Prevalence of bacterial vaginosis among reproductive age group women in a tertiary care centre

Background: Vaginal discharge in reproductive age poses a serious problem in the developing countries. Bacterial vaginosis also known as non-specific vaginitis is the most common cause of vaginal infections, detecting the organism at an early stage and initiating a proper treatment is very difficult in our country due to lack of awareness and proper follow-up. The disease manifests in the form of vaginal discharge with or without itching. It has a strong association with preterm labor, preterm premature rupture of membranes and low birth weight in pregnancy. The objective of this study was to find out the prevalence of bacterial vaginosis among the reproductive age group women, in a tertiary care centre.Methods: A cross sectional study was conducted among 150 women of the reproductive age group in the department of obstetrics and gynaecology Sree Mookambika Institute of Medical Sciences over a period of one month October 2018 the diagnosis was made with history and nugents scoring system.Results: Out of the total 150 women enrolled in the study 74 had positive results, 50% of them were of the age group 26-30.Conclusions: The study shows us the high prevalence of bacterial vaginosis

IDENTIFICATION OF ANTIULCER ACTIVITY BY INSILICO METHOD IN SELECTED MEDICINAL PLANTS

Ulcer occurs when stomach acid damages the lining of the digestive tract caused by the bacteria Helicobacter pylori. Many pharmacological activities such as antiulcer activity can act against ulcer. Medicinal plants like Mimosa pudica and Vachellia nilotica has the antiulcer activity in a wide range. To study the antiulcer activity in medicinal plants using insilco studies by comparing the phytocompounds of plants with histamine 2 receptor as a binding protein, which is present in the stomach lining of homosapiens. Histamine 2 receptor was modelled using Swiss model and the ligand structures are obtained from PUB-CHEM, viewed easily via PYMOL. All the phytocompounds showed good binding energy with modelled protein on the docking methodology. Specifically ascorbic acid exhibited the lower binding energy of value -3.24 kcal/mol, indole and catechin shows highest binding energy of value -4.99 kcal/mol and -4.98 kacl/mol respectively. The results can be useful for the design and development of phytocompounds having better inhibitory activity against several types of ulcer

Bronchiectasis in India:results from the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) and Respiratory Research Network of India Registry

BACKGROUND: Bronchiectasis is a common but neglected chronic lung disease. Most epidemiological data are limited to cohorts from Europe and the USA, with few data from low-income and middle-income countries. We therefore aimed to describe the characteristics, severity of disease, microbiology, and treatment of patients with bronchiectasis in India. METHODS: The Indian bronchiectasis registry is a multicentre, prospective, observational cohort study. Adult patients ( 6518 years) with CT-confirmed bronchiectasis were enrolled from 31 centres across India. Patients with bronchiectasis due to cystic fibrosis or traction bronchiectasis associated with another respiratory disorder were excluded. Data were collected at baseline (recruitment) with follow-up visits taking place once per year. Comprehensive clinical data were collected through the European Multicentre Bronchiectasis Audit and Research Collaboration registry platform. Underlying aetiology of bronchiectasis, as well as treatment and risk factors for bronchiectasis were analysed in the Indian bronchiectasis registry. Comparisons of demographics were made with published European and US registries, and quality of care was benchmarked against the 2017 European Respiratory Society guidelines. FINDINGS: From June 1, 2015, to Sept 1, 2017, 2195 patients were enrolled. Marked differences were observed between India, Europe, and the USA. Patients in India were younger (median age 56 years [IQR 41-66] vs the European and US registries; p<0\ub70001]) and more likely to be men (1249 [56\ub79%] of 2195). Previous tuberculosis (780 [35\ub75%] of 2195) was the most frequent underlying cause of bronchiectasis and Pseudomonas aeruginosa was the most common organism in sputum culture (301 [13\ub77%]) in India. Risk factors for exacerbations included being of the male sex (adjusted incidence rate ratio 1\ub717, 95% CI 1\ub703-1\ub732; p=0\ub7015), P aeruginosa infection (1\ub729, 1\ub710-1\ub750; p=0\ub7001), a history of pulmonary tuberculosis (1\ub720, 1\ub707-1\ub734; p=0\ub7002), modified Medical Research Council Dyspnoea score (1\ub732, 1\ub725-1\ub739; p<0\ub70001), daily sputum production (1\ub716, 1\ub703-1\ub730; p=0\ub7013), and radiological severity of disease (1\ub703, 1\ub701-1\ub704; p<0\ub70001). Low adherence to guideline-recommended care was observed; only 388 patients were tested for allergic bronchopulmonary aspergillosis and 82 patients had been tested for immunoglobulins. INTERPRETATION: Patients with bronchiectasis in India have more severe disease and have distinct characteristics from those reported in other countries. This study provides a benchmark to improve quality of care for patients with bronchiectasis in India. FUNDING: EU/European Federation of Pharmaceutical Industries and Associations Innovative Medicines Initiative inhaled Antibiotics in Bronchiectasis and Cystic Fibrosis Consortium, European Respiratory Society, and the British Lung Foundation

