Single-layer economic model predictive control for periodic operation

In this paper we consider periodic optimal operation of constrained periodic linear systems. We propose an economic model predictive controller based on a single layer that unites dynamic real time optimization and control. The proposed controller guarantees closed-loop convergence to the optimal periodic trajectory that minimizes the average operation cost for a given economic criterion. A priori calculation of the optimal trajectory is not required and if the economic cost function is changed, recursive feasibility and convergence to the new periodic optimal trajectory is guaranteed. The results are demonstrated with two simulation examples, a four tank system, and a simplified model of a section of Barcelona's water distribution network.Peer ReviewedPostprint (author’s final draft

Effects of bone morphogenic protein 4 (BMP4) and its inhibitor, Noggin, on in vitro maturation and culture of bovine preimplantation embryos

<p>Abstract</p> <p>Background</p> <p>BMP4 is a member of the transforming growth factor beta (TGFbeta) superfamily and Noggin is a potent BMP inhibitor that exerts its function by binding to BMPs preventing interactions with its receptors. The aim of this work was to investigate the role of BMP4 and Noggin, on oocytes <it>in vitro </it>maturation (m experiments) and embryos <it>in vitro </it>development (c experiments) of bovine.</p> <p>Methods</p> <p>For m experiments, COCs were collected from slaughterhouse ovaries and <it>in vitro </it>matured in TCM with 100 ng/ml of either BMP4 or Noggin. After 24 h, the nuclear stage of the oocytes was determined by staining with Hoechst 33342. In addition, RT-qPCR was performed on MII oocytes to study the relative concentration of <it>ZAR1, GDF9, BAX, MATER </it>and <it>HSP70 </it>transcripts. Treated oocytes were submitted to parthenogenic activation (PA) or <it>in vitro </it>fertilization (IVF) and cultured in CR2. For c experiments, non-treated matured oocytes were submitted to PA or IVF to generate embryos that were exposed to 100 ng/ml of BMP4 or Noggin in CR2 until day nine of culture. Cleavage, blastocyst and hatching rates, expression pattern of the transcription factor Oct-4 in blastocysts and embryo cell number at day two and nine post-activation or fertilization were evaluated.</p> <p>Results</p> <p>We found that Noggin, as BMP4, did not affect oocyte nuclear maturation. Noggin supplementation up-regulated the expression of <it>HSP70 and MATER </it>genes in matured oocytes. Moreover, BMP4 during maturation increased the proportion of Oct-4 positive cells in parthenogenic embryos. On the other hand, when Noggin was added to embryo culture medium, developmental rates of parthenogenic and <it>in vitro </it>fertilized embryos were reduced. However, BMP4 addition decreases the development only for <it>in vitro </it>fertilized embryos. BMP4 and Noggin during culture reduced the proportion of Oct-4-expressing cells.</p> <p>Conclusions</p> <p>Our results show that BMP4 is implicated in bovine oocytes maturation and embryo development. Moreover, our findings demonstrate, for the first time, that a correct balance of BMP signaling is needed for proper pre-implantation development of bovine embryos.</p

Fine‐Tuning the Photophysics of Donor‐Acceptor (D‐A 3 ) Thermally Activated Delayed Fluorescence Emitters Using Isomerisation

Here two D–A3 regioisomers, comprising three dibenzothiophene-S,S-dioxide acceptor units attached to a central triazatruxene core, are studied. Both molecules show thermally activated delayed fluorescence (TADF), however, the efficiency of the TADF mechanism is strongly affected by the D–A substitution position. The meta- substituted emitter (1 b) shows a slightly higher-lying singlet charge transfer state and a lower-lying triplet state than that observed in the para- substituted emitter (1 a), resulting in a larger singlet–triplet splitting (ΔEST) of 0.28 eV compared to only 0.01 eV found in 1 a. As expected, this ΔEST difference strongly impacts the reverse intersystem crossing (rISC) rates and the para- isomer 1 a exhibits a much faster delayed fluorescence emission. Calculations show that the triplet energy difference between the two isomers is due to steric hindrance variances along the donor–acceptor rotation axis in these molecules: as 1 b is less restricted, rotation of its acceptor unit leads to a lower T1 energy, further away from the region of high density of states (the region where larger vibronic coupling is found, favouring rISC). Therefore, our results show how the substitution pattern has a marked effect on triplet state energies and character, verifying the key structural designs for highly efficient TADF materials

