19 research outputs found
Alginate and chitosan fibers produced with olive pomace by wet spinning
- Publication venue
- Universidade do Minho. Escola de Engenharia (EEng)
- Publication date
- 01/01/2023
- Field of study
[Excerpt] Olive oil production generates a considerable amount of olive pomace (OP). This residue
is made of olive skins, pulp and stones. Furthermore, it is rich in phenolic compounds
which comprise antioxidant and antibacterial properties. This research envisages a
sustainable valorization of this relevant Mediterranean waste through the inclusion of
olive pomace powder to functionalize alginate and chitosan wet spun fibers. Both
biopolymers are natural and biocompatible polysaccharides with numerous favourable
properties, such as good biodegradation and non-toxicity
Development of sustainable techniques for cellulose recovery from leftovers and cellulose-containing garments
- Author
- Publication venue
- Publication date
- 01/01/2023
- Field of study
[Excerpt] Introduction Textile and clothing industry is one of the most polluting industries in
the world, with high impact on water and land consumption.
Approximately 5.8 million tons of textiles are discarded in Europe,
and only 1% is fiber-to-fiber recycled.This research was funded by FEDER funds through the Operational Competitiveness Program–COMPETE, under the project POCI-01-0247-FEDER047124, and by National Funds through Fundação para a Ciência e Tecnologia (FCT), under the project UID/CTM/00264/2020. Talita Nicolau and Cátia Alves acknowledge FCT, MCTES, FSE and UE PhD grants 2022.15386.BD and 2022.10454.BD, respectively
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
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- Balkhi Hicham
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- Barberet Guillaume
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- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
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- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat
- Aisiku Imo
- Ajetunmobi Olaitan
- Aker Mustafa
- Akyol Onat
- Al Dorzi Hasan M.
- Al Jabbary Ahmed
- Albaiceta Guillermo
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Alfonso Alec A. Tallet
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain
- Allan Russell
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier
- Altaf Wahid
- Alvarez António
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo
- Antonelli Massimo
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie
- Barberet Guillaume
- Baron Rebecca
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri
- Bauer Philippe
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Beloncle Francois
- Benslama Abdellatif
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Binti Pengiran Haji Ismail Dayangku Hajah Maizatul Aiman
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- Borotto Erika
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- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
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- Brown Samuel M.
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- Brunettini Barbara
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- Buensuseso Juan
- Bugedo Guillermo
- Buise Marc
- Bulpa Pierre A.
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- Burtenshaw Andrew
- Burtin Philippe
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- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
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- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon
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- Chena Ariel
- Cheng Meisy Perez
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- Chouchene Imed
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- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
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- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis
- Zacharowski Kai
- Zani Gianluca
- Zantua Kim
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao
- Zhu Wei H.
- Zogheib Elie
- Ñamendys-Silva Silvio A.
- ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Characterisation of microbial attack on archaeological bone
- Author
- Abrantes Ana M
- Abreu Ana C
- Abreu Renato
- Abreu Renato
- Abreu Wilson
- Acedo Guadalupe
- Afonso Carlos
- Afreixo Vera
- Agudelo Mª E
- Alarcão Violeta
- Albuquerque Carlos
- Albuquerque Carlos
- Albuquerque Carlos
- Alencar Liana
- Alferes Valentim R
- Aliseda Isabel R
- Almada Lívia F
- Almeia António
- Almeida Ana
- Almeida Ana
- Almeida António
- Almeida António
- Almeida Armando
- Almeida Armando
- Almeida Fabrícia M
- Almeida Henrique
- Almeida Henrique A
- Almeida Henrique A
- Almeida Inês
- Almeida Jorge
- Almeida José P
- Almeida Maria
- Almeida Pedro
- Almeida Sidalina
- Alvarenga-Martins Nathália
- Alves B.
- Alves B.
- Alves Celeste
- Alves Dina
- Alves Gilberto
- Alves Helder
- Alves Josiane
- Alves José M
- Alves Juliana
- Alves Júlia M
- Alves Nuno
- Alves Nuno
- Alves Samuel
- Amado Diogo
- Amado João
- Amado Sandra
- Amaral Ana P
- Amaral Ana P
- Amaral Odete
- Amaral Odete
- Amaral Odete
- Amaral Odete
- Amaral Odete
- Ambrósio Sara
- Amendoeira José
- Amorim Ana
- Amorim Ana P
- Amorim Helena
- Andrade Diogo
- Andrade Isabel
- Andrade Isabel
- Andrade Isabel
- Andrade Isabel
- Andrade Isabel
- Andrade Isabel
- Andrade J. A
- Andrade Karizia V
- Andrade Renato
- Andrade Renato
- Andrade Susana
- Antunes Ana
- Antunes Ana
- Antunes Cristina
- Antunes Lígia
- Antunes Sandra
- Antunes Sandra
- Aparício Graça
- Aparício Graça
- Aparício José
- Apolinário-Hagen Jennifer
- Apolinário-Hagen Jennifer
- Aquino Caroline Q
- Aquino Caroline Q
- Aquino Priscila S
- Aquino Priscila S
- Araujo André R
- Araújo Beatriz
- Araújo Elsa
- Araújo Lia
- Araújo Odete
- Araújo Odete
- Araújo Patrícia
- Araújo Patrícia
- Araújo Patrícia
- Armas-Gonzalez Yadira
- Arreguy-Sena Cristina
- Arreguy-Sena Cristina
- Ascenso Rita T
- Ascenso Rita T
- Assunção Victor
- Augusto Cláudia
- Avelelas Francisco
- Ayoub Rodrigo
- Azeredo Zaida
- Azeredo Zaida
- Azeredo Zaida
- Azeredo Zaida
- Azevedo Julieta
- Azevedo Julieta
- Azevedo Marcelo
- Azevedo Maria H
- Azevedo Mª H
- Azevedo Tatiana
- Azzalis L.
- Baffour Gabriel
- Baffour Gabriel
- Bairros Keila
- Baixinho Cristina L
- Bajo Roberto
- Baltazar Ana L
- Barbeiro Ana P
- Barbosa Flávio
- Barbosa Tiago
- Barreira Eduarda
- Barreiros Luísa
- Barros Luísa
- Barros Luísa
- Barros Teresa
- Barroso Isabel
- Barroso Isabel
- Barroso Isabel
- Barroso João
- Basto Marta L
- Basto Marta L
- Basto Marta L
- Bastos Fernanda
- Bastos Fernanda
- Batalha Joana
- Batista Marco
- Batista Marco
- Batista Marco
- Batista Rita
- Baylina Pilar
- Becerra Isabel A
- Bellém Fernando
- Bellém Fernando
- Belo Pedro
- Benevides Joana
- Benevides Joana
- Bento Elisabete
- Bento Elisabete
- Bento Sandrina
- Bento Teresa
- Bergland Astrid
- Bernardes Lúcia G
- Bernardes Tiago
- Bernardo Helena
- Bexiga Filipa
- Bianchini Bruna
- Bizarro Carla
- Björklund Anita
- Blanco Valeriana G
- Boavida José
- Bonfim Luís
- Bordin Ronaldo
- Bordin Ronaldo
- Bordini Magali
- Borges Raphaelle
- Botelho Mª F
- Braga Fátima
- Braga Luciene
- Braga Luciene M
- Braga Luciene M
- Braga Margarida
- Branco Marco
- Brandão Daniela
- Brandão Daniela
- Brandão Frederico
- Brandão Piedade
- Brandão Teresa
- Bravo Rafael
- Bravo Rafael
- Breda São J
- Brito Alice
- Brito António
- Brito Irma
- Brito Luísa S
- Brito Nuno
- Brooks Dina
- Brunhoso Germana
- Brás Carina
- Brás Manuel
- Brêda Mª S J
- Bye Asta
- Caballero Francisco P
- Caballero Francisco P
- Caballero Francisco P
- Cabral Cremilde
- Cabral Gil
- Cabral Isabel
- Cabral Joana
- Cabral Lídia
- Cabral Priscila P
- Cabrita José
- Caceiro Elisa F
- Cadorio Inês
- Caeiro Patrícia
- Caldeira Suzana N
- Calha António
- Calha António
- Calvo Cristina
- Calvo Mª C
- Camarinha Luís
- Camarinha Luís
- Camarneiro Ana
- Camarneiro Ana
- Caminha Madson
- Campi Liliana
- Campofiorito C.
- Campos Maria
- Campos Maria
- Campos Mariana
- Campos Mª J
- Capelas Sylvie
- Cardoso Américo
- Cardoso Andreia
- Cardoso Ilda
- Cardoso Margarida
- Cardoso Mário E
- Cardoso Sara
- Cardoso Susana
- Carecho Nélio
- Carmen Barriga
- Carmo A.
- Carmo Bruno M
- Carneiro Juliana
- Carneiro Lara
- Carneiro Lara
- Carneiro M. A
- CaroMinghelli Eulália
- Carreira Diana
- Carreiras Diogo
- Carrão Luís
- Carvalhais Maribel
- Carvalhais Maribel
- Carvalho Amâncio
- Carvalho António
- Carvalho Carla
- Carvalho Carla
- Carvalho Carla
- Carvalho Carla
- Carvalho Carla
- Carvalho Carla
- Carvalho Célia B
- Carvalho Célia B
- Carvalho Célia B
- Carvalho Daniel
- Carvalho Daniel
- Carvalho Daniel
- Carvalho Daniel
- Carvalho Daniel
- Carvalho Francisco L
- Carvalho Inês
- Carvalho Joana
- Carvalho Lisiane L
- Carvalho Lisiane L
- Carvalho Lucinda
- Carvalho Nelma
- Carvalho Rosa
- Carvalho Rui
- Carvalho Sara
- Carvalho Sérgio
- Carvalho Teresa
- Carvalho Teresa
- Carvalho Tiago
- Carvalho Yara M
- Casalta-Lopes João
- Casas-Novas Mónica
- Caseiro Armando
- Caseiro Armando
- Caseiro Armando
- Caseiro Armando
- Caseiro Armando
- Casimiro Ana P
- Castilho Amélia
- Castilho Amélia
- Castilho Amélia
- Castilho Amélia
- Castilho Paula
- Castro Conceição
- Castro Régia B
- Castuera Ruth J
- Catarino Elisabete
- Catarino Helena
- Catarino Helena
- Catarino Helena
- Catarino Helena
- Catela David
- Cavalheiro Luís
- Cavalheiro Luís
- Certo Ana
- Cervato-Mancuso Ana M
- Cezanne Catarina
- Charepe Zaida
- Charepe Zaida
- Cheio Mónica
- Chen Gang
- Chung Wu F
- Clara João G
- Coelho Alexandre
- Coelho André
- Coelho Carina
- Coelho Elza S
- Coelho Inês
- Coelho Inês
- Coelho Luís
- Coelho Luís
- Coelho P.
- Coelho Patrícia
- Coelho Patrícia
- Colaço Armanda
- Colaço Armanda
- Colaço Diogo
- Collado-Mateo Daniel
- Collado-Mateo Daniel
- Combadão Jaime
- Conceição Milena A
- Conde Jorge
- Cordeiro Eugénio
- Cordeiro Marina
- Cordeiro Marina
- Cordeiro Marina
- Cordeiro Marina
- Cordeiro Marina
- Cordeiro Marina
- Cordeiro Raul
- Correia André
- Correia Jony
- Correia Telma
- Costa Ana R
- Costa André
- Costa Cláudia
- Costa Diana
- Costa Diana
- Costa Emília
- Costa Joyce O
- Costa Joyce O
- Costa Pablo O
- Costa Ricardo
- Costa Rui
- Costa Tânia
- Costa Tânia
- Costa Vanessa
- Coucelo Tiago
- Coutinho André P
- Coutinho Paula
- Couto Cristina
- Couto Diana
- Couto Margarida
- Couto Margarida
- Cova Marco P
- Cruz Agostinho
- Cruz Agostinho
- Cruz Agostinho
- Cruz Agostinho
- Cruz Agostinho
- Cruz Agostinho
- Cruz Bárbara
- Cruz Graça
- Cruz Inês
- Cruz Inês
- Cruz Joana
- Cruz Joana
- Cruz João
- Cruz Pedro
- Cruz Rui
- Cruz Rui
- Cruz Rui
- Cruz Susana
- Cruz x
- Cunha Fátima
- Cunha Madalena
- Cunha Madalena
- Cunha Madalena
- Cunha Madalena
- Cunha Madalena
- Cunha Marina
- Cunha Marina
- Cunha Marina
- Cunha Marina
- Cunha Marina
- Cunha Marina
- Cunha Marina
- Cunha Marina
- Cunha Marina
- Cândido Anabela
- César Ana F
- Da Motta Carolina
- Da Motta Carolina
- Da Motta Carolina
- Daniel Fernanda
- Dantas Estélio
- Deodato Sérgio
- Desouzart Gustavo
- Dias Alberto P
- Dias António
- Dias Hélia
- Dias Sara S
- Dias Sara S
- Dias Sara S
- Dias Tiago
- Dinis Alexandra
- Dinis Alexandra
- Dixe Anjos
- Dixe Anjos
- Dixe Anjos
- Dixe Maria
- Dixe Maria D A
- Dixe Maria D A
- Dixe Mª A
- Dixe Mª A
- Dixe Mª A
- Dixe Mª A
- Dixe Mª A
- Dixe Mª A
- Domingos Joana
- Domingos Samuel
- Domingues Cátia
- Domingues Gabriela
- Domingues J. N
- Dreyer Laysa C
- Duarte Catarina
- Duarte Diana
- Duarte Diana
- Duarte Hugo
- Duarte Hugo
- Duarte João
- Duarte João
- Duarte João
- Duarte Mafalda
- Duarte Nuno
- Duarte Soraia
- Duarte Soraia
- Escanciano Susana R
- Escoval Ana
- Espada Mário
- Esteves Mª R
- Estevez Gustavo L
- Estrela Jéssica
- Evangelista Diana
- Faria Luís
- Faria Luís
- Faria Melissa
- Faria Paula
- Faria Paula
- Faustino António
- Faustino António
- Faustino António
- Fernandes Adília
- Fernandes Ana R
- Fernandes Andreia
- Fernandes Beatriz
- Fernandes Helder M
- Fernandes Jorge C
- Fernandes Morgana C
- Fernandes Patrícia
- Fernandes Patrícia
- Fernandes Paula
- Fernandes Paula O
- Fernandes Paula O
- Fernandes Renato
- Fernandes Rosina
- Fernandes Rosina
- Fernandes Rosina
- Fernandes Telma
- Fernandez Mª J L
- Ferraz Maira
- Ferraz Vera
- Ferreira Ana
- Ferreira Ana
- Ferreira Ana
- Ferreira Ana
- Ferreira António
- Ferreira António
- Ferreira Carlos
- Ferreira Cláudia
- Ferreira Cláudia
- Ferreira Cláudia
- Ferreira Cláudia
- Ferreira Dora
- Ferreira Eduardo
- Ferreira Eduardo
- Ferreira Irina
- Ferreira José
- Ferreira José
- Ferreira José P
- Ferreira Lino
- Ferreira Manuela
- Ferreira Manuela
- Ferreira Manuela
- Ferreira Manuela
- Ferreira Margarida
- Ferreira Margarida
- Ferreira Margarida
- Ferreira Margarida
- Ferreira Nelson
- Ferreira P.
