An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology

© 2017 Elsevier B.V. All rights reserved.Ethnopharmacological relevance: The management of diabetes mellitus management in African communities, especially in Gabon, is not well established as more than 60% of population rely on traditional treatments as primary healthcare. The aim of this review was to collect and present the scientific evidence for the use of medicinal plants that are in currect by Gabonese traditional healers to manage diabetes or hyperglycaemia based here on the pharmacological and toxicological profiles of plants with anti-diabetic activity. There are presented in order to promote their therapeutic value, ensure a safer use by population and provide some bases for further study on high potential plants reviewed. Materials and methods: Ethnobotanical studies were sourced using databases such as Online Wiley library, Pubmed, Google Scholar, PROTA, books and unpublished data including Ph.D. and Master thesis, African and Asian journals. Keywords including ‘Diabetes’ ‘Gabon’ ‘Toxicity’ ‘Constituents’ ‘hyperglycaemia’ were used. Results: A total of 69 plants currently used in Gabon with potential anti-diabetic activity have been identified in the literature, all of which have been used in in vivo or in vitro studies. Most of the plants have been studied in human or animal models for their ability to reduce blood glucose, stimulate insulin secretion or inhibit carbohydrates enzymes. Active substances have been identified in 12 out of 69 plants outlined in this review, these include Allium cepa and Tabernanthe iboga. Only eight plants have their active substances tested for anti-diabetic activity and are suitables for further investigation. Toxicological data is scarce and is dose-related to the functional parameters of major organs such as kidney and liver. Conclusion: An in-depth understanding on the pharmacology and toxicology of Gabonese anti-diabetic plants is lacking yet there is a great scope for new treatments. With further research, the use of Gabonese anti-diabetic plants is important to ensure the safety of the diabetic patients in Gabon.Peer reviewedFinal Accepted Versio

Philanthropy in Contemporary Africa: A Review

Despite the availability of a wide range of literature on what is can be construed to be philanthropic behaviour in Africa, there is limited conceptual discussion on what constitutes philanthropy in African context(s). Yet, philanthropic behaviour is culturally rooted phenomena manifesting in diverse forms, expressions, and models. This review contributes to a growing body of literature on conceptions and manifestations of African philanthropy. The review illustrates a complex plurality of actions that fall under cultures and practices of giving in Africa. These include the giving of money, time, knowledge, influence and visibility in support of a cause, valuable goods, and body parts/organs from living and dead. While some of these actions conform to dominant Western notions of philanthropy, others do not. From an analysis of these practices, this paper proposes that African philanthropy can be conceptually structured on the basis of spheres of philanthropic practice, and the underlying bases and motivations for philanthropy. On spheres of philanthropic practice, at least three forms of philanthropy exist: institutional (formal); non-institutional (non-formal/informal/direct); and a hybrid form that blends practices from the formal and informal spheres. On motivations for giving, the predominant forms are based on mutuality, solidarity and counter-obligation inherent in collectivist and humanistic African philosophies of life. Further, motivations are drawn from religious obligations, institutional requirements on corporate bodies, and institutional arrangements in the development process. There are, nonetheless, significant overlaps between spheres of practice and motivations in contemporary philanthropic practices in Africa. For instance, philanthropic culture in Africa manifests as religious giving, donations to individuals or institutions, mutual aid, reciprocal, self-help revolving fund organisations, corporate social responsibility activities, and individual/family donations to public benefit organisations. These practices highlight a rich tapestry of spheres of practice and motivations for giving practices, where the wealthy and the poor are equally involved. The review, concentrates (by choice) on giving of money and time (volunteering, especially informal volunteering) due to dearth of academic literature on other forms of giving as philanthropy in Africa