Associations of autozygosity with a broad range of human phenotypes

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (F-ROH) for >1.4 million individuals, we show that F-ROH is significantly associated (p <0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: F-ROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of F-ROH are confirmed within full-sibling pairs, where the variation in F-ROH is independent of all environmental confounding.Peer reviewe

Entropy Stable Finite Volume Approximations for Ideal Magnetohydrodynamics

This article serves as a summary outlining the mathematical entropy analysis of the ideal magnetohydrodynamic (MHD) equations. We select the ideal MHD equations as they are particularly useful for mathematically modeling a wide variety of magnetized fluids. In order to be self-contained we first motivate the physical properties of a magnetic fluid and how it should behave under the laws of thermodynamics. Next, we introduce a mathematical model built from hyperbolic partial differential equations (PDEs) that translate physical laws into mathematical equations. After an overview of the continuous analysis, we thoroughly describe the derivation of a numerical approximation of the ideal MHD system that remains consistent to the continuous thermodynamic principles. The derivation of the method and the theorems contained within serve as the bulk of the review article. We demonstrate that the derived numerical approximation retains the correct entropic properties of the continuous model and show its applicability to a variety of standard numerical test cases for MHD schemes. We close with our conclusions and a brief discussion on future work in the area of entropy consistent numerical methods and the modeling of plasmas

glabberimum

Epilobium glaberrimum Barbeyglaucous willowherbépilobe glabrenear Clear Creek in Mud Creek Canyoncommo

Effects of water pulsing on individual performance and competitive hierarchies in plants

In a glass house experiment, we investigated the effect of both the frequency of water pulses and the total amount of water supplied on individual performance in the absence and presence of neighbors. We used monocultures and all combinations of pairs of seedlings of three species of perennial grasses, characteristic of different points along a soil moisture gradient within a semi-arid grassland in New Mexico, USA. In the absence of neighbors, higher total water or more frequent (but smaller) pulses significantly increased growth of all three species. The species with the fastest intrinsic growth rate, and from the most productive habitat, exhibited the largest increase in absolute and relative growth in response to higher total water quantity. Competitive effects were highly significant overall and there were significant hierarchies of competitive ability. Under frequent pulses, the fast-growing species from the most productive environment was the best competitor in terms of both ability to suppress other plants and ability to tolerate the presence of neighbors. However, under infrequent pulses, the slowest growing species from the least productive environment became a much stronger competitor, again in terms of both suppression and tolerance of neighbors. While differences in total water availability had greater effects than differences in pulsing regime on individual plant performance in the absence of competition, pulsing regime had much stronger effects on relative competitive abilities and thus may be more likely to influence field distribution patterns.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74078/1/3236604.pd