- Ferreira Paulo P
- Ferreira Paulo P
- Ferreira Paulo P
- Ferreira Paulo P
- Ferreira Pedro
- Ferreira Pedro
- Ferreira Pedro
- Ferreira Pedro
- Ferreira Pedro
- Ferreira Pedro
- Ferreira Pedro L
- Ferreira Regina
- Ferrito Cândida
- Ferro-Lebres Vera
- Festas Clarinda
- Figueiredo Amélia
- Figueiredo Ana G
- Figueiredo Daniela
- Figueiredo J.
- Figueiredo João
- Figueiredo João P
- Figueiredo João P
- Figueiredo João P
- Figueiredo Mª C
- Figueiredo Mª H
- Figueiredo Mª H
- Figueiredo Paulo
- Filho Braulio L
- Filho João G
- Filho João G
- Filho João G
- Filipe Vítor
- Fiorin Bruno H
- Fleig Tânia C
- Fleig Tânia C
- Fonseca Ana R
- Fonseca F.
- Fonseca F.
- Fonseca Virgínia
- Fonseca Virgínia
- Fonseca-Pinto Rui
- Fonseca-Pinto Rui
- Fonseca-Pinto Rui
- Fonseca-Pinto Rui
- Fontana Karine C
- Fontes-Ribeiro Carlos
- Forte Henriqueta D
- Fotschl Ulrike
- Frade João G
- Frade João G
- Frade João G
- Francisco Irene
- Franco Débora
- Franco-Borges Graciete
- Freire Ana
- Freitas Alberto
- Freitas Gregório
- Freitas Gregório
- Freitas João
- Freitas Kátia
- Freitas Maria
- Freitas Otília
- Freitas Otília
- Freitas Vívien A
- Frigo Leticia
- Froemming Miriam B
- Fuentes-Broto Lorena
- Furtado Alessandra S
- Furtado G.
- Furtado Guilherme
- Furtado Guilherme
- Furtado Guilherme E
- G.Silva Anne
- Gabriel António
- Gabriel António
- Gabriel António
- Gabriel António
- Gabriel António
- Gabriel Joaquim
- Gabriel Joaquim
- Galhardo Ana
- Galhardo Ana
- Galhardo Ana
- Galhardo Ana
- Galvão Ana
- Galvão Ana
- Galvão Ana
- Galvão Sofia
- Gama Ester
- Gama João
- Ganho-Ávila Ana
- Garcia Ana P
- Garcia Inês
- Garcia Teresa
- Garcia-Gordillo Miguel A
- Garcia-Gordillo Miguel A
- Garrido António
- Gaspar Filomena
- Gaspar Filomena
- Gaudêncio Iris
- Gehrke F.
- Gehrke F.
- Gisin Stefan
- Glória Margarida
- Gomes Ana A
- Gomes Ana A
- Gomes Antônio T
- Gomes Catarina
- Gomes Fernando
- Gomes José
- Gomes José C
- Gomes José H
- Gomes José H
- Gomes José H
- Gomes João
- Gomes João
- Gomes João
- Gomes João
- Gomes João
- Gomes Lisa
- Gomes Maria
- Gomes Mª J
- Gomes Pedro
- Gomes Sofia
- Gomez Inmaculada R
- Gonzalez Estefania P
- González Jesús A
- Gonçalves Amadeu
- Gonçalves Ana
- Gonçalves Ana
- Gonçalves Ana C
- Gonçalves Guilherme
- Gonçalves Liliana
- Gonçalves Narcisa
- Gonçalves Rita
- Gonçalves Rodrigo
- Gonçalves Rui
- Gonçalves Rui
- Gonçalves Óscar
- Gordo Clementina
- Gordo Sara
- Goulart Cássia L
- Goulão Beatriz
- Grande Carla
- Granjo Paulo
- Graveto João
- Graveto João
- Graveto João
- Graveto João
- Graça Anabela
- Graça Pedro
- Guedelha Daniel
- Guedes Jenifer
- Guedes Jenifer
- Guedes Joana
- Guerra Magda
- Guerreiro Sabrina L
- Guerrero Jose T
- Guerrero Jose T
- Guerrero José T
- Guerrero José T
- Guimarães Pedro
- Guimarães Teresa
- Guimarães Teresa
- Gusi Narcis
- Gutierrez Milagros L
- Hall Andreia
- Heitor Mª J
- Henriques Carolina
- Henriques Carolina G
- Henriques Mª A
- Hernandez-Martinez Francisco J
- Hernandez-Martinez Francisco J
- Hernández-Martínez Francisco-José
- Hesse Camilla
- Honório Samuel
- Honório Samuel
- Honório Samuel
- Honório Samuel
- Honório Samuel
- Horta Lina G
- Huertas Mª J T
- Iezzi Angelo
- Jardim Ana
- Jardim Helena G
- Jardim Jacinto
- Jesus C.
- Jesus C.
- Jesus Carlos
- Jesus Luís
- Jesus Rita
- Jesus Ângelo
- Jesus Ângelo
- Jesus Ângelo
- Jesus Ângelo
- Jimenez Nuria R
- Jimenez-Castuera Ruth
- Jimenez-Diaz Juan F
- Jimenez-Diaz Juan F
- Jimenez-Rodriguez Carla
- Jiménez-Díaz Juan-Fernando
- Jiménez-Díaz Juan-Fernando
- Jiménez-Rodríguez Carla
- Jordão Célia
- Jorge Arminda
- José Helena
- João Paulo V
- João Paulo V
- Jácome Cristina
- Jácome Cristina
- Kaliniczenco A.
- Kniess Rosiane
- Kranz Luís F
- Kranz Luís F
- Kraus Teresa
- Kraus Teresa
- Kretzer Marcia
- Kretzer Marcia
- Kretzer Marcia
- Kretzer Marcia
- Kretzer Marcia
- Kretzer Marcia
- Kretzer Marcia R
- Kretzer Márcia R
- Kurcgant Paulina
- Lacerda Josimari T
- Lacerda Josimari T
- Lacerda Josimari T
- Lage Isabel
- Lagoa Matilde
- Lains Jorge
- Lapa Leila
- Laranjeira Carlos
- Laranjo Mafalda
- Leal Jéssica
- Lebre Paula
- Lebre Sara
- Lee Huei D
- Leitão Catarina
- Leitão Céu
- Leitão Céu
- Leitão José A
- Lessa Paula A
- Leça Andrea
- Lima Adman S
- Lima Cristóvão F
- Lima Teresa M
- Lima Vera
- Lima-Basto Marta
- Lindo João
- Lindo João
- Lirk Gerald
- Lobato João
- Lobão Catarina
- Lopes Albino
- Lopes Carla
- Lopes Carla
- Lopes Elisa
- Lopes José C
- Lopes João
- Lopes Luci S
- Lopes Nuno
- Lopes Nuno V
- Lopes Nuno V
- Lopes Rui S
- Lopes Sara
- Lopes Saudade
- Loura Raquel
- Loureiro Isabel
- Loureiro Mª H
- Loureiro Mª H
- Loureiro Mª H
- Lourenço Georgina
- Lourenço Marina
- Louro Clarisse
- Louro Clarisse
- Louro Mª C
- Lousada Marisa
- Lousada Marisa
- Lousada Marisa
- Lumini José
- Luz Leonardo
- Luz Leonardo
- Luz Tatiana
- Luz Tatiana D
- Luís Henrique
- Luís Luís
- Luís Mª J
- Luís Sara
- Macedo Ana P
- Macedo António
- Macedo António
- Machado Idalina
- Machado Mª M
- Machado Patrícia O
- Machado Paulo
- Machado Paulo
- Machado Sara
- Madeira Teresa
- Madureira António
- Madureira António
- Magajewski Flávio
- Magalhães Carlos
- Magalhães Celina
- Magalhães Cátia
- Magalhães Cátia
- Magalhães Cátia
- Maia Ana S
- Maia Ana S
- Maia Ana S
- Maia Ana S
- Maia Bruno
- Maia Bruno
- Maia Carla
- Malheiro Isabel
- Malheiro Isabel
- Mangas Catarina
- Mangas Catarina
- Manso Conceição
- Manso M. C
- Marante Nídia
- Margarida Couto
- Marinho Daniel
- Marinho Sara
- Marques Alda
- Marques Alda
- Marques Alda
- Marques Alda
- Marques Alda
- Marques Alda
- Marques Alda
- Marques Alda
- Marques Alda
- Marques Ana R
- Marques António
- Marques Catarina
- Marques Cristiana
- Marques Cristiana
- Marques Daniel R
- Marques Daniel R
- Marques Fátima M
- Marques Mariana
- Marques Mariana
- Marques Mariana
- Marques Mariana
- Marques Mª F
- Marques Mário
- Marques Rita
- Marques Rita
- Marques Rita
- Marques Rita
- Marques Rita
- Marques Rita
- Marques Silvana F
- Marques Silvana F
- Marques Sílvia
- Marques Tatiana
- Marques-Rodrigues Alexandre
- Marques-Vieira Cristina
- Marquez Laura A
- Marsi Teresa O
- Marta-Simões Joana
- Marta-Simões Joana
- Marta-Simões Joana
- Marta-Simões Joana
- Martin Inmaculada Z
- Martinez-Hernandez Francisco
- Martinho Liliana
- Martins Ana R
- Martins Anabela C
- Martins Anabela C
- Martins Anabela C
- Martins Anabela C
- Martins Anabela C
- Martins Anabela C
- Martins Anabela C
- Martins Anabela C
- Martins Carlos R
- Martins Cristina
- Martins Cristina
- Martins Emília
- Martins Emília
- Martins Emília
- Martins Eveliny S
- Martins Fernando
- Martins Fátima
- Martins Julian
- Martins Laura
- Martins Maria M
- Martins Matilde
- Martins Matilde
- Martins Patrícia
- Martins Raul
- Martins Rosa
- Martín Ignácio
- Marôco João
- Marôco João
- Mata Mª A
- Mata Mª A
- Mata Mª A
- Mateus Artur
- Mateus Artur
- Matheus Filipe
- Matos Ana R
- Matos Filomena
- Matos Maria
- Matos Rui
- Medeiros Anabela
- Medeiros Dayse C
- Medeiros-Garcia Lurdes
- Medina María S
- Meireles Alexandra
- Melo Elsa
- Melo Elsa
- Melo Elsa
- Melo Flávio
- Melo Rosa
- Melo Rosa
- Melo Rosa
- Melo Rosa
- Mendes Aida
- Mendes Ana
- Mendes Ana
- Mendes Ana
- Mendes Ana L
- Mendes Ana L
- Mendes Ana L
- Mendes Elenice
- Mendes F
- Mendes F.
- Mendes Felismina
- Mendes Fernando
- Mendes Fernando
- Mendes Fernando
- Mendes Fernando
- Mendes Fernando
- Mendes Fernando
- Mendes Fernando
- Mendes Francisco
- Mendes Francisco
- Mendes Francisco
- Mendes Isabel
- Mendes Isabel
- Mendes Joana
- Mendes Maria F
- Mendes Pedro
- Mendes Pedro
- Mendes Pedro
- Mendes Pedro
- Mendes Pedro
- Mendes Pedro
- Mendes Pedro
- Mendes Romeu
- Mendes Romeu
- Mendes Romeu
- Mendes Zaida
- Mendonça Carlos
- Mendonça Nuno
- Mendonça Paula
- Mendonça Paula
- Mendonça Verónica
- Mendonça Verónica
- Meneghetti Vanize
- Meneses Rui
- Menezes Ruth L
- Menino Eva
- Menino Eva
- Menino Eva
- Menino Eva
- Mercê Cristiana
- Mesquita Helena
- Mesquita Helena
- Mesquita João R
- Midões Cristiana
- Milanés Gemma M
- Minas Bárbara
- Minghelli Beatriz
- Minghelli Beatriz
- Miranda Cristiana
- Miranda Marta
- Miranda Natacha F
- Monago Fatima M
- Monago Fatima M
- Monago Fátima M
- Monago Rocio M
- Monteiro Diogo
- Monteiro Helena
- Monteiro Joana
- Monteiro Lina
- Monteiro Luís
- Monteiro M. J
- Monteiro M. J
- Monteiro Mª J
- Monteiro Sílvia
- Morais Carminda
- Morais Marina A
- Morais Mª C
- Morais Mª C
- Morais Mª C
- Morais Mª C
- Morais Nuno
- Moreira Eliana
- Moreira Fernando
- Moreira Fernando
- Moreira Fernando
- Moreira Fernando
- Moreira Fernando
- Moreira Fernando
- Moreira Isabel
- Moreira Liliana
- Moreira Liliana
- Moreira Rita L
- Moreno Ana L
- Morgado Alice
- Morgado Sónia
- Morgado Sónia
- Morna Clementina
- Morna Clementina
- Morouço Pedro
- Morouço Pedro
- Mota Maria
- Mota Maria
- Mota Priscilla
- Moura Cynthia B
- Moura-Ramos Mariana
- Mouroço Pedro
- Mourão Ricardo
- Mártires Alice
- Mónico Lisete
- Mónico Lisete
- Mónico Lisete M
- Mónico Lisete M
- Mónico Lisete M
- Mónico Lisete M
- Mónico Lisete M
- Mónico Lisete M
- Nascimento Daniela
- Nascimento Maria S
- Nascimento V. B
- Natal Sônia
- Nave Filipe
- Nave Filipe
- Nazario Nazare
- Nazario Nazare
- Nazario Nazare
- Nazaré Cristina
- Nazário Nazaré O
- Neco Sofia
- Nelas Paula
- Neto João S
- Neves Carmo
- Neves Joana
- Neves Joel
- Neves Jéssica
- Neves Jéssica
- Neves Miguel
- Neves Sofia
- Neves Vanessa
- Nicola Paulo
- Nogueira Conceição
- Nogueira Paulo
- Nogueira Paulo
- Noné Ana
- Novais Sandra
- Novais Sandra
- Novais Sónia
- Novais Sónia
- Novo André
- Nugem Rita C
- Nugem Rita C
- Nunes Amélia
- Nunes Amélia F
- Nunes Carla
- Nunes Carla
- Nunes Carla
- Nunes Hélder
- Nunes Liliana
- Nunes S.
