Acute pancreatitis in children. An Italian multicentre study

AIM: To evaluate the clinical, morphological and aetiological aspects of acute pancreatitis in children in Italy. PATIENTS: The hospital records of 50 consecutive patients with acute pancreatitis observed in 5 Italian Pediatric Departments were reviewed. RESULTS: A total of 25 males and 25 females (median age 10.5 years, range 2-17) were studied. Of these patients, 48 (96%) had abdominal pain. The pancreatitis was associated with biliary disease in 10 patients (20%); it was due to viral infection in 6 patients (12%), pancreatic duct abnormalities in 4 (8%, familial chronic pancreatitis in 3 (6%), trauma in 5 (10%) and other causes in 5 (10%); the pancreatitis was of unknown origin in 17 patients (34%). Previous attacks of the disease had occurred in 14 patients. A diagnosis of mild pancreatitis was made in 41 patients (82%) and of severe disease in 9 (18%). One patient with severe pancreatitis died from multiorgan failure. Patients with severe pancreatitis had significantly higher serum concentrations of C-reactive protein than patients with mild pancreatitis. Hospital stay was similar for patients with the mild form and those with the severe form of the disease. CONCLUSIONS: In Italian children, acute pancreatitis is of unknown origin in about one-third of the children and is recurrent in 28% of the cases. The disease is severe in 18% of the case

Cognitive thought diary in supportive psychology for people undergoing radiotherapy: a feasibility study.

BAC KGROUND: Radiation therapy (RT ) has become one of the most widely-used and efficient treatments for cancer; nevertheless, people who undergo radiotherapy suffer the physical and psychological consequences of this stressful treatment, in addition to the psychosocial distress related to cancer. However, a Radiotherapy Unit is often a place where several patients crowd in from various hospitals with restricted timetables and, for logistic reasons, it is not easy to provide regular psychological sessions for each one. It is important to find a setting that allows us the involvement of the largest number of patients referred to the unit. In this study, we aimed to evaluate the feasibility and the effect of a brief intervention of cognitive-oriented diary on the quality of life, anxiety and depressive symptoms of patients undergoing radiotherapy (RT ), compared to a control group. METH ODS: The sample was constituted of 68 experimental subjects and 78 controls, treated with RT . Both groups were assessed with the Toronto Alexithymia Scale (TAS -20), the Hamilton Anxiety and Depression Scale (HA DS) and the EORTC -QLQ at the beginning and at the end of their RT . Experimental subjects were instructed to report emotions and thoughts before attending the RT sessions in a thought diary. RES ULTS : The experimental group showed a good adherence to the diary, a reduction in mean scores of anxiety (P<0.001), depression (P<0.001), and alexithymia (P<0.001) together with an ameliorative effect on quality of life (P<0.014), compared to control group. CONCLUSI ONS: We observed a reduction in alexithymia scores in the experimental group, together with a significant reduction in anxiety and depression symptoms and an improvement in quality of life, with a moderator role of social disparity in treatment adherence. Our outcomes suggest the opportunity to consider the diary an affordable and effective device for psychologists operating in RT units, able to be extended to the majority of patients, in a simple and replicable setting

Analysis of the energetic, economic, and environmental performance of hydrogen utilization for port logistic activities

Hydrogen is a versatile energy carrier and storage medium that may be employed in a variety of applications. According to the industrial processes used for its production, hydrogen may be labelled using different colours: (i) grey hydrogen, produced from natural gas using steam methane reforming (SMR), (ii) blue hydrogen, like the grey one, but with carbon capture and storage (CCS), (iii) green hydrogen, produced by water electrolysis using electricity from renewable sources only, (iv) "grid" hydrogen, produced by electrolysis using grid electricity. In this study, process simulation is used to solve material and energy balances, as well as to estimate capital and maintenance costs for each technology investigated. Then, process simulation outcomes are used to estimate three key performance indicators focusing on sustainability issues: the Energy Return on Energy Invested (EROEI), the Levelized Cost of Hydrogen (LCOH) and the Life Cycle Assessment (LCA). With reference to the case study of the Trieste port in Italy, the potential of synthesizing and utilizing hydrogen to fuel transportation activities within a port is examined. Based on the daily hydrogen consumption in fuel cells installed on loco-motors and trucks, the design of the different processes considered is carried out, as well as their comparison in terms of EROEI, LCOH, and LCA. Furthermore, LCA and Total Cost of Ownership (TCO) evaluations for various hydrogen-fueled vehicles within the port are presented and compared to diesel-fueled ones to determine the impact of fuel-cell vehicles during operations. Results show that EROEI of hydrogen produced by electrolysis is larger than that produced by SMR with or without CCS. The LCOH for grey hydrogen is of the same order of magnitude of that of green or grid ones. The hydrogen compression step to 300 bar impacts on both energetic and economic performances. LCA indicates that the Global Warming Potential (GWP) of green hydrogen is at least half with respect to blue hydrogen, however other impact categories are less favourable. On the other hand, the TCO of hydrogen-fueled vehicles is higher than that of diesel-fueled ones, mainly because of the higher purchase costs. It is concluded that the methodology proposed in this paper, based on the evaluation of indicators at the design stage, is suitable for comparing hydrogen production processes. In addition, it is a powerful tool for policy decision-makers in defining the strategies for the development of hydrogen-based transport systems in port operations