Reconciling evidence from ancient and contemporary genomes: a major source for the European Neolithic within Mediterranean Europe

Important gaps remain in our understanding of the spread of farming into Europe, due partly to apparent contradictions between studies of contemporary genetic variation and ancient DNA. It seems clear that farming was introduced into central, northern, and eastern Europe from the south by pioneer colonization. It is often argued that these dispersals originated in the Near East, where the potential source genetic pool resembles that of the early European farmers, but clear ancient DNA evidence from Mediterranean Europe is lacking, and there are suggestions that Mediterranean Europe may have resembled the Near East more than the rest of Europe in the Mesolithic. Here, we test this proposal by dating mitogenome founder lineages from the Near East in different regions of Europe. We find that whereas the lineages date mainly to the Neolithic in central Europe and Iberia, they largely date to the Late Glacial period in central/eastern Mediterranean Europe. This supports a scenario in which the genetic pool of Mediterranean Europe was partly a result of Late Glacial expansions from a Near Eastern refuge, and that this formed an important source pool for subsequent Neolithic expansions into the rest of Europ

A genetic chronology for the Indian Subcontinent points to heavily sex-biased dispersals

Background India is a patchwork of tribal and non-tribal populations that speak many different languages from various language families. Indo-European, spoken across northern and central India, and also in Pakistan and Bangladesh, has been frequently connected to the so-called “Indo-Aryan invasions” from Central Asia ~3.5 ka and the establishment of the caste system, but the extent of immigration at this time remains extremely controversial. South India, on the other hand, is dominated by Dravidian languages. India displays a high level of endogamy due to its strict social boundaries, and high genetic drift as a result of long-term isolation which, together with a very complex history, makes the genetic study of Indian populations challenging. Results We have combined a detailed, high-resolution mitogenome analysis with summaries of autosomal data and Y-chromosome lineages to establish a settlement chronology for the Indian Subcontinent. Maternal lineages document the earliest settlement ~55–65 ka (thousand years ago), and major population shifts in the later Pleistocene that explain previous dating discrepancies and neutrality violation. Whilst current genome-wide analyses conflate all dispersals from Southwest and Central Asia, we were able to tease out from the mitogenome data distinct dispersal episodes dating from between the Last Glacial Maximum to the Bronze Age. Moreover, we found an extremely marked sex bias by comparing the different genetic systems. Conclusions Maternal lineages primarily reflect earlier, pre-Holocene processes, and paternal lineages predominantly episodes within the last 10 ka. In particular, genetic influx from Central Asia in the Bronze Age was strongly male-driven, consistent with the patriarchal, patrilocal and patrilineal social structure attributed to the inferred pastoralist early Indo-European society. This was part of a much wider process of Indo-European expansion, with an ultimate source in the Pontic-Caspian region, which carried closely related Y-chromosome lineages, a smaller fraction of autosomal genome-wide variation and an even smaller fraction of mitogenomes across a vast swathe of Eurasia between 5 and 3.5 ka

Short-term low-severity spring grassland fire impacts on soil extractable elements and soil ratios in Lithuania.