- Nuñez Cristina G
- Oliva Jefferson T
- Olivares Pedro R
- Oliveira Adriana
- Oliveira Ana
- Oliveira Ana
- Oliveira Ana
- Oliveira Ana I
- Oliveira Ana I
- Oliveira Ana I
- Oliveira Ana I
- Oliveira Ana I
- Oliveira Ana P
- Oliveira Anabela
- Oliveira Bibiana F
- Oliveira Bárbara
- Oliveira Camila A
- Oliveira Catarina
- Oliveira Denize C
- Oliveira Edmar S
- Oliveira Elizabete A
- Oliveira Emanuel
- Oliveira Eunice G
- Oliveira Eunice G
- Oliveira Isabel
- Oliveira Lara L
- Oliveira Manuel
- Oliveira Michelle T
- Oliveira Michelle T
- Oliveira Michelle T
- Oliveira Michelle T
- Oliveira Mirna F
- Oliveira Raul
- Oliveira Rita
- Oliveira Rita
- Oliveira Rita F
- Oliveira Rita F
- Oliveira Rita F
- Oliveira Sara
- Oliveira Sebastião T
- Oliveira Sebastião T
- Oliveira Suzete
- Oliveira Teresa C
- Oliveira Teresa T
- Oliveira Vânia P
- Olszewer Efrain O
- Ortiga Angela B
- Osório Nádia
- Osório Nádia
- Osório Nádia
- Osório Nádia
- Osório Nádia
- Pacheco José
- Padez Cristina
- Padilha José M
- Padilha José M
- Padilha José M
- Padilha José M
- Paixão S.
- Paixão Susana
- Paixão Susana
- Palmeira Lara
- Palmeira Lara
- Paraíso Nilson
- Paredes Hugo
- Parente Alexandra
- Parraça José A
- Parraça José A
- Parreira Pedro
- Parreira Pedro
- Parreira Pedro
- Parreira Pedro
- Parreira Pedro
- Parreira Pedro
- Parreira Pedro
- Parreira Pedro
- Parreira Pedro
- Parreira Pedro
- Parreira Pedro
- Parreira Pedro
- Parreira Pedro D
- Parreira Pedro M
- Parreira Pedro M
- Parreira Pedro M
- Passadouro Rui
- Passadouro Rui
- Paulo Rui
- Paulo Rui
- Paulo Rui
- Paulo Rui
- Paulo Rui
- Paulo Rui
- Paúl Constança
- Paúl Constança
- Paúl Constança
- Pedreiro Ana
- Pedro Ana R
- Pedro Ana R
- Pedro Luísa
- Pedrosa Dora
- Pedroso Rosa
- Peixoto Ermelindo
- Peixoto-Plácido Catarina
- Peralta Teresa
- Pereira A.
- Pereira Alexandre
- Pereira Alexandre
- Pereira Ana
- Pereira Ana
- Pereira Ana
- Pereira Ana
- Pereira Ana M
- Pereira Ana M
- Pereira Ana M
- Pereira Ana T
- Pereira Ana T
- Pereira Anabela
- Pereira Carlos
- Pereira Carlos
- Pereira Carlos
- Pereira Carlos
- Pereira Carlos
- Pereira Cristina
- Pereira Elayne
- Pereira Elsa S
- Pereira Filipe
- Pereira Filomena
- Pereira Filomena
- Pereira Juliana
- Pereira Marta
- Pereira Olívia R
- Pereira Rafael
- Petrica João
- Petrica João
- Petrica João
- Petrica João
- Petrica João
- Pimenta Luís
- Pimenta Rui
- Pimentel Francisco
- Pimentel João
- Pimentel Rafaela
- Pinheiro Ana B
- Pinheiro Ana B
- Pinheiro Arminda A
- Pinheiro Patrícia C
- Pinho Cláudia
- Pinho Cláudia
- Pinho Cláudia
- Pinho Cláudia
- Pinho Cláudia
- Pinho Tânia
- Pinto Carlos
- Pinto Francisca
- Pinto Isabel C
- Pinto Isabel C
- Pinto J. L
- Pinto Joana
- Pinto M R
- Pinto Mª R
- Pinto Paulo F
- Pinto Sara
- Pinto Ítalo N
- Pinto-Gouveia José
- Pinto-Gouveia José
- Pinto-Gouveia José
- Pinto-Gouveia José
- Pinto-Gouveia José
- Pinto-Gouveia José
- Pinto-Gouveia José
- Pinto-Gouveia José
- Pires Filipa
- Pires Filipa
- Pires Tânia
- Pires Tânia
- Pisco Jacinta
- Pivetta Hedioneia F
- Piñero Ana S
- Poeta Susana
- Porta-Nova Rui
- Postolache Gabriela
- Postolache Octavian
- Poço Mariana
- Prado Alessandro
- Prata Ana R
- Prebianchi Helena
- Presado Mª H
- Preto Vera
- Príncipe Fernanda
- Pulido-Fuentes Montserrat
- Pérez-Caballero Francisco L
- Pérez-Caballero Francisco L
- Queirós Paulo
- Quelhas Ana
- Querido Ana
- Querido Ana
- Querido Ana
- Querido Ana
- Querido Ana
- Querido Ana
- Querido Ana
- Querido Ana
- Querido Ana
- Quintana-Montesdeoca Mª P
- Quirino Diogo
- Rabiais Isabel
- Rafael Helga
- Rainho Conceição
- Rainho Conceição
- Rainho Conceição
- Rama Luís
- Rama Luís
- Rama Luís
- Ramalhete Cátia
- Ramalho André
- Ramalho André
- Ramalho Fátima
- Ramalho Sónia
- Ramalho Sónia
- Ramalho Sónia A
- Ramirez Francisco B
- Ramirez Francisco B
- Ramos Maurício R
- Raposo Vítor R
- Rei Ana C
- Reina Mercedes G
- Reis Alcinda C
- Reis Ana S
- Reis Arsénio
- Reis Cláudia
- Reis Laura
- Reis Victor M
- Reses Manoela
- Reuter Éboni M
- Ribas Patrícia
- Ribeiro Andrea
- Ribeiro Andrea
- Ribeiro Diana
- Ribeiro Fernando
- Ribeiro Jaime
- Ribeiro Jaime
- Ribeiro José C
- Ribeiro João
- Ribeiro Lígia C
- Ribeiro Maria
- Ribeiro Maria
- Ribeiro Maximiano
- Ribeiro Olivério
- Ribeiro Olivério
- Ribeiro Samila G
- Ribeiro Sandra
- Ribeiro Sandra
- Ribeiro Óscar
- Ribeiro Óscar
- Ribeiro Óscar
- Ribeiro-Varandas Edna
- Richaud Sylvina
- Rocha C.
- Rocha Clara
- Rocha Clara
- Rocha Clara
- Rocha Mª C
- Rocha Mª C
- Rocha Saulo V
- Rocha Saulo V
- Rodrigo António
- Rodrigues Alexandre
- Rodrigues Alexandre
- Rodrigues Alexandrina
- Rodrigues António
- Rodrigues Cátia
- Rodrigues Diana
- Rodrigues Rogério
- Rodrigues Rogério
- Rodrigues Rogério
- Rodrigues Rosa
- Rodrigues Sandra
- Rodrigues Sandra
- Rodrigues Sandra
- Rodrigues Sandra
- Rodrigues Teresa
- Rodrigues Vítor
- Rodrigues Vítor
- Rodriguez Cláudia K
- Rodriguez-De-Vera Bienvendida C
- Rodriguez-De-Vera Bienvenida
- Rodriguez-De-Vera Bienvenida C
- Rodríguez Ana B
- Rodríguez-De-Vera Bienvenida-Del-Carmen
- Rombo João
- Roque Fátima
- Rosa Manuel S
- Rosa Marlene C
- Rosa Marlene C
- Rosa Marlene C
- Rosa Marlene C
- Rosa Marlene C
- Rosa Roger S
- Rosa Roger S
- Rosado António
- Rosado António
- Rosário Rafaela
- Ruben Rui B
- Ruivo Joana
- Saavedra Francisco
- Saboga-Nunes Luís
- Saboga-Nunes Luís
- Sala José A
- Sala José A
- Sales Tiago
- Salgueiro Anabela
- Salgueiro-Oliveira Anabela
- Salgueiro-Oliveira Anabela
- Salgueiro-Oliveira Anabela
- Salgueiro-Oliveira Anabela
- Salgueiro-Oliveira Anabela
- Salvador Mª C
- San-Martin Elisabete A
- Santana Miguel
- Santana Paula
- Santiago Conceição
- Santiago Eujcely C
- Santiago Eujcely C
- Santiago Luiz
- Santo Inês
- Santo Inês
- Santos Adriana
- Santos Ana
- Santos Bruno
- Santos Bruno
- Santos Erica
- Santos Flávia
- Santos Joana
- Santos Joana
- Santos Jorge
- Santos João
- Santos Leonino S
- Santos Luísa
- Santos Marina S
- Santos Marlene
- Santos Marlene
- Santos Nuno
- Santos Osvaldo
- Santos Osvaldo
- Santos Osvaldo
- Santos Rafael B
- Santos Rafael B
- Santos Sofia
- Santos Sofia
- Santos Sofia
- Santos Sofia
- Santos-Rocha Rita
- Sardo Dolores
- Sardo Pedro
- Sardo Pedro
- Sarmento-Ribeiro Ana B
- Sarreira-Santos Alexandra
- Sarroeira Cassilda
- Schneider Dulcineia
- Schneider Dulcineia
- Schneiders Paloma B
- Schroeder Silvana S
- Schukg Susann
- Seabra André
- Seabra Daniel
- Seabra Daniel
- Seabra Paulo
- Seixas Adérito
- Seixas Adérito
- Seixas Adérito
- Seixas Adérito
- Seiça Luís
- Seppänen Ulla-Maija
- Serapioni Mauro
- Serra Ana
- Serrano João
- Serrano João
- Serrano João
- Serrano João
- Serrano João
- Severino Sandy
- Siba Wafa A
- Silva Ana M
- Silva Ana M
- Silva Andrea G
- Silva André
- Silva Antónia
- Silva Armando
- Silva Carina
- Silva Carla R
- Silva Carlos
- Silva Carlos F
- Silva Catarina
- Silva Cláudia
- Silva Cláudia D
- Silva Daniel
- Silva Daniel
- Silva Darlen
- Silva David
- Silva Eduardo
- Silva Elsa
- Silva Ernestina
- Silva Helena R
- Silva Helena R
- Silva Iryna
- Silva Isabel
- Silva Joana
- Silva Joana
- Silva Joana
- Silva Luís D
- Silva Luís D
- Silva Maiza M
- Silva Manuel C
- Silva Margarida
- Silva Margarida
- Silva Maria A
- Silva Marilene
- Silva Marilene
- Silva Norberto
- Silva Paula
- Silva Paula A
- Silva Pedro
- Silva Pedro
- Silva Rafael
- Silva Rita
- Silva Rita
- Silva Rita P
- Silva Sara
- Silva Sara
- Silva Sara
- Silva Susana
- Silva Tatiane M
- Silva Vânia
- Silveira Paulo
- Sim-Sim Margarida
- Simões Alexandra
- Simões Cristina
- Simões João
- Simões Paulo C
- Simões Sónia
- Simões Ângela
- Siqueira Mariana S
- Siqueira Mariana S
- Soar Cláudia
- Soares Célia
- Soares Fátima
- Soares Fátima
- Soares Raquel
- Soares Salete
- Soares Sérgio
- Soares Valter
- Sousa Ana P
- Sousa Ana S
- Sousa Anderson R
- Sousa Anderson R
- Sousa Anderson R
- Sousa Anderson R
- Sousa Carla
- Sousa Caroline R
- Sousa Cesar
- Sousa D.
- Sousa Diana
- Sousa Gilberta
- Sousa Gilberta
- Sousa Gracinda
- Sousa Jani
- Sousa Joana
- Sousa Joana
- Sousa Luís
- Sousa Marina
- Sousa Marina
- Sousa Nelson
- Sousa Nelson
- Sousa Patrícia
- Sousa Patrícia
- Sousa Patrícia
- Sousa Patrícia
- Sousa Patrícia
- Sousa Patrícia
- Sousa Paulino
- Sousa Paulino
- Sousa Paulino
- Sousa Paulino
- Sousa Pedro
- Sousa Pedro
- Sousa Pedro
- Sousa Pedro
- Sousa Pedro
- Souza Clóvis A
- Souza Géssica M
- Souza Juliana A
- Souza Nelba R
- Souza Nelba R
- Spolaôr Newton
- Svensson Lola
- Sá Dayse
- Tapadas Rodrigo
- Tavares Aida I
- Tavares Ana
- Tavares Ana S
- Tavares José
- Tavares Mariline
- Tavares Nuno
- Teixeira A.
- Teixeira Ana
- Teixeira Ana
- Teixeira Ana M
- Teixeira Laetitia
- Teixo Ricardo
- Teles Patrícia
- Tena José M
- Tena Maria J
- Tenedório José A
- Tim-Tim Carolina
- Tomaz Jorge
- Tomás Catarina
- Tomás Catarina
- Tomás Catarina
- Tomás Catarina
- Tomás Catarina
- Tomás Catarina
- Tomás Catarina
- Tomás Catarina C
- Tomás Teresa
- Topa Joana
- Torgal Jorge
- Torgal Jorge
- Torres Ana
- Torres Rui
- Trigo Africa P
- Trindade Inês A
- Trindade Inês A
- Trindade Inês A
- Trindade Inês A
- Tuna Ana R
- Tytgat Ite
- Uba-Chupel M.
