626 research outputs found
BCP crystals increase prostacyclin production and upregulate the prostacyclin receptor in OA synovial fibroblasts: potential effects on mPGES1 and MMP-13
SummaryObjectiveTo investigate the potential involvement of prostacyclin in basic calcium phosphate (BCP) crystal-induced responses in osteoarthritic synovial fibroblasts (OASF).MethodsOASF grown in culture were stimulated with BCP crystals. Prostacyclin production was measured by enzyme immunoassay. Expression of messenger RNA (mRNA) transcripts was assessed by real-time polymerase chain reaction (PCR). Expression of prostacyclin synthase (PGIS) and the prostacyclin (IP) receptor was measured. The effects of iloprost, a prostacyclin analogue, on expression of genes implicated in osteoarthritis such as microsomal prostaglandin E2 synthase 1 (mPGES1) and matrix metalloproteinases (MMPs) were also studied. FPT inhibitor II, a farnesyl transferase inhibitor, was used to antagonize iloprost-induced responses.ResultsBCP crystal stimulation led to a five-fold increase in prostacyclin production in OASF compared to untreated cells. This induction was attenuated by cyclooxygenase (COX)-2 and COX-1 inhibition at 4 and 32h, respectively. PGIS and IP receptor transcripts were constitutively expressed in OASF. BCP crystals upregulated IP receptor expression two-fold. While iloprost diminished BCP crystal-stimulated IP receptor upregulation, the inhibitory effect of iloprost was blocked by the farnesyl transferase inhibitor. In addition, iloprost upregulated mPGES1 and downregulated MMP-13 expression in BCP crystal-stimulated OASF, effects that were not influenced by the farnesyl transferase inhibitor.ConclusionsThese data showed for the first time that BCP crystals can increase prostacyclin production and upregulate expression of the IP receptor in OASF. The potential of prostacyclin to influence BCP crystal-stimulated responses was supported by the effects of iloprost on the expression of the IP receptor, mPGES1 and MMP-13. These data demonstrate the potential involvement of prostacyclin in BCP crystal-associated osteoarthritis (OA) and suggest that inhibition of PG synthesis with non-steroidal anti-inflammatory drugs may have both deleterious and beneficial effects in BCP crystal-associated OA
Degenerations of ideal hyperbolic triangulations
Let M be a cusped 3-manifold, and let T be an ideal triangulation of M. The
deformation variety D(T), a subset of which parameterises (incomplete)
hyperbolic structures obtained on M using T, is defined and compactified by
adding certain projective classes of transversely measured singular
codimension-one foliations of M. This leads to a combinatorial and geometric
variant of well-known constructions by Culler, Morgan and Shalen concerning the
character variety of a 3-manifold.Comment: 31 pages, 11 figures; minor changes; to appear in Mathematische
Zeitschrif
The Muonium Atom as a Probe of Physics beyond the Standard Model
The observed interactions between particles are not fully explained in the
successful theoretical description of the standard model to date. Due to the
close confinement of the bound state muonium () can be used as
an ideal probe of quantum electrodynamics and weak interaction and also for a
search for additional interactions between leptons. Of special interest is the
lepton number violating process of sponteanous conversion of muonium to
antimuonium.Comment: 15 pages,6 figure
Adiabatic Output Coupling of a Bose Gas at Finite Temperatures
We develop a general theory of adiabatic output coupling from trapped atomic
Bose-Einstein Condensates at finite temperatures. For weak coupling, the output
rate from the condensate, and the excited levels in the trap, settles in a time
proportional to the inverse of the spectral width of the coupling to the output
modes. We discuss the properties of the output atoms in the quasi-steady-state
where the population in the trap is not appreciably depleted. We show how the
composition of the output beam, containing condensate and thermal component,
may be controlled by changing the frequency of the output coupler. This
composition determines the first and second order coherence of the output beam.
