46 research outputs found
P2 receptor-mediated modulation of neurotransmitter releaseâan update
- Author
- A Abdipranoto
- A Loesch
- A Melani
- A Nicke
- A Wieraszko
- AB MacDermott
- AB Smith
- AD Powell
- AI Salgado
- Attila Heinrich
- AU Trendelenburg
- AU Trendelenburg
- AV Gourine
- AV Gourine
- B Sperlagh
- B Sperlagh
- B Sperlagh
- B Sperlagh
- B Sperlagh
- B Sperlagh
- B Sperlagh
- B Sperlagh
- B SperlĂĄgh
- BeĂĄta SperlĂĄgh
- BF King
- BG Frenguelli
- BS Khakh
- BS Khakh
- BS Khakh
- C Allgaier
- C Allgaier
- C Barajas-Lopez
- C Bohmann
- C Lewis
- C Sesti
- C Sesti
- C Stout
- C Verderio
- CA Jones
- CE Stout
- Cecilia Csölle
- CM Wang
- D Communi
- D Ferrari
- DB Arthur
- DJ Moore
- DJ Moore
- DN Bowser
- DS McGehee
- E Shigetomi
- EA Barnard
- EM Schwiebert
- EM Silinsky
- ES Vizi
- ES Vizi
- F Kato
- G Burnstock
- G Collo
- G Collo
- G Hollopeter
- G Queiroz
- GC Bennett
- GD Price
- GE Torres
- GE Torres
- H Aihara
- H Franke
- H Fuder
- H Kittner
- H Kittner
- H Koch
- H Koch
- H Miyahara
- H Zimmermann
- I Kugelgen von
- I Kugelgen von
- I Kugelgen von
- I Kugelgen von
- I Kugelgen von
- I Kugelgen von
- I Kugelgen von
- I Kugelgen von
- J Goncalves
- J Li
- J Sanchez-Nogueiro
- JA Calvert
- JA Calvert
- JA Sim
- JG Gu
- JH Reese
- JK Chambers
- JN Armstrong
- JR Gever
- JS Rhee
- K Braet
- K Hisanaga
- K Inoue
- K Inoue
- K Inoue
- K Kurz
- K Shinozuka
- K Shinozuka
- K Wirkner
- K Yoshioka
- KM Forsyth
- KT Le
- KT Le
- L Atkinson
- L Atkinson
- L Papp
- L Papp
- L Papp
- L Patti
- L Stjarne
- L Vulchanova
- L Vulchanova
- M Darby
- M Domercq
- M Fujioka
- M Fumagalli
- M Kawamura
- M Kukley
- M Neal
- M Okada
- M Rogers
- M Rubio
- MJ Moran-Jimenez
- MP Abbracchio
- MP Abbracchio
- MT Miras-Portugal
- N Braun
- NP Wiklund
- NP Wiklund
- OA Sergeeva
- P Ballerini
- P Gomes
- P Illes
- P Li
- PL Lutz
- PM Lundy
- Q al-Awqati
- R Frohlich
- R Gomez-Villafuertes
- R Kanjhan
- RA Cunha
- RA Cunha
- RA Cunha
- RA Cunha
- RA Cunha
- RA Giniatullin
- RA Nicholas
- RA North
- RA Pearson
- RJ Rodrigues
- S Amadio
- S Boehm
- S Boehm
- S Coco
- S Duan
- S Hugel
- S Hussl
- S Koizumi
- S Latini
- S Lorenzo De
- S Valera
- SA Deuchars
- SA Masino
- SC OâConnor
- SD Jeftinija
- SE Haynes
- SG Brown
- SG Lechner
- SJ Borvendeg
- SJ Ennion
- SJ Hong
- SP Cook
- ST Yao
- T Fellin
- T Machida
- T Nakatsuka
- T Nakatsuka
- T Pannicke
- T Watano
- TF Wang
- TF Wang
- TK Knott
- TM Egan
- TS Moores
- TV Dunwiddie
- U Krugel
- U Krugel
- U Krugel
- U Krugel
- V Mendoza-Fernandez
- W Norenberg
- WM Fu
- WM Fu
- X Wang
- X Zhang
- XP Sun
- Y Wang
- Y Zhu
- YH Jin
- YX Zhang
- YX Zhang
- Z Gerevich
- Z Juranyi
- Z Juranyi
- ZM Wang
- Publication venue
- Springer Netherlands
- Publication date
- 01/01/2007
- Field of study
Presynaptic nerve terminals are equipped with a number of presynaptic auto- and heteroreceptors, including ionotropic P2X and metabotropic P2Y receptors. P2 receptors serve as modulation sites of transmitter release by ATP and other nucleotides released by neuronal activity and pathological signals. A wide variety of P2X and P2Y receptors expressed at pre- and postsynaptic sites as well as in glial cells are involved directly or indirectly in the modulation of neurotransmitter release. Nucleotides are released from synaptic and nonsynaptic sites throughout the nervous system and might reach concentrations high enough to activate these receptors. By providing a fine-tuning mechanism these receptors also offer attractive sites for pharmacotherapy in nervous system diseases. Here we review the rapidly emerging data on the modulation of transmitter release by facilitatory and inhibitory P2 receptors and the receptor subtypes involved in these interactions
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- AbellĂĄn AN
- AbellĂĄn AN
- AbellĂĄn AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- AlcĂĄzar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- AlegrĂa L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- AntĂłn DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
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- Banderas-Bravo ME
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- Barcenilla F
- Barea-Mendoza JA
- Barinas OD
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- Bauer M
- Bauer PR
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- Bawin M
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- Bañeras J
- Beane A
- Beduneau G
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- Beeharry SD