- Uba-Chupel Mateus
- Ugalde Lierni U
- Ugartemendia Lierni
- Valado Ana
- Valado Ana
- Valado Ana
- Valado Ana
- Valado Ana
- Vale-Dias Luz
- Vale-Dias Maria L
- Valente Ana R
- Valente Carolina
- Valente Jorge
- Valente João
- Valim Frederico C
- Valim Frederico C
- Vaquinhas Marina
- Vaquinhas Marina
- Vaquinhas Marina
- Vaquinhas Marina
- Varandas Edna
- Vardasca Ricardo
- Vardasca Ricardo
- Vasconcelos Carlos
- Vasconcelos Carlos
- Vasconcelos Lélia R
- Vasconcelos Rita
- Vasconcelos Rita
- Vaz Daniela C
- Vaz Josiana A
- Vehreschild Viktor
- Vehreschild Viktor
- Veiga Nélio
- Veiga Nélio
- Veiga Nélio
- Veiga Nélio
- Veiga-Branco Mª
- Velosa Fábia
- Veloso Milene
- Ventura David
- Ventura Maria
- Ventura Rita
- Ventura Sandra
- Vicente Corália
- Vicente Corália
- Vicente Corália
- Vicente Sara
- Vicente Sónia
- Vidal Eglidia F
- Viega-Branco Maria
- Vieira André
- Vieira Margarida
- Vieira Viviane L
- Vieitez Juan G
- Villanueva Ana G
- Vincha Kellem R
- Vinha Ana F
- Virgolino Ana
- Vizzotto Betina P
- Vélez Marta M
- Welter Aline
- Xavier Ana
- Xavier Ana
- Xavier Sandra
- Xavier Sandra
- Zilhão Adriano
- Publication venue
- Publication date
- 01/01/2004
- Field of study
As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
- Author
- Aage Christiansen
- Aaradhana Adhikari
- Aaron Venti
- Aayesha Qadeer
- Abdellatif Benslama
- Abigail Beane
- Abu Hena Mostafa Kamal
- Abul Faiz
- Adam B Schlichting
- Adam Bell Bell
- Adenilton M R Ampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Aftab Akhtar
- Agreta Gecaj-Gashi
- Ahmed Farooq
- Ahmed S Al Jabbary
- Ahmet Dilek
- Ahmet Sukru Denker
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Akm Shamsul Alam
- Akut Aytulun
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Alastair Rose
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alek Kumar
- Alessandro Bacuzzi
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandra Siqueira Colombo
- Alexandre Biasi Cavalcanti
- Alexandre Biasi Cavalcanti
- Alexandre Chan
- Alexandre Demoule
- Alexandre Guilherme Ribeiro de Carvalho
- Alexandre Molin
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alison Ghosh
- Alistair Nichol
- Alistair Roy Roy
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amadeu Martinez
- Amanda Cowton
- Amanda Krstevski
- Amanda Maria R R de Oliveira
- Amanda Skinner
- Amanda Whileman
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Amy McInerney
- Ana Carolina P Antônio
- Ana Carolina Peçanha
- Ana G França
- Ana M Araujo
- Ana M Pellicer
- Anais Briquet
- Anand Dongre
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Andre Japiassu
- Andre Luiz Baptiston Nunes
- Andre Luiz Baptiston Nunes
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andrej Sribar
- Andrew Bentley
- Andrew Corner
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- André Peretti Torelly
- Angela Delsing
- Angela Pinder
- Aniko D Frigyik
- Anil Hormis
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna Rossi
- Anna T Dowling
- Anna Walker
- Anna-Karin Morin
- Anne Adolfsson
- Anne B Guttormsen
- Annop Piriyapatsom
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
- Antonio Carlos Nogueira
- Antonio G Jimenez
- Antonio Jorge Pereira
- Antonio L Ruiz-Aguilar
- Antonio P Nassar Jr
- Antonio Paulo Nassar Junior
- António M Alvarez
- António M Messias
- Aogan C O'Muircheartaigh
- Areef Ahsan
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arshad Taqi
- Arvind K Baronia
- Ary Serpa Neto
- Ashley Schomer
- Ashok S Raj
- Asisclo J Villagomez
- Asisclo Villagomez
- Asma Ben Souissi
- Asma Navasakulpong
- Asoka Gunaratne
- Atta Ur Rehman
- Aurelia M Martinho
- Aylin Seven
- Bao H Zhu
- Barbara Brunettini
- Barbara do Cs Martins
- Barrett T Kitch
- Barry Dixon
- Barry Kennedy
- Basak Ceyda Meco
- Batoul Khoundabi
- Beatriz C Tan
- Behzad Nadjm
- Ben Creagh-Brown
- Bernard Goubaux
- Bernhard Holzgraefe
- Bhagyesh Shah
- Bhuvana Krishna
- Bimal Kudavidanage
- Bin Li
- Bingyu Qin
- Bojan Jovanovic
- Boris G Villamagua
- Brenno Cardoso Gomes
- Brigit L Roberts
- Brit Å Sjøbø
- Bruno Franco Mazza
- Bruno Gelée
- Bruno S Oliveira
- Candelaria De Haro
- Carlo A Volta
- Carlo Alberto Volta
- Carlos A Pellegrini
- Carlos Eduardo Barboza
- Carlos Munhoz
- Carlos S Pereira
- Carly Brown
- Carmen Scott
- Carolina Quintana Grijalba
- Carolina S Insaurralde
- Carolina Serra
- Caroline Berghe
- Caroline C MacFie
- Caroline Wreybrown
- Cassia Righy
- Cassiano Teixeira
- Catalina Forteza
- Catherine Plowright
- Cecilia Carbayo-Gorriz
- Cecilia Hermosa
- Ceri E Battle
- Cesar A Cortez
- Cesar Milstein
- Cesar P Pere
- Chamila Pilimatalawwe
- Charlene Bigot
- Charlene Le Moal
- Charlotte Downes
- Chathurani Sigera
- Chern Min Voon
- Cheryl Padilla-Harris
- Chinni Krishna Kasi
- Chloe Hughes
- Christian C Rylander
- Christian Dellera
- Christian Frey
- Christian M Ramirez-Alfaro
- Christian Schlegel
- Christina Whitehead
- Christine Boyd
- Christine Brown
- Christine Ryan
- Christoph Muench
- Christopher J Scott
- Christopher Nutt
- Christopher Smalley
- Christopher Tainter
- Chunting Wang
- Claine Judy
- Clair Harris
- Claire Kaloo
- Claire Matthews
- Claire Miller
- Claire Pegg
- Claire Reynolds
- Clare Bullock
- Clare Mellis
- Clare Mellis
- Claude Guérin
- Claudia A Ortiz
- Claudia R Estrella
- Claudio H Gonçalves
- Claudio Piras
- Claudio Piras
- Claudio Piras
- Colette Seasman
- Colette Seasman
- Colin K Grissom
- Colin Mcarthur
- Colin S Black
- Cora Lavigne Moreira
- Corcoles G Virgilio
- Corinne Leemann-Refondini
- Cristiane Ritter
- Cristiane Tomasi Damiani
- Cristina M Cox
- Cristina Prata Amendola
- Cristina Santos
- Cristina Santos
- Cédric Daubin
- Daisuke Niimi
- Dale J Yeatts
- Dalton de Souza Barros
- Damien Roux
- Dan E Corneci
- Dan Hadfield
- Dana R Tomescu
- Daniel Aragão
- Daniel Beraldo
- Daniel Collins
- Daniel da Cunha Ribeiro
- Daniel F McAuley
- Daniel Hadfield
- Daniel Hull
- Daniel O Beraldo
- Daniel Prado
- Daniel R Crouch
- Daniel R Gonzalez
- Daniel V Collins
- Daniela Albiero
- Daniela M Palma
- Daniela N Vasquez
- Daniele M Combaux
- Danielle A Fawkes
- Danielle C Fontenele
- Danielle J Hacking
- Danielle Nobrega
- Danielle Reuter
- Danny McAuley
- Dany Goldgran-Toledano
- Dat Vu Quoc
- Davi Cristovao
- David D Llinares Moya
- David Pogson
- David Rogerson
- David Shaw
- David W Wrathall
- Davide D'Antini
- Dawn Trodd
- Debabrata Banik
- Debbie Weller
- Deborah M Inskip
- Deborah Smith
- Deborah Wilson
- Deeban Ganesan
- Demet Aydin
- Denis Doyen
- Denise Donaldson
- Denise Griffin
- Dharshinie Dorasamy
- Diego Pastor Marcos
- Dimitrios Matamis
- Dina Gomaa
- Dina Gomaa
- Dina Ismail
- Dk Maizatul Aiman B Pg Hj Ismail
- Donald A Irvine
- Donall O'Croinin
- Donatella Mestria
- Dora Mannarino
- Dorel Sandesc
- Dorothy M Breen
- Dorothée Carpentier
- Dulce M Dector
- Dyanne Moysés Dalcomune
- Dácil Parrilla Toribio
- Ed Bajwa
- Eddy Fan
- Edel A Meaney
- Edgardo E Tabhan
- Edgardo Nuñez
- Edgardo Tabhan
- Edison Moraes
- Eduardo Beck
- Eduardo Di Lauro
- Eduardo F Labarca
- Eimhin S Dunne
- Eizo Watanabe
- Elaine Ferreira
- Eldar Søreide
- Electra E Stamou
- Elena Frati
- Elena Gallego Curto
- Elena Perez Losada
- Eleni K Mouloudi
- Eleni V Massa
- Eliana Bernadete Caser
- Eliane Bernadete Caser
- Elie H Zogheib
- Eliezer Silva
- Elisa Estenssoro
- Elisa Seghelini
- Elisabetta Pecci
- Elise P Sauvadet
- Ellada V Kiourtzieva
- Elton Afonso Lopes
- Emanuel Cirstea
- Emilio M Osman
- Emma L Willett
- Emre Erbabacan
- Enrique A Piacentini
- Enrique Cereijo
- Eoin Young
- Erika E Borotto
- Erin Nishikawa
- Erna Alberts
- Esther Bermejo Lopez
- Esther Diaz-Rodriguez
- Ettore R Vascotto
- Eva O Nagy
- Evangelos Kalaitzis
- Evelin Drociunas Pacheco
- Evgeny Grigoriev
- Evren Senturk
- Ewan C Goligher
- Fa C Zhou
- Fabien Grelon
- Fabienne D Simonis
- Fabienne D Simonis
- Fabio Tarantino
- Fabrice Daviaud
- Fahd Amir
- Fan Zhang
- Farah Idrees
- Farooq Brohi
- Farshad Heidari
- Fatma Ulger
- Fayez M Kheir
- Feda Kahveci
- Federico Gordo
- Fekri Abroug
- Felipe A Aliaga
- Felipe Dal-Pizzol
- Felipe Saddy
- Felipe T Martinez
- Ferdinando Raimondi
- Fernanda Eugênia Fernandes
- Fernando Borges Rodriguez
- Fernando G George
- Fernando José da Silva Ramos
- Fernando Rios
- Ferran Roche-Campo
- Filipa M Barros
- Finn H Andersen
- Flavia A Loiacono
- Flavia Ribeiro Machado
- Francesco L Santoli
- Francesco Mojoli
- Francesco Raponi
- Francis Schneider
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- Raquel Montoiro Allue
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- Stefania Aguirre
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- Taohidul Majid Taohid
- Tarek Dendane
- Tarikul Hamid
- Tasmin Patel
- Tatjana Simurina
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- Terri-Ann Sewell
- Tharwat M Aisa
- Theonymfi G Papavasilopoulou
- Thiago Lisboa
- Thomas Baltus
- Thomas C Blakeman
- Thomas Collyer
- Thomas Kander
- Thomas Staudinger
- Thuy Duong Bich
- Théia Forny Wanderley Castellões
- Tiago Macruz
- Tie H Qin
- Tim Wenham
- Tom Hatton
- Tomas P Roser
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- Tomaz Mesar
- Tommaso Fossali
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- Tomofumi Harasawa
- Tomoyuki Nakamura
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- Tracey Evans
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- Ugur Goktas
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- Upeka Samaranayake
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- Vanessa Linnett
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- Vasilis Ourailogloy
- Venika Manoharan
- Venkatapura J Ramesh
- Veronica Villar
- Vesna Bumbasierevic
- Vesna Bumbasirevic
- Vicente Cés de Souza Dantas
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Russotto
- Vincenzo Schiavone
- Viratch Tangsujaritvijit
- Virginie Lemiale
- Visanthi Pinto
- Vivek Kakar
- Vladimir Cerny
- Vlasta Klaric
- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- Werner Schmid
- William Stigler
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Y A Hasitha Dilhani
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- Yasuaki Ogino
- Yavuz Orak
- Yen Lam Minh
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- Yves D Jarquin-Badiola
- Zerrin Demirtürk
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Álvaro Réa-Neto
- Ángela Algaba
- Ángela González-Salamanca
- Çiler Zincircioglu
- Érica Aranha Suzumura
- Ênio Rego
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies.
Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality.
Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p<0·0001).
Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study
- Author
- Abad Ricardo,
- Abe Toshikazu
- Abroug Fekri
- Adams John,
- Adamsson Richard,
- Adolfsson Anne
- Aguilar Ronald,
- Aguirre Janet,
- Aguirre-Bermeo Hernan
- Aisa Tharwat,
- Aisiku Imo
- Ajetunmobi Olaitan,
- Aker Mustafa
- Akyol Onat,
- Al Dorzi Hasan,
- Albaiceta Guillermo,
- Albaiceta Guillermo,
- Albarrak Mohamad,
- Albiero Daniela
- Alda Rosa,
- Alejandro Risso,
- Alexander Peter
- Alfonso Alec,
- Algaba Ángela
- Aliaga Felipe,
- Alisasis Alain,
- Aljabbary Ahmed,
- Allan Russell,
- Allue Raquel,
- Almekhlafi Ghaleb
- Alonso Javier,
- Altaf Wahid
- Alvarez António,
- Alvarez Javier
- Amado-Rodríguez Laura
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn,
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo,
- Antônio Ana,
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen,
- Arabi Yaseen,
- Araujo Ana,
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria,
- Artigas Antonio
- Ascoli Aline
- Avila Luis,
- Azad Raman
- Azevedo Luciano,
- Baboi Loredana
- Badie Julio,
- Bailey Irene,
- Bailey Mathew,
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Bannergoodspeed Valerie,
- Barberet Guillaume
- Baro Rebecca,
- Baronia Arvind,
- Barratt-Due Andreas
- Barros Filipa,
- Barros Nelson,
- Batra Hitesh
- Battle Ceri,
- Bauer Philippe,
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu,
- Beegle Scott,
- Beitler Jeremy,
- Bellani Giacomo
- Beloncle Francois
- Benslama Abdellatif
- Beraldo Daniel,
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien,
- Bettini Lisandro,
- Beuret Pascal
- Bezzi Marco,
- Bhardwaj Vallish,
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Binhjabul Wahab Ahmad,
- Biondi Rodrigo,
- Biscione Roberto,
- Bisso Mariano,
- Black Colin,
- Blakeman Thomas,
- Blanco Javier
- Bolon Stefan
- Borello Silvina,
- Borotto Erika,
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria,
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy,
- Briquet Anais
- Brito Vania,
- Brizuela Matias
- Brochard Laurent
- Broman Lars,
- Brown Samuel,
- Browne Troy,
- Bruhn Alejandro,
- Brunettini Barbara
- Bruns Monique,
- Buensuseso Juan,
- Bugedo Guillermo
- Buise Marc,
- Bulpa Pierre,
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew,
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis,
- Careless Jon,
- Carpentier Dorothée
- Carreño Nicolás,
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro,
- Castro Silvia
- Catorze Nuno,
- Cazorla-Barranquero Francisca,
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria,
- Cervantes Mavy,
- Cesar Palazon,
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon,
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy,
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna,
- Claraco-Vega Luis,
- Clarkson Kevin
- Clarkson Kevin,
- Claverias Laura
- Cohen Jason,
- Cole Jade,
- Collins Daniel,
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele,
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan,
- Cortegiani Andrea
- Cortez Cesar,
- Coxo Cristina,
- Cracchiolo Andrea,
- Cranshaw Julius,
- Crapelli Giulia
- Crouch Daniel,
- Crouch Daniel,
- Crova Philippe,
- Csabi Peter
- Curley Gerard
- Curto Elena,
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin Cédric
- Daviaud Fabrice
- Davies Kyle,
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael,
- Declercq Pierrelouis,
- Dector Dulce
- Deicas Alberto
- del Carmenlorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt Pieter
- Depuydt Pieter
- Derman Suleyman,
- Di Tomasso Nora,
- Di Yu,
- Diaz Juan,
- Diaz-Rodriguez Esther
- Dive Alain,
- Dixit Subhal,
- Do Vale Fernandes Antero
- Dolva Merete,
- Donnelly Adrian
- Dowling Anna,
- Doyen Denis
- Dres Martin
- Dreyer Kyle,
- Dunne Eimhin,
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia,
- Elkhayari Mina
- Ellis Helen,
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin,
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana,
- Estrella Claudia,
- Ezzouine Hanane
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela,
- Fawkes Danielle,
- Ferguson Andrew
- Ferguson Niall,
- Fernandez Adriana,
- Fernandez Ruben,
- Fierro Jonathan,
- Floris Leda
- Follin Arnaud
- Fontenele Danielle,
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- França Ana,
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko,
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan,
- Garcia Patricio,
- Gattinoni Luciano
- Gazenkampf Andrey,
- Gelée Bruno
- George Fernando,
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin,
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan,
- Gomaa Dina
- Gomaa Dina
- Gomes Rui,
- Gomez Pablo,
- Gomez-Flores Saira,
- Gonzalez Daniel,
- Gonzalez Marcos
- González Raquel,
- González-Salamanca Ángela
- Gonçalves Claudio,
- Goodson Jennifer,
- Gordo Federico
- Gosselin Ryan,
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth,
- Grigoriev Evgeny
- Grissom Colin,
- Gritsan Alexey,
- Grubissich Nicolas
- Gueret Renaud,
- Gurjar Mohan
- Guttormsen Anne,
- Guérin Claude
- Gómez Pilar,
- Hacking Danielle,
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha,
- Han Hui
- Han Yi
- Hang Ai,
- Hanlon Gabrielle,
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S,
- Hashemian Seyed,
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge,
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert,
- Heunks Leo,
- Heunks Leo,
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hansbernd,
- Hopkins Phil
- Hormis Anil,
- Hou Peter,
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma,
- Huang Qing,
- Huang Xiao,
- Huerta Francisco,
- Huff Nidhi,
- Humphreys Sally,
- Hunt Anna
- Hurtado Javier
- Hurtado Javier
- Hurtado Javier
- Hutchison Robyn,
- Hutton Paula,
- Ibañez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu,
- Imperio María,
- Insaurralde Carolina,
- Inskip Deborah,
- Ioannou Nicholas
- Iotti Giorgio,
- Irvine Donald,
- Isidro San
- Ismail Dina
- Ismail Maizatul
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola,
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola Yves,
- Jassal Mandeep
- Javeed Areej
- Jha Rajeev,
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio,
- Jimenez Juan,
- Jochmans Sébastien
- Jog Sameer,
- Jovanovic Bojan
- Judy Claine
- Jurado M,
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana,
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
- Kheir Fayez,
- Kimura Hiroyasu
- Kiourtzieva Ellada,
- Kitch Barrett,
- Knapman Karl,
- Knoll Jenny
- Knowles Serena
- Kol Mark,
- Kong Jing
- Koyama Kansuke
- Kraßler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- Laake Jon,
- Laake Jon,
- Labarca Eduardo,
- Laffey John,
- Laffey John,
- Lamb Keith,
- Lanspa Michael,
- Larsson Anders
- Larsson Anders
- Larsson Niklas
- Las Lomas Sanatorio
- Le Moal Charlene
- Lebbinck Herve
- Lee Jarone
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus Jordana,
- Leonyoshido Hector,
- Li Bin
- Li Qingdong
- Li Qiong,
- Li Wenwen
- Li Xiao,
- Li Xinyu
- Li Yimin
- Li Yuan,
- Li-Xin Zhou
- Liew Kong,
- Ling Long,
- Liu Haitao
- Liu Jian
- Liu Jing,
- Liu Ling
- Llano Iguel
- Lohner Ralph
- Loiacono Flavia,
- Lombardo Andrea
- Lopez Esther,
- Lopez-Delgado Juan,
- Lora Fredy,
- Lora Pilar
- Lorente Jose,
- Losada Elena,
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon,
- Luo Xiaoming
- Lynch Joan,
- López-Messa Juan,
- Maazouzi Wajdi
- Macfadyen Rosaleen
- Macfie Caroline,
- Madotto Fabiana
- Maeyama Hiroki,
- Maghrabi Khalid,
- Magret Monica
- Mahto Heera,
- Mancebo Jordi
- Manoharan Venika
- Marcos Diego,
- Marcu Alexandra
- Marin Julien
- Marin Maria,
- Martinez Felipe,
- Martinho Aurelia,
- Marum Susan,
- Massa Eleni,
- Mataloun Sergio
- Matamis Dimitrios
- Matsumoto Shuhei
- Mattei Alessia
- May Martin,
- Mcarthur Colin
- Mcauley Daniel,
- Mcauley Daniel,
- Mcauley Danny
- Mccalman Katie,
- Mckechnie Stuart
- Mckee Raymond
- Mckenna Toni,
- Mcleod Alex
- Mcnamee Lia
- Mcnamee Lia
- Meaney Edel,
- Meco Basak,
- Meersseman Philippe
- Mehta Sangeeta
- Mejia Francisco,
- Mellis Clare
- Memon Mohammedfaruk
- Mercat Alain
- Mesar Tomaz
- Messias António,
- Messika Jonathan
- Meybohm Patrick
- Michel Philippe
- Millar Rebecca,
- Miller Jennene,
- Miller Russel,
- Mirabella Lucia
- Mizuguchi Ichiko
- Mochizuki Katsunori
- Mohr Nicholas,
- Mojoli Francesco
- Moles Silvia,
- Molin Alexandre
- Montanha Gustavo,
- Monteiro Jorge,
- Montero Laura,
- Monti Giacomo
- Montini Luca,
- Moock Marcelo
- Morin Anna-Karin
- Mortaza Satar
- Morton Alex
- Mouloudi Eleni,
- Moya David,
- Mukkera Satyanarayana,
- Mustafa Ghanem,
- Muthuchellappan Radhakrishnan
- Máca Jan
- Nagy Eva,
- Nakamura Tomoyuki
- Namih Miriam
- Nassar Jr Antonio,
- Nasu Michitaka
- Navalpotro Miguel,
- Navarra Leanlove
- Navarro Gonzalo
- Neal John
- Negoita Silvius,
- Newby Lynette
- Nichol Alistair
- Nielsen Jonas
- Nielsen Jonas
- Niimi Daisuke
- Nin Nicolas
- Nin Nicolás
- Nishikawa Erin
- Nitta Kenichi
- Nobrega Danielle
- Noremark Kim,
- Nunci Lordian
- Nunes Silvia,
- Nunomiya Shin
- Nutt Christopher
- Nuñez Edgardo
- Nygren Ingela
- Occhipinti Giovanna
- Oetting Trevor,
- Ogino Yasuaki
- Oikonomou Marina,
- Okane Sinead,
- Okuda Nao
- Oldroyd Matthew,
- Olga Moreno,
- Oliveira Bruno,
- Oneill Orla
- Ortiz Claudia,
- Oscanoa Fredy,
- Osman Emilio,
- Oss Peteris
- Ouanes Islem
- Ourailogloy Vasilis
- Owens Robert,
- Ozcelik Menekse
- O’croinin Donall
- O’muircheartaigh Aogan,
- Palaniswamy Vijayanand
- Palma Daniela,
- Palmese Salvatore
- Palo Jose,
- Panarello Giovanna
- Papanikolaou Metaxia,
- Papavasilopoulou Theonymfi,
- Papazian Laurent
- Papurica Marius
- Para Luis,
- Parhar Ken
- Parotto Matteo
- Pasanting-Lim Rossini,
- Patroniti Nicolò
- Pattarino Ilaria
- Pecci Elisabetta
- Pellegrini Carlos,
- Pelletier Nicolas
- Pellicer Ana,
- Penuelas Oscar
- Pereira Carlos,
- Perez Cesar,
- Perez Manuel,
- Persson Linnea
- Pesenti Antonio
- Pham Tài
- Phan Nga,
- Piacentini Enrique,
- Pillai Suresh
- Pintado Maria,
- Piquilloud Lise
- Piras Claudio
- Pittini Gustavo
- Plotnikow Gustavo,
- Poblano Manuel
- Poli Michela,
- Pota Vincenzo
- Pozo Norberto,
- Pozzi Matteo
- Preez Pieter,
- Prietogonzález Miryam
- Pronovost Antoine
- Protti Alessandro
- Qin Bingyu
- Qin Junping
- Qin Shu,
- Qin Tie,
- Qiu Haibo
- Qiu Haibo
- Raaijmakers Monique
- Rafael Sánchez,
- Raimondi Ferdinando
- Raj Ashok,
- Ramakrishnan Nagarajan
- Ramesh Venkatapura,
- Ramirez-Alfaro Christian,
- Ramirez-Gutierrez Alvaro
- Rampinelli Adenilton,
- Ranero Jorge,
- Ranieri Marco
- Raponi Francesco
- Recio Noelia,
- Reschreiter Henrik
- Reske Andreas,
- Reuter Danielle
- Reynolds Claire
- Rhayakar Rachana,
- Rialp Gemma
- Richecoeur Jack,
- Ricome Sylvie
- Rigaud Jean-Philippe
- Rinia Myra
- Rios Fernando
- Riss Katharina,
- Rittayamai Nuttapol
- Roberts Brigit,
- Robine Adrien
- Robles Joanne,
- Rochecampo Ferran
- Rodgers Helen,
- Rodriguez Lucia,
- Rodriguez Ruben
- Rodríguez-Garcia Raquel
- Rojas Alejandro
- Rojas Manuel,
- Rosa Jonas,
- Roser Tomas,
- Rossi Anna
- Roux Damien
- Rubenfeld Gordon
- Rugonfalvi Szabolcs
- Ruiz Silvia,
- Ruizaguilar Antonio,
- Rylander Christian,
- Ryosuke Sekine
- Sabelnikovs Olegs
- Sable Safal,
- Saenz María,
- Saez Alejandro,
- Sagar Sudha,
- Saito Koji
- Saito Shigeki
- Salahuddin Nawal
- Salas Javier,
- Sales Vanessa,
- Samkaoui Nacer
- Sanchez Roberto,
- Sanchez-Hurtado Luis,
- Sanchez-Medina Jorge,
- Sandesc Dorel
- Santoli Francesco,
- Santos Cristina
- Sauvadet Elise,
- Savioli Monica
- Scafetti Sergio
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schiöler Fredrik
- Schlichting Adam,
- Schneider Francis
- Schomer Ashley
- Schouten Jeroen,
- Schuetz Michael
- Schultz Marcus,
- Schäfer Susanne
- Scott Christopher,
- Seasman Colette
- Seethala Raghu
- Sellors Gareth,
- Seoane-Quiroga Leticia
- Serra Carolina
- Serra Isabel,
- Setten Mariano,
- Seven Aylin
- Shah Bhagyesh
- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shindhe Suresh
- Shinn Iii John,
- Shiozaki Kyoko
- Silesky Juan
- Sim Malcolm
- Simon Philipp
- Simonis Fabienne,
- Sivashanmugavel Mageswaran
- Sjøbø Brit,
- Sklienka Peter
- Slutsky Arthur,
- Smith Mark,
- Smith Oliver
- Soler Juan,
- Solisquesada Jaime,
- Sottiaux Thierry
- Souissi Asma,
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra,
- Staudinger Thomas
- Stephenson Lorraine
- Stewart Richard
- Stigler William
- Strauch Ulrich
- Sula Hektor
- Sun Renhua
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Sánchez Rocío,
- Sánchez-Ballesteros Jesús
- Søreide Eldar
- Tabhan Edgardo
- Tabhan Edgardo,
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tan Beatriz,
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Taylor Thompson B
- Temprano Susana
- Terragni Pierpaolo
- Terzi Nicolas
- Thibault Sandrine
- Thomas Matthew
- Thompson Marlus,
- Tibblin Anna,
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana,
- Toribio Dácil,
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T,
- Trinidad Olivia,
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- van Haren Frank
- van Haren Frank
- van Wezel Hellen,
- Vargas Monica,
- Vascotto Ettore,
- Vasquez Daniela,
- Vega Luis,
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Villagomez Asisclo
- Villagomez Asisclo,
- Villamagua Boris,
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles,
- Vitale Michela,
- Volta Carlo,
- Wang Chunting
- Wang Hua,
- Wang Shou,
- Wang Wei
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg,
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma,
- Williams Alexandra,
- Williams Karen,
- Wittebole Xavier
- Wong Helen,
- Woods Paul,
- Wrathall David,
- Wrigge Hermann
- Wrigge Hermann
- Wu Ya,
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng,
- Yeatts Dale,
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob,
- Yuste Luis,
- Zacharas Giannis,
- Zacharowski Kai,
- Zani Gianluca
- Zantua Charing,
- Zazu Alan
- Zeggwagh Amine,
- Zeggwagh Amine,
- Zein Salem,
- Zender Hervé,
- Zhai Zhe
- Zhang Fan
- Zhang Xing,
- Zhao Huiying
- Zhao Jun
- Zhao Xian,
- Zheng Ruiqiang
- Zhou Fa,
- Zhou Suming
- Zhu Bao,
- Zhu Wei,
- Zogheib Elie,
- Ñamendys-Silva Silvio,
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 25/12/2022
- Field of study
International audienceBackground: Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods: Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/ hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results: From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77] vs 74 [64-80] years, p < 0.001) and had lower driving (12 [8-16] vs 15 [11-17] cmH 2 O, p < 0.001), plateau (20 [15-23] vs 22 [19-26] cmH 2 O, p < 0.001) and peak (21 [17-27] vs 26 [20-32] cmH 2 O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60-1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16-2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06-1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52-0.93], p = 0.015) were related to survival. Conclusions: Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury
Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study
- Author
- Aage Christiansen
- Aaron Venti
- Abdellatif Benslama
- Adam B Schlichting
- Adenilton M Rampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Ahmad Yazid Bin Hj Abul Wahab
- Ahmed S Al Jabbary
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alejandro Rojas
- Alek Kumar
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandre Demoule
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alistair Nichol
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amanda Krstevski
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Ana Carolina P Antônio
- Ana G França
- Ana M Araujo
- Ana M Pellicer
- Anais Briquet
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Anders Larsson
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andres Esteban
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- Angela Delsing
- Aniko D Frigyik
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna T Dowling
- Anna-Karin Morin
- Anne Adolfsson
- Anne B Guttormsen
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
- Antonio G Jimenez
- Antonio L RuizAguilar
- Antonio P Nassar Jr
- Antonio Pesenti
- António M Alvarez
- António M Messias
- Aogan C O'Muircheartaigh
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arthur S Slutsky
- Arvind K Baronia
- Ashley Schomer
- Ashok S Raj
- Asisclo J Villagomez
- Asisclo Villagomez
- Asma Ben Souissi
- Aurelia M Martinho
- Aylin Seven
- B Taylor Thompson
- Bao H Zhu
- Barbara Brunettini
- Barrett T Kitch
- Barry Kennedy
- Basak Ceyda Meco
- Beatriz C Tan
- Bellani Giacomo
- Bernard Goubaux
- Bernhard Holzgraefe
- Bhagyesh Shah
- Bin Li
- Bingyu Qin
- Bojan Jovanovic
- Boris G Villamagua
- Brigit L Roberts
- Brit Å Sjøbø
- Brochard Laurent J.
