Magnetic Rossby waves in the solar tachocline and Rieger-type periodicities

Apart from the 11-year solar cycle, another periodicity around 155-160 days was discovered during solar cycle 21 in high energy solar flares, and its presence in sunspot areas and strong magnetic flux has been also reported. This periodicity has an elusive and enigmatic character, since it usually appears only near the maxima of solar cycles, and seems to be related with a periodic emergence of strong magnetic flux at the solar surface. Therefore, it is probably connected with the tachocline, a thin layer located near the base of the solar convection zone, where strong dynamo magnetic field is stored. We study the dynamics of Rossby waves in the tachocline in the presence of a toroidal magnetic field and latitudinal differential rotation. Our analysis shows that the magnetic Rossby waves are generally unstable and that the growth rates are sensitive to the magnetic field strength and to the latitudinal differential rotation parameters. Variation of the differential rotation and the magnetic field strength throughout the solar cycle enhance the growth rate of a particular harmonic in the upper part of the tachocline around the maximum of the solar cycle. This harmonic is symmetric with respect to the equator and has a period of 155-160 days. A rapid increase of the wave amplitude could give place to a magnetic flux emergence leading to observed periodicities in solar activity indicators related with magnetic flux.Comment: 34 pages, 5 figures, accepted in Ap

System-wide analyses of the fission yeast poly(A)+ RNA interactome reveal insights into organization and function of RNA–protein complexes

Large RNA-binding complexes play a central role in gene expression and orchestrate production, function, and turnover of mRNAs. The accuracy and dynamics of RNA–protein interactions within these molecular machines are essential for their function and are mediated by RNA-binding proteins (RBPs). Here, we show that fission yeast whole-cell poly(A)+ RNA–protein crosslinking data provide information on the organization of RNA–protein complexes. To evaluate the relative enrichment of cellular RBPs on poly(A)+ RNA, we combine poly(A)+ RNA interactome capture with a whole-cell extract normalization procedure. This approach yields estimates of in vivo RNA-binding activities that identify subunits within multiprotein complexes that directly contact RNA. As validation, we trace RNA interactions of different functional modules of the 3′ end processing machinery and reveal additional contacts. Extending our analysis to different mutants of the RNA exosome complex, we explore how substrate channeling through the complex is affected by mutation. Our data highlight the central role of the RNA helicase Mtl1 in regulation of the complex and provide insights into how different components contribute to engagement of the complex with substrate RNA. In addition, we characterize RNA-binding activities of novel RBPs that have been recurrently detected in the RNA interactomes of multiple species. We find that many of these, including cyclophilins and thioredoxins, are substoichiometric RNA interactors in vivo. Because RBPomes show very good overall agreement between species, we propose that the RNA-binding characteristics we observe in fission yeast are likely to apply to related proteins in higher eukaryotes as well

Inconsistent boundaries

Research on this paper was supported by a grant from the Marsden Fund, Royal Society of New Zealand.Mereotopology is a theory of connected parts. The existence of boundaries, as parts of everyday objects, is basic to any such theory; but in classical mereotopology, there is a problem: if boundaries exist, then either distinct entities cannot be in contact, or else space is not topologically connected (Varzi in Noûs 31:26–58, 1997). In this paper we urge that this problem can be met with a paraconsistent mereotopology, and sketch the details of one such approach. The resulting theory focuses attention on the role of empty parts, in delivering a balanced and bounded metaphysics of naive space.PostprintPeer reviewe

