251 research outputs found
Children’s and adolescent’s self - assessment of metabolic control versus professional judgment: a cross-sectional retrospective and prospective cohort study
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- 'Springer Science and Business Media LLC'
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Full text linkPrecise measurement of the W-boson mass with the CDF II detector
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- Aaltonen T.
- Abbaneo D
- Adzic P
- Aguilar-Benitez M
- Ahmad M
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
Get PDFWe have measured the W-boson mass MW using data corresponding to 2.2/fb of
integrated luminosity collected in proton-antiproton collisions at 1.96 TeV
with the CDF II detector at the Fermilab Tevatron collider. Samples consisting
of 470126 W->enu candidates and 624708 W->munu candidates yield the measurement
MW = 80387 +- 12 (stat) +- 15 (syst) = 80387 +- 19 MeV. This is the most
precise measurement of the W-boson mass to date and significantly exceeds the
precision of all previous measurements combined
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
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- Yilmaz Y
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- Yumiceva F
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- Zatserklyaniy A
- Zeinali M
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- Zeuner WD
- Zeyrek M
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- Zheng Y
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- Zhu RY
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- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
Get PDFThe performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
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- Abbiendi G
- Abbrescia M
- Abdullin S
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- Christiansen T
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- Yilmaz Y
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- Yumiceva F
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- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
Get PDFThe performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
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- Abbiendi G
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- Yilmaz Y
- Yohay R
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- Yumiceva F
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- Zakaria M
- Zalewski P
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- Zhukov V
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- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
Get PDFThe azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
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- 'IOP Publishing'
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- Field of study
Get PDFThe Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Post-drug consequences of chronic atypical antipsychotic drug administration on the ability to adjust behavior based on feedback in young monkeys
- Author
- A Schotte
- Alan Unis
- AN Samaha
- B Levinson
- C Kellendonk
- D Wahlstrom
- DJ Mandell
- Dorothy J. Mandell
- EK Lambe
- FI Tarazi
- FI Tarazi
- Gene P. Sackett
- GJ Pandina
- GJ Pandina
- HC Margolese
- HF Harlow
- HF Harlow
- HW Reese
- HY Meltzer
- JR Bishop
- JW Haycock
- KD Chang
- L Tremblay
- LI Anderson
- MG Aman
- P Seeman
- PGF Browning
- R Cools
- R Cools
- RA Kowatch
- SL Andersen
- SL Andersen
- T Gunther
- T Kuroki
- T Moran-Gates
- W Aichhorn
- W Schultz
- Y Roke
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
Get PDFGenomic and Proteomic Analysis of the Impact of Mitotic Quiescence on the Engraftment of Human CD34+ Cells
- Author
- A Evangelou
- A Gothot
- A Gothot
- A Gothot
- A Rosemary Siafakas
- AC Ladd
- AI Saeed
- AI Saeed
- AS Rakeman
- AV Terskikh
- B Futcher
- Brahmananda Reddy Chitteti
- C Nunez
- DH Geschwind
- Dimas Covas
- DR Senger
- Edward F. Srour
- F Liu
- G de Haan
- G Dennis Jr
- GA Colvin
- H Wang
- HK Habibian
- I Roeder
- I Staniszewska
- J Guhaniyogi
- J Ross
- J Wilpshaar
- J Wilpshaar
- JE Till
- L Anderson
- M Mielcarek
- M Ogawa
- M Ramalho-Santos
- M Yamauchi
- MA Kirkland
- MM Bradford
- NB Ivanova
- PC Chulada
- PGF Dawn
- PJ Quesenberry
- PJ Quesenberry
- PJ Quesenberry
- PS Hegde
- Q Tian
- Q Zhan
- QH Sheng
- R Snodgrass
- RA Young
- RE Higgs
- RL Phillips
- S Abramson
- SP Gygi
- SR Hough
- SS Nunes
- W Huang da
- W Tao
- Y Takada
- YC Kim
- Yunlong Liu
- Z Li
- ZQ Wang
- Publication venue
- Public Library of Science
- Publication date
- 07/03/2011
- Field of study