- Bruhn Alejandro
- Bruno Gelée
- Bruno S Oliveira
- Bugedo Guillermo
- Candelaria De Haro
- Carlo A Volta
- Carlos A Pellegrini
- Carlos S Pereira
- Carolina Quintana Grijalba
- Carolina S Insaurralde
- Carolina Serra
- Caroline Berghe
- Caroline C MacFie
- Catalina Forteza
- Cecilia Carbayo-Gorriz
- Cecilia Hermosa
- Ceri E Battle
- Cesar A Cortez
- Cesar P Perez
- Charlene Bigot
- Charlene Le Moal
- Christian C Rylander
- Christian Dellera
- Christian M Ramirez-Alfaro
- Christina Whitehead
- Christopher J Scott
- Christopher Nutt
- Christopher Tainter
- Chunting Wang
- Claine Judy
- Claire Reynolds
- Clare Mellis
- Claude Guérin
- Claudia A Ortiz
- Claudia R Estrella
- Claudio H Gonçalves
- Claudio Piras
- Colette Seasman
- Colin K Grissom
- Colin McArthur
- Colin S Black
- Corcoles G Virgilio
- Corinne Leemann-Refondini
- Cristina M Coxo
- Cristina Santos
- Cédric Daubin
- Daisuke Niimi
- Dale J Yeatts
- Damien Roux
- Dan E Corneci
- Dan Hadfield
- Dana R Tomescu
- Daniel F McAuley
- Daniel F McAuley
- Daniel O Beraldo
- Daniel R Crouch
- Daniel R Crouch
- Daniel R Gonzalez
- Daniel V Collins
- Daniela Albiero
- Daniela M Palma
- Daniela N Vasquez
- Daniele M Combaux
- Danielle A Fawkes
- Danielle C Fontenele
- Danielle J Hacking
- Danielle Nobrega
- Danielle Reuter
- Danny McAuley
- Dany Goldgran-Toledano
- David D Llinares Moya
- David W Wrathall
- Deborah M Inskip
- Deeban Ganesan
- Denis Doyen
- Diego Pastor Marcos
- Dimitrios Matamis
- Dina Gomaa
- Dina Gomaa
- Dina Ismail
- Donald A Irvine
- Donall O'Croinin
- Dorel Sandesc
- Dorothy M Breen
- Dorothée Carpentier
- Dulce Dector
- Dácil Parrilla Toribio
- Ed Bajwa
- Eddy Fan
- Eddy Fan
- Edel A Meaney
- Edgardo E Tabhan
- Edgardo Nuñez
- Edgardo Tabhan
- Eduardo Beck
- Eduardo F Labarca
- Eimhin S Dunne
- Eizo Watanabe
- Eldar Søreide
- Electra E Stamou
- Elena Frati
- Elena Gallego Curto
- Elena Perez Losada
- Eleni K Mouloudi
- Eleni V Massa
- Elie H Zogheib
- Elisa Estenssoro
- Elisabetta Pecci
- Elise P Sauvadet
- Ellada V Kiourtzieva
- Emilio M Osman
- Emma L Willett
- Emre Erbabacan
- Enrique A Piacentini
- Enrique Cereijo
- Erika E Borotto
- Erin Nishikawa
- Esteban Andres
- Esther Bermejo Lopez
- Esther Diaz-Rodriguez
- Ettore R Vascotto
- Eva O Nagy
- Evangelos Kalaitzis
- Evgeny Grigoriev
- Ewan C Goligher
- Fa C Zhou
- Fabien Grelon
- Fabienne D Simonis
- Fabio Tarantino
- Fabrice Daviaud
- Fahd Amir
- Fan Zhang
- Fan Eddy
- Farshad Heidari
- Fayez Kheir
- Fayez M Kheir
- Federico Gordo
- Fekri Abroug
- Felipe A Aliaga
- Felipe T Martinez
- Ferdinando Raimondi
- Fernandes Antero do Vale
- Fernando G George
- Fernando Rios
- Ferran RocheCampo
- Filipa M Barros
- Finn H Andersen
- Flavia A Loiacono
- Francesco L Santoli
- Francesco Mojoli
- Francesco Raponi
- Francis Schneider
- Francisca G Cazorla-Barranquero
- Francisco Esteve
- Francisco Javier Flores Mejia
- Francisco P Huerta
- Francois Beloncle
- Frank van Haren
- Frank van Haren
- Frantz Berkelmans
- Fredrik Schiöler
- Fredy A Montes Oscanoa
- Fredy S Lora
- Fumihito Ito
- Gabriel Démpaire
- Gabrielle C Hanlon
- Gaetan Béduneau
- Galen Henderson
- Garcia M Elisabet
- Gareth P Sellors
- Gattinoni Luciano
- Gautier Buzancais
- Ged Dempsey
- Gemma Rialp
- Gerard Curley
- Ghaleb Almekhlafi
- Ghanem M Mustafa
- Ghassan Kamel
- Giacomo Bellani
- Giacomo Bellani
- Giacomo Monti
- Gianluca Zani
- Giannis A Zacharas
- Gilda Cinnella
- Giorgio A Iotti
- Giovanna Occhipinti
- Giovanna Panarello
- Giulia Crapelli
- Giuseppe Foti
- Gonzalo Navarro
- Gordon Rubenfeld
- Guillaume Barberet
- Guillaume Carteaux
- Guillermo Bugedo
- Guillermo M Albaiceta
- Gustavo A Plotnikow
- Gustavo M Montanha
- Gustavo Pittini
- Gyorgy Frendl
- Haibo Qiu
- Haibo Qiu
- Haitao Liu
- Hamidreza Jamaati
- Hanane Ezzouine
- Hans Kedelv
- HansBernd F Hopf
- Hasan M Al Dorzi
- Hector H Leon Yoshido
- Heera L Mahto
- Heidi Dawson
- Hektor Sula
- Helen E Ellis
- Helen J Rodgers
- Helen S Wong
- Helga Ceunen
- Hellen M van Wezel
- Henrik Appelberg
- Henrik Reschreiter
- Hermann Wrigge
- Hermann Wrigge
- Hernan Aguirre-Bermeo
- Hernan Gianinetto
- Herve Dupont
- Herve Lebbinck
- Hervé O Zender
- Hicham Balkhi
- Hiroki N Maeyama
- Hiroshi Imai
- Hiroyasu Kimura
- Hiroyuki Honda
- Hiroyuki Suzuki
- Hiroyuki Tanaka
- Hitesh Batra
- Hua X Wang
- Huanzhang Shao
- Hui Han
- Huiying Zhao
- Ichiko Mizuguchi
- Iguel Llano
- Ilaria Pattarino
- Ilkay Ceylan
- Imed Chouchene
- Imo Aisiku
- Ingeborg D Welters
- Ingela Nygren
- Irene M Bailey
- Isabel M Serra
- Islem Ouanes
- Istvan Kajtor
- Jack R Richecoeur
- Jacob S Yumha
- Jacques Duranteau
- Jade M Cole
- Jaime E SolisQuesada
- Jakob Gjedsted
- Jan Máca
- Janet S Aguirre
- Jarone Lee
- Jason E Cohen
- Javier Alvarez
- Javier Blanco
- Javier E Salas
- Javier G Alonso
- Javier Hurtado
- Javier Hurtado
- Javier Hurtado
- Jean Dellamonica
- Jean-Daniel Chiche
- Jean-Etienne Herbrecht
- Jean-Michel Arnal
- Jean-Philippe Rigaud
- Jennene J Miller
- Jennifer C Goodson
- Jenny Knoll
- Jens Kraßler
- Jeremy R Beitler
- Jeroen A Schouten
- Jerome Biehler
- Jessica Warren
- Jesús Sánchez-Ballesteros
- Jian Liu
- Jing Kong
- Jing L Liu
- Joan M Lynch
- Joana M Estilita
- Joanna Wessbergh
- Joanne B Robles
- Johan Helleberg
- Johanna E Citalán
- John C Adams
- John G Laffey
- John G Laffey
- John Laffey
- John Neal
- John O Shinn Iii
- Jon Bramall
- Jon H Laake
- Jon Henrik Laake
- Jon P Careless
- Jonas I Rosa
- Jonas Nielsen
- Jonas Nielsen
- Jonathan Casement
- Jonathan Chelly
- Jonathan M Fierro
- Jonathan Messika
- Jordana S Lemus
- Jordi Mancebo
- Jorge Luis Ranero
- Jorge M Monteiro
- Jorge R Sanchez-Medina
- Joris Vermassen
- Jose A Lorente
- Jose Emmanuel Palo
- Josette Gally
- Juan A Buensuseso
- Juan A Buensuseso
- Juan Alfonso Soler
- Juan B López-Messa
- Juan C Lopez-Delgado
- Juan Carlos J Sotillo Diaz
- Juan I Silesky Jimenez
- Juan Silesky
- Juanhong Shen
- Julie Camsooksai
- Julien Marin
- Julio C Badie
- Julio Daldin
- Julius H Cranshaw
- Jun Zhao
- Junping Qin
- Kai Chen
- Kai D Zacharowski
- Kansuke Koyama
- Karen E Williams
- Karin E Eriksson
- Karina Jakubowska
- Karl M Knapman
- Katharina C Riss
- Katie H McCalman
- Katsunori Mochizuki
- Kaushik Bhowmick
- Kazuya Ichikado
- Kazuyoshi Shimizu
- Keiko Ueno
- Keith D Lamb
- Ken Parhar
- Kenichi Nitta
- Kevin Clarkson
- Kevin P Clarkson
- Khalid A Maghrabi
- Kim Andre L Noremark
- Kim S Zantua
- Kiyoyasu Kurahashi
- Kohei Kusumoto
- Kohkichi Andoh
- Koji Saito
- Kong Y Liew
- Kyle G Davies
- Kyle R Dreyer
- Kyoko Shiozaki
- Laffey John G
- Lars Hedlund
- Lars M Broman
- Larsson Anders
- Latha Srinivasa
- Laura Alvarez Montero
- Laura Claverias
- Laura Ortiz-Ruiz de Gordoa
- Laurence Dangers
- Laurent Brochard
- Laurent Papazian
- Leanlove Navarra
- Leda Floris
- Leo M Heunks
- Leo M Heunks
- Leticia Seoane-Quiroga
- Lia McNamee
- Lia McNamee
- Liangyan Jiang
- Linda Twohey
- Ling Liu
- Linnea Persson
- Lisandro R Bettini
- Lise Piquilloud
- Lise Piquilloud
- Long L Ling
- Lordian Nunci
- Loredana Baboi
- Lorente José Angel
- Lorenzo Schiavoni
- Lorraine Stephenson
- Luca Brazzi
- Luca M Montini
- Lucia L Rodriguez
- Lucia Mirabella
- Luciano Cesar Azevedo
- Luciano Gattinoni
- Luis A Sanchez-Hurtado
- Luis D Vega
- Luis E Avila
- Luis Herrera Para
- Luis J Yuste
- Luis M Claraco-Vega
- Luis P Cardonnet
- Lynette Newby
- Ma X Hua
- Mageswaran Sivashanmugavel
- Maizatul Ismail
- Malcolm Sim
- Mandeep Jassal
- Manuel A González Rojas
- Manuel Jibaja
- Manuel P Perez
- Manuel Poblano
- Manuel Poblano
- Manuel Todeschini
- Marc P Buise
- Marcelo Moock
- Marco Botteri
- Marco G Bezzi
- Marco Ranieri
- Marcos Gonzalez
- Marcos Ibañez-Santacruz
- Marcus J Schultz
- Maria C Marin
- Maria C Pintado
- Maria Del Carmen Lorente
- Maria J Bouw
- Maria Jose D Artiga
- Mariano Carboni Bisso
- Mariano G Setten
- Marina A Oikonomou
- Marius Papurica
- Mark J Smith
- Mark R Kol
- Marlus M Thompson
- Martin Dres
- Martin M May
- Mary Elmasri
- María C Imperio
- María G Saenz
- Masayo Izawa
- Massimo M Antonelli
- Mathew B Bailey
- Matias Brizuela
- Matteo Parotto
- Matteo Pozzi
- Matthew G Oldroyd
- Matthew Thomas
- Mauricio Vinzio
- Maurizio Fusari
- Mavy Ramirez Cervantes
- McAuley Daniel F.