- Beerepoot M
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- Bernal FF
- Berric A
- Berrutti D
- Berthelsen RE
- Bertini P
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- Berto MB
- Besevli SG
- Bestle MH
- Bettex D
- Bettex DA
- Beunders R
- Bhasin D
- Bhattal MK
- Bhide S
- Bianchi I
- Bianchi I
- Bianzina S
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- Bishop J
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- Buddi S
- Buise M
- Buitinck SH
- Buranavanich P
- Bureau C
- Burle JF
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- CAPCRI Study
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- Castañeda DP
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- Charitidou E
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- Chen CM
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- Chen GQ
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- Chen YS
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- Cheng CC
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- Cheng CC
- Cheng KC
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- Chernyshuk S
- Chevret S
- Chhor V
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- Chiappa C
- Chiou KR
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- Chiou KR
- Chiu LC
- Chiumello D
- Chiurazzi C
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- Christopher KB
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- de Abreu MG
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- De Brito-Ashurst I
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- Hayakawa M
- Hayakawa M
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- HernĂĄndez A
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- HernĂĄndez AA
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- HernĂĄndez AA
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- HernĂĄndez G
- HernĂĄndez-Tejedor A
- Herpain A
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- Hillier SD
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- Hodgson LE
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- Houzé S
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- Hraiech S
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- Hua Y
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- Hualde JB
- Hualde JB
- Hualde JB
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- Huang CH
- Huang WC
- Huang WC
- Huang WC
- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
- Hung WT
- Hung WT
- Hung WT
- Hung WT
- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- IPREA Study Group
- Irazabal JM
- Irazabal JM
- Ishimatsu S
- Itenov TS
- Iwamoto M
- Izawa M
- Izdes S
- Jaber S
- Jacky A
- Jacobs FM
- Jacques T
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- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
- Jeon YD
- Jeong IY
- Jeong IY
- Jeong WY
- Jeong WY
- Jian Z
- Jiao LR
- Jibaja M
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- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
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- Kalenka A
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- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
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- Kang PL
- Kang PL
- Kang PL
- Kang Y
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- Kara A
- Karachi F
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- Karsten E
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- Kashyap R
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- Katabami K
- Katabami K
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- Kavanagh BP
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- Kayambu G
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- Kim DJ
- Kim HJ
- Kim JM
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- Kim JW
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- Kim KS
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- Kim KS
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- Kim MH
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- Kleinpell R
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- Knight LD
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- Ko SB
- Kobayashi A
- Koco E
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- Kodate A
- Kodate A
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- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
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- Kosuk ME
