1,846 research outputs found
Top squark and neutralino decays in a R-parity violating model constrained by neutrino oscillation data
In a R-parity violating (RPV) model of neutrino mass with three bilinear
couplings and three trilinear couplings , where is
the lepton index, we find six generic scenarios each with a distinctive pattern
of the trilinear couplings consistent with the oscillation data. These patterns
may be reflected in direct RPV decays of the lighter top squark or in the RPV
decays of the lightest superparticle, assumed to be the lightest neutralino.
Typical signal sizes at the Tevatron RUN II and the LHC have been estimated
and the results turn out to be encouraging.Comment: 20 pages, 4 figures, LaTex,typos corrected and reference added for
section 2, a paragraph has been added in the conclusion par
Comparative study of quality of life in breast cancer patients receiving two different chemotherapy regimens using European Organization for Research and Treatment of Cancer Quality of Questionnaire-Core 30 questionnaire module; for tolerability and safety
Background: Breast cancer is one of the most frequent occurring cancers in women and burgeoning worldwide. It is the second most common malignancy in India after carcinoma of the uterine cervix. In clinical trials, quality of life (QOL) outcome measurements is an important as endpoints with improving subjects physical, emotional, and social well-being.Methods: In this study, we were evaluated the comparison of the QOL in breast cancer patients on anthracycline-based regimen (six cycles of 5-fluorouracil, adriamycin, and cyclophosphamide [FAC] for a period of 18Â weeks) and taxane-containing regimen (four cycles of adriamycin and cyclophosphamide [AC] followed by four cycles of paclitaxel [PTX] for a period of 24Â weeks) using European Organization for Research and Treatment of Cancer Quality of Questionnaire-Core 30.Results: During first 3Â months of therapy, both treatment groups exhibited a reduction in health-related QOL (HRQOL) with no clinically significant difference between them. The effect on HRQOL was less evident 3Â weeks after completing chemotherapy with HRQOL of both groups returning to near baseline scores.Conclusions: Both treatment regimens (FAC and AC â PTX [AC followed by PTX]) were equally tolerated in patients
Selection of chromosomal DNA libraries using a multiplex CRISPR system.
The directed evolution of biomolecules to improve or change their activity is central to many engineering and synthetic biology efforts. However, selecting improved variants from gene libraries in living cells requires plasmid expression systems that suffer from variable copy number effects, or the use of complex marker-dependent chromosomal integration strategies. We developed quantitative gene assembly and DNA library insertion into the Saccharomyces cerevisiae genome by optimizing an efficient single-step and marker-free genome editing system using CRISPR-Cas9. With this Multiplex CRISPR (CRISPRm) system, we selected an improved cellobiose utilization pathway in diploid yeast in a single round of mutagenesis and selection, which increased cellobiose fermentation rates by over 10-fold. Mutations recovered in the best cellodextrin transporters reveal synergy between substrate binding and transporter dynamics, and demonstrate the power of CRISPRm to accelerate selection experiments and discoveries of the molecular determinants that enhance biomolecule function
Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq
Genome editing has shown great promise for clinical translation but also revealed the risk of genotoxicity caused by off-target effects of programmable nucleases. Here we describe chromosomal aberrations analysis by single targeted linker-mediated PCR sequencing (CAST-Seq), a preclinical assay to identify and quantify chromosomal aberrations derived from on-target and off-target activities of CRISPR-Cas nucleases or transcriptional activator-like effector nucleases (TALENs), respectively, in human hematopoietic stem cells (HSCs). Depending on the employed designer nuclease, CAST-Seq detected translocations in 0%â0.5% of gene-edited human CD34+ HSCs, and up to 20% of on-target loci harbored gross rearrangements. Moreover, CAST-Seq detected distinct types of chromosomal aberrations, such as homology-mediated translocations, that are mediated by homologous recombination and not off-target activity. CAST-Seq is a sensitive assay able to identify and quantify unintended chromosomal rearrangements in addition to the more typical mutations at off-target sites. CAST-Seq analyses may be particularly relevant for therapeutic genome editing to enable thorough risk assessment before clinical application of gene-edited products
Effect of size reduction on the ferromagnetism of the manganite La1-xCaxMnO3 (x = 0.33)
In this paper we report an investigation on the ferromagnetic state and the
nature of ferromagnetic transition of nanoparticles of
using magnetic measurements and neutron
diffraction. The investigation was made on nanoparticles with crystal size down
to nm. The neutron data show that even down to a size of nm the
nanoparticles show finite spontaneous magnetization () although the value
is much reduced compared to the bulk sample. We observed a non-monotonic
variation of the ferromagnetic to paramagnetic transition temperature
with size and found that initially enhances on size reduction, but
for nm it decreases again. The initial enhancement in was
related to an increase in the bandwidth that occured due to a compaction of the
Mn-O bond length and a straightening of the Mn-O-Mn bond angle, as determined
form the neutron data. The size reduction also changes the nature of the
ferromagnetic to paramagnetic transition from first order to second order with
critical exponents approaching mean field values. This was explained as arising
from a truncation of the coherence length by the finite sample size.Comment: 12 figure
Use of prasugrel vs clopidogrel and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention in contemporary clinical practice: Results from the PROMETHEUS study
Background and objectivesWe sought to determine the frequency of use and association between prasugrel and outcomes in acute coronary syndrome patients undergoing percutaneous coronary intervention (PCI) in clinical practice
Scaling of the Equilibrium Magnetization in the Mixed State of Type-II Superconductors
We discuss the analysis of mixed-state magnetization data of type-II
superconductors using a recently developed scaling procedure. It is based on
the fact that, if the Ginzburg-Landau parameter kappa does not depend on
temperature, the magnetic susceptibility is a universal function of H/H_c2(T),
leading to a simple relation between magnetizations at different temperatures.
Although this scaling procedure does not provide absolute values of the upper
critical fieldH_c2(T), its temperature variation can be established rather
accurately. This provides an opportunity to validate theoretical models that
are usually employed for the evaluation of H_c2(T) from equilibrium
magnetization data. In the second part of the paper we apply this scaling
procedure for a discussion of the notorious first order phase transition in the
mixed state of high temperature superconductors. Our analysis, based on
experimental magnetization data available in the literature, shows that the
shift of the magnetization accross the transition may adopt either sign,
depending on the particular chosen sample. We argue that this observation is
inconsistent with the interpretation that this transition always represents the
melting transition of the vortex lattice.Comment: 18 pages, 12 figure
Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC
The uncertainty on the calorimeter energy response to jets of particles is
derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the
calorimeter response to single isolated charged hadrons is measured and
compared to the Monte Carlo simulation using proton-proton collisions at
centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009
and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter
response to specific types of particles (positively and negatively charged
pions, protons, and anti-protons) is measured and compared to the Monte Carlo
predictions. Finally, the jet energy scale uncertainty is determined by
propagating the response uncertainty for single charged and neutral particles
to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3%
for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table,
submitted to European Physical Journal
Standalone vertex ďŹnding in the ATLAS muon spectrometer
A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at âs = 7 TeV collected with the ATLAS detector at the LHC during 2011
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