A Critical Review of Sensors for the Continuous Monitoring of Smart and Sustainable Railway Infrastructures

Real-time and continuous monitoring through smart sensors is considered to be the evolution of traditional track testing, enabling the earlier detection of the main failure modes that degrade railway tracks. Through carrying out preventive maintenance operations, infrastructure resources may be optimized, leading to smarter and more sustainable infrastructure. For this reason, under the larger goal of creating a synergy with various types of sensors for railway tracks, this article presents a critical review on the di erent, currently available sensors for smart and continuous monitoring. Specifically, the most appropriate monitoring technologies for each of the main railway track failure modes have been assessed and identified, thus deriving the advantages and capacities of each solution. Furthermore, this review presents some of the main experiences carried out to date in literature by using sensor technologies, such as strain gauges, piezoelectric sensors, fiber-optics, geophones and accelerometers. These technologies have proven to o er appropriate characteristics and accuracy for the continuous monitoring of a railway track’s structural state, being capable of measuring di erent parameters, such as deflections, deformations, stresses or accelerations that would permit the technical tracking of various forms of degradation

Coastal Line Changes in Mediterranean Cities: Man or Nature?

Despite being a relatively stable sea compared to the great oceans, the Mediterranean is not a risk-free place of changes in the coast, both anthropogenic and natural. The coast is home to a large part of the population and cities which are generally in constant growth due to the quality of life and the possibilities offered (i.e. tourism and other activities linked to the sea). In Mediterranean coastal cities, the first maritime line is usually the one with the highest economical value and, where the space is used intensively. For this reason, land managers have developed strategies to occupy the maximum extension of the coast. Some of these are new uses for old port areas, take advantage of coastal containment works, extending the beaches mean artificial regenerations, the construction of breakwaters and, adding waste materials in order to increment the land, gain it to the sea. So that, the urban coastal lines of Mediterranean cities have been changing a long time. This work presents these changes in the past years (last 60 years) through a methodology based on the comparison of aerial photography from different times (1956–1957 and PNOA 2014–2016) in the following settlements of the South-East of Spain: Alicante, El Campello, Santa Pola, Torrevieja, Altea and Villajoyosa). The changes have been categorized so that we can quantify the type and proportion of the changes and discriminate if those are natural or artificial. The results showed that most of the municipalities have registered changes, those were due to land reclaimed to the sea and man is the main driver of this change. These changes mask and correct those due to natural erosion, soil loss or geological changes in the coastline

GRIDMAT—A Sustainable Material Combining Mat and Geogrid Concept for Ballasted Railways

Under ballast mats (UBM) have demonstrated their capacity to reduce section stiffness and ballast degradation. However, UBM can cause ballast destabilisation under some circumstances due to excessive vertical track deflections, requiring the installation of geogrids over the mat which increases costs and time. As alternative to this solution, this paper shows the design of GridMat: a sustainable technology for ballasted railways that combines the concepts of geogrids and under ballast mats (UBM) manufactured from recycled crumb rubber. This aims to provide damping capacity while limiting the oscillations and settlement of ballast layer. To obtain the optimal GridMat design, five different configurations varying the aperture size and void areas were assessed through laboratory box tests reproducing the track section including the GridMat. Results showed that the optimal Gridmat was of 55 mm aperture seize and 25% void area. To evaluate the sustainability of this design, the expected number of conservation and renewal operations were calculated from full-scale laboratory tests and a life-cycle assessment and life-cycle cost analysis were undertaken. GridMat showed long-term reduction in ballast degradation and track settlement, reducing need for maintenance and renewal operations in comparison with standard mats.Spanish Government RTI2018-102124-J-IO

End of life in patients attended by pediatric palliative care teams: what factors influence the place of death and compliance with family preferences?

Each year, more than 8 million children worldwide require specialized palliative care, yet there is little evidence available in pediatrics on the characteristics of the end of life in this context. Our aim is to analyze the characteristics of patients who die in the care of specific pediatric palliative care teams. This is ambispective, analytical observational, multicenter study conducted between 1 January and 31 December 2019. Fourteen specific pediatric palliative care teams participated. There are 164 patients, most of them suffering from oncologic, neurologic, and neuromuscular processes. The follow-up time was 2.4 months. The parents voiced preferences in respect of the place of death for 125 of the patients (76.2%). The place of death for 95 patients (57.9%) was at the hospital and 67 (40.9%) was at home. The existence of a palliative care team for over 5 years is more likely to be related to families voicing preferences and their fulfillment. Longer follow-up times by pediatric palliative care teams were observed in families with whom preferences regarding the place of death were discussed and in patients who died at home. Patients who did not receive home visits, when the pediatric palliative care team did not provide full care and when preferences regarding the place of death were not discussed with parents, were more likely to die in the hospital. Conclusions: Advance planning of end-of-life care is one of the most important aspects of pediatric palliative care. The provision of services by the teams and the follow-up time are related to parents’ expressed preferences and the place of death.Funding for open access charge: Universidad de Málaga / CBU

