Stabilization and Performance over a Gaussian Communication Channel for a Plant with Time Delay

Two problems that have received much attention are those of finding the minimum channel signal to noise ratio compatible with closed loop stability, and of finding the optimal performance, in terms of disturbance attenuation, for a channel with specified signal to noise ratio. In this paper, we study these problems for the case in which the plant has relative degree greater than one, and thus introduces a delay greater than one time step. We show that, unlike the relative degree one case, for the problem of stabilization linear time varying control and communication strategies may have advantages over linear time invariant strategies. We derive a lower bound on optimal disturbance response at a fixed terminal time. If the encoder has access to the state of the plant, then this bound is achievable using linear time varying communication and control

Piezoelectric power scavenging of mechanical vibration energy

The process of acquiring the energy surrounding a system and converting it into usable electrical energy is termed power harvesting. With piezoceramic materials, it is possible to harvest power from vibrating structures. It has been proven that micro-to milliwatts of power can be generated from vibrating systems. The project targets the transformation of mechanical vibration into electrical energy using piezoelectric material. In some mining applications, eg water jet drilling; large high frequency vibrations may be present. If successfully harvested, this energy could be used to eliminate batteries in wireless sensors. This article presents a model of a piezoelectric transducer, a mechanical vibration spectrum, the simulation of the model, prototype of the power scavenging circuit, experimental results and its future perspectives

Piezoelectric power scavenging of mechanical vibration energy

The process of acquiring the energy surrounding a system and converting it into usable electrical energy is termed power harvesting. With piezoceramic materials, it is possible to harvest power from vibrating structures. It has been proven that micro-to milliwatts of power can be generated from vibrating systems. The project targets the transformation of mechanical vibration into electrical energy using piezoelectric material. In some mining applications, eg water jet drilling; large high frequency vibrations may be present. If successfully harvested, this energy could be used to eliminate batteries in wireless sensors. This article presents a model of a piezoelectric transducer, a mechanical vibration spectrum, the simulation of the model, prototype of the power scavenging circuit, experimental results and its future perspectives

Fundamental Limitations in Control over a Communication Channel

Fundamental limitations in feedback control is a well established area of research. In recent years it has been extended to the study of limitations imposed by the consideration of a communication channel in the control loop. Previous results characterised these limitations in terms of a minimal data transmission rate necessary for stabilisation. In this paper a signal-to-noise ratio (SNR) approach is used to obtain a tight condition for the linear time invariant output feedback stabilisation of a continuous-time, unstable, non minimum phase (NMP) plant with time-delay over an additive Gaussian coloured noise communication channel. By working on a linear setting the infimal SNR for stabilisability is defined as the infimal achievable H2 norm between the channel noise input and the channel signal input. The result gives a guideline in estimating the severity of the fundamental SNR limitation imposed by the plant unstable poles, NMP zeros, time-delay as well as the channel NMP zeros, bandwidth, and channel noise colouring

Minimum Variance Control over a Gaussian Communication Channel

We consider the problem of minimizing the response of a plant output to a stochastic disturbance using a control law that relies on the output of a noisy communication channel. We discuss a lower bound on the performance achievable at a specified terminal time using nonlinear timevarying communication and control strategies, and show that this bound may be achieved using strategies that are linear

Reducing computational time via order reduction of a class of reaction–diffusion systems

In this paper, we consider a class of reaction– diffusion PDEs. For this class, a suitable state transformation allows conversion to a heat equation together with a lower order PDE set. By giving an explicit solution to the heat equation we are able to obtain a complete solution to the original PDE. By focusing on the computational load, we give a comparison of the pure numerical, analytical/numerical, analytical/approximated, and approximated methods of solving the PDE. In some examples, we note an almost order of magnitude improvement in computational load

A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424

BACKGROUND: Src is involved in cancer invasion and metastasis. AZD0424, an oral inhibitor of Src and ABL1, has shown evidence of anti-tumour activity in pre-clinical studies. METHODS: A phase Ia, dose escalation study was performed to assess the safety of continuous oral dosing with AZD0424 in advanced solid tumours. Secondary objectives included investigation of AZD0424 pharmacokinetics, effect on Src activity using markers of bone turnover, and anti-tumour activity. RESULTS: 41 patients were treated; 34 received AZD0424 once-daily at doses ranging from 5 mg to 150 mg, and 7 received 40 mg bi-daily 41.5% of patients experienced at least one AZD0424-related adverse event that was Grade 3-5 in severity, with patients treated at doses above 60 mg per day experiencing multiple treatment-related toxicities. The most commonly observed AZD0424-related adverse events were nausea, fatigue, anorexia and alopecia. Cmaxand AUC increased linearly with dose and the mean±standard deviation t1/2was 8.4±2.8 h. Clear evidence of Src target inhibition was seen at doses ⩾20 mg per day. No responses were observed and 7 patients (17.1%) achieved stable disease lasting 6 weeks or more. CONCLUSIONS: AZD0424 displayed no evidence of efficacy as monotherapy despite a clear pharmacodynamic effect. Further evaluation of AZD0424 monotherapy in patients with solid tumours is not recommended

Scaling and self-averaging in the three-dimensional random-field Ising model

We investigate, by means of extensive Monte Carlo simulations, the magnetic critical behavior of the three-dimensional bimodal random-field Ising model at the strong disorder regime. We present results in favor of the two-exponent scaling scenario, $\bar{\eta}=2\eta$, where $\eta$ and $\bar{\eta}$ are the critical exponents describing the power-law decay of the connected and disconnected correlation functions and we illustrate, using various finite-size measures and properly defined noise to signal ratios, the strong violation of self-averaging of the model in the ordered phase.Comment: 8 pages, 6 figures, to be published in Eur. Phys. J.

Observation of a new chi_b state in radiative transitions to Upsilon(1S) and Upsilon(2S) at ATLAS

The chi_b(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb^-1, these states are reconstructed through their radiative decays to Upsilon(1S,2S) with Upsilon->mu+mu-. In addition to the mass peaks corresponding to the decay modes chi_b(1P,2P)->Upsilon(1S)gamma, a new structure centered at a mass of 10.530+/-0.005 (stat.)+/-0.009 (syst.) GeV is also observed, in both the Upsilon(1S)gamma and Upsilon(2S)gamma decay modes. This is interpreted as the chi_b(3P) system.Comment: 5 pages plus author list (18 pages total), 2 figures, 1 table, corrected author list, matches final version in Physical Review Letter

Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS

We present the results of a search for new, heavy particles that decay at a significant distance from their production point into a final state containing charged hadrons in association with a high-momentum muon. The search is conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS detector operating at the Large Hadron Collider. Production of such particles is expected in various scenarios of physics beyond the standard model. We observe no signal and place limits on the production cross-section of supersymmetric particles in an R-parity-violating scenario as a function of the neutralino lifetime. Limits are presented for different squark and neutralino masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final version to appear in Physics Letters