44 research outputs found
[18F]FDG-6-P as a novel in vivo tool for imaging staphylococcal infections
- Author
- A Beceiro
- A Bunschoten
- A Signore
- AL Hook
- BJ Fueger
- BM Diederen
- C Kim
- C Love
- C Zoccali
- CJ Palestro
- DA Etzioni
- EA Weinstein
- ECDC
- ECDC
- ED Charlebois
- EJ Gorak
- F Jamar
- FD Lowy
- G Gowrishankar
- HA Carleton
- HH Winkler
- J Kluytmans
- JJ Lukawska
- JL Kadurugamuwa
- JM Yarwood
- K Kaarstad
- KD Stumpe
- L Moberg
- LR Thurlow
- M DallâAntonia
- M Watanabe
- MF Kluytmans-Vandenbergh
- N Dumarey
- NA Kuklin
- NK Archer
- RL Burns
- S Basu
- SJ Rosenbaum
- SY Aksoy
- TA Sasser
- TK Chacko
- V Kumar
- W Becker
- WHO
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Background
Management of infection is a major clinical problem. Staphylococcus aureus is a Gram-positive bacterium which colonises approximately one third of the adult human population. Staphylococcal infections can be life-threatening and are frequently complicated by multi-antibiotic resistant strains including methicillin-resistant S. aureus (MRSA). Fluorodeoxyglucose ([18F]FDG) imaging has been used to identify infection sites; however, it is unable to distinguish between sterile inflammation and bacterial load. We have modified [18F]FDG by phosphorylation, producing [18F]FDG-6-P to facilitate specific uptake and accumulation by S. aureus through hexose phosphate transporters, which are not present in mammalian cell membranes. This approach leads to the specific uptake of the radiopharmaceutical into the bacteria and not the sites of sterile inflammation.
Methods
[18F]FDG-6-P was synthesised from [18F]FDG. Yield, purity and stability were confirmed by RP-HPLC and iTLC. The specificity of [18F]FDG-6-P for the bacterial universal hexose phosphate transporter (UHPT) was confirmed with S. aureus and mammalian cell assays in vitro. Whole body biodistribution and accumulation of [18F]FDG-6-P at the sites of bioluminescent staphylococcal infection were established in a murine foreign body infection model.
Results
In vitro validation assays demonstrated that [18F]FDG-6-P was stable and specifically transported into S. aureus but not mammalian cells. [18F]FDG-6-P was elevated at the sites of S. aureus infection in vivo compared to uninfected controls; however, the increase in signal was not significant and unexpectedly, the whole-body biodistribution of [18F]FDG-6-P was similar to that of [18F]FDG.
Conclusions
Despite conclusive in vitro validation, [18F]FDG-6-P did not behave as predicted in vivo. However at the site of known infection, [18F]FDG-6-P levels were elevated compared with uninfected controls, providing a higher signal-to-noise ratio. The bacterial UHPT can transport hexose phosphates other than glucose, and therefore alternative sugars may show differential biodistribution and provide a means for specific bacterial detection
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
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- Akin IV
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- Albayrak EA
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- Albergo S
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- Altsybeev I
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- 'IOP Publishing'
- Publication date
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- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
A new species of Stenobiella Tillyard (Neuroptera, Berothidae) from Australia
- Author
- A Dahlberg
- A Ekblad
- A Johansen
- A Johansen
- A Johansen
- A Tunlid
- ADM Rayner
- AG Jongmans
- B Bago
- B Bago
- B Bago
- B Brandes
- B Mosse
- C Gazey
- C Logi
- CF Friese
- CM Hepper
- D Robinson
- DH Jennings
- DH Lewis
- DH Lewis
- DJ Read
- DJ Read
- DJ Read
- DP Horan
- EJ Joner
- EJ Joner
- EJ Joner
- EL Charnov
- F Brand
- F Paris
- G BĂŠcard
- GD Bending
- GD Bending
- H Ek
- H Green
- H Kroon
- H Wallander
- H Wallander
- H Wallander
- H Wallander
- H Wallander
- H Wallander
- I Jakobsen
- IC Tommerup
- J Baar
- J Dighton
- J Larsen
- J Larsen
- J-E Nylund
- JCC Miranda
- JH Wessel
- JO Siqueira
- JV Colpaert
- JV Colpaert
- JWG Cairney
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- K Cromack
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- K Wiklund
- KM Cooper
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- L Bolan
- LJ Hutchinson
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- M Cui
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- M Giovannetti
- M Giovannetti
- M Giovannetti
- M Giovannetti
- M Kling
- M Ogawa
- MD Jones
- MJ Harrison
- MJ Hutchings
- MP Coutts
- NK Watkins
- P Bonello
- P HĂśgberg
- PA Olsson
- PA Olsson
- PA Olsson
- PA Olsson
- PA Olsson
- PA Olsson
- PA Olsson
- PA Olsson
- PA Olsson
- PE Pfeffer
- RD Finlay
- RD Finlay
- RH Arthur
- RL Sinsabaugh
- RM Miller
- RP Griffiths
- RP Griffiths
- S Erland
- S Mahmood
- S Olsson
- S Olsson
- S Ravnskov
- SE Smith
- SF Wright
- T Unestam
- T Unestam
- T Wallenda
- TD Bruns
- TJ Carleton
- TV John
- X-L Li
- X-L Li
- Publication venue
- Pensoft Publishers
- Publication date
- 01/01/2002
- Field of study
Stenobiella variola sp. n., a new species of beaded lacewing (Neuroptera: Berothidae), is described and figured from south-eastern Australia. A preliminary key to Stenobiella species is presented
Community-based intervention for blood pressure reduction in Nepal (COBIN trial): study protocol for a cluster-randomized controlled trial
- Author
- A Alwan
- A Haines
- A Krishnan
- Arjun Karki
- B Almeida-Pittito
- Bo Christensen
- Craig S. McLachlan
- D Neupane
- D Neupane
- D Neupane
- Dinesh Neupane
- Eastern Stroke and Coronary Heart Disease Collaborative Research Group
- FP Cappuccio
- GK Dowse
- Henry B. Perry
- J Chen
- KK Aryal
- L Kish
- NK Janz
- P Puska
- Per Kallestrup
- PK Whelton
- QN Nguyen
- R DamiĂŁo
- R Kelishadi
- R Stamler
- RA Carleton
- RE Gearing
- SA Lewin
- TH Jafar
- YC Hsieh
- YY Lee
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
CMS Data Processing Workflows during an Extended Cosmic Ray Run
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- Abbiendi G
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- Cockerill DJA
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