N-heterocyclic iminium ions catalyzed Friedel–Crafts type alkenylation of arenes with alkynes: A metal free and solvent free approach

The current manuscript elucidates a pioneering approach for achieving regioselective Markovnikov-type hydroarylation of alkynes, without the use of any metal catalysts. The aforementioned process is expedited through the implementation of 2-amino-perimidinium bromide and TFA as catalyst systems and is executed in the absence of solvents, thereby expanding the range of substrates (including arenes and alkynes). The correlation between the stoichiometric reactions and experimental data substantiates the postulated reaction mechanism

Vitamin D deficiency in postmenopausal women with pelvic floor disorders

Introduction: The aim of this study is to evaluate the association of vitamin D deficiency and pelvic floor disorders (PFD) including pelvic organ prolapse (POP) and stress urinary incontinence in postmenopausal women. Materials and Methods: This is a prospective case control study on 120 women with or without symptoms of PFD. Relevant history and clinical examination were conducted. Serum 25-hydroxy vitamin D levels were measured in all women. Chi square and student t test were used to test significance of association. Logistic regression was used to adjust for age. Odds ratios and 95% confidence intervals were calculated. Results: Of the 120 postmenopausal women included, 51 had PFD on clinical examination. Of the 51 cases, 28 women had POP and 14 women had stress incontinence (SUI) while nine women had both POP and SUI. The study showed that vitamin D levels were significantly lower in women with PFD than those without PFD. Menopausal status of more than 5 years was also significantly associated with PFD. Conclusion: Findings suggest association of vitamin D deficiency and PFD in postmenopausal women. In addition, postmenopausal women have a high prevalence of vitamin D deficiency indicating a need to evaluate vitamin D levels in these women

Hierarchical Ternary Sulfides as Effective Photocatalyst for Hydrogen Generation Through Water Splitting: A Review on the Performance of ZnIn₂S₄

One of the major aspects and advantages of solar energy conversion is the photocatalytic hydrogen generation using semiconductor materials for an eco-friendly technology. Designing a low-cost efficient material to overcome limited light absorption as well as rapid recombination of photogenerated charge carriers is essential to achieve considerable hydrogen generation. In recent years, sulfide based semiconductors have attracted scientific research interest due to their excellent solar response and narrow band gap. The present review focuses on the recent approaches in the development of hierarchical ternary sulfide based photocatalysts with a special focus on ZnIn2S4. We also observe how the electronic structure of ZnIn2S4 is beneficial for water splitting and the various strategies involved for improving the material efficiency for photocatalytic hydrogen generation. The review places emphasis on the latest advancement/new insights on ZnIn2S4 being used as an efficient material for hydrogen generation through photocatalytic water splitting. Recent progress on essential aspects which govern light absorption, charge separation and transport are also discussed in detail