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- Kou PS
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- Kox M
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- Krenn CG
- Krishna B
- Kristof J
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- Kruger A
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- Ku NS
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- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
- Kurtz P
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- Kwon HM
- Kwon WY
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- Kyle UG
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- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
- Lafuente E
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- Lagos R
- Lahmer T
- Lai CC
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- Lake K
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- Latini R
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- Latini R
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- Lichtenstein D
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- Lin KC
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- Lischinsky A
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- Liu CP
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- Lukaszewicz AC
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- Midwinter MJ
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- Olavarria E
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- PICS- HCPA: Programa Intrahospitalar de Combate Ă Sepse do Hospital de ClĂnicas de Porto Alegre
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- Rapid Diagnosis of Infections in the Critically Ill Team
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- Rydingsward JE
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- Santana MC
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- Ălvarez JT
- Ălvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Measurement of the cross-section for b-jets produced in association with a Z boson at root s=7 TeV with the ATLAS detector ATLAS Collaboration
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
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- Abolins M
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- Zajacova Z
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- Zanello L
- Zarzhitsky P
- Zaytsev A
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- Zemla A
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- Zenin O
- Zenis T
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- Zerwas D
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- Zhemchugov A
- Zheng S
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- Zhuravlov V
- Zieminska D
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
A measurement is presented of the inclusive cross-section for b-jet production in association with a Z boson in pp collisions at a centre-of-mass energy of root s = 7 TeV. The analysis uses the data sample collected by the ATLAS experiment in 2010, corresponding to an integrated luminosity of approximately 36 pb(-1). The event selection requires a Z boson decaying into high P-T electrons or muons, and at least one b-jet, identified by its displaced vertex, with transverse momentum p(T) > 25 GeV and rapidity vertical bar y vertical bar < 2.1. After subtraction of background processes, the yield is extracted from the vertex mass distribution of the candidate b-jets. The ratio of this cross-section to the inclusive Z cross-section (the average number of b-jets per Z event) is also measured. Both results are found to be in good agreement with perturbative QCD predictions at next-to-leading order
Gene regulatory networks in plants: learning causality from time and perturbation
- Author
- A Greenfield
- A Pokhilko
- A Pokhilko
- AM Middleton
- Amy Marshall Colon
- BO Bargmann
- C Espinosa-Soto
- C La Rota
- CR Lickwar
- D Marbach
- Dennis Shasha
- E Breeze
- E Carrera
- E Oh
- ES Coen
- F Wang
- G Krouk
- G Monke
- Gabriel Krouk
- Gloria Coruzzi
- H Salgado
- J Carrera
- J SchÀfer
- J Yuan
- JC Locke
- JD Salazar
- Jesse Lingeman
- JJ Petricka
- JL Pruneda-Paz
- JM Lingeman
- JY Zhu
- K Nakabayashi
- K Nakashima
- K Robison
- KA Havens
- KE Jaeger
- KH Ryu
- L Mao
- M Gorte
- M Sankar
- M Suzuki
- MA Edwards
- MA Mendoza-Parra
- MH Kuo
- MS Katari
- N Bujdoso
- OE Akman
- P Ingkasuwan
- R Albert
- R Bonneau
- R Bonneau
- R Bustos
- R Sulpice
- RA Gutierrez
- RA Gutierrez
