Primary double tooth with partial anodontia of permanent dentition: a case report

Dental anomalies of number and forms may occur in the primary and permanent dentition. Various terms have been used to describe dental twinning anomalies: gemination, fusion, concrescence, double teeth, cojoined teeth, twinned teeth, geminifusion and vicinifusion. Double tooth is a term used to describe connate tooth and includes both dental fusion and gemination. The phenomenon of gemination occurs when two teeth develop from one single bud leading to a larger tooth. Fusion is a condition in which the crowns of two separate teeth have been joined toge- ther during the crown development. Fusion occurs infrequently but could cause esthetic, spacing and periodontal problems. The present article highlights the presence of a primary double tooth in an 11 year old boy involving primary mandibular left lateral incisor and canine. Clinical examination and radiographic examination confirmed the absence of the permanent left mandibular lateral incisor. Cases with primary double tooth necessitate careful examination as they may be associated with anomalies in the succeeding permanent dentition and require proper treatment plannin

Approximate Multiplier based on Low power and reduced latency with Modified LSB design

The devised approximation multiplier can adapt the precision and processing power needed formul triplication sat run-time based on the needs of the user. To decrease error distance, we also suggest a straight forward error compensation circuit. There are two types of approximate multi pliers. Dynamic voltages caling can be used for the first kind, which controls the timing route of the multiplier. If the voltage is lower, the critical path will take longer to complete. As a result, when the time path is violated, errors occurs and approximated results are produced. These cond types involves redesigning precise multiplier circuits like the Wallace Tree Multiplier and Dadda Tree Multiplier in order to change the functional behaviors of multipliers. Most of the earlier research on rebuilding multipliers suggested erroneous m-n compressors, which have m inputs and producen outputs. It dynamically reduces the area covered under the multiplier LSB which enables the MSB in accurate manner and LSB in approximate manner. This convolution al system approach is regarded to sequential cover up more than 32 bit multiplier. Since the accompanied circuit reduce then tire area by10times lesser than original multiplier, this conventional unit is regarded as abled circuit in the segment. Since the process of compressing partial products absorbed the majority of the multiplier energy and resulted in a consider able route delay, these incorrect compressors were utilized to compress the partial products within multiplication. These functionality are over come through our experimental setup

HLA-DQA1*05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's Disease

Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to identify patients at increased risk for development of anti-drug antibodies would facilitate selection of therapy and use of preventative strategies.This article is freely available via Open Access. Click on Publisher URL to access the full-text

Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 1990-2019 : a systematic analysis from the Global Burden of Disease Study 2019