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- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
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- Akimenko S
- Akin IV
- Alagoz E
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- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
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- Alexander J
- Alidra M
- Aliev T
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- Almeida N
- Altenhofer G
- Altsybeev I
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- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
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- Andreev V
- Andreev Y
- Anghel IM
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- Publication venue
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Commissioning of the CMS high-level trigger with cosmic rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
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- Publication venue
- 'IOP Publishing'
- Publication date
- 26/11/2009
- Field of study
This is the Pre-print version of the Article. The official published version of the paper can be accessed from the link below - Copyright @ 2010 IOPThe CMS High-Level Trigger (HLT) is responsible for ensuring that data samples with potentially interesting events are recorded with high efficiency and good quality. This paper gives an overview of the HLT and focuses on its commissioning using cosmic rays. The selection of triggers that were deployed is presented and the online grouping of triggered events into streams and primary datasets is discussed. Tools for online and offline data quality monitoring for the HLT are described, and the operational performance of the muon HLT algorithms is reviewed. The average time taken for the HLT selection and its dependence on detector and operating conditions are presented. The HLT performed reliably and helped provide a large dataset. This dataset has proven to be invaluable for understanding the performance of the trigger and the CMS experiment as a whole.This work is supported by FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ,
and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS
(Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia);
Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR
(Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTDS (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)
Identification and Filtering of Uncharacteristic Noise in the CMS Hadron Calorimeter
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/1
- Field of study
VertaisarvioitupeerReviewe
Performance of CMS Hadron Calorimeter Timing and Synchronization using Test Beam, Cosmic Ray, and LHC Beam Data
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
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- Andelin D
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- Andreev Y
- Anghel IM
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- Arnold B
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- Ashby S
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- Zachariadou A
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- Zhang J
- Zhang L
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- Zhang Z
- Zheng Y
- Zhiltsov V
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- Zhukov V
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/1
- Field of study
Peer reviewe
Performance of the CMS drift tube chambers with cosmic rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
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- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
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- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
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- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
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- Andreev Y
- Anghel IM
- Anguelov T
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- Auffray E
- Aurisano A
- Autermann C
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- Avetisyan A
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- Bakken JA
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- Banerjee S
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- Belotelov I
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- Zabolotny W
- Zachariadou A
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- Zang SL
- Zarubin A
- Zatzerklyany A
- Zeidler C
- Zeinali M
- Zeise M
- Zelepoukine S
- Zeuner WD
- Zeyrek M
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- Zheng Y
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- Zhokin A
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- Zhukova V
- Ziebarth EB
- Zielinski M
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/1
- Field of study
This is the Pre-print version of the Article. The official published version of the paper can be accessed from the link below - Copyright @ 2010 IOPStudies of the performance of the CMS drift tube barrel muon system are described, with results based on data collected during the CMS Cosmic Run at Four Tesla. For most of these data, the solenoidal magnet was operated with a central field of 3.8 T. The analysis of data from 246 out of a total of 250 chambers indicates a very good muon reconstruction capability, with a coordinate resolution for a single hit of about 260 Îźm, and a nearly 100% efficiency for the drift tube cells. The resolution of the track direction measured in the bending plane is about 1.8 mrad, and the efficiency to reconstruct a segment in a single chamber is higher than 99%. The CMS simulation of cosmic rays reproduces well the performance of the barrel muon detector.This work is supported by FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ,
and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS
(Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia);
Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG,
and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF (Korea); LAS (Lithuania); CINVESTAV, CONACYT,
SEP, and UASLP-FAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTDS (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)