- RJ Prill
- S de Folter
- S Ma
- S Ruffel
- SM Brady
- T Vernoux
- VA Huynh-Thu
- WM Reeves
- WP Hsieh
- Y Zheng
- YH Chew
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Search for the standard model Higgs boson in the diphoton decay channel with 4.9fb -1 of pp collision data at âs=7TeV with atlas
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
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- Acharya BS
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- Ă kesson TPA
- Ă sman B
- Publication venue
- Publication date
- 01/01/2012
- Field of study
A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9ââfb-1 collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of âs=7ââTeV. In the diphoton mass range 110â150 GeV, the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations. Taking the look-elsewhere effect into account in the range 110â150 GeV, this significance becomes 1.5 standard deviations. The standard model Higgs boson is excluded at 95% confidence level in the mass ranges of 113â115 GeV and 134.5â136 GeV
Search for the standard model Higgs boson in the diphoton decay channel with 4.9fb -1 of pp collision data at âs=7TeV with atlas
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- Abdallah J
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- Zhemchugov A
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- Zsenei A
- Zur Nedden M
- Zutshi V
- Zwalinski L
- Ă kesson TPA
- Ă sman B
- Publication venue
- Publication date
- 01/01/2012
- Field of study
A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9ââfb-1 collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of âs=7ââTeV. In the diphoton mass range 110â150 GeV, the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations. Taking the look-elsewhere effect into account in the range 110â150 GeV, this significance becomes 1.5 standard deviations. The standard model Higgs boson is excluded at 95% confidence level in the mass ranges of 113â115 GeV and 134.5â136 GeV
Seven new species of Urocleidoides (Monogenea: Dactylogyridae) from Brazilian fishes supported by morphological and molecular data
- Author
- A Trujillo-GonzĂĄlez
- AA Acosta
- AA Acosta
- AA Acosta
- AA Agostinho
- AA Camargo
- AC Zago
- AC Zago
- AE Lockyer
- Aline Cristina Zago
- AO Bush
- B Mendoza-Garfias
- BB Evans
- CA Mendoza-Palmero
- CA Mendoza-Palmero
- CA Mendoza-Palmero
- CA Mendoza-Palmero
- CE Bautista-HernĂĄndez
- D Janzen
- D Posada
- DC Kritsky
- DF Rosim
- DM Suriano
- DR Brooks
- DTJ Littlewood
- EF Mendoza-Franco
- EF Mendoza-Franco
- EF Mendoza-Franco
- EF Mendoza-Franco
- EF Mendoza-Franco
- EF Mendoza-Franco
- EF Mendoza-Franco
- EM RuĂz
- F Pleijel
- F Ronquist
- FH Yamada
- FĂĄbio Hideki Yamada
- G Guidelli
- G PĂ©rez-Ponce de LeĂłn
- G Salgado-Maldonado
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- J Iannacone
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- JD Mizelle
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- JD Mizelle
- JJ Barrios-Gutiérrez
- K Molnar
- K Tamura
- KDC Ferreira
- KGA Dias
- L Franceschini
- L Franceschini
- L Plaisance
- LA Ăacari
- Lidiane Franceschini
- LL CorrĂȘa
- LS Gasques
- M Kearse
- M Nitta
- MA Rossin
- Marcela Fontes Bongiovani
- MSB Oliveira
- NM AlcĂąntara
- Priscilla de Oliveira Fadel Yamada
- R Ergens
- R Pineda-LĂłpez
- RA Gonçalves
- Reinaldo José da Silva
- RJ Graça
- S Guindon
- S Kumar
- SC Cohen
- SJ Agosta
- VE Thatcher
- W Jogunoori
- X Xia
- XY Wu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Compound effect of EHD and surface roughness in pool boiling and CHF with R-123
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- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
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- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
This article is a post-print version of the fianl published article which may be accessed at the link below.Saturated pool boiling of R-123 at 1 bar, including the critical heat flux (CHF), was enhanced by modifying the surface characteristics and applying a high intensity electrostatic field, the latter termed electrohydrodynamic (and abbreviated EHD) enhancement. The heat flux was varied from very low values in the natural convection regime up to CHF. Experiments were performed with increasing and decreasing heat flux to study boiling hysteresis without and with EHD. Boiling occurred on the sand blasted surface of a
