The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase

The Athena X-ray Integral Unit (X-IFU) is the high resolution X-ray spectrometer, studied since 2015 for flying in the mid-30s on the Athena space X-ray Observatory, a versatile observatory designed to address the Hot and Energetic Universe science theme, selected in November 2013 by the Survey Science Committee. Based on a large format array of Transition Edge Sensors (TES), it aims to provide spatially resolved X-ray spectroscopy, with a spectral resolution of 2.5 eV (up to 7 keV) over an hexagonal field of view of 5 arc minutes (equivalent diameter). The X-IFU entered its System Requirement Review (SRR) in June 2022, at about the same time when ESA called for an overall X-IFU redesign (including the X-IFU cryostat and the cooling chain), due to an unanticipated cost overrun of Athena. In this paper, after illustrating the breakthrough capabilities of the X-IFU, we describe the instrument as presented at its SRR, browsing through all the subsystems and associated requirements. We then show the instrument budgets, with a particular emphasis on the anticipated budgets of some of its key performance parameters. Finally we briefly discuss on the ongoing key technology demonstration activities, the calibration and the activities foreseen in the X-IFU Instrument Science Center, and touch on communication and outreach activities, the consortium organisation, and finally on the life cycle assessment of X-IFU aiming at minimising the environmental footprint, associated with the development of the instrument. Thanks to the studies conducted so far on X-IFU, it is expected that along the design-to-cost exercise requested by ESA, the X-IFU will maintain flagship capabilities in spatially resolved high resolution X-ray spectroscopy, enabling most of the original X-IFU related scientific objectives of the Athena mission to be retained. (abridged).Comment: 48 pages, 29 figures, Accepted for publication in Experimental Astronomy with minor editin

Planck pre-launch status : The Planck mission

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The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase

The Athena X-ray Integral Unit (X-IFU) is the high resolution X-ray spectrometer studied since 2015 for flying in the mid-30s on the Athena space X-ray Observatory. Athena is a versatile observatory designed to address the Hot and Energetic Universe science theme, as selected in November 2013 by the Survey Science Committee. Based on a large format array of Transition Edge Sensors (TES), X-IFU aims to provide spatially resolved X-ray spectroscopy, with a spectral resolution of 2.5 eV (up to 7 keV) over a hexagonal field of view of 5 arc minutes (equivalent diameter). The X-IFU entered its System Requirement Review (SRR) in June 2022, at about the same time when ESA called for an overall X-IFU redesign (including the X-IFU cryostat and the cooling chain), due to an unanticipated cost overrun of Athena. In this paper, after illustrating the breakthrough capabilities of the X-IFU, we describe the instrument as presented at its SRR (i.e. in the course of its preliminary definition phase, so-called B1), browsing through all the subsystems and associated requirements. We then show the instrument budgets, with a particular emphasis on the anticipated budgets of some of its key performance parameters, such as the instrument efficiency, spectral resolution, energy scale knowledge, count rate capability, non X-ray background and target of opportunity efficiency. Finally, we briefly discuss the ongoing key technology demonstration activities, the calibration and the activities foreseen in the X-IFU Instrument Science Center, touch on communication and outreach activities, the consortium organisation and the life cycle assessment of X-IFU aiming at minimising the environmental footprint, associated with the development of the instrument. Thanks to the studies conducted so far on X-IFU, it is expected that along the design-to-cost exercise requested by ESA, the X-IFU will maintain flagship capabilities in spatially resolved high resolution X-ray spectroscopy, enabling most of the original X-IFU related scientific objectives of the Athena mission to be retained. The X-IFU will be provided by an international consortium led by France, The Netherlands and Italy, with ESA member state contributions from Belgium, Czech Republic, Finland, Germany, Poland, Spain, Switzerland, with additional contributions from the United States and Japan.The French contribution to X-IFU is funded by CNES, CNRS and CEA. This work has been also supported by ASI (Italian Space Agency) through the Contract 2019-27-HH.0, and by the ESA (European Space Agency) Core Technology Program (CTP) Contract No. 4000114932/15/NL/BW and the AREMBES - ESA CTP No.4000116655/16/NL/BW. This publication is part of grant RTI2018-096686-B-C21 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”. This publication is part of grant RTI2018-096686-B-C21 and PID2020-115325GB-C31 funded by MCIN/AEI/10.13039/501100011033