Interpretation Chewing tobacco remains a substantial public health problem in several regions of the world, and predominantly in south Asia. We found little change in the prevalence of chewing tobacco use between 1990 and 2019, and that control efforts have had much larger effects on the prevalence of smoking tobacco use than on chewing tobacco use in some countries. Mitigating the health effects of chewing tobacco requires stronger regulations and policies that specifically target use of chewing tobacco, especially in countries with high prevalence. Findings In 2019, 273 center dot 9 million (95% uncertainty interval 258 center dot 5 to 290 center dot 9) people aged 15 years and older used chewing tobacco, and the global age-standardised prevalence of chewing tobacco use was 4 center dot 72% (4 center dot 46 to 5 center dot 01). 228 center dot 2 million (213 center dot 6 to 244 center dot 7; 83 center dot 29% [82 center dot 15 to 84 center dot 42]) chewing tobacco users lived in the south Asia region. Prevalence among young people aged 15-19 years was over 10% in seven locations in 2019. Although global agestandardised prevalence of smoking tobacco use decreased significantly between 1990 and 2019 (annualised rate of change: -1 center dot 21% [-1 center dot 26 to -1 center dot 16]), similar progress was not observed for chewing tobacco (0 center dot 46% [0 center dot 13 to 0 center dot 79]). Among the 12 highest prevalence countries (Bangladesh, Bhutan, Cambodia, India, Madagascar, Marshall Islands, Myanmar, Nepal, Pakistan, Palau, Sri Lanka, and Yemen), only Yemen had a significant decrease in the prevalence of chewing tobacco use, which was among males between 1990 and 2019 (-0 center dot 94% [-1 center dot 72 to -0 center dot 14]), compared with nine of 12 countries that had significant decreases in the prevalence of smoking tobacco. Among females, none of these 12 countries had significant decreases in prevalence of chewing tobacco use, whereas seven of 12 countries had a significant decrease in the prevalence of tobacco smoking use for the period. Summary Background Chewing tobacco and other types of smokeless tobacco use have had less attention from the global health community than smoked tobacco use. However, the practice is popular in many parts of the world and has been linked to several adverse health outcomes. Understanding trends in prevalence with age, over time, and by location and sex is important for policy setting and in relation to monitoring and assessing commitment to the WHO Framework Convention on Tobacco Control. Methods We estimated prevalence of chewing tobacco use as part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 using a modelling strategy that used information on multiple types of smokeless tobacco products. We generated a time series of prevalence of chewing tobacco use among individuals aged 15 years and older from 1990 to 2019 in 204 countries and territories, including age-sex specific estimates. We also compared these trends to those of smoked tobacco over the same time period. Findings In 2019, 273 & middot;9 million (95% uncertainty interval 258 & middot;5 to 290 & middot;9) people aged 15 years and older used chewing tobacco, and the global age-standardised prevalence of chewing tobacco use was 4 & middot;72% (4 & middot;46 to 5 & middot;01). 228 & middot;2 million (213 & middot;6 to 244 & middot;7; 83 & middot;29% [82 & middot;15 to 84 & middot;42]) chewing tobacco users lived in the south Asia region. Prevalence among young people aged 15-19 years was over 10% in seven locations in 2019. Although global age standardised prevalence of smoking tobacco use decreased significantly between 1990 and 2019 (annualised rate of change: -1 & middot;21% [-1 & middot;26 to -1 & middot;16]), similar progress was not observed for chewing tobacco (0 & middot;46% [0 & middot;13 to 0 & middot;79]). Among the 12 highest prevalence countries (Bangladesh, Bhutan, Cambodia, India, Madagascar, Marshall Islands, Myanmar, Nepal, Pakistan, Palau, Sri Lanka, and Yemen), only Yemen had a significant decrease in the prevalence of chewing tobacco use, which was among males between 1990 and 2019 (-0 & middot;94% [-1 & middot;72 to -0 & middot;14]), compared with nine of 12 countries that had significant decreases in the prevalence of smoking tobacco. Among females, none of these 12 countries had significant decreases in prevalence of chewing tobacco use, whereas seven of 12 countries had a significant decrease in the prevalence of tobacco smoking use for the period. Interpretation Chewing tobacco remains a substantial public health problem in several regions of the world, and predominantly in south Asia. We found little change in the prevalence of chewing tobacco use between 1990 and 2019, and that control efforts have had much larger effects on the prevalence of smoking tobacco use than on chewing tobacco use in some countries. Mitigating the health effects of chewing tobacco requires stronger regulations and policies that specifically target use of chewing tobacco, especially in countries with high prevalence. Copyright (c) 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019 : a systematic analysis from the Global Burden of Disease Study 2019

Background Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. Methods We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. We modelled multiple smoking-related indicators from 3625 nationally representative surveys. We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. We used a direct estimation approach to estimate attributable burden, providing more comprehensive estimates of the health effects of smoking than previously available. Findings Globally in 2019, 1.14 billion (95% uncertainty interval 1.13-1.16) individuals were current smokers, who consumed 7.41 trillion (7.11-7.74) cigarette-equivalents of tobacco in 2019. Although prevalence of smoking had decreased significantly since 1990 among both males (27.5% [26. 5-28.5] reduction) and females (37.7% [35.4-39.9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0.99 billion (0.98-1.00) in 1990. Globally in 2019, smoking tobacco use accounted for 7.69 million (7.16-8.20) deaths and 200 million (185-214) disability-adjusted life-years, and was the leading risk factor for death among males (20.2% [19.3-21.1] of male deaths). 6.68 million [86.9%] of 7.69 million deaths attributable to smoking tobacco use were among current smokers. Interpretation In the absence of intervention, the annual toll of 7.69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades. Substantial progress in reducing the prevalence of smoking tobacco use has been observed in countries from all regions and at all stages of development, but a large implementation gap remains for tobacco control. Countries have a dear and urgent opportunity to pass strong, evidence-based policies to accelerate reductions in the prevalence of smoking and reap massive health benefits for their citizens. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