- Mehvish Ismail
- Meisy Perez Cheng
- Menekse Ozcelik
- Merete S Dolva
- Messabi Boukhazna
- Metaxia N Papanikolaou
- Michael J Lanspa
- Michael Kalkoff
- Michael N Dean
- Michael Schuetz
- Michela M Poli
- Michela N Vitale
- Michele Umbrello
- Michitaka Nasu
- Miguel Angel Blasco Navalpotro
- Mina Elkhayari
- Miriam Namih
- Miryam PrietoGonzález
- Mohamad M Albarrak
- Mohammed Ghazi
- Mohammedfaruk Memon
- Mohan Gurjar
- Monica Magret
- Monica P Vargas
- Monica Savioli
- Monique M Bruns
- Monique Raaijmakers
- Moreno F Olga
- Mourad Amor
- Muriel Fartoukh
- Mustafa Aker
- Myra Rinia
- Mª Teresa Jurado
- Nacer Samkaoui
- Nagarajan Ramakrishnan
- Nao Okuda
- Nawal Salahuddin
- Necmettin Ünal
- Nedim Cimic
- Nelson C Barros
- Nermin Kelebek Girgin
- Nga T Phan
- Niall D Ferguson
- Nicholas Ioannou
- Nicholas M Mohr
- Nicolas de Prost
- Nicolas Grubissich
- Nicolas Nin
- Nicolas Pelletier
- Nicolas Terzi
- Nicolás G Carreño
- Nicolás Nin
- Nicolò Patroniti
- Nidhi G Huff
- Nieves Franco
- Niklas Larsson
- Nobumasa Aoki
- Noelia N Recio
- Nora N Di Tomasso
- Norberto C Pozo
- Norberto Tiribelli
- Nuala Treanor
- Nuno T Catorze
- Nuttapol Rittayamai
- Oktay Demirkiran
- Olaitan O Ajetunmobi
- Olegs Sabelnikovs
- Oliver Beck
- Oliver Smith
- Olivia A Trinidad
- Onat O Akyol
- Orla Oneill
- Osamu Yamaguchi
- Oscar Penuelas
- Ovidiu H Bedreag
- Owen Boyd
- Pablo E Gomez
- Pablo Lovazzano
- Palazon Sanchez Cesar
- Palazon Sanchez Eugenio Luis
- Pamela A Farías
- Paolo Casalena
- Paolo Formenti
- Pascal Beuret
- Patricio H Garcia
- Patrick Meybohm
- Paul W Woods
- Paula J Hutton
- Pawel Andruszkiewicz
- Pesenti Antonio
- Peter Alexander
- Peter C Hou
- Peter Csabi
- Peter Sklienka
- Peteris Oss
- Pham Tài
- Phil Hopkins
- Philip Watt
- Philipp Simon
- Philippe Burtin
- Philippe J Crova
- Philippe Meersseman
- Philippe Michel
- Philippe R Bauer
- Pierpaolo Terragni
- Pierre A Bulpa
- Pierre-Eric Danin
- PierreLouis M Declercq
- Pieter D Preez
- Pieter Depuydt
- Pieter Depuydt
- Pilar Lora
- Pilar Ricart Aroa Gómez
- Piroska Toth-Tarsoly
- Pravin Amin
- Qiang Xin-Hua
- Qing Q Huang
- Qingchun Yao
- Qingdong Li
- Qiong J Li
- Rachana V Rhayakar
- Radhakrishnan Muthuchellappan
- Raghu Seethala
- Rajeev R Jha
- Ralph Lohner
- Raman Azad
- Ramesh Unnikrishnan
- Ranieri Marco
- Raphael Cooper
- Raquel Montiel González
- Raquel Montoiro Allue
- Raul De Pablo
- Raymond Mckee
- Rebecca M Baro
- Rebecca T Millar
- Renaud M Gueret
- Renhua Sun
- Rhiannon Chapman
- Ricardo Diaz Abad
- Riccardo Colombo
- Richard Stewart
- Rik Verstraete
- Rios Fernando
- Risso V Alejandro
- Rita Glietsch
- Rob Cirone
- Robert J Hessell
- Robert L Owens
- Roberto Jimenez Sanchez
- Roberto R Biscione
- Robyn A Hutchison
- Rocío Manzano Sánchez
- Rodrigo S Biondi
- Rola F Jaafar
- Romain Tapponnier
- Romano Graziani
- Ronald Zumaran Aguilar
- Rongguo Yu
- Rory Dwyer
- Rosa S Alda
- Rosaleen Macfadyen
- Rossini Abbie B Pasanting-Lim
- Ruben O Fernandez
- Ruben Rodriguez
- Rubenfeld Gordon
- Rui M Gomes
- Rui Tang
- Ruiqiang Zheng
- Russel R Miller
- Russell Chabanne
- Russell M Allan
- Ruth O Griffin
- Ryan J Gosselin
- S M Hashemian
- Safal D Sable
- Saira S Gomez-Flores
- Salem Ould Zein
- Sally K Humphreys
- Salma Kamoun
- Salvatore Palmese
- Samantha J Hagan
- Sameer A Jog
- Sami Hraiech
- Samuel M Brown
- Samy Khebbeb
- Sandrine Thibault
- Sangeeta Mehta
- Santhana G Kannan
- Santiago Ilutovich
- Sara De Cima-Iglesias
- Sarah Gillis
- Satar Mortaza
- Satoru Futami
- Satyanarayana Reddy Mukkera
- Savino Spadaro
- Scott H Beegle
- Sebastien L Besset
- Sekine Ryosuke
- Sen-Kuang Hou
- Serena Knowles
- Serge J Heines
- Sergio Canestrini
- Sergio Mataloun
- Sergio Scafetti
- Seyed Mohammadreza Hashemian
- Shailesh Bihari
- Shazia Choudry
- Shigeki Saito
- Shin Nunomiya
- Shou H Wang
- Shreedhar Kulkarni
- Shu H Qin
- Shuhei Matsumoto
- Shunsuke Takagi
- Silvia Castro
- Silvia Iglesias Moles
- Silvia L Nunes
- Silvia Rodriguez Ruiz
- Silvina A Borello
- Silvio A Ñamendys-Silva
- Silvius Ioan Negoita
- Simon K Chau
- Sinead C Okane
- Siu-Ming Au
- Slaheddine Bouchoucha
- Sophie Symmonds
- Souheil Elatrous
- Stefan Bolon
- Stuart Mckechnie
- Subhal B Dixit
- Sudha V Sagar
- Suleyman S Derman
- Suming Zhou
- Suresh Pillai
- Suresh Shindhe
- Susan M Marum
- Susana TempranoSusana
- Susanne Schäfer
- Sylvie Ricome
- Szabolcs Rugonfalvi
- Sánchez I Rafael
- Sébastien Jochmans
- T John Trinder
- Tadaaki Takada
- Takeshi Ueda
- Tamas Szakmany
- Tao Yu
- Tarek Dendane
- Teresa Honrubia
- Tharwat M Aisa
- Theonymfi G Papavasilopoulou
- Thierry Sottiaux
- Thomas Baltus
- Thomas C Blakeman
- Thomas Collyer
- Thomas Kander
- Thomas Staudinger
- Thompson B. Taylor
- Tie H Qin
- Tim Wenham
- Tomas P Roser
- Tomaz MesarJarone Lee
- Tommaso Fossali
- Tomoaki Hashida
- Tomofumi Harasawa
- Tomoyuki Nakamura
- Toni E McKenna
- Toshikazu Abe
- Trevor W Oetting
- Troy S Browne
- Tài Pham
- Tài Pham
- Tài Pham
- Ulrich Strauch
- Ushio Higashijima
- Valeria I Cerrato
- Valerie M Banner-Goodspeed
- Vallish K Bhardwaj
- Vallverdu P Imma
- Van Haren Frank
- Vanessa M Sales
- Vania A Brito
- Varsha Kadaba
- Vasilis Ourailogloy
- Venika Manoharan
- Venkatapura J Ramesh
- Veronica Villar
- Vesna Bumbasierevic
- Vesna Bumbasirevic
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Schiavone
- Virginie Lemiale
- Vivek Kakar
- Vladimir Cerny
- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- William Stigler
- Wrigge Hermann
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- Yaseen M Arabi
- Yasuaki Ogino
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- Yves D Jarquin-Badiola
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Ángela Algaba
- Ángela González-Salamanca
- Publication venue
- 'European Respiratory Society (ERS)'
- Publication date
- 01/01/2021
- Field of study
Background: Current incidence and outcome of patients with acute hypoxaemic respiratory failure requiring mechanical ventilation in the intensive care unit (ICU) are unknown, especially for patients not meeting criteria for acute respiratory distress syndrome (ARDS).
Methods: An international, multicentre, prospective cohort study of patients presenting with hypoxaemia early in the course of mechanical ventilation, conducted during four consecutive weeks in the winter of 2014 in 459 ICUs from 50 countries (LUNG SAFE). Patients were enrolled with arterial oxygen tension/inspiratory oxygen fraction ratio ≤300 mmHg, new pulmonary infiltrates and need for mechanical ventilation with a positive end-expiratory pressure of ≥5 cmH2O. ICU prevalence, causes of hypoxaemia, hospital survival and factors associated with hospital mortality were measured. Patients with unilateral versus bilateral opacities were compared.
Findings: 12 906 critically ill patients received mechanical ventilation and 34.9% with hypoxaemia and new infiltrates were enrolled, separated into ARDS (69.0%), unilateral infiltrate (22.7%) and congestive heart failure (CHF; 8.2%). The global hospital mortality was 38.6%. CHF patients had a mortality comparable to ARDS (44.1% versus 40.4%). Patients with unilateral-infiltrate had lower unadjusted mortality, but similar adjusted mortality compared to those with ARDS. The number of quadrants on chest imaging was associated with an increased risk of death. There was no difference in mortality comparing patients with unilateral-infiltrate and ARDS with only two quadrants involved.
Interpretation: More than one-third of patients receiving mechanical ventilation have hypoxaemia and new infiltrates with a hospital mortality of 38.6%. Survival is dependent on the degree of pulmonary involvement whether or not ARDS criteria are reached
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study
- Author
- Aage Christiansen
- Aaron Venti
- Abdellatif Benslama
- Adam B Schlichting
- Adenilton M Rampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Ahmad Yazid BinHJAbul Wahab
- AhmedS AlJabbary
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Albaiceta Guillermo M
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alejandro Rojas
- Alek Kumar
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandre Demoule
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alistair Nichol
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amado-Rodríguez Laura
- Amanda Krstevski
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Ana Carolina P Antônio
- Ana G França
- Ana M Pellicer
- Anais Briquet
- AnaM Araujo
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Anders Larsson
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andres Esteban
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- Angela Delsing
- Aniko D Frigyik
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna Rossi
- Anna-Karin Morin
- AnnaT Dowling
- Anne Adolfsson
- AnneB Guttormsen
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
- Antonio P Nassar Jr
- Antonio Pesenti
- AntonioG Jimenez
- AntonioL RuizAguilar
- António M Alvarez
- António M Messias
- Aogan C O'Muircheartaigh
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arthur S Slutsky
- Arvind K Baronia
- Ashley Schomer
- Ashok S Raj
- Asisclo Villagomez
- AsiscloJ Villagomez
- Asma Ben Souissi
- Aurelia M Martinho
- Aylin Seven
- B Taylor Thompson
- Bao H Zhu
- Barbara Brunettini
- Barrett T Kitch
- Barry Kennedy
- Basak Ceyda Meco
- Beatriz C Tan
- Bellani Giacomo
- Bernard Goubaux
- Bernhard Holzgraefe
- Bhagyesh Shah
- Bin Li
- Bingyu Qin
- Bojan Jovanovic
- BorisG Villamagua
- Brigit L Roberts
- BritÅ Sjøbø
- Bruno Gelée
- Bruno S Oliveira
- Candelaria De Haro
- Carlo A Volta
- Carlos A Pellegrini
- Carlos S Pereira
- Carolina S Insaurralde
- Carolina Serra
- Caroline Berghe
- Caroline C MacFie
- Catalina Forteza
- Cecilia Carbayo-Gorriz
- Cecilia Hermosa
- Ceri E Battle
- Cesar A Cortez
- CesarP Perez
- Charing Kim S Zantua
- Charlene Bigot
- Charlene Le Moal
- Christian C Rylander
- Christian Dellera
- ChristianM Ramirez-Alfaro
- Christina Whitehead
- Christopher Nutt
- Christopher Tainter
- ChristopherJ Scott
- Chunting Wang
- Claine Judy
- Claire Reynolds
- Clare Mellis
- Claude Guérin
- Claudia A Ortiz
- Claudia R Estrella
- Claudio H Gonçalves
- Claudio Piras
- Colette Seasman
- Colin McArthur
- ColinK Grissom
- ColinS Black
- CorcolesG Virgilio
- Corinne Leemann-Refondini
- Cristina M Coxo
- Cristina Santos
- Cédric Daubin
- Daisuke Niimi
- DaleJ Yeatts
- Damien Roux
- Dan E Corneci
- Dan Hadfield
- Dana R Tomescu
- Daniel O Beraldo
- Daniel R Crouch
- Daniel R Crouch
- Daniel R Gonzalez
- Daniel V Collins
- Daniela Albiero
- Daniela M Palma
- Daniela N Vasquez
- DanieleM Combaux
- DanielF McAuley
- DanielF McAuley
- Danielle A Fawkes
- Danielle C Fontenele
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- Danielle Reuter
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- Danny McAuley
- Dany Goldgran-Toledano
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- Deborah M Inskip
- Deeban Ganesan
- Denis Doyen
- Diego Pastor Marcos
- Dimitrios Matamis
- Dina Gomaa
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- Dorothée Carpentier
- Dulce Dector
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- Eduardo Beck
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- Eizo Watanabe
- Eldar Søreide
- Electra E Stamou
- Elena Frati
- Elena Gallego Curto
- Elena Perez Losada
- Eleni K Mouloudi
- Eleni V Massa
- Elie H Zogheib
- Elisa Estenssoro
- Elisabetta Pecci
- EliseP Sauvadet
- Ellada V Kiourtzieva
- Emilio M Osman
- EmmaL Willett
- Emre Erbabacan
- Enrique A Piacentini
- Enrique Cereijo
- Erika E Borotto
- Erin Nishikawa
- Esther Bermejo Lopez
- Esther Diaz-Rodriguez
- EttoreR Vascotto
- Eva O Nagy
- Evangelos Kalaitzis
- Evgeny Grigoriev
- Ewan C Goligher
- Fa C Zhou
- Fabien Grelon
- Fabienne D Simonis
- Fabio Tarantino
- Fabrice Daviaud
- Fahd Amir
- Fan Zhang
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- Farshad Heidari
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- Felipe A Aliaga
- Felipe T Martinez
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- Fernando Rios
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- Filipa M Barros
- Finn H Andersen
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- Fumihito Ito
- Gabriel Démpaire
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- Giulia Crapelli
- Giuseppe Foti
- Gonzalo Navarro
- Gordon Rubenfeld
- Guillaume Barberet
- Guillaume Carteaux
- Guillermo Bugedo
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- Gustavo M Montanha
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- Gyorgy Frendl
- Haibo Qiu
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- Hamidreza Jamaati
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- Helen J Rodgers
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- Ingeborg D Welters
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- Janet S Aguirre
- Jarone Lee
- Jason E Cohen
- Javier Alvarez
- Javier Blanco
- Javier E Salas
- Javier G Alonso
- Javier Hurtado
- Javier Hurtado
- Javier Hurtado
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- Jean-Daniel Chiche
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- Kansuke Koyama
- Karen E Williams
- Karina Jakubowska
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- Karl M Knapman
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- Katsunori Mochizuki
- Kaushik Bhowmick
- Kazuya Ichikado
- Kazuyoshi Shimizu
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- Ken Parhar
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- Patricio H Garcia
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- PaulaJ Hutton
- Pawel Andruszkiewicz
- Peter Alexander
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- Radhakrishnan Muthuchellappan
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- Raphael Cooper
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- Raquel Montoiro Allue
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- Raymond Mckee
- Rebecca M Baro
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- Renaud M Gueret
- Renhua Sun
- Rhiannon Chapman
- Ricardo Diaz Abad
- Riccardo Colombo
- Richard O Adamsson
- Richard Stewart
- Rik Verstraete
- Risso V Alejandro
- Rita Glietsch
- Rob Cirone
- Robert J Hessell
- RobertL Owens
- Roberto Jimenez Sanchez
- RobertoR Biscione
- Robyn A Hutchison
- Rocío Manzano Sánchez
- Rodrigo S Biondi
- Rodríguez-Garcia Raquel