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors.

Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored. In the present study, we studied the effect of genetic deletion of P2rx7 on neurochemical changes in the hippocampus that might underlie the antidepressant phenotype. P2X7 receptor deficient mice (P2rx7-/-) displayed decreased immobility in the tail suspension test (TST) and an attenuated anhedonia response in the sucrose preference test (SPT) following bacterial endotoxin (LPS) challenge. The attenuated anhedonia was reproduced through systemic treatments with P2rx7 antagonists. The activation of P2rx7 resulted in the concentration-dependent release of [3H]glutamate in P2rx7+/+ but not P2rx7-/- mice, and the NR2B subunit mRNA and protein was upregulated in the hippocampus of P2rx7-/- mice. The brain-derived neurotrophic factor (BDNF) expression was higher in saline but not LPS-treated P2rx7-/- mice; the P2rx7 antagonist Brilliant blue G elevated and the P2rx7 agonist benzoylbenzoyl ATP (BzATP) reduced BDNF level. This effect was dependent on the activation of NMDA and non-NMDA receptors but not on Group I metabotropic glutamate receptors (mGluR1,5). An increased 5-bromo-2-deoxyuridine (BrdU) incorporation was also observed in the dentate gyrus derived from P2rx7-/- mice. Basal level of 5-HT was increased, whereas the 5HIAA/5-HT ratio was lower in the hippocampus of P2rx7-/- mice, which accompanied the increased uptake of [3H]5-HT and an elevated number of [3H]citalopram binding sites. The LPS-induced elevation of 5-HT level was absent in P2rx7-/- mice. In conclusion there are several potential mechanisms for the antidepressant phenotype of P2rx7-/- mice, such as the absence of P2rx7-mediated glutamate release, elevated basal BDNF production, enhanced neurogenesis and increased 5-HT bioavailability in the hippocampus

Effective Rheology of Bubbles Moving in a Capillary Tube

We calculate the average volumetric flux versus pressure drop of bubbles moving in a single capillary tube with varying diameter, finding a square-root relation from mapping the flow equations onto that of a driven overdamped pendulum. The calculation is based on a derivation of the equation of motion of a bubble train from considering the capillary forces and the entropy production associated with the viscous flow. We also calculate the configurational probability of the positions of the bubbles.Comment: 4 pages, 1 figur

Two-particle differential transverse momentum and number density correlations in p- Pb collisions at 5.02 TeV and Pb-Pb collisions at 2.76 TeV at the CERN Large Hadron Collider

We present measurements of two-particle differential number correlation functions R2 and transverse momentum correlation functions P2, obtained from p-Pb collisions at 5.02 TeV and Pb-Pb collisions at 2.76 TeV. The results are obtained by using charged particles in the pseudorapidity range |η|&lt;1.0 and transverse momentum range 0.

