The Relationship between Skinfold and Ultrasound Measures of Subcutaneous Fat in Untrained Healthy Males

Ultrasound measurement of adipose tissue offers an alternative measure of body composition with less technical skill requirement than skinfolds. However, the relationship between skinfold and ultrasound measurements of adipose tissue is uncertain. The aim of this study was to compare these measures in a healthy untrained male population. One hundred male participants (aged 18–40 years) of varying body compositions had skinfold measures taken at the biceps, triceps and front thigh sites. Ultrasound measures were also taken at the same sites using B-wave ultrasound with a linear probe in the transverse plane. Strong, significant (p < 0.01), positive correlations were observed between skinfold and ultrasound measures at the biceps (r = 0.828), triceps (r = 0.813), and front thigh (r = 0.888) sites. However, there was significant (p < 0.01) variance between the techniques at all measurement sites. Whilst skinfold and ultrasound measures of adipose tissue have good linear agreement, skinfolds are consistently higher at all sites indicating a difference in the nature of the tissue measured via each technique. The exact nature of the relationship should be established on a population-specific basis

Raising awareness of Asperger’s Syndrome amongst coaches and athletes: the power of virtual support networks

The Virtual Alliance for sport technology (V.A.S.T) is an online tool utilised by a community of experts and practitioners to facilitate the generation and sharing of knowledge in order to promote inclusion in sport. The principal aim of the present study was to utilise this platform to create and evaluate an online teaching resource to provide support for coaches working with athletes with Asperger’s Syndrome. At present little information is provided by National governing bodies about Asperger’s, and as a consequence many athletes can be marginalised in sports provision. A methods-driven evaluative framework was adopted in order to assess the impact of the web-tool. Gantt timelines and a programme theory were produced prior to the project, and programme processes were evaluated throughout. Website impact was assessed via triangulation of statistical analysis regarding website usage with interviews conducted with network users. Results were interpreted using a figurational framework to investigate how information about the web-tool was disseminated and transformed through virtual networks of interdependencies which linked participants diagnosed with Asperger syndrome, their coaches and the online community. Results gained from this project are expected to highlight how web-based platforms have the capability to bring together otherwise marginalised groups with virtual networks of sports experts, athletes and practitioners. The implications of these results will increase awareness of participants with Asperger’s syndrome within sport and provide coaches, athletes and policy makers with information that will enable them to effectively teach and support sports participants with Asperger’s syndrome in an athlete-centric manner

Neocortical Axon Arbors Trade-off Material and Conduction Delay Conservation

The brain contains a complex network of axons rapidly communicating information between billions of synaptically connected neurons. The morphology of individual axons, therefore, defines the course of information flow within the brain. More than a century ago, Ramón y Cajal proposed that conservation laws to save material (wire) length and limit conduction delay regulate the design of individual axon arbors in cerebral cortex. Yet the spatial and temporal communication costs of single neocortical axons remain undefined. Here, using reconstructions of in vivo labelled excitatory spiny cell and inhibitory basket cell intracortical axons combined with a variety of graph optimization algorithms, we empirically investigated Cajal's conservation laws in cerebral cortex for whole three-dimensional (3D) axon arbors, to our knowledge the first study of its kind. We found intracortical axons were significantly longer than optimal. The temporal cost of cortical axons was also suboptimal though far superior to wire-minimized arbors. We discovered that cortical axon branching appears to promote a low temporal dispersion of axonal latencies and a tight relationship between cortical distance and axonal latency. In addition, inhibitory basket cell axonal latencies may occur within a much narrower temporal window than excitatory spiny cell axons, which may help boost signal detection. Thus, to optimize neuronal network communication we find that a modest excess of axonal wire is traded-off to enhance arbor temporal economy and precision. Our results offer insight into the principles of brain organization and communication in and development of grey matter, where temporal precision is a crucial prerequisite for coincidence detection, synchronization and rapid network oscillations

The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Background: Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy. Methods: Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored. Results: A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays. Conclusions: IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

The Role of Risk Preferences in Responses to Messaging about COVID-19 Vaccine Take-up

Data and R code to reproduce the results reported in the paper with the same title

Financial Instability, Emotions, and Beliefs about COVID-19

Data and analysis scripts for the manuscript titled "A Tale of Two Crises: Financial Fragility and Beliefs about the Spread of COVID-19" available on the PsyArXiv: https://psyarxiv.com/xfrz3

Financial Constraint and Perceptions of COVID-19

De-identified data used in a paper with this title along with the data analysis script