Get PDFIt is well established that in adults, long-term repopulating hematopoietic stem cells (HSC) are mitotically quiescent cells that reside in specialized bone marrow (BM) niches that maintain the dormancy of HSC. Our laboratory demonstrated that the engraftment potential of human HSC (CD34+ cells) from BM and mobilized peripheral blood (MPB) is restricted to cells in the G0 phase of cell cycle but that in the case of umbilical cord blood (UCB) -derived CD34+ cells, cell cycle status is not a determining factor in the ability of these cells to engraft and sustain hematopoiesis. We used this distinct in vivo behavior of CD34+ cells from these tissues to identify genes associated with the engraftment potential of human HSC. CD34+ cells from BM, MPB, and UCB were fractionated into G0 and G1 phases of cell cycle and subjected in parallel to microarray and proteomic analyses. A total of 484 target genes were identified to be associated with engraftment potential of HSC. System biology modeling indicated that the top four signaling pathways associated with these genes are Integrin signaling, p53 signaling, cytotoxic T lymphocyte-mediated apoptosis, and Myc mediated apoptosis signaling. Our data suggest that a continuum of functions of hematopoietic cells directly associated with cell cycle progression may play a major role in governing the engraftment potential of stem cells. While proteomic analysis identified a total of 646 proteins in analyzed samples, a very limited overlap between genomic and proteomic data was observed. These data provide a new insight into the genetic control of engraftment of human HSC from distinct tissues and suggest that mitotic quiescence may not be the requisite characteristic of engrafting stem cells, but instead may be the physiologic status conducive to the expression of genetic elements favoring engraftment
Cost-effectiveness and cost-utility analyses of hospital-based home care compared to hospital-based care for children diagnosed with type 1 diabetes; a randomised controlled trial; results after two years’ follow-up
- Author
- A American Diabetes
- A Gerber-Grote
- A Wennick
- A Wennick
- Annelie Carlsson
- B Milton
- Björn Lindgren
- C Sparud-Lundin
- C Sparud-Lundin
- CA Estabrooks
- DG Altman
- DP Group
- E Heintz
- I Tiberg
- I Tiberg
- I Tiberg
- I Tiberg
- I Tiberg
- I Tiberg
- IM Hein
- Inger Hallström
- Irén Tiberg
- J Brazier
- J Raftery
- J Rycroft-Malone
- JE Brazier
- JN Kostraba
- JW Varni
- JW Varni
- JW Varni
- K Bolin
- K Hawthorne
- K Steen Carlsson
- KF Schulz
- KN Tonyushkina
- L Jönsson
- L Lowes
- L Lowes
- L Lowes
- LM Siminerio
- LO Persson
- M Sullivan
- M Sullivan
- M Sullivan
- ME Craig
- MF Drummond
- PGF Swift
- S Sjöblad
- T Simell
- WR Shadish
- Y Berhan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Full text linkImproved Cellular Specificity of Plasmonic Nanobubbles versus Nanoparticles in Heterogeneous Cell Systems
- Author
- A Vogel
- A Vogel
- AE Prigodich
- AWG Adamson
- B Kim
- BD Chithrani
- BD Chithrani
- Brian P. Danysh
- C Loo
- C Yao
- CF Bohren
- CM Pitsillides
- CP Lin
- CP Yao
- D Lapotko
- D Lapotko
- D Lapotko
- D Lapotko
- D Lapotko
- D Lapotko
- D Mandal
- D Peer
- D Pissuwan
- D Stevenson
- Daniel D. Carson
- Daniel S. Wagner
- Derek L. Shenefelt
- Dmitri O. Lapotko
- DO Lapotko
- DO Lapotko
- DP O'Neal
- DS Wagner
- E Boisselier
- E Hleb
- E Hleb
- E Lukianova-Hleb
- E Lukianova-Hleb
- E Lukianova-Hleb
- E Lukianova-Hleb
- E Lukianova-Hleb
- Ekaterina Y. Lukianova-Hleb
- EY Hleb
- EY Lukianova-Hleb
- EY Lukianova-Hleb
- EY Lukianova-Hleb
- EY Lukianova-Hleb
- EY Lukianova-Hleb
- EY Lukianova-Hleb
- F Wang
- G Mie
- G Oberdoester
- G Qin
- G Wu
- GB Braun
- H Meng
- HK Sajja
- HT Haigler
- I Sokolov
- IH El-Sayed
- J Neumann
- J Yguerabide
- J Yguerabide
- JL Li
- JL West
- K Cho
- K Sokolov
- L Anderson
- L François
- L Paasonen
- L Paasonen
- L Tong
- L Vigderman
- L Yang
- LH Wang
- M Hu
- Mary C. Farach-Carson
- MS Hutson
- N Lewinski
- NG Khlebtsov
- NG Khlebtsov
- P Prentice
- Pamela E. Constantinou
- PD Gregor
- PGF de Gennes
- PK Jain
- R Huschka
- R Shukla
- RJ Bernardi
- RR Anderson
- Ryan Keith Roeder
- S Kumar
- S Mallidi
- S Salmaso
- V Kohli
- Vladimir A. Kulchitsky
- W Cai
- W Chen
- WCW Chan
- X Huang
- Xiangwei Wu
- Xiaoyang Ren
- XJ Liang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Get PDFThe limited specificity of nanoparticle (NP) uptake by target cells associated with a disease is one of the principal challenges of nanomedicine. Using the threshold mechanism of plasmonic nanobubble (PNB) generation and enhanced accumulation and clustering of gold nanoparticles in target cells, we increased the specificity of PNB generation and detection in target versus non-target cells by more than one order of magnitude compared to the specificity of NP uptake by the same cells. This improved cellular specificity of PNBs was demonstrated in six different cell models representing diverse molecular targets such as epidermal growth factor receptor, CD3 receptor, prostate specific membrane antigen and mucin molecule MUC1. Thus PNBs may be a universal method and nano-agent that overcome the problem of non-specific uptake of NPs by non-target cells and improve the specificity of NP-based diagnostics, therapeutics and theranostics at the cell level
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