Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods: This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results: 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. Conclusions: After 100 years since the first Hartmann's procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment's choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Educomunicação e suas áreas de intervenção: Novos paradigmas para o diálogo intercultural

oai:omp.abpeducom.org.br:publicationFormat/1O material aqui divulgado representa, em essência, a contribuição do VII Encontro Brasileiro de Educomunicação ao V Global MIL Week, da UNESCO, ocorrido na ECA/USP, entre 3&nbsp;e 5 de novembro de 2016. Estamos diante de um conjunto de 104 papers executivos, com uma média de entre 7 e 10 páginas, cada um. Com este rico e abundante material, chegamos ao sétimo e-book publicado pela ABPEducom, em seus seis primeiros anos de existência. A especificidade desta obra é a de trazer as “Áreas de Intervenção” do campo da Educomunicação, colocando-as a serviço de uma meta essencial ao agir educomunicativo: o diálogo intercultural, trabalhado na linha do tema geral do evento internacional: Media and Information Literacy: New Paradigms for Intercultural Dialogue

The Genome of Anopheles darlingi, the main neotropical malaria vector

Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vectorhuman and vectorparasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles- darlingi. © 2013 The Author(s)

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Paisagens urbanas: fotografia e modernidade na cidade de Belém (1846-1908)

Paisagens Urbanas: fotografia e modernidade na cidade de Belém (1846-1908) propõe uma discussão sobre os documentos fotográficos que serviam de instrumentos de propaganda dos governantes na última década do século XIX e no início do século XX. A linguagem visual desta dissertação permite mostrar a forma como os indivíduos se fizeram representar nos cenários urbanos, dando visibilidade aos tipos sociais que foram flagrados sutilmente pelas câmeras fotográficas a serviço da propaganda do governo que tinha por objetivo divulgar uma cidade moderna, revelando a intensidade e a rapidez com que desejava alcançar a modernidade, ao mesmo tempo em que traz a luz uma cidade de acordo com os modelos provenientes da Europa, percebe-se o registro de uma outra cidade que nos remete a espaços de convivência de diferentes realidades. A imagem fotográfica, assim como outras fontes e objetos visuais, constitui-se em importantes instrumentos de investigação histórica para identificar novos objetos e novos problemas. A contribuição deste estudo se ancora no uso da fotografia como principal documento de análise para produção historiográfica, entendendo que a fotografia representa um testemunho que “fala” do passado na intensidade que o historiador a questiona. Este estudo busca analisar a relação entre fotografia e cidade a partir da narrativa visual dos álbuns e relatórios de Belém que foram produzidos no período de 1898 a 1908. A interpretação dos álbuns, enquanto narrativa que visualiza uma cidade moderna, constituí-se em uma das estratégias metodológicas para abordagem do uso da fotografia como documento para o historiador, considerando que nesse tipo de documentação pode mostrar dados dispersos ou mesmo silenciados por outras fontes de pesquisas.ABSTRACT: Paisagens Urbanas: fotografia e modernidade na cidade de Belém (1846-1908) considers a quarrel on the photographic documents that served of instruments of propaganda of the governing in the last decade of century XIX and in the beginning of century XX. The documentary of this study show the form as the individuals if they had made to represent in the urban scenes, giving visibility to the social types that had been photographed subtle by the cameras the service of the propaganda of the government. Objective to divulge a city modern, disclosing the intensity and the rapidity with that it desired to reach modernity, at the same time where a modern city brings the light in accordance with the models proceeding from the Europe, the register of a other city is perceived that in it sends the spaces of connivance of different realities. The photographic image, as well as other visual sources and objects, consists in important instruments of historical inquiry to identify to new objects and new problems. The contribution of this study if anchors in the use of the photograph as main document of analysis for historiography production, understanding that the photograph represents a certification that "speaks" of the past in the intensity that the historian questions it. This study it search to analyze the relation between photograph and city from the visual narrative of the albums and reports of Belém that had been produced in the period of 1898 the 1908. The interpretation of the albums, while narrative that visualizes a city modern, I consisted in one of the methodological strategies for boarding of the use of the photograph as document for the historian, considering that in this type of documentation it can show given dispersed or exactly silenced for other sources of research

