Adverse Effect? Dealing with Forgotten MOA Commitments

Section 106 of the National Historic Preservation Act has the potential to impact a project even after construction. This presentation is designed for LPAs with projects that may have resulted in an adverse effect finding on cultural resources during a Section 106 review, thus requiring a memorandum of agreement (MOA). The panel will explore what it means to have an MOA, provide insight on common conceptual mitigation measures, and define responsibilities for the implementation of MOA stipulations

JB-2: America's First Cruise Missile

My research provides a historical and archaeological context for this thesis, in which I argue the JB-2 missile is historically significant as a unique example of the rapid duplication of enemy technology for both physical and psychological retaliation, as a crucial link in the chain of development for America’s cruise missile program, and for its role in early Cold War deterrence. Jet Bomb model number 2 (JB-2), America’s first operationally successful, mass produced cruise missile, developed as a direct copy of the German V-1, with slight variation in manufacture due to differences between German and American components, machinery and tooling. Continuing modifications of the JB-2 during its service life led to improvements in performance, control, and accuracy. From 1944 to 1953, the JB-2 transitioned from a weapon quickly prepared for wartime deployment to an essential test vehicle for the United States Army, Air Force and Navy while supporting the U.S. policy of containment during the early Cold War

Cultural Resources Investigations Along Whiteoak Bayou, Harris County, Texas

In 1986, cultural resources investigations were carried out to prepare a synthesis of the archeology of the Whiteoak Bayou area in western Harris County, Texas, and to conduct subsurface testing at prehistoric sites that may be affected by the U.S. Army Corps of Engineers Upper Whiteoak Bayou Flood Damage Reduction Project. The tasks undertaken during these investigations are: (1) background research into the environment and archeology of the area; (2) historic/archival research and reconnaissance survey to summarize the historical development of Whiteoak Bayou and to identify any important sites in the project area; (3) intensive survey of Vogel Creek, a tributary to Whiteoak Bayou, to assess the potential for intact cultural remains; (4) National Register testing and assessment of nine aboriginal sites; (5) geoarcheological investigations to establish the geological context of the archeological remains, to identify the depositional environments represented, and to establish an alluvial sequence for the project area; and (6) analysis of a large collection of artifacts from 46 Whiteoak Bayou sites made prior to 1986 by members of the Houston Archeological Society, as well as the materials recovered during 1986. The nine archeological sites tesLed during this project are 41HR241, 4lHR259, 41HR273, 41HR278, 41HR279, 41HR283, 41HR290, 41HR298, and 41HR541. The testing showed that only three -- 41HR259, 41HR273, and 41HR541 -- have substantial, intact cultural deposits. Two of these -- 41HR273 and 41HR541 -- are judged to be eligible for listing on the National Register of Historic Places and for designation as State Archeological Landmarks. One site, 4lHR259, is currently listed on the National Register, although the remaining part of this site is judged to have a limited potential to yield additi0nal information. The other seven sites are judged to be ineligible for listing

Creative Media Approaches for Cultural Mitigation

Transportation projects do more than connect people, they provide opportunities to connect cultures. Explore how media production was incorporated as unique mitigation in two projects to address the cultural history of two different geographic areas. Participants will learn of the successes and challenges in producing the Cultural Audio Tours for the INDOT-sponsored I-69 project and the video documentary for the historically African American “Foot” Neighborhood as part of the Missouri DOT-sponsored Rex Whitton Expressway

Mediport use as an acceptable standard for CAR T cell infusion.

INTRODUCTION: Mediport use as a clinical option for the administration of chimeric antigen receptor T cell (CAR T cell) therapy in patients with B-cell malignancies has yet to be standardized. Concern for mediport dislodgement, cell infiltration, and ineffective therapy delivery to systemic circulation has resulted in variable practice with intravenous administration of CAR T cell therapy. With CAR T cell commercialization, it is important to establish practice standards for CAR T cell delivery. We conducted a study to establish usage patterns of mediports in the clinical setting and provide a standard of care recommendation for mediport use as an acceptable form of access for CAR T cell infusions. METHODS: In this retrospective cohort study, data on mediport use and infiltration rate was collected from a survey across 34 medical centers in the Pediatric Real-World CAR Consortium, capturing 504 CAR T cell infusion routes across 489 patients. Data represents the largest, and to our knowledge sole, report on clinical CAR T cell infusion practice patterns since FDA approval and CAR T cell commercialization in 2017. RESULTS: Across 34 sites, all reported tunneled central venous catheters, including Broviac® and Hickman® catheters, as accepted standard venous options for CAR T cell infusion. Use of mediports as a standard clinical practice was reported in 29 of 34 sites (85%). Of 489 evaluable patients with reported route of CAR T cell infusion, 184 patients were infused using mediports, with no reported incidences of CAR T cell infiltration. DISCUSSION/CONCLUSION: Based on current clinical practice, mediports are a commonly utilized form of access for CAR T cell therapy administration. These findings support the safe practice of mediport usage as an accepted standard line option for CAR T cell infusion

Common Strategies and Technologies for the Ecosafety Assessment and Design of Nanomaterials Entering the Marine Environment

The widespread use of engineered nanomaterials (ENMs) in a variety of technologies and consumer products inevitably causes their release into aquatic environments and final deposition into the oceans. In addition, a growing number of ENM products are being developed specifically for marine applications, such as antifouling coatings and environmental remediation systems, thus increasing the need to address any potential risks for marine organisms and ecosystems. To safeguard the marine environment, major scientific gaps related to assessing and designing ecosafe ENMs need to be filled. In this Nano Focus, we examine key issues related to the state-of-the-art models and analytical tools being developed to understand ecological risksand to design safeguards for marine organisms

A Study of heavy flavor production using muons in hadronic Z0 decays

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