Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option?

Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell damage that affects the retinal circulation. In turn, this causes hypoxia leading to release of vascular endothelial growth factor (VEGF) to induce the angiogenesis process. Alpha-1 antitrypsin (AAT) is the most important circulating inhibitor of serine proteases (SERPIN). Its targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, proteinase 3 (PR-3) and plasminogen activator (PAI). AAT modulates the effect of protease-activated receptors (PARs) during inflammatory responses. Plasma levels of AAT can increase 4-fold during acute inflammation then is so-called acute phase protein (APPs). Individuals with low serum levels of AAT could develop disease in lung, liver and pancreas. AAT is involved in extracellular matrix remodeling and inflammation, particularly migration and chemotaxis of neutrophils. It can also suppress nitric oxide (NO) by nitric oxide sintase (NOS) inhibition. AAT binds their targets in an irreversible way resulting in product degradation. The aim of this review is to focus on the points of contact between multiple factors involved in diabetic retinopathy and AAT resembling pleiotropic effects that might be beneficial.Fil: Ortiz, Gustavo Alfredo. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Salica, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas; ArgentinaFil: Chuluyan, Hector Eduardo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gallo, Juan Eduardo Maria. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Dieta y ámbito hogareño del gato feral, Felis catus (Carnivora: Felidae) en la Isla Socorro, Archipiélago de Revillagigedo, México

Socorro is an oceanic island rich in biodiversity and endemisms. However, the island has been threatened by feral cats since 1957. The diet of this predator, determined through the analysis of stomach contents of 79 cats, consisted mostly of house mice (Mus musculus, 22.16%), endemic lizards (Urosaurus auriculatus, 15.09%), anthropogenic rubbish (15.09%), and insects (Orthoptera, 13.20%). The home range of the feral cat was identified through telemetry using four individuals with GPS/VHF radio-collars. The three males had a much larger average home range of 219.10 ha, as compared with 118.86 ha of the female. Knowing the home range of the Socorro Island feral cat is critical for the successful eradication of the island's invasive population. Thanks to this information, it is possible to calculate the trapping effort and the amount of bait needed per unit area to successfully carry out the ongoing eradication, contributing to the conservation of global biodiversity.Isla Socorro es una isla oceánica rica en biodiversidad y endemismos. Sin embargo, la isla ha sido impactada por el gato asilvestrado desde 1957. A través del análisis del contenido estomacal de 79 gatos se determinó la dieta de este depredador, la cual está constituida mayormente por el ratón doméstico (Mus musculus, 22.16%), la lagartija endémica (Urosaurus auriculatus, 15.09%), residuos antropogénicos (15.09%), e insectos (Orthoptera, 13.20%). Se identificó el ámbito hogareño de los gatos a través de telemetría, utilizando cuatro individuos con radio-collares GPS/VHF. El ámbito hogareño de los machos resultó de 219.10 ha en promedio, mucho mayor que el de las hembras que fue de 118.86 ha. Conocer el ámbito hogareño del gato asilvestrado de Isla Socorro es clave para la erradicación exitosa de la población de la isla. Gracias a esta información se ha podido calcular el esfuerzo de trampeo o la cantidad de carnada que deben ser empleadas por unidad de área durante la erradicación en curso, que es relevante para la conservación de la biodiversidad global

Comportamento etológico do gado Bos taurus, Bos indicus e crioulo Caqueteño em três sistemas de cobertura de árvores de Brachiaria decumbens paddocks no sopé da Amazônia na Colômbia