We discuss the changes in the composition of the bose gas left in the trap and
show how nonresonant output coupling can stimulate either the evaporation of
thermal excitations in the trap or the growth of non-thermal excitations, when
pairs of correlated atoms leave the condensate.Comment: 22 pages, 6 Figs. To appear in Physical Review A All the typos from
the previous submission have been fixe
Quantum Kinetic Theory III: Quantum kinetic master equation for strongly condensed trapped systems
We extend quantum kinetic theory to deal with a strongly Bose-condensed
atomic vapor in a trap. The method assumes that the majority of the vapor is
not condensed, and acts as a bath of heat and atoms for the condensate. The
condensate is described by the particle number conserving Bogoliubov method
developed by one of the authors. We derive equations which describe the
fluctuations of particle number and phase, and the growth of the Bose-Einstein
condensate. The equilibrium state of the condensate is a mixture of states with
different numbers of particles and quasiparticles. It is not a quantum
superposition of states with different numbers of particles---nevertheless, the
stationary state exhibits the property of off-diagonal long range order, to the
extent that this concept makes sense in a tightly trapped condensate.Comment: 3 figures submitted to Physical Review
Aquatic food security:insights into challenges and solutions from an analysis of interactions between fisheries, aquaculture, food safety, human health, fish and human welfare, economy and environment
Fisheries and aquaculture production, imports, exports and equitability of distribution determine the supply of aquatic food to people. Aquatic food security is achieved when a food supply is sufficient, safe, sustainable, shockproof and sound: sufficient, to meet needs and preferences of people; safe, to provide nutritional benefit while posing minimal health risks; sustainable, to provide food now and for future generations; shock-proof, to provide resilience to shocks in production systems and supply chains; and sound, to meet legal and ethical standards for welfare of animals, people and environment. Here, we present an integrated assessment of these elements of the aquatic food system in the United Kingdom, a system linked to dynamic global networks of producers, processors and markets. Our assessment addresses sufficiency of supply from aquaculture, fisheries and trade; safety of supply given biological, chemical and radiation hazards; social, economic and environmental sustainability of production systems and supply chains; system resilience to social, economic and environmental shocks; welfare of fish, people and environment; and the authenticity of food. Conventionally, these aspects of the food system are not assessed collectively, so information supporting our assessment is widely dispersed. Our assessment reveals trade-offs and challenges in the food system that are easily overlooked in sectoral analyses of fisheries, aquaculture, health, medicine, human and fish welfare, safety and environment. We highlight potential benefits of an integrated, systematic and ongoing process to assess security of the aquatic food system and to predict impacts of social, economic and environmental change on food supply and demand
How European Fans in Training (EuroFIT), a lifestyle change program for men delivered in football clubs, achieved its effect : a mixed methods process evaluation embedded in a randomised controlled trial
Funding This project has received funding from the European Unionâs Seventh Framework Program for research, technological development, and demonstration under grant agreement number 602170. The Health Services Research Unit, University of Aberdeen, receives core funding from the Chief Scientist Office of the Scottish Government Health Directorates. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgements We are grateful to participants who took part in the research, coaches and club managers at fifteen football clubs and UEFAâs Football and Social Responsibility department for supporting the proposal at bidding stage. Ciaran Clissman of Pintail Ltd managed the project and provided invaluable editorial input into the funding application and delivery of the program. Prof Nanette Mutrie was substantially involved in the development of the EuroFIT program. Dr Lisa Macauley administered the UK data collection in the UK and Alan Pollok supported some UK data collection. Dr Mattias Rost and Prof Mathew Chalmers were substantially involved in the development of MatchFIT and Drs Douglas Maxwell and Nikos Mourselas of PAL Technologies in the technical development of the SitFIT. Views and opinions expressed are those of the authors and do not necessarily reflect those of the European Union.Peer reviewedPublisher PD
Specific Local Cardiovascular Changes of NÉ-(Carboxymethyl)lysine, Vascular Endothelial Growth Factor, and Smad2 in the Developing Embryos Coincide With Maternal DiabetesâInduced Congenital Heart Defects
Origins of the Ambient Solar Wind: Implications for Space Weather
The Sun's outer atmosphere is heated to temperatures of millions of degrees,
and solar plasma flows out into interplanetary space at supersonic speeds. This
paper reviews our current understanding of these interrelated problems: coronal
heating and the acceleration of the ambient solar wind. We also discuss where
the community stands in its ability to forecast how variations in the solar
wind (i.e., fast and slow wind streams) impact the Earth. Although the last few
decades have seen significant progress in observations and modeling, we still
do not have a complete understanding of the relevant physical processes, nor do
we have a quantitatively precise census of which coronal structures contribute
to specific types of solar wind. Fast streams are known to be connected to the
central regions of large coronal holes. Slow streams, however, appear to come
from a wide range of sources, including streamers, pseudostreamers, coronal
loops, active regions, and coronal hole boundaries. Complicating our
understanding even more is the fact that processes such as turbulence,
stream-stream interactions, and Coulomb collisions can make it difficult to
unambiguously map a parcel measured at 1 AU back down to its coronal source. We
also review recent progress -- in theoretical modeling, observational data
analysis, and forecasting techniques that sit at the interface between data and
theory -- that gives us hope that the above problems are indeed solvable.Comment: Accepted for publication in Space Science Reviews. Special issue
connected with a 2016 ISSI workshop on "The Scientific Foundations of Space
Weather." 44 pages, 9 figure
Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment
This paper describes an analysis of the angular distribution of W->enu and
W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with
the ATLAS detector at the LHC in 2010, corresponding to an integrated
luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and
the missing transverse energy, the W decay angular distribution projected onto
the transverse plane is obtained and analysed in terms of helicity fractions
f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV
and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw
> 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour,
are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017
+/- 0.030, where the first uncertainties are statistical, and the second
include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables,
revised author list, matches European Journal of Physics C versio
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