20 research outputs found

    Incorporation of genuine prior information in cost-effectiveness analysis of clinical trial data

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    The Bayesian approach to statistics has been growing rapidly in popularity as an alternative to the frequentist approach in the appraisal of heathcare technologies in clinical trials. Bayesian methods have significant advantages over classical frequentist statistical methods and the presentation of evidence to decision makers. A fundamental feature of a Bayesian analysis is the use of prior information as well as the clinical trial data in the final analysis. However, the incorporation of prior information remains a controversial subject that provides a potential barrier to the acceptance of practical uses of Bayesian methods. The pur pose of this paper is to stimulate a debate on the use of prior information in evidence submitted to decision makers. We discuss the advantages of incorporating genuine prior information in cost-effectiveness analyses of clinical trial data and explore mechanisms to safeguard scientific rigor in the use of such prior information

    Search for single production of a heavy vector-like T quark decaying to a Higgs boson and a top quark with a lepton and jets in the final state

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    The performing arts and the public purse An economic analysis

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    A report commissioned by the Arts CouncilAvailable from British Library Document Supply Centre- DSC:89/15740(Performing) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

    The economy of Ireland Policy and performance

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    LD:82/25331(Economy) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

    Access to and participation in the arts The case of those with low incomes/educational attainment

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    SIGLEAvailable from British Library Document Supply Centre-DSC:6543.326992(96/1) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

    D-specific dehalogenases, a review

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    Bacterial dehalogenases cleave carbon-halogen bonds with different stereo-configurations. Rhizobium sp. RC1 produces a D-haloalkanoic-specific dehalogenase (DehD) that can cleave the carbon-halogen bond of halogenated organic pollutants. The sequence identity for DehD and HadD from Pseudomonas putida AJ1 is 27%, and 20 amino acid residues are highly conserved in these two enzymes. Therefore, DehD and HadD may have active sites that contain the same charged catalytic residues. The activity of DehD rapidly increases with increasing pH and is optimum at pH 9.5. It also has lower Km values and higher kcat values for various substrates than do other D-specific dehalogenases. Because DehD catalyzes the hydrolytic dehalogenation of D-haloalkanoic acids with inversion around the chiral carbon, it has potential industrial applications. Site-directed mutagenesis of DehD can be exploited for industrial production of chemicals, pharmaceutical and medical applications, and in environmental remediation

    The probability of cost-effectiveness

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    SIGLEAvailable from British Library Document Supply Centre-DSC:7769.086(no 519/01) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

    Case study in the Bayesian analysis of a cost-effectiveness trial in the evaluation of health care technologies Depression

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    SIGLEAvailable from British Library Document Supply Centre-DSC:7769.086(no 526/02) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

    Adaptive Response Correction for Surrogate-Based Airfoil Shape Optimization

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