cylindrical copper block with embedded electrical heating elements, with standardized surface parameter Pa = 3.5 ÎŒm. The electric field was generated by a potential of 5 kV to 25 kV, applied through a 40 mm diameter circular electrode of ss-304 wire mesh, aperture size 5.1 mm, located at distances of 5 - 60 mm from the surface, with most of the data obtained for 20 mm. The data for the rough surface were compared with earlier data for a smooth surface and indicated a significant increase in the heat transfer rates. EHD produced a further increase in the heat transfer rates, particularly at low heat flux values and near the CHF. Boiling hysteresis was reduced progressively by EHD and eliminated at high field strength.This work was supported by Government of Pakistan under a scholarship programme
To each his own: no evidence of gyrodactylid parasite host switches from invasive poeciliid fishes to Goodea atripinnis Jordan (Cyprinodontiformes: Goodeidae), the most dominant endemic freshwater goodeid fish in the Mexican Highlands
- Author
- A GarcĂa-VĂĄsquez
- A GarcĂa-VĂĄsquez
- A GarcĂa-VĂĄsquez
- A GarcĂa-VĂĄsquez
- A MartĂnez-Aquino
- A Paredes-Trujillo
- A Tripathi
- A Valero
- ADM Dove
- Adriana GarcĂa-VĂĄsquez
- Andrew P. Shinn
- AP Shinn
- CA Mendoza-Palmero
- CD Pinacho-Pinacho
- CD Pinacho-Pinacho
- CE Price
- D Darriba
- DA Thoney
- E DĂaz-Pardo
- EF Mendoza-Franco
- F Ronquist
- FAO yearbook
- G Malmberg
- G Paladini
- G Paladini
- G PĂ©rez-Ponce de LeĂłn
- G Ruiz-Campos
- G Salgado-Maldonado
- G Salgado-Maldonado
- G Salgado-Maldonado
- G Salgado-Maldonado
- G Salgado-Maldonado
- G Salgado-Maldonado
- G Schwarz
- GH Pyke
- Giuseppe Paladini
- International Commission on Zoological Nomenclature
- J Cable
- J Flores-Crespo
- J Flores-Crespo
- M HernĂĄndez-MartĂnez
- M Rubio-Godoy
- M Rubio-Godoy
- M Rubio-Godoy
- Mark A. Freeman
- MI Grano-Maldonado
- Miguel Rubio-Godoy
- MY Vega-Salazar De la
- MY Vega-Salazar De la
- N Galtier
- N Mercado-Silva
- O DomĂnguez-DomĂnguez
- P SĂĄnchez-Nava
- R Aguilar-Aguilar
- R Aguilar-Aguilar
- R Mendoza
- R Pineda-LĂłpez
- RA Pettersen
- RC Edgar
- RJ Whittington
- RR Miller
- S Guindon
- S Kumar
- S Monks
- T Contreras-MacBeath
- T Hall
- T Huyse
- T Scholz
- TA Bakke
- TM Holitzki
- U Razo-Mendivil
- Ulises Razo-Mendivil
- VM Vidal-MartĂnez
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Stability Depends on Positive Autoregulation in Boolean Gene Regulatory Networks
- Author
- A Becskei
- A Fauré
- A Wagner
- AJ Stewart
- B Aronson
- C Espinosa-Soto
- D Bell-Pedersen
- D McDonald
- DJ Hogan
- E Bateman
- EH Snoussi
- F Greil
- F Greil
- F Li
- GP Wagner
- H Jeong
- H Salgado
- HH McAdams
- J Jaeger
- J-P Comet
- JCW Locke
- JJ Hopfield
- K Klemm
- KE Kurten
- KE Thum
- L Mendoza
- M-C King
- Manuel Irimia
- Marcel Salathé
- Marcus W. Feldman
- MI Davidich
- ML Siegal
- N Barkai
- N Bonzanni
- R Albert
- R Jaenisch
- R Milo
- R Pinho
- R Thomas
- R Thomas
- R Thomas
- RA Cameron
- RA Young
- RBR Azevedo
- RD Leclerc
- Ricardo Pinho
- RW Hamming
- S Ciliberti
- SA Kauffman
- SB Carroll
- SM KieĆbasa
- SS Shen-Orr
- TI Lee
- U Alon
- Victor Garcia
- WA Whyte
- WS McCulloch
- Publication venue
- Publication date
- 01/11/2014
- Field of study
<div><p>Network motifs have been identified as building blocks of regulatory networks, including gene regulatory networks (GRNs). The most basic motif, autoregulation, has been associated with bistability (when positive) and with homeostasis and robustness to noise (when negative), but its general importance in network behavior is poorly understood. Moreover, how specific autoregulatory motifs are selected during evolution and how this relates to robustness is largely unknown. Here, we used a class of GRN models, Boolean networks, to investigate the relationship between autoregulation and network stability and robustness under various conditions. We ran evolutionary simulation experiments for different models of selection, including mutation and recombination. Each generation simulated the development of a population of organisms modeled by GRNs. We found that stability and robustness positively correlate with autoregulation; in all investigated scenarios, stable networks had mostly positive autoregulation. Assuming biological networks correspond to stable networks, these results suggest that biological networks should often be dominated by positive autoregulatory loops. This seems to be the case for most studied eukaryotic transcription factor networks, including those in yeast, flies and mammals.</p></div