The study was conducted at the Amazon Research Center CIMAZ - MACAGUAL of the University of Amazonia, Colombia, with a tropical rain forest climate (Af). The behavior of Bos taurus, Bos indicus, and Caqueteño Creole cattle, the animals were observed in paddocks with three levels of scattered tree cover density. The pasture was composed of Braquiaria decumbens with 35 days of regrowth. Direct observations were made from 9:00 a.m. to 5:00 p.m. with 10-minute intervals between the recording of the activities. The activity performed most often during the day by all of the animals was grazing under the sun, and those who pasture the most are the Caqueteño Creole, followed by the Bos indicus and, finally, the Bos taurus. Ruminating was the second most important activity performed by the cattle, having presented the same tendency. In the paddocks with a low level of tree cover, the animals pasture more in the shade; this trend is more relevant among B. taurus cattle. Caqueteño Creole cattle dedicate less time to water consumption and rest, spending more time grazing, in the high and medium cover levels, they interrupt the grazing at noon for a shorter time compared to B. indicus and B. taurus; after 2 p.m., the creoles vertiginously increase grazing. At the high cover level, the peak of grazing of the Caqueteño Creoles is at 9 a.m. and from 1-1:30 p.m., while at the medium tree cover level, the peak of pasturing was at noon, 1:30 p.m., and 4:30 p.m., at the high tree level of cover, the peak for the three breeds was at 11 a.m. Only at the average tree level of cover did the Caquetaño creoles and B. indicus present a similar peak. In 9-9:30 a.m. and 4-5 p.m., the breeds substantially reduce rumination.O estudo foi realizado no Centro de Pesquisa Amazônica CIMAZ - MACAGUAL da Universidade da Amazônia, Colômbia, com um clima de floresta tropical úmida (Af). O comportamento do gado Bos taurus, Bos indicus e Caqueteño crioulo, os animais foram observados em cercados com três níveis de densidade de cobertura arbórea dispersa. A pastagem era composta de Braquiaria decumbens com 35 dias de recrescimento. Observações diretas foram feitas das 9h às 17h com intervalos de 10 minutos entre o registro das atividades. A atividade mais executada durante o dia por todos os animais era o pasto sob o sol, e aqueles que mais pastam são os Caqueteño crioulo, seguido pelo Bos indicus e, finalmente, o Bos taurus. A ruminação foi a segunda atividade mais importante desempenhada pelo gado, tendo apresentado a mesma tendência. Nos cercados com um baixo nível de cobertura arbórea, os animais pastam mais à sombra; esta tendência é mais relevante entre o gado B. taurus. O gado crioulo Caqueteño dedica menos tempo ao consumo de água e descanso, passando mais tempo pastando, nos níveis de cobertura alta e média, interrompem o pastoreio ao meio-dia por um tempo mais curto em comparação com o B. indicus e B. taurus; depois das 14 horas, os crioulos aumentam vertiginosamente o pastoreio. No nível de cobertura alta, o pico de pastagem dos Caqueteño crioulos é às 9h e das 13h30, enquanto no nível médio de cobertura de árvores, o pico de pastagem era ao meio-dia, 13h30 e 16h30, no nível alto de cobertura de árvores, o pico para as três raças era às 11h. Nas 9-9h30 e 16-17h, as raças reduzem substancialmente a ruminação

Conocimiento y empoderamiento en el manejo de Caiman yacare en la cuenca del río Iténez (Amazonía boliviana)