This online publication has been corrected. The corrected version first appeared at thelancet.com on September 28, 2023BACKGROUND : Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050. METHODS : Estimates of diabetes prevalence and burden were computed in 204 countries and territories, across 25 age groups, for males and females separately and combined; these estimates comprised lost years of healthy life, measured in disability-adjusted life-years (DALYs; defined as the sum of years of life lost [YLLs] and years lived with disability [YLDs]). We used the Cause of Death Ensemble model (CODEm) approach to estimate deaths due to diabetes, incorporating 25 666 location-years of data from vital registration and verbal autopsy reports in separate total (including both type 1 and type 2 diabetes) and type-specific models. Other forms of diabetes, including gestational and monogenic diabetes, were not explicitly modelled. Total and type 1 diabetes prevalence was estimated by use of a Bayesian meta-regression modelling tool, DisMod-MR 2.1, to analyse 1527 location-years of data from the scientific literature, survey microdata, and insurance claims; type 2 diabetes estimates were computed by subtracting type 1 diabetes from total estimates. Mortality and prevalence estimates, along with standard life expectancy and disability weights, were used to calculate YLLs, YLDs, and DALYs. When appropriate, we extrapolated estimates to a hypothetical population with a standardised age structure to allow comparison in populations with different age structures. We used the comparative risk assessment framework to estimate the risk-attributable type 2 diabetes burden for 16 risk factors falling under risk categories including environmental and occupational factors, tobacco use, high alcohol use, high body-mass index (BMI), dietary factors, and low physical activity. Using a regression framework, we forecast type 1 and type 2 diabetes prevalence through 2050 with Socio-demographic Index (SDI) and high BMI as predictors, respectively. FINDINGS : In 2021, there were 529 million (95% uncertainty interval [UI] 500–564) people living with diabetes worldwide, and the global age-standardised total diabetes prevalence was 6·1% (5·8–6·5). At the super-region level, the highest age-standardised rates were observed in north Africa and the Middle East (9·3% [8·7–9·9]) and, at the regional level, in Oceania (12·3% [11·5–13·0]). Nationally, Qatar had the world’s highest age-specific prevalence of diabetes, at 76·1% (73·1–79·5) in individuals aged 75–79 years. Total diabetes prevalence—especially among older adults—primarily reflects type 2 diabetes, which in 2021 accounted for 96·0% (95·1–96·8) of diabetes cases and 95·4% (94·9–95·9) of diabetes DALYs worldwide. In 2021, 52·2% (25·5–71·8) of global type 2 diabetes DALYs were attributable to high BMI. The contribution of high BMI to type 2 diabetes DALYs rose by 24·3% (18·5–30·4) worldwide between 1990 and 2021. By 2050, more than 1·31 billion (1·22–1·39) people are projected to have diabetes, with expected age-standardised total diabetes prevalence rates greater than 10% in two super-regions: 16·8% (16·1–17·6) in north Africa and the Middle East and 11·3% (10·8–11·9) in Latin America and Caribbean. By 2050, 89 (43·6%) of 204 countries and territories will have an age-standardised rate greater than 10%. INTERPRETATION : Diabetes remains a substantial public health issue. Type 2 diabetes, which makes up the bulk of diabetes cases, is largely preventable and, in some cases, potentially reversible if identified and managed early in the disease course. However, all evidence indicates that diabetes prevalence is increasing worldwide, primarily due to a rise in obesity caused by multiple factors. Preventing and controlling type 2 diabetes remains an ongoing challenge. It is essential to better understand disparities in risk factor profiles and diabetes burden across populations, to inform strategies to successfully control diabetes risk factors within the context of multiple and complex drivers.Bill & Melinda Gates Foundation.http://www.thelancet.comam2024School of Health Systems and Public Health (SHSPH)SDG-03:Good heatlh and well-bein

Qualitative research analysis of Review of Accounting Studies Journal: scientometric, citation and collaboration analysis

