Variability and periodicity of field M dwarfs revealed by multichannel monitoring

We present simultaneous, multiband monitoring of 19 field M dwarfs (spectral types M2-M9). Significant variability was found in seven objects in at least one out of the three channels I, R and G. Two objects, LHS370 (M5V) and 2M1707+64 (M9V), show periods of 5.9+-2.0 and 3.65+-0.1 hours respectively. On account of the agreement with the typical values of v*sin(i) published for M dwarfs (Mohanty & Basri 2003), we claim these to be the objects' rotation periods. In the case of 2M1707+64 we furthermore find evidence for the presence of magnetically-induced cool spots as the reason for the observed variability (at a temperature contrast of 4-8 percent, with a projected surface coverage factor of less than 0.075) and can rule out the scenario of dust clouds (as represented by the COND or DUSTY models). Comparing the frequency of occurrence of variability in this and various L dwarf samples published over the past few years, we find that variability is more common in field L dwarfs than in field M dwarfs. This implies a change in the physical nature and/or extent of surface features when moving from M to L dwarfs.Comment: 15 pages, 14 figures, accepted for publication by A&

Load Distribution in the Lumbar Spine During Modeled Compression Depends on Lordosis

Excessive or incorrect loading of lumbar spinal structures is commonly assumed as one of the factors to accelerate degenerative processes, which may lead to lower back pain. Accordingly, the mechanics of the spine under medical conditions, such as scoliosis or spondylolisthesis, is well-investigated. Treatments via both conventional therapy and surgical methods alike aim at restoring a “healthy” (or at least pain-free) load distribution. Yet, surprisingly little is known about the inter-subject variability of load bearings within a “healthy” lumbar spine. Hence, we utilized computer tomography data from 28 trauma-room patients, whose lumbar spines showed no visible sign of degeneration, to construct simplified multi-body simulation models. The subject-specific geometries, measured by the corresponding lumbar lordosis (LL) between the endplates of vertebra L1 and the sacrum, served as ceteris paribus condition in a standardized forward dynamic compression procedure. Further, the influence of stimulating muscles from the M. multifidus group was assessed. For the range of available LL from 28 to 66°, changes in compressive and shear forces, bending moments, as well as facet joint forces between adjacent vertebrae were calculated. While compressive forces tended to decrease with increasing LL, facet forces were tendentiously increasing. Shear forces decreased between more cranial vertebrae and increased between more caudal ones, while bending moments remained constant. Our results suggest that there exist significant, LL-dependent variations in the loading of “healthy” spinal structures, which should be considered when striving for individually appropriate therapeutic measures

Identification of red high proper-motion objects in Tycho-2 and 2MASS catalogues using Virtual Observatory tools

Aims: With available Virtual Observatory tools, we looked for new M dwarfs in the solar neighbourhood and M giants with high tangential velocities. Methods: From an all-sky cross-match between the optical Tycho-2 and the near-infrared 2MASS catalogues, we selected objects with proper motions >50mas/yr and very red V-Ks colours. For the most interesting targets, we collected multi-wavelength photometry, constructed spectral energy distributions, estimated effective temperatures and surface gravities from fits to atmospheric models, performed time-series analysis of ASAS V-band light curves, and assigned spectral types from low-resolution spectroscopy obtained with CAFOS at the 2.2m Calar Alto telescope. Results: We got a sample of 59 bright red high proper-motion objects, including fifty red giants, four red dwarfs, and five objects reported in this work for the first time. The five new stars have magnitudes V~10.8-11.3mag, reduced proper motions midway between known dwarfs and giants, near-infrared colours typical of giants, and effective temperatures Teff~2900-3400K. From our time-series analysis, we discovered a long secondary period in Ruber 4 and an extremely long primary period in Ruber 6. With the CAFOS spectra, we confirmed the red giant nature of Ruber 7 and 8, the last of which seems to be one of the brightest metal-poor M giants ever identified.Comment: Accepted in Astronomy & Astrophysic

The triple system HIP96515: a low-mass eclipsing binary with a DB white dwarf companion

