Correlation and path analysis between yield and different morphological characters in Kinnow Mandarin (C. Noballis × C. Deliciosa)

A study of interrelationship and cause-effect analysis of yield of Kinnow Mandarin (C. Noballis × C. deliciosa) and its component traits for 104 and 96 trees from Indora (Location L-1) and Indpur (Location L-2) blocks of Kangra district respectively had been done in 2014-15. F-test suggested that there was significant (1.47) variation among yield characteristics between these two locations except for fruit weight (gm) and LD ratio. Results obtained from path coefficient analysis, showed that for location L-1, number of fruits per branch (0.229), plant height (0.215) and tree girth (0.212) had highest and direct effect on yield per tree whereas for location L-2, fruit weight (0.38), number of flowers per branch (0.176) and plant girth (0.161) had highest direct effect on yield per plant. Thus, number of fruits per branch, number of flowers per branch and tree girth were the most important yield components of kinnow crop which should be exploited through a breeding programme for improving its yield potential

Protective Effect of Phyllanthus niruri on DMBA/Croton Oil Mediated Carcinogenic Response and Oxidative Damage in Accordance to Histopathological Studies in Skin of Mice

The current study has been designed to unveil the preventive effect of Phyllanthus niruri extract (PNE) on two stage skin carcinogenesis and oxidative damage in Swiss albino mice. Single topical application of 7, 12-dimethylbenz (a) anthracene (DMBA), followed by croton oil thrice weekly produced 100% incidence of tumors in carcinogen control animals (Gr. III) by 16 weeks. On the other hand, oral administration of animals with PNE (1 week before of DMBA application & continued until the end of experiment, Gr. IV), significantly reduced the tumor incidence, tumor burden, tumor volume and weight and the number of tumors but  prolong the latent period of tumor occurrence, as compared with carcinogen control animals. Furthermore, administration of PNE protected against the losses provoked in levels of glutathione, Vit.C, total proteins and activity of catalase and superoxide dismutase in skin and liver of animals by the application of DMBA/croton oil, concomitantly, the levels of lipid peroxidation were also reduced significantly. P. niruri administration profoundly reverted back the pathological changes observed in skin and liver of cancerous animals. From the results, P. niruri extract proves to scavenge free radical and found to be a potent chemopreventive agent against chemical induced skin carcinogenesis. Keywords: carcinogenesis, Phyllanthus niruri, cancer chemoprevention, tumor incidence, reactive oxygen species (ROS), antioxidant enzyme

Autosomal recessive long QT syndrome, type 1 in eight families from Saudi Arabia.

One of the most common primary cardiac arrhythmia syndromes is autosomal dominant long QT syndrome, type 1 (LQT1), chiefly caused by mono-allelic mutations in the javax.xml.bind.JAXBElement@1ece3341 gene. Bi-allelic mutations in the javax.xml.bind.JAXBElement@7269232c gene are causal to Jervell and Lange-Nielsen syndrome (JLNS), characterized by severe and early-onset arrhythmias with prolonged QTc interval on surface ECG and sensorineural deafness. Occasionally, bi-allelic mutations in javax.xml.bind.JAXBElement@2001e7dc are also found in patients without any deafness, referred to as autosomal recessive long QT syndrome, type 1 (AR LQT1). We used Sanger sequencing to detect the pathogenic mutations in javax.xml.bind.JAXBElement@4f6526ea gene in eight families from Saudi Arabia with autosomal recessive LQT1. We have detected pathogenic mutations in all eight families, two of the mutations are founder mutations, which are c.387-5T>A and p.Val172Met/p.Arg293Cys ( javax.xml.bind.JAXBElement@205e407c ). QTc and cardiac phenotype was found to be pronounced in all the probands comparable to the cardiac phenotype in JLNS patients. Heterozygous carriers for these mutations did not exhibit any clinical phenotype, but a significant number of them have sinus bradycardia. To the best of our knowledge, this is the first description of a large series of patients with familial autosomal recessive LQT, type 1. These mutations could be used for targeted screening in cardiac arrhythmia patients in Saudi Arabia and in people of Arabic ancestry

Disposition kinetics and urinary excretion of ciprofloxacin in goats following single intravenous administration

We evaluated the pharmacokinetics of ciprofloxacin in serum (n = 6) and urine (n = 4) in goats following a single intravenous administration of 4 mg/kg body weight. The serum concentration-time curves of ciprofloxacin were best fitted by a two-compartment open model. The drug was detected in goat serum up to 12 h. The elimination rate constant (β) and elimination half-life (t1/2β) were 0.446 ± 0.04 h-1 and 1.630 ± 0.17 h, respectively. The apparent volume of distribution at steady state (Vdss) was 2.012 ± 0.37 l/kg and the total body clearance (ClB) was 16.27 ± 1.87 ml/min/kg. Urinary recovery of ciprofloxacin was 29.70% ± 10.34% of the administered dose within 36 h post administration. In vitro serum protein binding was 41% ± 13.10%. Thus, a single daily intravenous dose of 4 mg/kg is sufficient to maintain effective levels in serum and for 36 h in urine, allowing treatment of systemic, Gram-negative bacterial infections and urinary tract infections by most pathogens

Acoustic Diagnostics of Electrical Origin Fault Modes with Readily Available Consumer-Grade Sensors

Acoustic diagnostics, traditionally associated with mechanical fault modes, can potentially solve a wider range of monitoring applications. Typically, fault modes are induced purposefully by the researcher through physical component damage whilst the system is shutdown. This paper presents low-cost real-time fault diagnostics of a previously unreported acute electrical origin fault that manifests sporadically during system operation with no triggering intervention. A suitability study into acoustic measurements from readily available consumer-grade sensors for low-cost real-time diagnostics of audible faults, and a brief overview of the theory and configuration of the wavelet packet transform (including optimal wavelet selection methods) and empirical mode decomposition processing algorithms is also included. The example electrical origin fault studied here is an unpredictable current instability arising with the PWM-controller of a BrushLess DC motor. Experimental trials positively detect 99.9 % of the 1160 resultant high-bandwidth torque transients using acoustic measurements from a USB microphone and a smartphone. While the use of acoustic techniques for detecting emerging electrical origin faults remains largely unexplored, the techniques demonstrated here can be readily adopted for the prevention of catastrophic failure of drive and power electronic components

Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate results to policy-relevant administrative and national levels. Additionally, we provide subnational disparity analyses to provide a comprehensive overview of anemia prevalence inequalities within these countries and predict progress toward the World Health Organization’s Global Nutrition Target (WHO GNT) to reduce anemia by half by 2030. Our results demonstrate widespread moderate improvements in overall anemia prevalence but identify only three LMICs with a high probability of achieving the WHO GNT by 2030 at a national scale, and no LMIC is expected to achieve the target in all their subnational administrative units. Our maps show where large within-country disparities occur, as well as areas likely to fall short of the WHO GNT, offering precision public health tools so that adequate resource allocation and subsequent interventions can be targeted to the most vulnerable populations.Peer reviewe

Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3b

We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTC-2020 March 27 17:00 UTC). We conduct two independent searches: A generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate. © 2022. The Author(s). Published by the American Astronomical Society