Background: The objective of this study is to evaluate the research performance using scientometric related indicators i.e., quantity, quality, citations, and international collaboration of the “Review of Accounting Studies” Journal. Purpose: this journal provides an outlet for significant academic research in accounting, including theoretical, empirical, and experimental work. This journal indexed with many leading citation indexes (Social Science Citation Index, SCOPUS, WoS, etc.) and top-ranked in the management journal ranking agencies in the globe i.e., ABS & ABDC. This top-ranked journal acceptance rate is very minimal due to high standards for publishing research articles. Methods: the qualitative research analysis carried out during the study period (1996 – 2018) based on Elsevier\u27s Scopus Results: The Journal has one executive editor, ten members of the editors, and forty-one members on the editorial board. 41 editorial members from 23 leading universities in America. The study found that 564 documents were cited (16,907 cites), 81 documents were not cited and averaged to citation per paper (CPP) is 26.21 in percent. Other than business, management, and accounting 24 major subjects cited in Review of Accounting Studies journal publications. Five authors recorded an impact on the average of 36.29 citations per publication. Eight authors have registered over a 5.18 average in the h-index calculation. Seven authors published research articles with international collaboration above the group average of 26.92. The study reveals though the author h-index is high, it requires the International collaboration of authorship to receive more score in TC and CPP. The total Citation score is higher for the articles published with international collaborations. Conclusion: an international collaboration of authorship gives a wider range of reachability of authors (h-Index) and their academic content, which will get higher citation scores (TC and ACPP). This study contributes to identify the quality publication with top-ranked Journals in the accounting domain. keywords: scientometric analysis, Review of Accounting Studies, citation, collaboration, qualitative researc

Qualitative research analysis of Review of Accounting Studies Journal: scientometric, citation and collaboration analysis

Background: The objective of this study is to evaluate the research performance using scientometric related indicators i.e., quantity, quality, citations, and international collaboration of the “Review of Accounting Studies” Journal. Purpose: this journal provides an outlet for significant academic research in accounting, including theoretical, empirical, and experimental work. This journal indexed with many leading citation indexes (Social Science Citation Index, SCOPUS, WoS, etc.) and top-ranked in the management journal ranking agencies in the globe i.e., ABS & ABDC. This top-ranked journal acceptance rate is very minimal due to high standards for publishing research articles. Methods: the qualitative research analysis carried out during the study period (1996 – 2018) based on Elsevier\u27s Scopus Results: The Journal has one executive editor, ten members of the editors, and forty-one members on the editorial board. 41 editorial members from 23 leading universities in America. The study found that 564 documents were cited (16,907 cites), 81 documents were not cited and averaged to citation per paper (CPP) is 26.21 in percent. Other than business, management, and accounting 24 major subjects cited in Review of Accounting Studies journal publications. Five authors recorded an impact on the average of 36.29 citations per publication. Eight authors have registered over a 5.18 average in the h-index calculation. Seven authors published research articles with international collaboration above the group average of 26.92. The study reveals though the author h-index is high, it requires the International collaboration of authorship to receive more score in TC and CPP. The total Citation score is higher for the articles published with international collaborations. Conclusion: an international collaboration of authorship gives a wider range of reachability of authors (h-Index) and their academic content, which will get higher citation scores (TC and ACPP). This study contributes to identify the quality publication with top-ranked Journals in the accounting domain. keywords: scientometric analysis, Review of Accounting Studies, citation, collaboration, qualitative researc

Evaluation of Blackgram Genotypes for their Drought Tolerance at Seedling and Vegetative Phase

Aim: To screen and identify blackgram genotypes for drought tolerance at seedlings and vegetative stage. Study Design:  Completely randomized complete block design. Place of Study: National Pulses Research Centre (NPRC), Tamil Nadu Agricultural University, Vamban, Pudukkottai District. Methodology: Laboratory experiments was conducted at NPRC, Vamban. Twenty-Five blackgram varieties were used for this study. For screening at seedling stage, the treatments were T1 - Control – Water (0 Mpa) and T2 - PEG 6000 induced drought stress (-0.5 MPa). Blackgram seeds were germinated in water and PEG 6000 solution (-0.5 MPa).  On the eighth day various seedling growth indices were recorded. For pot culture experiments, the two treatments were imposed T1 – Control and T2 – Drought stress (50% Field capacity) after the appearance of two trifoliate leaves by gravimetric approach. The stress was imposed for five days. At the end of fifth day, growth parameters, relative water content and leaf chlorophyll content was recorded. Two-way ANOVA was used to analyze the data. Results: In blackgram, drought stress at seedling stage affects the seedling germination, establishment and its growth indices. At vegetative stage, drought stress negatively affects the plant growth, leaf area, leaf relative water content and chlorophyll content. Among the blackgram genotypes screened, the genotypes VBG 11031 and VBG 1711 were found to be tolerant to PEG 6000 induced drought stress at seedling stage. At vegetative stage, the genotypes VBG 11062, VBG 11024 and VBG 1725 were tolerant to drought stress at vegetative stage. Conclusion: Present study concluded that the blackgram genotypes VBG 11031, VBG 1711, VBG 11062, VBG 11024 and VBG 1725 were found to be tolerant to drought stress at seedling and vegetative stage