HIP96515A is a double-lined spectroscopic binary with a visual companion (HIP96515B) at 8.6 arcsec. It is included in the SACY catalog as a potential young star and classified as an eclipsing binary in the ASAS Catalog. We have analyzed spectroscopic and photometric observations of the triple system. The high-resolution optical spectrum of HIP96515A has been used to derive a mass ratio, M_2/M_1, close to 0.9, with the SB2 components showing spectral types of M1 and M2. The ASAS and Hipparcos light-curves of HIP96515A show periodic variations with P=2.3456 days, confirming that HIP96515A is an eclipsing binary with preliminary parameters of i=89, M_Aa=0.59+-0.03 Msun and M_Ab=0.54+-0.03 Msun, for the primary and secondary, respectively, at an estimated distance of 42+-3 pc. This is a new eclipsing binary with component masses below 0.6 Msun. Multi-epoch observations of HIP 96515 A&B show that the system is a common proper motion pair. The optical spectrum of HIP 96515B is consistent with a pure helium atmosphere (DB) white dwarf. We estimate a total age (main-sequence lifetime plus cooling age) of 400 Myr for the white dwarf. If HIP 96515 A&B are coeval, and assuming a common age of 400 Myr, the comparison of the masses of the eclipsing binary members with evolutionary tracks shows that they are underestimated by ~15% and ~10%, for the primary and secondary, respectively.Comment: Accepted for publication in A&A, 9 pages, 9 figure

A mutation of EPT1 (SELENOI) underlies a new disorder of Kennedy pathway phospholipid biosynthesis.

Mutations in genes involved in lipid metabolism have increasingly been associated with various subtypes of hereditary spastic paraplegia, a highly heterogeneous group of neurodegenerative motor neuron disorders characterized by spastic paraparesis. Here, we report an unusual autosomal recessive neurodegenerative condition, best classified as a complicated form of hereditary spastic paraplegia, associated with mutation in the ethanolaminephosphotransferase 1 (EPT1) gene (now known as SELENOI), responsible for the final step in Kennedy pathway forming phosphatidylethanolamine from CDP-ethanolamine. Phosphatidylethanolamine is a glycerophospholipid that, together with phosphatidylcholine, constitutes more than half of the total phospholipids in eukaryotic cell membranes. We determined that the mutation defined dramatically reduces the enzymatic activity of EPT1, thereby hindering the final step in phosphatidylethanolamine synthesis. Additionally, due to central nervous system inaccessibility we undertook quantification of phosphatidylethanolamine levels and species in patient and control blood samples as an indication of liver phosphatidylethanolamine biosynthesis. Although this revealed alteration to levels of specific phosphatidylethanolamine fatty acyl species in patients, overall phosphatidylethanolamine levels were broadly unaffected indicating that in blood EPT1 inactivity may be compensated for, in part, via alternate biochemical pathways. These studies define the first human disorder arising due to defective CDP-ethanolamine biosynthesis and provide new insight into the role of Kennedy pathway components in human neurological function

Diacylglycerol triggers Rim101 pathway dependent necrosis in yeast: a model for lipotoxicity

The loss of lipid homeostasis can lead to lipid overload and is associated with a variety of disease states. However, little is known as to how the disruption of lipid regulation or lipid overload affects cell survival. In this study we investigated how excess diacylglycerol (DG), a cardinal metabolite suspected to mediate lipotoxicity, compromises the survival of yeast cells. We reveal that increased DG achieved by either genetic manipulation or pharmacological administration of 1,2-dioctanoyl-sn-glycerol (DOG) triggers necrotic cell death. The toxic effects of DG are linked to glucose metabolism and require a functional Rim101 signaling cascade involving the Rim21 dependent sensing complex and activation of a calpain-like protease. The Rim101 cascade is an established pathway that triggers a transcriptional response to alkaline or lipid stress. We propose that the Rim101 pathway senses DG-induced lipid perturbation and conducts a signaling response that either facilitates cellular adaptation or triggers lipotoxic cell death. Using established models of lipotoxicity i.e. high fat diet in Drosophila and palmitic acid administration in cultured human endothelial cells, we present evidence that the core mechanism underlying this calpain-dependent lipotoxic cell death pathway is phylogenetically conserved