- Rola F Jaafar
- Romain Tapponnier
- Romano Graziani
- Ronald Zumaran Aguilar
- Rongguo Yu
- Rory Dwyer
- Rosa S Alda
- Rosaleen Macfadyen
- Rossini Abbie B Pasanting-Lim
- Ruben O Fernandez
- Ruben Rodriguez
- Rui M Gomes
- Rui Tang
- Ruiqiang Zheng
- Russel R Miller
- Russell Chabanne
- Russell M Allan
- Ruth O Griffin
- Ryan J Gosselin
- S M Hashemian
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- Sally K Humphreys
- Salma Kamoun
- Salvatore Palmese
- SamanthaJ Hagan
- Sameer A Jog
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- Samy Khebbeb
- San Isidro
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- Sandrine Thibault
- Sangeeta Mehta
- Santhana G Kannan
- Santiago Ilutovich
- Sara De Cima-Iglesias
- Sara Sher
- Sarah Gillis
- Satar Mortaza
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- Savino Spadaro
- Scott H Beegle
- Sebastien L Besset
- Sekine Ryosuke
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- Sergio Scafetti
- Seyed Mohammadreza Hashemian
- Shailesh Bihari
- Shazia Choudry
- Shigeki Saito
- Shin Nunomiya
- ShouH Wang
- Shreedhar Kulkarni
- Shu H Qin
- Shuhei Matsumoto
- Shunsuke Takagi
- Silvia Castro
- Silvia Iglesias Moles
- Silvia Rodriguez Ruiz
- SilviaL Nunes
- Silvina A Borello
- Silvio A Ñamendys-Silva
- Silvius Ioan Negoita
- SimonK Chau
- Sinead C Okane
- Slaheddine Bouchoucha
- Sophie Symmonds
- Souheil Elatrous
- Stefan Bolon
- Stuart Mckechnie
- Subhal B Dixit
- Sudha V Sagar
- SuleymanS Derman
- Suming Zhou
- Suresh Pillai
- Suresh Shindhe
- Susan M Marum
- Susana Temprano
- Susanne Schäfer
- Sylvie Ricome
- Szabolcs Rugonfalvi
- Sánchez I Rafael
- Sébastien Jochmans
- T John Trinder
- Tadaaki Takada
- Takeshi Ueda
- Tamas Szakmany
- Tao Yu
- Tarek Dendane
- Teresa Honrubia
- Tharwat M Aisa
- Theonymfi G Papavasilopoulou
- Thierry Sottiaux
- Thomas Baltus
- Thomas C Blakeman
- Thomas Collyer
- Thomas Kander
- Thomas Staudinger
- Tie H Qin
- Tim Wenham
- Tomas P Roser
- Tomaz Mesar
- Tommaso Fossali
- Tomoaki Hashida
- Tomofumi Harasawa
- Tomoyuki Nakamura
- Toni E McKenna
- Toshikazu Abe
- Trevor W Oetting
- Troy S Browne
- Ulrich Strauch
- Ushio Higashijima
- Valeria I Cerrato
- Valerie M BannerGoodspeed
- VallishK Bhardwaj
- Vallverdu P Imma
- Vanessa M Sales
- Vania A Brito
- Varsha Kadaba
- Vasilis Ourailogloy
- Venika Manoharan
- Venkatapura J Ramesh
- Veronica Villar
- Vesna Bumbasierevic
- Vesna Bumbasirevic
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Schiavone
- Virginie Lemiale
- Vivek Kakar
- Vladimir Cerny
- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- William Stigler
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- YaseenM Arabi
- Yasuaki Ogino
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- YvesD Jarquin-Badiola
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Ángela Algaba
- Ángela González-Salamanca
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 25/12/2022
- Field of study
Background: Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods: Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results: From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77] vs 74 [64-80] years, p < 0.001) and had lower driving (12 [8-16] vs 15 [11-17] cmH2O, p < 0.001), plateau (20 [15-23] vs 22 [19-26] cmH2O, p < 0.001) and peak (21 [17-27] vs 26 [20-32] cmH2O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60-1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16-2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06-1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52-0.93], p = 0.015) were related to survival. Conclusions: Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury. Trial registration Clinicaltrials.gov NCT02010073
Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis
- Author
- 1amendys-Silva Silvio A
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C
- Adamsson Richard O
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S
- Aguirre-Bermeo Hernan
- Aisa Tharwat M
- Aisiku Imo
- Ajetunmobi Olaitan O
- Aker Mustafa
- Akyol Onat O
- Al Dorzi Hasan M
- Al Jabbary Ahmed S
- Albaiceta Guillermo M
- Albarrak Mohamad M
- Albiero Daniela
- Alda Rosa S
- Alejandro Risso V
- Alexander Peter
- Alfonso Alec A Tallet
- Algaba \uc1ngela
- Aliaga Felipe A
- Alisasis Alain U
- Allan Russell M
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G
- Altaf Wahid
- Alvarez Ant\uf3nio M
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- Jiang Liangyan
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- Jurado M\uaa Teresa
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- Kra fler Jens
- Krstevski Amanda
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- Kurahashi Kiyoyasu
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- Laake Jon Henrik
- Labarca Eduardo F
- Laffey John
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- Larsson Anders
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- Martinho Aurelia M
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- Mataloun Sergio
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- Matthay Michael A
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- Messika Jonathan
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- Miller Russel R
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- Mirabella Lucia
- Mizuguchi Ichiko
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- Mojoli Francesco
- Moles Silvia Iglesias
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- Monteiro Jorge M
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- Montini Luca M
- Moock Marcelo
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- Nakamura Tomoyuki
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- Nassar Jr Antonio P
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- Neal John
- Negoita Silvius Ioan
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- Nielsen Jonas
- Nielsen Jonas
- Niimi Daisuke
- Nin Nicolas
- Nishikawa Erin
- Nitta Kenichi
- Nobrega Danielle
- Noremark Kim Andre L
- Nu\uf1ez Edgardo
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- Nunes Silvia L
- Nunomiya Shin
- Nutt Christopher
- Nygren Ingela
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- Oldroyd Matthew G
- Olga Moreno F
- Oliveira Bruno S
- Oneill Orla
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- Oscanoa Fredy A Montes
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- Palmese Salvatore
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- Penuelas Oscar
- Pere Cesar P
- Pereira Carlos S
- Perez Cheng Meisy
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- Piacentini Enrique A
- Pillai Suresh
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- Pittini Gustavo
- Plotnikow Gustavo A
- Poblano Manuel
- Poli Michela M
- Pota Vincenzo
- Pozo Norberto C
- Pozzi Matteo
- Preez Pieter D
- Prieto-Gonz\ue1lez Miryam
- Pronovost Antoine
- Protti Alessandro
- Qin Bingyu
- Qin Junping
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- Qin Tie H
- Qiu Haibo
- Qiu Haibo
- Raaijmakers Monique
- Rafael S\ue1nchez I
- Raimondi Ferdinando
- Raj Ashok S
- Ramakrishnan Nagarajan
- Ramesh Venkatapura J
- Ramirez-Alfaro Christian M
- Ramirez-Gutierrez Alvaro
- Ranero Jorge Luis
- Raponi Francesco
- Recio Noelia N
- Reschreiter Henrik
- Reske Andreas W
- Reuter Danielle
- Reynolds Claire
- Rezoagli Emanuele
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- Rialp Gemma
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- Ricome Sylvie
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- Rodriguez Ruben
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- Rugonfalvi Szabolcs
- Ruiz Silvia Rodriguez
- Ruiz-Aguilar Antonio L
- Rylander Christian C
- Ryosuke Sekine
- S\ue1nchez Roc\uedo Manzano
- S\ue1nchez-Ballesteros Jes\ufas
- S\uf8reide Eldar
- Sabelnikovs Olegs
- Sable Safal D
- Saenz Mar\ueda G
- Saez Alejandro A
- Sagar Sudha V
- Saito Koji
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- Sales Vanessa M
- Samkaoui Nacer
- Sanchez Roberto Jimenez
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- Sanchez-Medina Jorge R
- Sandesc Dorel
- Santoli Francesco L
- Santos Cristina
- Sarma Aartik
- Sauvadet Elise P
- Savioli Monica
- Scafetti Sergio
- Sch\ue4fer Susanne
- Schi\uf6ler Fredrik
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schlichting Adam B
- Schneider Francis
- Schomer Ashley
- Schouten Jeroen A
- Schuetz Michael
- Schultz Marcus J
- Scott Christopher J
- Seasman Colette
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- Seoane-Quiroga Leticia
- Serra Carolina
- Serra Isabel M
- Setten Mariano G
- Seven Aylin
- Shah Bhagyesh
- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shindhe Suresh
- Shinn Iii John O
- Shiozaki Kyoko
- Silesky Jimenez Juan I
- Silesky Juan
- Sim Malcolm
- Simon Philipp
- Simonis Fabienne D
- Sinha Pratik
- Sivashanmugave Mageswaran
- Sj\uf8b\uf8 Brit \uc5
- Sklienka Peter
- Smith Mark J
- Smith Oliver
- Soler Juan Alfonso
- Solis-Quesada Jaime E
- Sottiaux T
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra E
- Stansil Frank
- Staudinger Thomas
- Steinberg Jack
- Stephenson Lorraine
- Stewart Richard
- Stigler William
- Sula Hektor
- Sun Renhua
- Surbatovic Maja
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Tabhan Edgardo
- Tabhan Edgardo E
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tan Beatriz C
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Temprano Susana
- Terragni Pierpaolo
- Terzi Nicolas
- Thibault Sandrine
- Thomas Rajeev R Jha Matthew
- Thompson Marlus M
- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana R
- Toribio D\ue1cil Parrilla
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T John
- Trinidad Olivia A
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- Van Haren Frank
- Van Wezel Hellen M
- Vargas Monica P
- Vascotto Ettore R
- Vasquez Daniela N
- Vega Luis D
- Veljovic Milic
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Vessel Kathryn
- Villagomez Asisclo
- Villagomez Asisclo J
- Villamagua Boris G
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G
- Vitale Michela N
- Volta Carlo A
- Wang Chunting
- Wang Chunxue
- Wang Hua X
- Wang Shou H
- Wang Wei
- Ware Lorraine B
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg D
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Wickersham Nancy
- Willett Emma L
- Williams Alexandra J
- Williams Karen E
- Wise Matt P
- Wittebole Xavier
- Wong Helen S
- Woods Paul W
- Wrathall David W
- Wrigge Hermann
- Wu Ya Q
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L
- Yeatts Dale J
- Yoshido Hector H Leon
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S
- Yuste Luis J
- Zacharas Giannis A
- Zacharowski Kai D
- Zani Gianluca
- Zantua Kim S
- Zazu Alan
- Zeggwagh Amine Ali
- Zeggwagh Amine Ali
- Zender Herv\ue9 O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y
- Zhao Huiying
- Zhao Jun
- Zhao Wendi
- Zhao Xian Y
- Zheng Ruiqiang
- Zhou Fa C
- Zhou Suming
- Zhu Bao H
- Zhu Wei H
- Zhuo Hanjing
- Zogheib Elie H
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
International audienceTwo acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and differential treatment responses have been identified using latent class analysis (LCA) in seven individual cohorts. To facilitate bedside identification of subphenotypes, clinical classifier models using readily available clinical variables have been described in four randomised controlled trials. We aimed to assess the performance of these models in observational cohorts of ARDS. Methods: In this observational, multicohort, retrospective study, we validated two machine-learning clinical classifier models for assigning ARDS subphenotypes in two observational cohorts of patients with ARDS: Early Assessment of Renal and Lung Injury (EARLI; n=335) and Validating Acute Lung Injury Markers for Diagnosis (VALID; n=452), with LCA-derived subphenotypes as the gold standard. The primary model comprised only vital signs and laboratory variables, and the secondary model comprised all predictors in the primary model, with the addition of ventilatory variables and demographics. Model performance was assessed by calculating the area under the receiver operating characteristic curve (AUC) and calibration plots, and assigning subphenotypes using a probability cutoff value of 0·5 to determine sensitivity, specificity, and accuracy of the assignments. We also assessed the performance of the primary model in EARLI using data automatically extracted from an electronic health record (EHR; EHR-derived EARLI cohort). In Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE; n=2813), a multinational, observational ARDS cohort, we applied a custom classifier model (with fewer variables than the primary model) to determine the prognostic value of the subphenotypes and tested their interaction with the positive end-expiratory pressure (PEEP) strategy, with 90-day mortality as the dependent variable. Findings: The primary clinical classifier model had an area under receiver operating characteristic curve (AUC) of 0·92 (95% CI 0·90–0·95) in EARLI and 0·88 (0·84–0·91) in VALID. Performance of the primary model was similar when using exclusively EHR-derived predictors compared with manually curated predictors (AUC=0·88 [95% CI 0·81–0·94] vs 0·92 [0·88–0·97]). In LUNG SAFE, 90-day mortality was higher in patients assigned the hyperinflammatory subphenotype than in those with the hypoinflammatory phenotype (414 [57%] of 725 vs 694 [33%] of 2088; p<0·0001). There was a significant treatment interaction with PEEP strategy and ARDS subphenotype (p=0·041), with lower 90-day mortality in the high PEEP group of patients with the hyperinflammatory subphenotype (hyperinflammatory subphenotype: 169 [54%] of 313 patients in the high PEEP group vs 127 [62%] of 205 patients in the low PEEP group; hypoinflammatory subphenotype: 231 [34%] of 675 patients in the high PEEP group vs 233 [32%] of 734 patients in the low PEEP group). Interpretation: Classifier models using clinical variables alone can accurately assign ARDS subphenotypes in observational cohorts. Application of these models can provide valuable prognostic information and could inform management strategies for personalised treatment, including application of PEEP, once prospectively validated. Funding: US National Institutes of Health and European Society of Intensive Care Medicine