Severe early onset preeclampsia: short and long term clinical, psychosocial and biochemical aspects

Preeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension and proteinuria after 20 weeks gestational age. It occurs in approximately 3-5% of pregnancies and it is still a major cause of both foetal and maternal morbidity and mortality worldwide1. As extensive research has not yet elucidated the aetiology of preeclampsia, there are no rational preventive or therapeutic interventions available. The only rational treatment is delivery, which benefits the mother but is not in the interest of the foetus, if remote from term. Early onset preeclampsia (<32 weeks’ gestational age) occurs in less than 1% of pregnancies. It is, however often associated with maternal morbidity as the risk of progression to severe maternal disease is inversely related with gestational age at onset2. Resulting prematurity is therefore the main cause of neonatal mortality and morbidity in patients with severe preeclampsia3. Although the discussion is ongoing, perinatal survival is suggested to be increased in patients with preterm preeclampsia by expectant, non-interventional management. This temporising treatment option to lengthen pregnancy includes the use of antihypertensive medication to control hypertension, magnesium sulphate to prevent eclampsia and corticosteroids to enhance foetal lung maturity4. With optimal maternal haemodynamic status and reassuring foetal condition this results on average in an extension of 2 weeks. Prolongation of these pregnancies is a great challenge for clinicians to balance between potential maternal risks on one the eve hand and possible foetal benefits on the other. Clinical controversies regarding prolongation of preterm preeclamptic pregnancies still exist – also taking into account that preeclampsia is the leading cause of maternal mortality in the Netherlands5 - a debate which is even more pronounced in very preterm pregnancies with questionable foetal viability6-9. Do maternal risks of prolongation of these very early pregnancies outweigh the chances of neonatal survival? Counselling of women with very early onset preeclampsia not only comprises of knowledge of the outcome of those particular pregnancies, but also knowledge of outcomes of future pregnancies of these women is of major clinical importance. This thesis opens with a review of the literature on identifiable risk factors of preeclampsia

Search for narrow resonances using the dijet mass spectrum in pp collisions at s√=8 TeV

Results are presented of a search for the production of new particles decaying to pairs of partons (quarks, antiquarks, or gluons), in the dijet mass spectrum in proton-proton collisions at s√=8  TeV. The data sample corresponds to an integrated luminosity of 4.0  fb−1, collected with the CMS detector at the LHC in 2012. No significant evidence for narrow resonance production is observed. Upper limits are set at the 95% confidence level on the production cross section of hypothetical new particles decaying to quark-quark, quark-gluon, or gluon-gluon final states. These limits are then translated into lower limits on the masses of new resonances in specific scenarios of physics beyond the standard model. The limits reach up to 4.8 TeV, depending on the model, and extend previous exclusions from similar searches performed at lower collision energies. For the first time mass limits are set for the Randall–Sundrum graviton model in the dijet channel

Erratum: search for new physics in events with same-sign dileptons and bb jets in pppp collisions at s=8\sqrt{s}=8 TeV

Erratum to: JHEP03(2013)03

Measurement of the Y1S, Y2S and Y3S polarizations in pppp collisions at s=7\sqrt{s}=7 TeV

HEPDATA CERN-LHC. Measurement of the polarizations of the Upsilon(1S),(2S) and (3S) from their decay into two muons in proton-proton collisions at a centre of mass energy of 7 TeV using data with a total integrated luminosity of 4.9 fb-1. Data are presented on the Lambda (Theta, Phi and Theta-Phi) parameters of the di-muon angular distributions where Theta and Phi are the polar and azimuthal angles, respectively, of the positive muon with respect to the Z axis of the chosen polarization frame. Three frames are used, the Collins-Soper (CS) frame, the centre-of-mass Helicity (HX) frame and the perpendicular Helicity (PX) frame, orthogonal to the CS frame. Data are also given for the frame-invariant quantity, Lambda(Tilde). The data are presented as a function of the PT of the Upsilon in two rapidity regions. The tables show the results with total uncertainties (reflecting statistical and systematic effects) for 3 different Confidence Levels (68.3%, 95.5% and 99.7%). The last column, for comparison, gives the results only considering statistical uncertainties (at 68.3%) The final 3 tables show the estimated number of signal events for each Upsilon state. arXiv The polarizations of the Y(1S), Y(2S), and Y(3S) mesons are measured in proton-proton collisions at sqrt(s) = 7 TeV, using a data sample of Y(nS) to oppositely charged muon pair decays collected by the CMS experiment, corresponding to an integrated luminosity of 4.9 inverse femtobarns. The dimuon decay angular distributions are analyzed in three different polarization frames. The polarization parameters lambda[theta], lambda[phi], and lambda[theta,phi], as well as the frame-invariant quantity lambda-tilde, are presented as a function of the Y(nS) transverse momentum between 10 and 50 GeV, in the rapidity ranges abs(y) < 0.6 and 0.6 < abs(y) < 1.2. No evidence of large transverse or longitudinal polarizations has been seen in the explored kinematic region. APS The polarizations of the Υ(1S), Υ(2S), and Υ(3S) mesons are measured in proton-proton collisions at s=7 TeV, using a data sample of Υ(nS)→μ+μ- decays collected by the CMS experiment, corresponding to an integrated luminosity of 4.9 fb-1. The dimuon decay angular distributions are analyzed in three different polarization frames. The polarization parameters λϑ, λφ, and λϑφ, as well as the frame-invariant quantity λ˜, are presented as a function of the Υ(nS) transverse momentum between 10 and 50 GeV, in the rapidity ranges |y|<0.6 and 0.6<|y|<1.2. No evidence of large transverse or longitudinal polarizations is seen in the explored kinematic region

Search for new physics in events with opposite-sign leptons, jets, and missing transverse energy in pp collisions at sqrt(s) = 7 TeV

A search is presented for physics beyond the standard model (BSM) in final states with a pair of opposite-sign isolated leptons accompanied by jets and missing transverse energy. The search uses LHC data recorded at a center-of-mass energy sqrt(s) = 7 TeV with the CMS detector, corresponding to an integrated luminosity of approximately 5 inverse femtobarns. Two complementary search strategies are employed. The first probes models with a specific dilepton production mechanism that leads to a characteristic kinematic edge in the dilepton mass distribution. The second strategy probes models of dilepton production with heavy, colored objects that decay to final states including invisible particles, leading to very large hadronic activity and missing transverse energy. No evidence for an event yield in excess of the standard model expectations is found. Upper limits on the BSM contributions to the signal regions are deduced from the results, which are used to exclude a region of the parameter space of the constrained minimal supersymmetric extension of the standard model. Additional information related to detector efficiencies and response is provided to allow testing specific models of BSM physics not considered in this paper