-violating decays Bs0→e±μ∓ and B0→e±μ∓

A search for the lepton-flavor-violating decays Bs0→e±μ∓ and B0→e±μ∓ is performed with a data sample, corresponding to an integrated luminosity of 1.0  fb-1 of pp collisions at √s=7  TeV, collected by the LHCb experiment. The observed number of Bs0→e±μ∓ and B0→e±μ∓ candidates is consistent with background expectations. Upper limits on the branching fractions of both decays are determined to be B(Bs0→e±μ∓)101  TeV/c2 and MLQ(B0→e±μ∓)>126  TeV/c2 at 95% C.L., and are a factor of 2 higher than the previous bounds