El año 1997, Bolivia inició el Programa Nacional para la Conservación y Aprovechamiento Sostenible de Lagarto (Caiman yacare) (PNCASL). Desde entonces se exporta anualmente de forma legal entre 30 000 y 45 000 pieles provenientes de la Amazonia boliviana. En más de diez años de vigencia del PNCASL, los primeros eslabones de la cadena productiva del lagarto siguen débiles, por lo que se considera fundamental el fortalecimiento del actor local a través de la participación y el uso del conocimiento ecológico tradicional integrado con aportes técnicos científicos que orienten las prácticas de manejo del recurso hacia un manejo adaptativo a nivel local y regional. El presente trabajo describe métodos participativos utilizados en el marco de la elaboración del plan de manejo de lagarto en el sur del Parque Departamental y Área Natural de Manejo Integrado (PD ANMI) Iténez, situado al noreste de la Amazonia boliviana. En primer lugar, se describe el método utilizado para la zonificación del área de aprovechamiento en función a las potencialidades de uso de cada zona. Segundo, se describe cómo se realizó el monitoreo de las poblaciones naturales de lagarto y se discute como los resultados de monitoreo fueron interpretados por los actores locales para sugerir un cupo de aprovechamiento. Finalmente, se presentan y discuten dos métodos de monitoreo participativo ampliamente utilizado: el cálculo de la Captura por Unidad de Esfuerzo (CPUE) y la medición del tamaño de los individuos cazados. Este último método también permite transparentar el beneficio económico colectivo y per cápita de la venta de las pieles a las curtiembres.Em 1997, a Bolívia iniciou o Programa Nacional para a Conservação e Aproveitamento Sustentável do jacaré (Caiman yacare) (PNCASL). Desde então, sao legalmente exportados anualmente entre 30.000 e 45.000 peles provenientes da Amazônia boliviana. Em mais de dez anos de vigencia do PNCASL, os primeiros elos na cadeia produtiva do jacaré continuam fracos, motivo pelo qual é considerado essencial fortalecer o ator local através da participação e uso de conhecimento ecológico tradicional integrado, além de insumos técnico-científicos que orientem as práticas de manejo do recurso para gestão adaptativa a nivel local e regional. O presente trabalho descreve métodos participativos utilizados no marco de elaboração do plano de manejo do jacaré no sul do parque departamental AMNI Iténez, localizado no nordeste da Amazôníia boliviana. Primeiro, é descrito o método utilizado para o zoneamento da área de explorado de acordo com as potencialidades de uso de cada zona. Segundo, é descrito como se realiza o monitoramento das populações naturais dos jacarés e apresentada urna discussáo sobre a interpretação dos resultados do monitoramento pelos atores locais para sugerir urna quota de exploração. Finalmente, são apresentados e discutidos dois métodos de monitoramento participativo amplamente utilizados: o cálculo de Captura por Unidade de Esforço (CPUE) e a medição de tamanho dos indivíduos cagados. O último método também permite analisar com maior clareza o benefício econômico coletivo e per capita da venda de peles para os curtumes.In 1997, Bolivia initiated the National Program for the Conservation and Sustainable Use of the spectacled caiman (iCaiman yacare) (PNCASL). Bolivia has exported between 30 000 and 45 000 caiman skins annually from the Bolivian Amazon since this time. In more than 10 years of the PNCASL, the first link in the value chain of this caiman species (the hunters) remains weak. It is essential to strengthen the local stakeholders making better use of their practices and traditional ecological knowledge and integrating them with scientific inputs to guide adaptive resource management at local, regional and national levels. This paper describes participatory methods used in the context of preparing the Management Plan for the Southern part of the Departmental Park and Natural Integrated Management Area Iténez, located in the northeastern Bolivian Amazon. First, we describe the method used for zonation according to the hunting potential of each area. Second, we describe how local hunters conducted the monitoring of natural caiman populations and discuss how the monitoring results were used to suggest hunting quota. Finally, we present and discuss two methods widely used in participatory monitoring: the calculation of the catch per unit effort (CPUE) and recording the size of individuals hunted. The latter method also provides transparent data on collective and individual economic benefits from the sales of the caiman skins