Percepção visual da cidade: iconografias da natureza urbana de Belém (1808 – 1908)

This study proposes an analysis of urban iconography of Belém, produced during the nineteenth and early twentieth centuries. The thesis aims to analyze the representation of nature in Belém, specifically in the years 1808 to 1908. The initial commitment of the thesis concentrated on researching the various types of iconography of Belém during the nineteenth century. The questions that sought to highlight deal on how travelers seized the city in his visit to Belém, both from a narrative point of view as the visual until the year 1890. From then also identify how governments have promoted the city beyond the Amazon region. Brazilian nature It is observed that came to be represented, from the nineteenth century, through written and iconographic, that thanks to the influence of scientism and romantic artistic sensibility that permeated the knowledge of the country. The romantic sensibility made the relationship between science and esthetic to apprehend and represent nature in an overall view, inaugurating a new conception of landscape and trying to "invent" and view an urbane nature, which is the main theme of this study; is the phenomenon of urbanization, which was registere, especially by means of photography. In this type of photos, nature appears domesticated, adapted to urban design, its artful and geometric shape is valued. Urban photography from the late nineteenth century reintroduces the "ideal beauty" in the nature of the images ordered on the model of French gardens, English and Italian From assumption that contemplation of nature is adapted to the reality of the Amazon region, although they were present models from Europe. The perception of nature in the Amazon the second half of the nineteenth century, the influence of new ways of conceiving the nature were designed to cities in the redesign of spaces to form the green area, especially in Belém.. To think historically the representation of nature is to reflect on its appropriation by human action while different individuals and social groups circulated and left their specific marks in places built from a domesticated nature in the urban landscape.Este estudo propõe uma análise das iconografias urbanas de Belém, produzidas no decorrer do século XIX e início do XX. A tese tem por objetivo, então, analisar a representação da natureza em Belém, especificamente nos anos de 1808 a 1908. O compromisso inicial desse estudo se concentrou em pesquisar os diversos tipos de iconografias sobre Belém no decorrer dos Oitocentos. As questões que se procurou evidenciar tratam sobre a forma como os viajantes apreenderam a cidade, em sua passagem por Belém, tanto sob o ponto de vista narrativo quanto o visual, até os anos de 1890. A partir de então, também identificar como os governantes promoveram a cidade para além da região Amazônica. Observa-se que a natureza brasileira passou a ser representada, a partir do século XIX, por meio de linguagem escrita e iconográfica, isto graças à influência do cientificismo e da sensibilidade artística romântica, que perpassaram pelo conhecimento do país. A sensibilidade romântica realizou a aproximação entre ciência e estética ao apreender e representar a natureza, numa visão totalizante, inaugurando uma nova concepção de paisagem e a tentativa de “inventar” e visualizar uma natureza urbana, a qual é tema principal desse estudo; representa o fenômeno da urbanização que foi registrado, especialmente, por meio da fotografia. Nesse tipo de fotografias, a natureza aparece domesticada, adaptada ao desenho urbano, sua forma artificiosa e geométrica é valorizada. A fotografia urbana do final do século XIX reintroduz o “belo ideal” nas imagens da natureza ordenada segundo o modelo dos jardins franceses, ingleses e italianos. Parto do pressuposto de que a contemplação da natureza é adaptada para a realidade da região Amazônica, embora estivessem presentes modelos provenientes da Europa, mas encontram as suas especificidades a partir de uma natureza exuberante da Amazônia A percepção de natureza na Amazônia da segunda metade do século XIX e a influência de novas formas de conceber a natureza foram projetadas para as cidades na reformulação dos espaços para constituir a área verde, especialmente de Belém. Pensar historicamente a representação da natureza é refletir sobre a sua apropriação pela ação humana ao mesmo tempo em que diferentes indivíduos e grupos sociais circularam e deixaram suas marcas específicas nos lugares construídos a partir de uma natureza domesticada na paisagem urbana