Active faulting within a megacity: the geometry and slip rate of the Pardisan thrust in central Tehran, Iran

Tehran, the capital city of Iran with a population of over 12 million, is one of the largest urban centres within the seismically active Alpine–Himalayan orogenic belt. Although several historic earthquakes have affected Tehran, their relation to individual faults is ambiguous for most. This ambiguity is partly due to a lack of knowledge about the locations, geometries and seismic potential of structures that have been obscured by dramatic urban growth over the past three decades, and which have covered most of the young geomorphic markers and natural exposures. Here we use aerial photographs from 1956, combined with an ~1 m DEM derived from stereo Pleiades satellite imagery to investigate the geomorphology of a growing anticline above a thrust fault—the Pardisan thrust—within central Tehran. The topography across the ridge is consistent with a steep ramp extending from close to the surface to a depth of ~2 km, where it presumably connects with a shallow-dipping detachment. No primary fault is visible at the surface, and it is possible that the faulting dissipates in the near surface as distributed shearing. We use optically stimulated luminescence to date remnants of uplifted and warped alluvial deposits that are offset vertically across the Pardisan fault, providing minimum uplift and slip-rates of at least 1 mm yr$^{−1}$. Our study shows that the faults within the Tehran urban region have relatively rapid rates of slip, are important in the regional tectonics, and have a great impact on earthquake hazard assessment of the city and surrounding region.Geological Survey of Iran, Christ Church College Oxford, Natural Environment Research Council, Economic and Social Research Counci

Assessing the activity of faults in continental interiors: Palaeoseismic insights from SE Kazakhstan

The presence of fault scarps is a first-order criterion for identifying active faults. Yet the preservation of these features depends on the recurrence interval between surface rupturing events, combined with the rates of erosional and depositional processes that act on the landscape. Within arid continental interiors single earthquake scarps can be preserved for thousands of years, and yet the interval between surface ruptures on faults in these regions may be much longer, such that the lack of evidence for surface faulting in the morphology may not preclude activity on those faults. In this study we investigate the 50 km-long ‘Toraigyr’ thrust fault in the northern Tien Shan. From palaeoseismological trenching we show that two surface rupturing earthquakes occurred in the last $\textbf{39.9±2.7 ka}$ BP, but only the most recent event (3.15–3.6 ka BP) has a clear morphological expression. We conclude that a landscape reset took place in between the two events, likely as a consequence of the climatic change at the end of the last glacial maximum. These findings illustrate that in the Tien Shan evidence for the most recent active faulting can be easily obliterated by climatic processes due to the long earthquake recurrence intervals. Our results illustrate the problems related to the assessment of active tectonic deformation and seismic hazard assessments in continental interior settings.This study was financed by NERC and ESRC (Earthquakes without Frontiers project, Grant code: EwF_NE/J02001X/1_1), and the Centre for Observation and Modelling of Earthquakes and Tectonics (COMET). KOMPSAT-2 imagery was obtained through a category-1 award to RTW. EJC thanks St. Edmund Hall for travel support. RTW was supported during this research by a University Research Fellowship from the Royal Society of London

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of SARS-CoV-2 genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three available genomic nomenclature systems for SARS-CoV-2 to all sequence data from the WHO European Region available during the COVID-19 pandemic until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation. We provide a comparison of the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.Peer reviewe

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Educating for anti-racism: producing and reproducing race and power in a university classroom

In this paper I explore some of the issues associated with teaching about race, culture and ethnicity in a psychology program. These curriculum initiatives are part of a broader agenda of raising awareness about racialised oppression and exclusion and contributing to the development of ways of researching and practising psychology that are transformative and culturally sensitive. I overview the broader context and describe our subject and the guiding principles. This is followed by a description and analysis of two events in the classroom that illustrate the ways in which students differentially respond to the challenges posed by writings that challenge taken for granted understandings of race. Part of the analysis shows that students can often engage in the reproduction of oppressive practices and invest in whiteness. It is suggested that more than single semester subjects are required to promote and support the development of critical capacities for anti-racism practice