Mamíferos continentales del Mioceno tardío a la actualidad en la Argentina: cincuenta años de estudios

Ameghiniana was created 50 years ago. During this lapse, the late Cenozoic paleomastozoology developed exponentially in Argentina. Many of the papers dealed with systematics. However, fossil mammals were also used for establish the chronological scale based on a biostratigraphic sequence of faunas mainly from the Pampean area. This scale proved valid for other South American areas. Besides, mammals were used as proxies for understanding the continental climatic evolution and, at the same time, biogeographic studies flourished. In recent years, many paleoecological and morphofunctional studies were carried out. Certainly, the last 50 years were the most productive time in Argentina since the pioneering work of Florentino Ameghino

The Trans-Neptunian Object (84922) 2003 VS2 through Stellar Occultations

We present results from three world-wide campaigns that resulted in the detections of two single-chord and one multi-chord stellar occultations by the plutino object (84922) 2003 VS2. From the single-chord occultations in 2013 and 2014 we obtained accurate astrometric positions for the object, while from the multi-chord occultation on 2014 November 7, we obtained the parameters of the best-fitting ellipse to the limb of the body at the time of occultation. We also obtained short-term photometry data for the body in order to derive its rotational phase during the occultation. The rotational light curve present a peak-to-peak amplitude of 0.141 ± 0.009 mag. This allows us to reconstruct the 3D shape of the body, with principal semi-axes of a = 313.8 ± 7.1 km, = - + b 265.5 9.8 8.8 km, and = - + c 247.3 43.6 26.6 km, which is not consistent with a Jacobi triaxial equilibrium figure. The derived spherical volume equivalent diameter of - + 548.3 44.6 29.5 km is about 5% larger than the radiometric diameter of 2003 VS2 derived from Herschel data of 523 ± 35 km, but still compatible with it within error bars. From those results we can also derive the geometric albedo ( - + 0.123 0.014 0.015) and, under the assumption that the object is a Maclaurin spheroid, the density r = - + 1400 300 1000 for the plutino. The disappearances and reappearances of the star during the occultations do not show any compelling evidence for a global atmosphere considering a pressure upper limit of about 1 microbar for a pure nitrogen atmosphere, nor secondary features (e.g., rings or satellite) around the main body.Fil: Benedetti Rossi, Gustavo. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; Brasil. Centre National de la Recherche Scientifique. Observatoire de Paris; Francia. Laboratório Interinstitucional de e-Astronomia; BrasilFil: Santos Sanz, P.. Instituto de Astrofísica de Andalucía; EspañaFil: Ortiz, J. L.. Instituto de Astrofísica de Andalucía; EspañaFil: Assafin, M.. Observatório do Valongo; BrasilFil: Sicardy, B.. Sorbonne University; Francia. Centre National de la Recherche Scientifique. Observatoire de Paris; FranciaFil: Morales, N.. Instituto de Astrofísica de Andalucía; EspañaFil: Vieira Martins, R.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; Brasil. Laboratório Interinstitucional de e-Astronomia; Brasil. Centre National de la Recherche Scientifique. Observatoire de Paris; FranciaFil: Duffard, R.. Instituto de Astrofísica de Andalucía; EspañaFil: Braga Ribas, F.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; Brasil. Laboratório Interinstitucional de e-Astronomia; Brasil. Centre National de la Recherche Scientifique. Observatoire de Paris; Francia. Universidade Tecnologia Federal do Parana; BrasilFil: Rommel, F. L.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; Brasil. Laboratório Interinstitucional de e-Astronomia; BrasilFil: Camargo, J. I. B.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; Brasil. Laboratório Interinstitucional de e-Astronomia; BrasilFil: Desmars, J.. Instituto de Astrofísica de Andalucía; EspañaFil: Colas, A. F.. Centre National de la Recherche Scientifique. Observatoire de Paris; FranciaFil: Vachier, F.. Centre National de la Recherche Scientifique. Observatoire de Paris; FranciaFil: Alvarez Candal, A.. Ministério de Ciencia, Tecnologia e Innovacao. Observatorio Nacional; BrasilFil: Fernández Valenzuela, E.. University of Central Florida; Estados UnidosFil: Almenares, L.. Universidad de la Republica; UruguayFil: Artola, R.. Estación Astrofísica de Bosque Alegre; ArgentinaFil: Baum, T. P.. Observatoire Astronomique des Makes; FranciaFil: Behrend, R.. Observatoire de Genève; ItaliaFil: Bérard, D.. Centre National de la Recherche Scientifique. Observatoire de Paris; FranciaFil: Bianco, F. B.. University of Delaware; Estados Unidos. University of New York; Estados UnidosFil: Brosch, N.. Universitat Tel Aviv; IsraelFil: Ceretta, A.. Observatorio Astronómico Los Molinos; UruguayFil: Colazo, C. A.. Estación Astrofísica de Bosque Alegre; ArgentinaFil: Gomes Junior, A. R.. Laboratório Interinstitucional de e-Astronomia; Brasil. Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Engenharia; BrasilFil: Ivanov, V. D.. Observatorio Europeo del Sur; AlemaniaFil: Jehin, E.. Université de Liège; BélgicaFil: Kaspi, S.. Universitat Tel Aviv; IsraelFil: Gil Hutton, Ricardo Alfredo. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Geofísica y Astronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Complejo Astronómico "El Leoncito". Universidad Nacional de Córdoba. Complejo Astronómico "El Leoncito". Universidad Nacional de la Plata. Complejo Astronómico "El Leoncito". Universidad Nacional de San Juan. Complejo Astronómico "El Leoncito"; Argentin

Land mammal from the late miocene to recent in Argentina: Fifty years of research

Ameghiniana was created 50 years ago. During this lapse, the late Cenozoic paleomastozoology developed exponentially in Argentina. Many of the papers dealed with systematics. However, fossil mammals were also used for establish the chronological scale based on a biostratigraphic sequence of faunas mainly from the Pampean area. This scale proved valid for other South American areas. Besides, mammals were used as proxies for understanding the continental climatic evolution and, at the same time, biogeographic studies flourished. In recent years, many paleoecological and morphofunctional studies were carried out. Certainly, the last 50 years were the most productive time in Argentina since the pioneering work of Florentino Ameghino.Museo de La Plat

Land mammal from the late miocene to recent in Argentina: Fifty years of research

Ameghiniana was created 50 years ago. During this lapse, the late Cenozoic paleomastozoology developed exponentially in Argentina. Many of the papers dealed with systematics. However, fossil mammals were also used for establish the chronological scale based on a biostratigraphic sequence of faunas mainly from the Pampean area. This scale proved valid for other South American areas. Besides, mammals were used as proxies for understanding the continental climatic evolution and, at the same time, biogeographic studies flourished. In recent years, many paleoecological and morphofunctional studies were carried out. Certainly, the last 50 years were the most productive time in Argentina since the pioneering work of Florentino Ameghino.Museo de La Plat

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London