Large amplitude oscillation of a polar crown filament in the pre-eruption phase

We report observation of a large-amplitude filament oscillation followed by an eruption. This is used to probe the pre-eruption condition and the trigger mechanism of solar eruptions. We used the EUV images from the Extreme-Ultraviolet Imaging Telescope on board SOHO satellite and the H-alpha images from the Flare Monitoring Telescope at Hida Observatory. The observed event is a polar crown filament that erupted on 15 Oct. 2002. The filament clearly exhibited oscillatory motion in the slow-rising, pre-eruption phase. The amplitude of the oscillation was larger than 20 km/s, and the motion was predominantly horizontal. The period was about 2 hours and seemed to increase during the oscillation, indicating weakening of restoring force. These results strongly indicate that, even in the slow-rise phase before the eruption, the filament retained equilibrium and behaved as an oscillator, and the equilibrium is stable to nonlinear perturbation. Moreover, the transition from such nonlinear stability to either instabilities or a loss of equilibrium that leads to the eruption occurred in the Alfven time scale. This suggests that the onset of the eruption was triggered by a fast magnetic reconnection that stabilized the pre-eruption magnetic configuration, rather than by the slow shearing motion at the photosphere.Comment: 4 pages, 3 figures, accepted for publication in A&

Physics of Solar Prominences: II - Magnetic Structure and Dynamics

Observations and models of solar prominences are reviewed. We focus on non-eruptive prominences, and describe recent progress in four areas of prominence research: (1) magnetic structure deduced from observations and models, (2) the dynamics of prominence plasmas (formation and flows), (3) Magneto-hydrodynamic (MHD) waves in prominences and (4) the formation and large-scale patterns of the filament channels in which prominences are located. Finally, several outstanding issues in prominence research are discussed, along with observations and models required to resolve them.Comment: 75 pages, 31 pictures, review pape

Rules for Growth: Promoting Innovation and Growth Through Legal Reform

The United States economy is struggling to recover from its worst economic downturn since the Great Depression. After several huge doses of conventional macroeconomic stimulus - deficit-spending and monetary stimulus - policymakers are understandably eager to find innovative no-cost ways of sustaining growth both in the short and long runs. In response to this challenge, the Kauffman Foundation convened a number of America’s leading legal scholars and social scientists during the summer of 2010 to present and discuss their ideas for changing legal rules and policies to promote innovation and accelerate U.S. economic growth. This meeting led to the publication of Rules for Growth: Promoting Innovation and Growth Through Legal Reform, a comprehensive and groundbreaking volume of essays prescribing a new set of growth-promoting policies for policymakers, legal scholars, economists, and business men and women. Some of the top Rules include: • Reforming U.S. immigration laws so that more high-skilled immigrants can launch businesses in the United States. • Improving university technology licensing practices so university-generated innovation is more quickly and efficiently commercialized. • Moving away from taxes on income that penalize risk-taking, innovation, and employment while shifting toward a more consumption-based tax system that encourages saving that funds investment. In addition, the research tax credit should be redesigned and made permanent. • Overhauling local zoning rules to facilitate the formation of innovative companies. • Urging judges to take a more expansive view of flexible business contracts that are increasingly used by innovative firms. • Urging antitrust enforcers and courts to define markets more in global terms to reflect contemporary realities, resist antitrust enforcement from countries with less sound antitrust regimes, and prohibit industry trade protection and subsidies. • Reforming the intellectual property system to allow for a post-grant opposition process and address the large patent application backlog by allowing applicants to pay for more rapid patent reviews. • Authorizing corporate entities to form digitally and use software as a means for setting out agreements and bylaws governing corporate activities. The collective essays in the book propose a new way of thinking about the legal system that should be of interest to policymakers and academic scholars alike. Moreover, the ideas presented here, if embodied in law, would augment a sustained increase in U.S. economic growth, improving living standards for U.S. residents and for many in the rest of the world

