Baryon Resonances

In this talk I show recent results on how many excited baryon resonances appear as systems of one meson and one baryon, or two mesons and one baryon, with the mesons being either pseudoscalar or vectors. Connection with experiment is made including a discussion on old predictions and recent results for the photoproduction of the $\Lambda(1405)$ resonance, as well as the prediction of one $1/2^+$ baryon state around 1920 MeV which might have been seen in the $\gamma p \to K^+ \Lambda$ reaction.Comment: Talk given at the 10th International Conference on Hypernuclear and Strange Particle Physics, Tokai, Japan, Sptember 200

Monochromatic neutrino beams

In the last few years spectacular results have been achieved with the demonstration of non vanishing neutrino masses and flavour mixing. The ultimate goal is the understanding of the origin of these properties from new physics. In this road, the last unknown mixing [Ue3] must be determined. If it is proved to be non-zero, the possibility is open for Charge Conjugation-Parity (CP) violation in the lepton sector. This will require precision experiments with a very intense neutrino source. Here a novel method to create a monochromatic neutrino beam, an old dream for neutrino physics, is proposed based on the recent discovery of nuclei that decay fast through electron capture. Such nuclei will generate a monochromatic directional neutrino beam when decaying at high energy in a storage ring with long straight sections. We also show that the capacity of such a facility to discover new physics is impressive, so that fine tuning of the boosted neutrino energy allows precision measurements of the oscillation parameters even for a [Ue3] mixing as small as 1 degree. We can thus open a window to the discovery of CP violation in neutrino oscillations

A global view of drug-therapy interactions

Network science is already making an impact on the study of complex systems and offers a promising variety of tools to understand their formation and evolution (1-4) in many disparate fields from large communication networks (5,6), transportation infrastructures (7) and social communities (8,9) to biological systems (1,10,11). Even though new highthroughput technologies have rapidly been generating large amounts of genomic data, drug design has not followed the same development, and it is still complicated and expensive to develop new single-target drugs. Nevertheless, recent approaches suggest that multi-target drug design combined with a network-dependent approach and large-scale systems-oriented strategies (12-14) create a promising framework to combat complex multigenetic disorders like cancer or diabetes. Here, we investigate the human network corresponding to the interactions between all US approved drugs and human therapies, defined by known drug-therapy relationships. Our results show that the key paths in this network are shorter than three steps, indicating that distant therapies are separated by a surprisingly low number of chemical compounds. We also identify a sub-network composed by drugs with high centrality measures (15), which represent the structural back-bone of the drug-therapy system and act as hubs routing information between distant parts of the network. These findings provide for the first time a global map of the largescale organization of all known drugs and associated therapies, bringing new insights on possible strategies for future drug development. Special attention should be given to drugs which combine the two properties of (a) having a high centrality value and (b) acting on multiple targets.Comment: 16 pages, 4 figures. It was submitted to peer review on August 15, 200

Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway

During early brain development, N-methyl-d-aspartate (NMDA) receptors are involved in cell migration, neuritogenesis, axon guidance and synapse formation, but the mechanisms which regulate NMDA receptor density and function remain unclear. The kynurenine pathway of tryptophan metabolism includes an agonist (quinolinic acid) and an antagonist (kynurenic acid) at NMDA receptors and we have previously shown that inhibition of the pathway using the kynurenine-3-monoxygenase inhibitor Ro61-8048 in late gestation produces rapid changes in protein expression in the embryos and effects on synaptic transmission lasting until postnatal day 21 (P21). The present study sought to determine whether any of these effects are maintained into adulthood. After prenatal injections of Ro61-8048 the litter was allowed to develop to P60 when some offspring were euthanized and the brains removed for examination. Analysis of protein expression by Western blotting revealed significantly reduced expression of the GluN2A subunit (32%) and the morphogenetic protein sonic hedgehog (31%), with a 29% increase in the expression of doublecortin, a protein associated with neurogenesis. No changes were seen in mRNA abundance using quantitative real-time polymerase chain reaction. Neuronal excitability was normal in the CA1 region of hippocampal slices but paired-pulse stimulation revealed less inhibition at short interpulse intervals. The amount of long-term potentiation was decreased by 49% in treated pups and recovery after low-frequency stimulation was delayed. The results not only strengthen the view that basal, constitutive kynurenine metabolism is involved in normal brain development, but also show that changes induced prenatally can affect the brains of adult offspring and those changes are quite different from those seen previously at weaning (P21). Those changes may be mediated by altered expression of NMDAR subunits and sonic hedgehog

Novedoso asignador de talla de calzado para la venta por Internet

[ES] MADE IN ME (www.madeinmeshoes.com) es una empresa dedicada al comercio electrónico de calzado diseñado por el propio cliente en función de sus gustos y preferencias. El Instituto de Biomecánica (IBV) ha desarrollado para esta empresa un nuevo asignador de talla de calzado de mujer basado en la antropometría de la población femenina española. Además, el asignador está personalizado para los distintos modelos de calzado que comercializa la empresa.Solves Camallonga, C.; Nacher Fernandez, B.; Gonzalez Garcia, JC.; Herraiz, E.; Benages, L.; Uriel-Molto, J.; Gil Mora, S.... (2017). Novedoso asignador de talla de calzado para la venta por Internet. Revista de Biomecánica (Online). (64). http://hdl.handle.net/10251/104225S6

Validation of the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being-Expanded (FACIT-Sp-Ex) Across English and Spanish-Speaking Hispanics/Latinos: Results From the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study

The validity of the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being (FACIT-Sp) has been examined in primarily non-Hispanics/Latinos with chronic illness. This study assessed the psychometric properties of the nonillness, expanded FACIT-Sp (FACIT-Sp-Ex) in 5,163 U.S. Hispanic/Latino adults. Measures were interviewer-administered in English or Spanish. Confirmatory factor analyses indicated 4 factors: meaning, peace, faith, and relational. The scale demonstrated measurement invariance across English and Spanish. Subscales displayed adequate internal and test-retest reliability. Scores were positively associated with Duke Religion Index (DUREL; Koenig, Parkerson, & Meador, 1997) subscales. When all subscales were entered in a single model, meaning and peace were inversely associated with depressive symptoms and positively associated with physical health-related quality of life (HRQOL). Faith was positively associated with depressive symptoms and inversely associated with HRQOL. Relational was not associated with any outcome. FACIT-Sp-Ex subscales were generally more strongly associated than DUREL subscales with well-being. The FACIT-Sp-Ex appears to be a valid measure of spiritual well-being in U.S. Hispanics/Latinos