154 research outputs found
Nutrient profile of pond water in north-eastern state of Tripura and impact of water acidity on aquaculture productivity
Physicochemical parameters of 31 fish pond water samples of Tripura were studied to ascertain the nutrient profile of acidic soil zone and the impact of water acidity towards aquaculture productivity. The pH was acidic (mean 6.63±0.44) with high Fe (mean1.04±0.40 mglˉ¹) and AI (mean 2.67±2.41 mglˉ¹) contents. These were mostly responsible for pond water acidity and poor productivity with low nitrogen, phosphate and total alkalinity. The study also showed strong negative relationship between water pH and redox potential (R²=0.5251). However, pH was positively significant with electrical conductivity. The roles of redox potential and electrical conductivity in water acidity were found highly important. Available calcium content was also found low (mean 2.91±2.96 mglˉ¹). Elevating level of pH of pond water could be the possible management practices in acidic water so that such unproductive water might be productive enough with higher phosphate and nitrogen levels for better biological production
Superpositions of the dual family of nonlinear coherent states and their non-classical properties
Nonlinear coherent states (CSs) and their {\it dual families} were introduced
recently. In this paper we want to obtain their superposition and investigate
their non-classical properties such as antibunching effect, quadrature
squeezing and amplitude squared squeezing. For this purpose two types of
superposition are considered. In the first type we neglect the normalization
factors of the two components of the dual pair, superpose them and then we
normalize the obtained states, while in the second type we superpose the two
normalized components and then again normalize the resultant states. As a
physical realization, the formalism will then be applied to a special physical
system with known nonlinearity function, i.e., Hydrogen-like spectrum. We
continue with the (first type of) superposition of the dual pair of
Gazeau-Klauder coherent states (GKCSs) as temporally stable CSs. An application
of the proposal will be given by employing the P\"oschl-Teller potential
system. The numerical results are presented and discussed in detail, showing
the effects of this special quantum interference.Comment: 19 pages, 18 figures, Accpeted for Publication in Optics
Communications, 201
In silico analysis of whole genome of Solanum lycopersicum for alpha-crystallin domains associated with heat stress tolerance.
Not AvailableLiving organisms alter their gene-expression patterns to withstand stressful conditions. Drought, salinity, heat and chilling are potent abiotic stresses causing an alteration in gene expression. Among these, high temperature stress stimulates Heat Shock Transcription Factors (HSF) which activate heat shock promoters, thus turning on the heat shock genes. Heat shock proteins are, therefore, products of heat shock genes and are classified as per their molecular weight, including small heat shock proteins (sHsps). Hsps are chaperones playing an important role in stress tolerance. These consist of a conserved domain, flanked by N- and C-terminal regions termed the alphacrystallin domain (ACD), and are widely distributed in living beings. Their role as chaperones is to help the other proteins in protein-folding and prevent irreversible protein aggregation. The conserved domains in sHsps are essential for heat-stress tolerance and for their molecular chaperone activity, enabling plant survival under increasing temperatures, leading to adaptations needed for coping with extremes climatic conditions. The present study focusses on identification of ACDs in the whole-genome of Solanum lycopersicum. A multinational consortium, International Tomato Annotation Group (ITAG), funded in part by the EU-SOL Project, provides annotation of the whole genome of S. lycopersicum available in the public domain. We used several in silico methods for exploring alpha-crystallin domains in all the chromosomes of S. lycopersicum. Surprisingly, these ACDs were found to be present in all the chromosomes excepting Chromosome 4; these are highly conserved in sHsps and are related to heat tolerance.Not Availabl
Cell therapies in the clinic
Cell therapies have emerged as a promising therapeutic modality with the potential to treat and even cure a diverse array of diseases. Cell therapies offer unique clinical and therapeutic advantages over conventional small molecules and the growing number of biologics. Particularly, living cells can simultaneously and dynamically perform complex biological functions in ways that conventional drugs cannot; cell therapies have expanded the spectrum of available therapeutic options to include key cellular functions and processes. As such, cell therapies are currently one of the most investigated therapeutic modalities in both preclinical and clinical settings, with many products having been approved and many more under active clinical investigation. Here, we highlight the diversity and key advantages of cell therapies and discuss their current clinical advances. In particular, we review 28 globally approved cell therapy products and their clinical use. We also analyze >1700 current active clinical trials of cell therapies, with an emphasis on discussing their therapeutic applications. Finally, we critically discuss the major biological, manufacturing, and regulatory challenges associated with the clinical translation of cell therapies
Neutron star properties in the quark-meson coupling model
The effects of internal quark structure of baryons on the composition and
structure of neutron star matter with hyperons are investigated in the
quark-meson coupling (QMC) model. The QMC model is based on mean-field
description of nonoverlapping spherical bags bound by self-consistent exchange
of scalar and vector mesons. The predictions of this model are compared with
quantum hadrodynamic (QHD) model calibrated to reproduce identical nuclear
matter saturation properties. By employing a density dependent bag constant
through direct coupling to the scalar field, the QMC model is found to exhibit
identical properties as QHD near saturation density. Furthermore, this modified
QMC model provides well-behaved and continuous solutions at high densities
relevant to the core of neutron stars. Two additional strange mesons are
introduced which couple only to the strange quark in the QMC model and to the
hyperons in the QHD model. The constitution and structure of stars with
hyperons in the QMC and QHD models reveal interesting differences. This
suggests the importance of quark structure effects in the baryons at high
densities.Comment: 28 pages, 10 figures, to appear in Physical Review
Mapping child growth failure across low- and middle-income countries
Childhood malnutrition is associated with high morbidity and mortality globally1. Undernourished children are more likely to experience cognitive, physical, and metabolic developmental impairments that can lead to later cardiovascular disease, reduced intellectual ability and school attainment, and reduced economic productivity in adulthood2. Child growth failure (CGF), expressed as stunting, wasting, and underweight in children under five years of age (0�59 months), is a specific subset of undernutrition characterized by insufficient height or weight against age-specific growth reference standards3�5. The prevalence of stunting, wasting, or underweight in children under five is the proportion of children with a height-for-age, weight-for-height, or weight-for-age z-score, respectively, that is more than two standard deviations below the World Health Organization�s median growth reference standards for a healthy population6. Subnational estimates of CGF report substantial heterogeneity within countries, but are available primarily at the first administrative level (for example, states or provinces)7; the uneven geographical distribution of CGF has motivated further calls for assessments that can match the local scale of many public health programmes8. Building from our previous work mapping CGF in Africa9, here we provide the first, to our knowledge, mapped high-spatial-resolution estimates of CGF indicators from 2000 to 2017 across 105 low- and middle-income countries (LMICs), where 99 of affected children live1, aggregated to policy-relevant first and second (for example, districts or counties) administrative-level units and national levels. Despite remarkable declines over the study period, many LMICs remain far from the ambitious World Health Organization Global Nutrition Targets to reduce stunting by 40 and wasting to less than 5 by 2025. Large disparities in prevalence and progress exist across and within countries; our maps identify high-prevalence areas even within nations otherwise succeeding in reducing overall CGF prevalence. By highlighting where the highest-need populations reside, these geospatial estimates can support policy-makers in planning interventions that are adapted locally and in efficiently directing resources towards reducing CGF and its health implications. © 2020, The Author(s)
Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020
We show the distribution of SARS-CoV-2 genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three available genomic nomenclature systems for SARS-CoV-2 to all sequence data from the WHO European Region available during the COVID-19 pandemic until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation. We provide a comparison of the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.Peer reviewe
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