Grado en Geología de la Universidad de Alicante (2010-2014). Red de seguimiento

Con el comienzo del cuarto y último curso del grado en Geología en 2013-14, en la Facultad de Ciencias de la Universidad de Alicante se constituyó una red de seguimiento formada por todos los profesores coordinadores de semestre del citado grado. Esta red se enmarca en el programa de Redes de Investigación en Docencia Universitaria que la Universidad de Alicante ha implementado desde la implantación de los títulos de grado. El objetivo principal de esta red docente se ha centrado en realizar un seguimiento de la titulación en el marco de Sistema de Garantía Interno de Calidad (SGIC) y en desarrollar herramientas que favorezcan, tanto el buen funcionamiento del título, como la gestión interna del seguimiento del mismo. El método de trabajo se ha basado en reuniones en las que los miembros de la red han planteado y debatido los parámetros e indicadores de seguimiento de la red. Esta red ha trabajado conjuntamente con otras comisiones de la titulación como la Comisión del Grado en Geología (CGG), la Comisión de Trabajo de Fin de Grado en Geología (CTFGG) o la Comisión de Garantía de Calidad de la Facultad de Ciencias (CGCFC)

Red de seguimiento del grado en Geología (Facultad de Ciencias, UA)

Con el comienzo del cuarto y último curso del grado en Geología en el año académico 2013-14 y en el marco del programa de Redes de Investigación en Docencia Universitaria de la Universidad de Alicante, en la Facultad de Ciencias se ha constituido una red de trabajo formada por los profesores coordinadores de semestre del Grado en Geología, que tiene como principal objetivo favorecer, tanto el buen funcionamiento del título, como la gestión interna del seguimiento del mismo. Se persigue pues detectar posibles deficiencias en la implementación del título, proponiendo recomendaciones y sugerencias de mejora, así como evidenciar los progresos del título en el desarrollo del Sistema de Garantía Interno de Calidad (SGIC), tanto en lo relativo a la revisión de la aplicación del plan de estudios, como a la propuesta de acciones para mejorar su diseño e implantación. El método de trabajo se ha basado en reuniones en las que los miembros de la red han planteado y debatido los parámetros e indicadores de seguimiento de la red

Influence of COVID-19 on the Perception of Academic Self-Efficacy, State Anxiety, and Trait Anxiety in College Students

We are grateful to Ms. Ana Yara Postigo-Fuentes for her assistance with the English language.The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fpsyg. 2020.570017/full#supplementary-materialThe worldwide pandemic situation caused by coronavirus disease 2019 (COVID-19) has led to a state of confinement of the population, which has caused, following consulted research, an increase in stress. Faced with this situation, the Spanish university not only had to adapt to the changes derived from the causes of the pandemic but also had to face a new methodological model—e-learning teaching—for which not all teachers and students were prepared. This could cause an increase in stress due to the uncertainty caused by this time of change. This research analyzes the relationship between perceived self-efficacy in the confinement period and the level of trait anxiety (TA) and state anxiety (SA) during COVID-19. Four hundred twenty-seven students from the University of Granada (Spain) participated in this study. The adaptation of two scales that measure perceived academic self-efficacy and anxiety (TA and SA) has been applied. The results indicated that there was an inversely proportional relationship between anxiety and self-efficacy; men showed the highest perception of self-efficacy, while women had higher scores in TA and SA; the latter was accentuated in cases when a relative died. To conclude, students who show a higher level of anxiety (TA and SA) express more negative emotions and also perceive themselves with less academic self-efficacy. Therefore, a stressful situation (pandemic and confinement) together with a critical event (illness and death of a relative/friend due to COVID-19) increases anxiety levels and influences the perception of academic self-efficacy

Spread of a SARS-CoV-2 variant through Europe in the summer of 2020.

Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3–5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes. © 2021, The Author(s), under exclusive licence to Springer Nature Limited

Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.

Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes

Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study

Background: Sepsis and severe focal infections represent a substantial disease burden in children admitted to hospital. We aimed to understand the burden of disease and outcomes in children with life-threatening bacterial infections in Europe. Methods: The European Union Childhood Life-threatening Infectious Disease Study (EUCLIDS) was a prospective, multicentre, cohort study done in six countries in Europe. Patients aged 1 month to 18 years with sepsis (or suspected sepsis) or severe focal infections, admitted to 98 participating hospitals in the UK, Austria, Germany, Lithuania, Spain, and the Netherlands were prospectively recruited between July 1, 2012, and Dec 31, 2015. To assess disease burden and outcomes, we collected demographic and clinical data using a secured web-based platform and obtained microbiological data using locally available clinical diagnostic procedures. Findings: 2844 patients were recruited and included in the analysis. 1512 (53·2%) of 2841 patients were male and median age was 39·1 months (IQR 12·4–93·9). 1229 (43·2%) patients had sepsis and 1615 (56·8%) had severe focal infections. Patients diagnosed with sepsis had a median age of 27·6 months (IQR 9·0–80·2), whereas those diagnosed with severe focal infections had a median age of 46·5 months (15·8–100·4; p<0·0001). Of 2844 patients in the entire cohort, the main clinical syndromes were pneumonia (511 [18·0%] patients), CNS infection (469 [16·5%]), and skin and soft tissue infection (247 [8·7%]). The causal microorganism was identified in 1359 (47·8%) children, with the most prevalent ones being Neisseria meningitidis (in 259 [9·1%] patients), followed by Staphylococcus aureus (in 222 [7·8%]), Streptococcus pneumoniae (in 219 [7·7%]), and group A streptococcus (in 162 [5·7%]). 1070 (37·6%) patients required admission to a paediatric intensive care unit. Of 2469 patients with outcome data, 57 (2·2%) deaths occurred: seven were in patients with severe focal infections and 50 in those with sepsis. Interpretation: Mortality in children admitted to hospital for sepsis or severe focal infections is low in Europe. The disease burden is mainly in children younger than 5 years and is largely due to vaccine-preventable meningococcal and pneumococcal infections. Despite the availability and application of clinical procedures for microbiological diagnosis, the causative organism remained unidentified in approximately 50% of patients