Spring grassland fires are common in boreal areas as a consequence of slash and burn agriculture used to remove dry grass to increase soil nutrient properties and crop production. However, fewworks have investigated fire impacts on these grassland ecosystems, especially in the immediate period after the fire. The objective of this work was to study the short-termimpacts of a spring grassland fire in Lithuania. Four days after the firewe established a 400 m2 sampling grid within the burned area and in an adjacent unburned area with the same topographical, hydrological and pedological characteristics. Wecollected topsoil samples immediately after the fire (0 months), 2, 5, 7 and 9 months after the fire. We analysed soil pH, electrical conductivity (EC), major nutrients including calcium(Ca), magnesium(Mg), sodium(Na), and potassium(K), and theminor elements aluminium(Al), manganese (Mn), iron (Fe) and zinc (Zn). We also calculated the soil Na and K adsorption ratio (SPAR), Ca:Mg and Ca:Al. The results showed that this low-severity grassland fire significantly decreased soil pH, Al, and Mn but increased EC, Ca,Mg, and K,. There was no effect on Na, Fe, and Zn. Therewas a decrease of EC, Ca,Mg, and Na from 0months after the fire until 7 months after the fire,with an increase during the last sampling period. Fire did not significantly affect SPAR. Ca:Mg decreased significantly immediately after the fire, but not to critical levels. Ca:Al increased after the fire, reducing the potential effects of Al on plants. Overall, fire impactsweremainly limited to the immediate period after the fire

Dispositivos de atención psicológica, en atención primaria de saludd en la ciudad de Rio Cuarto

En Argentina, el Plan Federal de Salud (2004-2007) plantea que la salud mental es un área de creciente preocupación que requiere la implementación de acciones específicas y recolección de datos epidemiológicos. Todo profesional que trabaja a nivel comunitario se ocupa de problemas sociales que afectan a una población desfavorecida y muchas veces trabaja con pocos recursos. El trabajo realizado en estas condiciones impacta en el bienestar del colectivo atendido y tiene implicaciones en la salud física y emocional del profesionnal. Conocer los dispositivos actuales de intervención psicosocial permitiría una evaluación de las demandas de asistencia que aún persisten y detectar aspectoos que requieran mejoras, así como factores y oportunidades que posibilitan su foortalecimiento. El objetivo del presente trabajo fue describir el dispositivo de atención psicológica en el nivel de atención primaria de la salud en Río Cuarto. Se utilizó un diseño de teoría fundamentada y se aplicó una entrevista semi-estruucturada a ocho psicólogos que atienden en los dispensarios municipales. Se realizó un análisis de contenido utilizando categorías a priori. Se encontró que las intervenciones son dirigidas a resolver el emergente del momento a corto plazo lo cual requiere profesionales flexibles. Asimismo, según los profesionales la demanda del servicio sobrepasa la capacidad de atención, lo que conlleva: una dificultad de realizar un enfoque comunitario, guiar su trabajo clínico a partir de una línea teórica de base alternando con herramientas de otras teorías que aparentan ser adecuadas a fines prácticos, así como una sensación de insatisfacción profesional vinculada a una inestabilidad y sobrecarga laboral. Ante estto, el equipo de profesionales busca generar espacios de discusión, supervisióón e intercambio para mejorar su práctica. Se observa un modelo de atención primaria de la salud donde prevalece un enfoque de atención clínico con un abordaje individual de la patología, por sobre un enfoque comunitario con un abordaje gruupal preventivo

TESS asteroseismology of the known red-giant host stars HD 212771 and HD 203949

International audienc

Subwavelength-grating metamaterial integrated devices for the near- and mid-infrared wavelengths

The subwavelength patterning of planar structures is now widely used in silicon photonics, enabling the synthesis of metamaterials with engineered optical properties, including refractive index, dispersion, and anisotropy. A wide range of integrated devices based on subwavelength grating (SWG) metamaterials have been demonstrated at telecom wavelengths, some with unprecedented performance. The benefits of SWG metamaterials can be leveraged not only in the typical telecom near-infrared bands, but also at the longer mid-infrared wavelengths. In this invited presentation, we will review our latest developments in SWG-based silicon and germanium photonic devices for the near- and the mid-infrared.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research.

The study of the three protagonists in malaria-the Plasmodium parasite, the Anopheles mosquito, and the human host-is key to developing methods to control and eventually eliminate the disease. Genomic technologies, including the recent development of next-generation sequencing, enable interrogation of this triangle to an unprecedented level of scrutiny, and promise exciting progress toward real-time epidemiology studies and the study of evolutionary adaptation. We discuss the use of genomics by the International Centers of Excellence for Malaria Research, a network of field sites and laboratories in malaria-endemic countries that undertake cutting-edge research, training, and technology transfer in malarious countries of the world