I. The effect of symmetric and spatially varying equilibria and flow on MHD wave modes : slab geometry

Realistic theoretical models of magnetohydrodynamic wave propagation in the different solar magnetic configurations are required to explain observational results, allowing magnetoseismology to be conducted and provide more accurate information about local plasma properties. The numerical approach described in this paper allows a dispersion diagram to be obtained for any arbitrary symmetric magnetic slab model of solar atmospheric features. This proposed technique implements the shooting method to match necessary boundary conditions on continuity of displacement and total pressure of the waveguide. The algorithm also implements fundamental physical knowledge of the sausage and kink modes such that both can be investigated. The dispersion diagrams for a number of analytic cases which model magnetohydrodynamic waves in a magnetic slab were successfully reproduced. This work is then extended by considering density structuring modelled as a series of Gaussian profiles and a sinc(x) function. A further case study investigates properties of MHD wave modes in a coronal slab with a non-uniform background plasma flow, for which the governing equations are derived. It is found that the dispersive properties of slow body modes are more greatly altered than those of fast modes when any equilibrium inhomogeneity is increased, including background flow. The spatial structure of the eigenfunctions is also modified, introducing extra nodes and points of inflexion which may be of interest to observers

Lineage Plasticity in SCLC Generates Non-Neuroendocrine Cells Primed for Vasculogenic Mimicry

Introduction: Vasculogenic mimicry (VM), the process of tumor cell transdifferentiation to endow endothelial-like characteristics supporting de novo vessel formation, is associated with poor prognosis in several tumor types, including SCLC. In genetically engineered mouse models (GEMMs) of SCLC, NOTCH, and MYC co-operate to drive a neuroendocrine (NE) to non-NE phenotypic switch, and co-operation between NE and non-NE cells is required for metastasis. Here, we define the phenotype of VM-competent cells and molecular mechanisms underpinning SCLC VM using circulating tumor cell–derived explant (CDX) models and GEMMs. Methods: We analyzed perfusion within VM vessels and their association with NE and non-NE phenotypes using multiplex immunohistochemistry in CDX, GEMMs, and patient biopsies. We evaluated their three-dimensional structure and defined collagen-integrin interactions. Results: We found that VM vessels are present in 23/25 CDX models, 2 GEMMs, and in 20 patient biopsies of SCLC. Perfused VM vessels support tumor growth and only NOTCH-active non-NE cells are VM-competent in vivo and ex vivo, expressing pseudohypoxia, blood vessel development, and extracellular matrix organization signatures. On Matrigel, VM-primed non-NE cells remodel extracellular matrix into hollow tubules in an integrin β1–dependent process. Conclusions: We identified VM as an exemplar of functional heterogeneity and plasticity in SCLC and these findings take considerable steps toward understanding the molecular events that enable VM. These results support therapeutic co-targeting of both NE and non-NE cells to curtail SCLC progression and to improve the outcomes of patients with SCLC in the future

Application of infrared thermography in computer aided diagnosis

The invention of thermography, in the 1950s, posed a formidable problem to the research community: What is the relationship between disease and heat radiation captured with Infrared (IR) cameras? The research community responded with a continuous effort to find this crucial relationship. This effort was aided by advances in processing techniques, improved sensitivity and spatial resolution of thermal sensors. However, despite this progress fundamental issues with this imaging modality still remain. The main problem is that the link between disease and heat radiation is complex and in many cases even non-linear. Furthermore, the change in heat radiation as well as the change in radiation pattern, which indicate disease, is minute. On a technical level, this poses high requirements on image capturing and processing. On a more abstract level, these problems lead to inter-observer variability and on an even more abstract level they lead to a lack of trust in this imaging modality. In this review, we adopt the position that these problems can only be solved through a strict application of scientific principles and objective performance assessment. Computing machinery is inherently objective; this helps us to apply scientific principles in a transparent way and to assess the performance results. As a consequence, we aim to promote thermography based Computer-Aided Diagnosis (CAD) systems. Another benefit of CAD systems comes from the fact that the diagnostic accuracy is linked to the capability of the computing machinery and, in general, computers become ever more potent. We predict that a pervasive application of computers and networking technology in medicine will help us to overcome the shortcomings of any single imaging modality and this will pave the way for integrated health care systems which maximize the quality of patient care