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

ETUDE EXPERIMENTALE DE L'INFLUENCE DE L'AERODYNAMIQUE SUR LE COMPORTEMENT ET LA STRUCTURE DU FRONT DE FLAMME DANS LES CONDITIONS D'UN MOTEUR A ALLUMAGE COMMANDE

ORLEANS-BU Sciences (452342104) / SudocSudocFranceF

Évolution de la fonction visuelle après adénomectomie hypophysaire

Les adénomes hypophysaires peuvent entraîner une altération de la fonction visuelle, classiquement une hémianopsie bitemporale. Nous avons étudié après adénomectomie la cinétique de récupération de l'acuité visuelle et du champ visuel à long terme. Nous avons réalisé une étude rétrospective des patients opérés avec succès d'un adénome hypophysaire par voie transphénoïdale entre 1986 et 2005 au CHU d'Angers. Les paramètres étudiés principaux étaient la déviation globale et la déviation dans chaque quadrant des champs visuels, ainsi que l'acuité visuelle de loin. Trente sept patients ont été inclus, 23 hommes et 14 femmes âgés en moyenne de 52 ans [22 -77]. Le recul moyen était de 17 mois [1 -36]. Les examens étaient réalisés à 1 mois, 2 mois, puis tous les six mois. La cinétique d'évolution de l'acuité visuelle montre une phase de récupération rapide jusqu'à 2 mois sans récupération tardive au delà. La cinétique d'évolution des champs visuels montre une phase de récupération rapide jusqu'à 2 mois, une seconde phase plus lente de 2 à 13 mois concernant le secteur temporal et nasal. Le secteur temporal est le plus atteint et conserve un déficit séquellaire plus important que l'hémi champ nasal. Ces deux phases de récupération reflètent probablement des phénomènes biologiques différents tels que la récupération des flux axonaux et la remyélinisation. Les facteurs prédictifs préopératoires d'une meilleur récupération visuelle dans cette étude ont été, l'absence de pâleur papillaire et le jeune âge ; dans la littérature on retrouve également la courte durée des symptômes et une acuité supérieure à 20/100. Tout ceci justifie un suivi ophtalmologique régulier.ANGERS-BU Médecine-Pharmacie (490072105) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

SIDGET: A first composite clock prototype

International audienc

Résistances bactériennes et consommations d'antibiotiques en réanimation à Bichat en 2002 et 2003 (état des lieux et comparaison à trois autres réanimations)

PARIS6-Bibl.Pitié-Salpêtrie (751132101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Experimental Investigation of a Small-Scale Organic Rankine Cycle Turbo-Generator Supported on Gas-Lubricated Bearings

Waste heat recovery (WHR) is expected to contribute to reducing CO2 emissions from trucks. Organic Rankine cycle (ORC) systems show the highest potential for this application, but still lack efficient small-scale expansion devices, in practice. A novel turbogenerator (TG) supported on gas-lubricated bearings is presented in this paper. The device combines a single-stage radial-inflow turbine and a permanent-magnet machine in a single rotating part supported on aerodynamic bearings, lubricated with the working fluid (R245fa). The oil-free expander was tested within a dedicated ORC test setup. It was driven up to its nominal speed of 100 krpm, generated up to 2.3 kW of electrical power, and reached a peak overall efficiency of 67%. Although the prototype was not actively cooled, the mechanical losses of the rotor shaft and the iron loss of the electrical machine reached their nominal levels. Only the copper loss was at a part-load level. The electromechanical efficiency of the TG reached 91% and is expected to increase while testing the device at higher load. This proof of concept confirms the high-speed and low-loss potential of gas-lubricated bearings for small-scale dynamic expanders