Overthrowing the dictator: a game-theoretic approach to revolutions and media

A distinctive feature of recent revolutions was the key role of social media (e.g. Facebook, Twitter and YouTube). In this paper, we study its role in mobilization. We assume that social media allow potential participants to observe the individual participation decisions of others, while traditional mass media allow potential participants to see only the total number of people who participated before them. We show that when individuals’ willingness to revolt is publicly known, then both sorts of media foster a successful revolution. However, when willingness to revolt is private information, only social media ensure that a revolt succeeds, with mass media multiple outcomes are possible, one of which has individuals not participating in the revolt. This suggests that social media enhance the likelihood that a revolution triumphs more than traditional mass media

Alignment of the ALICE Inner Tracking System with cosmic-ray tracks

37 pages, 15 figures, revised version, accepted by JINSTALICE (A Large Ion Collider Experiment) is the LHC (Large Hadron Collider) experiment devoted to investigating the strongly interacting matter created in nucleus-nucleus collisions at the LHC energies. The ALICE ITS, Inner Tracking System, consists of six cylindrical layers of silicon detectors with three different technologies; in the outward direction: two layers of pixel detectors, two layers each of drift, and strip detectors. The number of parameters to be determined in the spatial alignment of the 2198 sensor modules of the ITS is about 13,000. The target alignment precision is well below 10 micron in some cases (pixels). The sources of alignment information include survey measurements, and the reconstructed tracks from cosmic rays and from proton-proton collisions. The main track-based alignment method uses the Millepede global approach. An iterative local method was developed and used as well. We present the results obtained for the ITS alignment using about 10^5 charged tracks from cosmic rays that have been collected during summer 2008, with the ALICE solenoidal magnet switched off.Peer reviewe

Chronos: A NIR spectroscopic galaxy survey to probe the most fundamental stages of galaxy evolution

We propose a dedicated, ultra-deep spectroscopic survey in the near infrared (NIR), that will target a mass-limited sample of galaxies during two of the most fundamental epochs of cosmic evolution: the formation of the first galaxies (at z ≳ 6; comsmic dawn), and at the peak of galaxy formation activity (at redshift z∼1–3; cosmic noon). By way of NIR observations (λ= 0.8–2μ m), it is possible to study the UV Lyman-α region in the former, and the optical rest-frame in the latter, allowing us to extract fundamental observables such as gas and stellar kinematics, chemical abundances, and ages, providing a unique legacy database covering these two crucial stages of cosmic evolution. The need to work in the NIR at extremely low flux levels makes a ground-based approach unfeasible due to atmospheric emission and absorption. Only with the largest facilities of the future (e.g. ELT) will be possible to observe a reduced set of targets, comprising at most of order thousands of galaxies. Likewise, from space, the small field of view of JWST and its use as a general purpose facility will yield a rather small set of high quality NIR spectra of distant galaxies (in the thousands, at best). Our project (codename Chronos) aims to produce ∼1 million high quality spectra, with a high S/N in the continuum, where information about the underlying stellar populations is encoded. The main science drivers are: - The connection between the star formation history and the mass assembly history. - The role of AGN and supernova feedback in shaping the formation histories of galaxies, with a quantitative estimate of quenching timescales. - The formation of the first galaxies. - The source of reionization. - Evolution of the metallicity-mass relation, including [α/Fe] and individual abundances. - Precision cosmology through detailed studies of the “baryon physics” of galaxy formation, probing the power spectrum over scales k∼1 Mpc− 1

Purinergic signalling links mechanical breath profile and alveolar mechanics with the pro-inflammatory innate immune response causing ventilation-induced lung injury

Severe pulmonary infection or vigorous cyclic deformation of the alveolar epithelial type I (AT I) cells by mechanical ventilation leads to massive extracellular ATP release. High levels of extracellular ATP saturate the ATP hydrolysis enzymes CD39 and CD73 resulting in persistent high ATP levels despite the conversion to adenosine. Above a certain level, extracellular ATP molecules act as danger-associated molecular patterns (DAMPs) and activate the pro-inflammatory response of the innate immunity through purinergic receptors on the surface of the immune cells. This results in lung tissue inflammation, capillary leakage, interstitial and alveolar oedema and lung injury reducing the production of surfactant by the damaged AT II cells and deactivating the surfactant function by the concomitant extravasated serum proteins through capillary leakage followed by a substantial increase in alveolar surface tension and alveolar collapse. The resulting inhomogeneous ventilation of the lungs is an important mechanism in the development of ventilation-induced lung injury. The high levels of extracellular ATP and the upregulation of ecto-enzymes and soluble enzymes that hydrolyse ATP to adenosine (CD39 and CD73) increase the extracellular adenosine levels that inhibit the innate and adaptive immune responses rendering the host susceptible to infection by invading microorganisms. Moreover, high levels of extracellular adenosine increase the expression, the production and the activation of pro-fibrotic proteins (such as TGF-β, α-SMA, etc.) followed by the establishment of lung fibrosis